-
1
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang J, Yang PL, Gray NS: Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009;9:28-39.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
2
-
-
40549123675
-
Current in vitro kinase assay technologies: The quest for a universal format
-
Jia Y, Quinn CM, Kwak S, Talanian RV: Current in vitro kinase assay technologies: the quest for a universal format. Curr Drug Discov Technol 2008;5:59-69.
-
(2008)
Curr Drug Discov Technol
, vol.5
, pp. 59-69
-
-
Jia, Y.1
Quinn, C.M.2
Kwak, S.3
Talanian, R.V.4
-
3
-
-
67349233597
-
Evaluating the utility of the HTRF Transcreener ADP assay technology: A comparison with the standard HTRF assay technology
-
Hong L, Quinn CM, Jia Y: Evaluating the utility of the HTRF Transcreener ADP assay technology: a comparison with the standard HTRF assay technology. Anal Biochem 2009;391:31-38.
-
(2009)
Anal Biochem
, vol.391
, pp. 31-38
-
-
Hong, L.1
Quinn, C.M.2
Jia, Y.3
-
4
-
-
0013223828
-
A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases
-
Rodems SM, Hamman BD, Lin C, Zhao J, Shah S, Heidary D, et al.: A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases. Assay Drug Dev Technol 2002;1:9-19.
-
(2002)
Assay Drug Dev Technol
, vol.1
, pp. 9-19
-
-
Rodems, S.M.1
Hamman, B.D.2
Lin, C.3
Zhao, J.4
Shah, S.5
Heidary, D.6
-
6
-
-
64349092077
-
A Basis for reduced chemical library inhibition of firefl y luciferase obtained from directed evolution
-
Auld DS, Zhang Y-Q, Southall NT, Rai G, Landsman M, Maclure J, et al.: A Basis for reduced chemical library inhibition of firefl y luciferase obtained from directed evolution. J Med Chem 2009;52:1450-1458.
-
(2009)
J Med Chem
, vol.52
, pp. 1450-1458
-
-
Auld, D.S.1
Zhang, Y.-Q.2
Southall, N.T.3
Rai, G.4
Landsman, M.5
MacLure, J.6
-
7
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, et al.: NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002;277:16639-16647.
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
-
8
-
-
0024336627
-
Purification and characterisation of bovine brain protein kinase C isotypes alpha, beta and gamma
-
Marais RM, Parker PJ: Purification and characterisation of bovine brain protein kinase C isotypes alpha, beta and gamma. Eur J Biochem 1989;182:129-137.
-
(1989)
Eur J Biochem
, vol.182
, pp. 129-137
-
-
Marais, R.M.1
Parker, P.J.2
-
9
-
-
0029899904
-
The major catalytic subunit isoforms of cAMPdependent protein kinase have distinct biochemical properties in vitro and in vivo
-
Gamm DM, Baude EJ, Uhler MD: The major catalytic subunit isoforms of cAMPdependent protein kinase have distinct biochemical properties in vitro and in vivo. J Biol Chem 1996;271:15736-15742.
-
(1996)
J Biol Chem
, vol.271
, pp. 15736-15742
-
-
Gamm, D.M.1
Baude, E.J.2
Uhler, M.D.3
-
10
-
-
3843135141
-
Isoformspecific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
-
Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, et al.: Isoformspecific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem 2004;12:4749-4759.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 4749-4759
-
-
Knight, Z.A.1
Chiang, G.G.2
Alaimo, P.J.3
Kenski, D.M.4
Ho, C.B.5
Coan, K.6
-
11
-
-
0029559182
-
Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions
-
Boerner RJ, Barker SC, Knight WB: Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions. Biochemistry 1995;34:16419-16423.
-
(1995)
Biochemistry
, vol.34
, pp. 16419-16423
-
-
Boerner, R.J.1
Barker, S.C.2
Knight, W.B.3
-
12
-
-
0029895645
-
Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system
-
Isakov N, Wange RL, Watts JD, Aebersold R, Samelson LE: Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system. J Biol Chem 1996;271:15753-15761.
-
(1996)
J Biol Chem
, vol.271
, pp. 15753-15761
-
-
Isakov, N.1
Wange, R.L.2
Watts, J.D.3
Aebersold, R.4
Samelson, L.E.5
-
13
-
-
24944497371
-
Features of selective kinase inhibitors
-
Knight ZA, Shokat KM: Features of selective kinase inhibitors. Chem Biol 2005;12:621-637.
-
(2005)
Chem Biol
, vol.12
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
14
-
-
19944433628
-
Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors
-
Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE, et al.: Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J 2005;385:399-408.
-
(2005)
Biochem J
, vol.385
, pp. 399-408
-
-
Barnett, S.F.1
Defeo-Jones, D.2
Fu, S.3
Hancock, P.J.4
Haskell, K.M.5
Jones, R.E.6
-
15
-
-
0030884527
-
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
-
Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, et al.: Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 1997;326(Pt 1):139-147.
-
(1997)
Biochem J
, vol.326
, Issue.PART 1
, pp. 139-147
-
-
Domin, J.1
Pages, F.2
Volinia, S.3
Rittenhouse, S.E.4
Zvelebil, M.J.5
Stein, R.C.6
-
16
-
-
0029788103
-
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
-
Latour S, Chow LM, Veillette A: Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem 1996;271:22782-22790.
-
(1996)
J Biol Chem
, vol.271
, pp. 22782-22790
-
-
Latour, S.1
Chow, L.M.2
Veillette, A.3
-
17
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang JH, Chung TD, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999;4:67-73.
-
(1999)
J Biomol Screen
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
18
-
-
33947178455
-
Gold nanoparticle-based electrochemical detection of protein phosphorylation
-
DOI 10.1016/j.aca.2007.02.001, PII S0003267007002735
-
Kerman K, Chikae M, Yamamura S, Tamiya E: Gold nanoparticle-based electrochemical detection of protein phosphorylation. Anal Chim Acta 2007;588:26-33. (Pubitemid 46402910)
-
(2007)
Analytica Chimica Acta
, vol.588
, Issue.1
, pp. 26-33
-
-
Kerman, K.1
Chikae, M.2
Yamamura, S.3
Tamiya, E.4
-
19
-
-
5644297083
-
The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: Implications for the design of selective inhibitors
-
Jin L, Pluskey S, Petrella EC, Cantin SM, Gorga JC, Rynkiewicz MJ, et al.: The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors. J Biol Chem 2004;279:42818-42825.
-
(2004)
J Biol Chem
, vol.279
, pp. 42818-42825
-
-
Jin, L.1
Pluskey, S.2
Petrella, E.C.3
Cantin, S.M.4
Gorga, J.C.5
Rynkiewicz, M.J.6
-
20
-
-
36448945847
-
Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase
-
Kast R, Schirok H, Figueroa-Perez S, Mittendorf J, Gnoth MJ, Apeler H, et al.: Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br J Pharmacol 2007;152:1070-1080.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1070-1080
-
-
Kast, R.1
Schirok, H.2
Figueroa-Perez, S.3
Mittendorf, J.4
Gnoth, M.J.5
Apeler, H.6
-
21
-
-
20144388779
-
Discovery of 2, 3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
-
Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, et al.: Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorg Med Chem Lett 2005;15:905-909.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 905-909
-
-
Zhao, Z.1
Leister, W.H.2
Robinson, R.G.3
Barnett, S.F.4
Defeo-Jones, D.5
Jones, R.E.6
-
22
-
-
58149385489
-
Expression and Purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay
-
Boldyreff B, Rasmussen TL, Jensen HH, Cloutier A, Beaudet L, Roby P, et al.: Expression and Purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay. J Biomol Screen 2008;13:1035-1040.
-
(2008)
J Biomol Screen
, vol.13
, pp. 1035-1040
-
-
Boldyreff, B.1
Rasmussen, T.L.2
Jensen, H.H.3
Cloutier, A.4
Beaudet, L.5
Roby, P.6
-
23
-
-
0024394417
-
Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases
-
Ruegg UT, Burgess GM: Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci 1989;10:218-220.
-
(1989)
Trends Pharmacol Sci
, vol.10
, pp. 218-220
-
-
Ruegg, U.T.1
Burgess, G.M.2
-
24
-
-
0031574365
-
Staurosporineinduced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential
-
Prade L, Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D: Staurosporineinduced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Structure 1997;5:1627-1637.
-
(1997)
Structure
, vol.5
, pp. 1627-1637
-
-
Prade, L.1
Engh, R.A.2
Girod, A.3
Kinzel, V.4
Huber, R.5
Bossemeyer, D.6
-
25
-
-
0038536296
-
A versatile high-throughput screen for inhibitors of lipid kinase activity: Development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma
-
Fuchikami K, Togame H, Sagara A, Satoh T, Gantner F, Bacon KB, et al.: A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma. J Biomol Screen 2002;7:441-450.
-
(2002)
J Biomol Screen
, vol.7
, pp. 441-450
-
-
Fuchikami, K.1
Togame, H.2
Sagara, A.3
Satoh, T.4
Gantner, F.5
Bacon, K.B.6
-
26
-
-
0033634827
-
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
-
Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, et al.: Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 2000;6:909-919.
-
(2000)
Mol Cell
, vol.6
, pp. 909-919
-
-
Walker, E.H.1
Pacold, M.E.2
Perisic, O.3
Stephens, L.4
Hawkins, P.T.5
Wymann, M.P.6
-
27
-
-
0029965452
-
Wortmannin inactivates phosphoinositide 3-kinase by covalent modifi cation of Lys-802, a residue involved in the phosphate transfer reaction
-
Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, et al.: Wortmannin inactivates phosphoinositide 3-kinase by covalent modifi cation of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 1996;16:1722-1733.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1722-1733
-
-
Wymann, M.P.1
Bulgarelli-Leva, G.2
Zvelebil, M.J.3
Pirola, L.4
Vanhaesebroeck, B.5
Waterfield, M.D.6
|