NMR analysis of G-protein βγ subunit complexes reveals a dynamic Gα-Gβγ subunit interface and multiple protein recognition modes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 639-644

  Smrcka, Alan V ^a,b   Kichika, Nessim ^a   Tarragó, Teresa ^a   Burroughs, Michael ^b   Park, Min Sun ^b   Itoga, Nathan K ^c   Stern, Harry A ^b   Willardson, Barry M ^c   Giralt, Ernest ^a,d  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b UNIVERSITY OF ROCHESTER   (United States)

^c Brigham Young University   (United States)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Beta gamma subunits; Clam shell; Hot spots; Molecular recognition; Subunit interactions

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;

ARTICLE; BINDING SITE; ISOTOPE LABELING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NITROGEN ISOTOPES; PEPTIDES; PROTEIN CONFORMATION; PROTEIN SUBUNITS; QUANTUM THEORY; TRYPTOPHAN;

BIVALVIA; HEXAPODA;

EID: 76249115582     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909503107     Document Type: Article

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