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Volumn 70, Issue 3, 2010, Pages 1090-1100

FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FK 506 BINDING PROTEIN; FULVESTRANT; SERINE; TAMOXIFEN;

EID: 76249098981     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2515     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 33746639733 scopus 로고    scopus 로고
    • Biologic basis of sequential and combination therapies for hormone-responsive breast cancer
    • Pietras RJ. Biologic basis of sequential and combination therapies for hormone-responsive breast cancer. Oncologist 2006;11:704-17.
    • (2006) Oncologist , vol.11 , pp. 704-717
    • Pietras, R.J.1
  • 2
    • 0034751220 scopus 로고    scopus 로고
    • Estrogen receptor and breast cancer
    • Sommer S, Fuqua SA. Estrogen receptor and breast cancer. Semin Cancer Biol 2001;11:339-52.
    • (2001) Semin Cancer Biol , vol.11 , pp. 339-352
    • Sommer, S.1    Fuqua, S.A.2
  • 3
    • 0036051896 scopus 로고    scopus 로고
    • Evolving uses of hormonal agents for breast cancer therapy
    • Cummings FJ. Evolving uses of hormonal agents for breast cancer therapy. Clin Ther 2002;24 Suppl C:C3-25.
    • (2002) Clin Ther , vol.24 , Issue.SUPPL. C
    • Cummings, F.J.1
  • 4
    • 0031778177 scopus 로고    scopus 로고
    • Basic guide to the mechanisms of antiestrogen action
    • MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 1998;50:151-96.
    • (1998) Pharmacol Rev , vol.50 , pp. 151-196
    • MacGregor, J.I.1    Jordan, V.C.2
  • 6
    • 30344479480 scopus 로고    scopus 로고
    • Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv 2005;5: 343-57.
    • Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv 2005;5: 343-57.
  • 7
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med 1998;339:1609-18.
    • (1998) N Engl J Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 8
    • 0034463079 scopus 로고    scopus 로고
    • Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation
    • Oesterreich S, Zhang Q, Hopp T, et al. Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol Endocrinol 2000;14:369-81.
    • (2000) Mol Endocrinol , vol.14 , pp. 369-381
    • Oesterreich, S.1    Zhang, Q.2    Hopp, T.3
  • 9
    • 0038012730 scopus 로고    scopus 로고
    • Smad4 as a transcription corepressor for estrogen receptor α
    • Wu L, Wu Y, Gathings B, et al. Smad4 as a transcription corepressor for estrogen receptor α. J Biol Chem 2003;278:15192-200.
    • (2003) J Biol Chem , vol.278 , pp. 15192-15200
    • Wu, L.1    Wu, Y.2    Gathings, B.3
  • 10
    • 0032721670 scopus 로고    scopus 로고
    • A novel human stress response-related gene with a potential role in induced radioresistance
    • Robson T, Joiner MC, Wilson GD, et al. A novel human stress response-related gene with a potential role in induced radioresistance. Radiat Res 1999;152:451-61.
    • (1999) Radiat Res , vol.152 , pp. 451-461
    • Robson, T.1    Joiner, M.C.2    Wilson, G.D.3
  • 11
    • 0034128724 scopus 로고    scopus 로고
    • Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: Implications for induced radioresistance
    • Robson T, Price ME, Moore ML, et al. Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. Int J Radiat Biol 2000;76: 617-23.
    • (2000) Int J Radiat Biol , vol.76 , pp. 617-623
    • Robson, T.1    Price, M.E.2    Moore, M.L.3
  • 12
    • 0030050335 scopus 로고    scopus 로고
    • Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding
    • Ratajczak T, Carrello A. Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding. J Biol Chem 1996;271:2961-5.
    • (1996) J Biol Chem , vol.271 , pp. 2961-2965
    • Ratajczak, T.1    Carrello, A.2
  • 13
    • 12344249855 scopus 로고    scopus 로고
    • Regulation of p21 (WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein
    • Jascur T, Brickner H, Salles-Passador I, et al. Regulation of p21 (WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. Mol Cell 2005;17:237-49.
    • (2005) Mol Cell , vol.17 , pp. 237-249
    • Jascur, T.1    Brickner, H.2    Salles-Passador, I.3
  • 14
    • 54349110735 scopus 로고    scopus 로고
    • Effect of WISp39 on proliferation, cell cycle and apoptosis of U937 cells
    • Li YY, Liu LQ, Yang J, et al. Effect of WISp39 on proliferation, cell cycle and apoptosis of U937 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007;15:733-7.
    • (2007) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.15 , pp. 733-737
    • Li, Y.Y.1    Liu, L.Q.2    Yang, J.3
  • 15
    • 54349084788 scopus 로고    scopus 로고
    • A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling
    • McKeen HD, McAlpine K, Valentine A, et al. A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. Endocrinology 2008;149:5724-34.
    • (2008) Endocrinology , vol.149 , pp. 5724-5734
    • McKeen, H.D.1    McAlpine, K.2    Valentine, A.3
  • 16
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein
    • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein. Endocr Rev 1997;18:306-60.
    • (1997) Endocr Rev , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 17
    • 0033490140 scopus 로고    scopus 로고
    • Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer
    • Ward BK, Mark PJ, Ingram DM, Minchin RF, Ratajczak T. Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. Breast Cancer Res Treat 1999;58: 267-80.
    • (1999) Breast Cancer Res Treat , vol.58 , pp. 267-280
    • Ward, B.K.1    Mark, P.J.2    Ingram, D.M.3    Minchin, R.F.4    Ratajczak, T.5
  • 18
    • 0034809942 scopus 로고    scopus 로고
    • Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells
    • Kumar P, Mark PJ, Ward BK, Minchin RF, Ratajczak T. Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. Biochem Biophys Res Commun 2001;284:219-25.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 219-225
    • Kumar, P.1    Mark, P.J.2    Ward, B.K.3    Minchin, R.F.4    Ratajczak, T.5
  • 19
    • 63149192776 scopus 로고    scopus 로고
    • Pharmacologic unmasking of epigenetically silenced genes in breast cancer
    • Ostrow KL, Park HL, Hoque MO, et al. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res 2009;15:1184-91.
    • (2009) Clin Cancer Res , vol.15 , pp. 1184-1191
    • Ostrow, K.L.1    Park, H.L.2    Hoque, M.O.3
  • 20
    • 18144405740 scopus 로고    scopus 로고
    • Estrogen receptor α and β subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells
    • Gougelet A, Bouclier C, Marsaud V, et al. Estrogen receptor α and β subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells. J Steroid Biochem Mol Biol 2005;94:71-81.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 71-81
    • Gougelet, A.1    Bouclier, C.2    Marsaud, V.3
  • 21
    • 0032915424 scopus 로고    scopus 로고
    • Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction
    • Knoblauch R, Garabedian MJ. Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol 1999; 19:3748-59.
    • (1999) Mol Cell Biol , vol.19 , pp. 3748-3759
    • Knoblauch, R.1    Garabedian, M.J.2
  • 22
    • 33745821260 scopus 로고    scopus 로고
    • The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion
    • Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol 2006;26:5205-13.
    • (2006) Mol Cell Biol , vol.26 , pp. 5205-5213
    • Oxelmark, E.1    Roth, J.M.2    Brooks, P.C.3    Braunstein, S.E.4    Schneider, R.J.5    Garabedian, M.J.6
  • 24
    • 38549141939 scopus 로고    scopus 로고
    • Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    • Iorns E, Turner NC, Elliott R, et al. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. Cancer Cell 2008;13:91-104.
    • (2008) Cancer Cell , vol.13 , pp. 91-104
    • Iorns, E.1    Turner, N.C.2    Elliott, R.3
  • 25
    • 59149083664 scopus 로고    scopus 로고
    • Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions
    • Wen J, Li R, Lu Y, Shupnik MA, et al. Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions. Oncogene 2009;28:575-86.
    • (2009) Oncogene , vol.28 , pp. 575-586
    • Wen, J.1    Li, R.2    Lu, Y.3    Shupnik, M.A.4
  • 26
    • 34250652449 scopus 로고    scopus 로고
    • Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
    • Desmedt C, Piette F, Loi S, et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 2007;13:3207-14.
    • (2007) Clin Cancer Res , vol.13 , pp. 3207-3214
    • Desmedt, C.1    Piette, F.2    Loi, S.3
  • 27
    • 13844310310 scopus 로고    scopus 로고
    • Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    • Wang Y, Klijn JG, Zhang Y, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005;365:671-9.
    • (2005) Lancet , vol.365 , pp. 671-679
    • Wang, Y.1    Klijn, J.G.2    Zhang, Y.3
  • 28
    • 44949121510 scopus 로고    scopus 로고
    • Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen
    • Loi S, Haibe-Kains B, Desmedt C, et al. Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics 2008;9:239.
    • (2008) BMC Genomics , vol.9 , pp. 239
    • Loi, S.1    Haibe-Kains, B.2    Desmedt, C.3
  • 29
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
    • Sotiriou C, Wirapati P, Loi S, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 2006;98:262-72.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 262-272
    • Sotiriou, C.1    Wirapati, P.2    Loi, S.3
  • 30
    • 2942578063 scopus 로고    scopus 로고
    • A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    • Ma XJ, Wang Z, Ryan PD, et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 2004;5:607-16.
    • (2004) Cancer Cell , vol.5 , pp. 607-616
    • Ma, X.J.1    Wang, Z.2    Ryan, P.D.3
  • 31
    • 33750336243 scopus 로고    scopus 로고
    • Multiplatform genome-wide identification and modeling of functional human estrogen receptor binding sites
    • Vega VB, Lin CY, Lai KS, et al. Multiplatform genome-wide identification and modeling of functional human estrogen receptor binding sites. Genome Biol 2006;7:R82.
    • (2006) Genome Biol , vol.7
    • Vega, V.B.1    Lin, C.Y.2    Lai, K.S.3
  • 32
    • 38349137676 scopus 로고    scopus 로고
    • Tamoxifen-stimulated growth of breast cancer due to p21 loss
    • Abukhdeir AM, Vitolo MI, Argani P, et al. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A 2008;105:288-93.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 288-293
    • Abukhdeir, A.M.1    Vitolo, M.I.2    Argani, P.3
  • 33
    • 0021327660 scopus 로고
    • Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density shift technique
    • Eckert RL, Mullick A, Rorke EA, Katzenellenbogen BS. Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density shift technique. Endocrinology 1984;114:629-37.
    • (1984) Endocrinology , vol.114 , pp. 629-637
    • Eckert, R.L.1    Mullick, A.2    Rorke, E.A.3    Katzenellenbogen, B.S.4
  • 34
    • 0022998095 scopus 로고
    • Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo
    • Nardulli AM, Katzenellenbogen BS. Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo. Endocrinology 1986;119:2038-46.
    • (1986) Endocrinology , vol.119 , pp. 2038-2046
    • Nardulli, A.M.1    Katzenellenbogen, B.S.2
  • 35
    • 19944428232 scopus 로고    scopus 로고
    • Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor
    • Tateishi Y, Kawabe Y, Chiba T, et al. Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J 2004;23:4813-23.
    • (2004) EMBO J , vol.23 , pp. 4813-4823
    • Tateishi, Y.1    Kawabe, Y.2    Chiba, T.3
  • 36
    • 28144439277 scopus 로고    scopus 로고
    • CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-α
    • Fan M, Park A, Nephew KP. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-α. Mol Endocrinol 2005;19:2901-14.
    • (2005) Mol Endocrinol , vol.19 , pp. 2901-2914
    • Fan, M.1    Park, A.2    Nephew, K.P.3
  • 37
    • 0033013126 scopus 로고    scopus 로고
    • Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
    • Ballinger CA, Connell P, Wu Y, et al. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 1999;19:4535-45.
    • (1999) Mol Cell Biol , vol.19 , pp. 4535-4545
    • Ballinger, C.A.1    Connell, P.2    Wu, Y.3
  • 38
    • 4544233003 scopus 로고    scopus 로고
    • Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice
    • Golden T, Aragon IV, Zhou G, Cooper SR, Dean NM, Honkanen RE. Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. Cancer Lett 2004;215:95-100.
    • (2004) Cancer Lett , vol.215 , pp. 95-100
    • Golden, T.1    Aragon, I.V.2    Zhou, G.3    Cooper, S.R.4    Dean, N.M.5    Honkanen, R.E.6
  • 39
    • 33744532403 scopus 로고    scopus 로고
    • Estrogen receptor-α binds p53 tumor suppressor protein directly and represses its function
    • Liu W, Konduri SD, Bansal S, et al. Estrogen receptor-α binds p53 tumor suppressor protein directly and represses its function. J Biol Chem 2006;281:9837-40.
    • (2006) J Biol Chem , vol.281 , pp. 9837-9840
    • Liu, W.1    Konduri, S.D.2    Bansal, S.3
  • 40
    • 33645825183 scopus 로고    scopus 로고
    • Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer
    • Ein-Dor L, Zuk O, Domany E. Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer. Proc Natl Acad Sci U S A 2006;103:5923-5928.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5923-5928
    • Ein-Dor, L.1    Zuk, O.2    Domany, E.3
  • 41
    • 33646546654 scopus 로고    scopus 로고
    • Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer
    • Han W, Han MR, Kang JJ, et al. Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer. BMC Cancer 2006;6:92.
    • (2006) BMC Cancer , vol.6 , pp. 92
    • Han, W.1    Han, M.R.2    Kang, J.J.3
  • 42
    • 33846827373 scopus 로고    scopus 로고
    • Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models
    • Kuske B, Naughton C, Moore K, et al. Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models. Endocr Relat Cancer 2006;13:1121-33.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1121-1133
    • Kuske, B.1    Naughton, C.2    Moore, K.3
  • 43
    • 0035315762 scopus 로고    scopus 로고
    • Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors
    • Gaci Z, Bouin-Pineau MH, Gaci M, Daban A, Ingrand P, Metaye T. Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors. Int J Oncol 2001;18:793-800.
    • (2001) Int J Oncol , vol.18 , pp. 793-800
    • Gaci, Z.1    Bouin-Pineau, M.H.2    Gaci, M.3    Daban, A.4    Ingrand, P.5    Metaye, T.6
  • 44
    • 22944451470 scopus 로고    scopus 로고
    • Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer
    • Rodriguez J, Vazquez J, Corte MD, et al. Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer. Int J Biol Markers 2005;20:103-11.
    • (2005) Int J Biol Markers , vol.20 , pp. 103-111
    • Rodriguez, J.1    Vazquez, J.2    Corte, M.D.3
  • 45
  • 46
    • 24044525270 scopus 로고    scopus 로고
    • c-myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells
    • Mukherjee S, Conrad SE. c-myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells. J Biol Chem 2005;280:17617-25.
    • (2005) J Biol Chem , vol.280 , pp. 17617-17625
    • Mukherjee, S.1    Conrad, S.E.2
  • 47
    • 33645234316 scopus 로고    scopus 로고
    • Bidirectional cross talk between ERα and EGFR signalling pathways regulates tamoxifen-resistant growth
    • Britton DJ, Hutcheson IR, Knowlden JM, et al. Bidirectional cross talk between ERα and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat 2006;96:131-46.
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 131-146
    • Britton, D.J.1    Hutcheson, I.R.2    Knowlden, J.M.3
  • 48
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand PA, Miksicek RJ, Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-83.
    • (1996) EMBO J , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.A.2    Miksicek, R.J.3    Picard, D.4
  • 49
    • 33751101625 scopus 로고    scopus 로고
    • Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression
    • Sarwar N, Kim JS, Jiang J, et al. Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression. Endocr Relat Cancer 2006;13:851-61.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 851-861
    • Sarwar, N.1    Kim, J.S.2    Jiang, J.3
  • 50
    • 4444324186 scopus 로고    scopus 로고
    • Phospho-serine-118 estrogen receptor-α expression is associated with better disease outcome in women treated with tamoxifen
    • Murphy LC, Niu Y, Snell L, Watson P. Phospho-serine-118 estrogen receptor-α expression is associated with better disease outcome in women treated with tamoxifen. Clin Cancer Res 2004;10: 5902-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 5902-5906
    • Murphy, L.C.1    Niu, Y.2    Snell, L.3    Watson, P.4


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