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Volumn 11, Issue 7, 2006, Pages 707-717

Biologic basis of sequential and combination therapies for hormone-responsive breast cancer

Author keywords

AKT kinase signaling; Aromatase inhibitors; Estrogen receptors; Fulvestrant; Growth factors; MAP kinase signaling pathway Genes, HER 2

Indexed keywords

ANASTROZOLE; ANTIESTROGEN; AROMATASE INHIBITOR; BEVACIZUMAB; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; ESTROGEN RECEPTOR; EXEMESTANE; FORMESTANE; FULVESTRANT; GEFITINIB; LAPATINIB; LETROZOLE; LONAFARNIB; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; RALOXIFENE; SORAFENIB; TAMOXIFEN; TAMOXIFEN CITRATE; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; VASCULOTROPIN RECEPTOR;

EID: 33746639733     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.11-7-704     Document Type: Review
Times cited : (42)

References (102)
  • 1
    • 2142652244 scopus 로고    scopus 로고
    • Therapeutic targeting in the estrogen receptor hormonal pathway
    • Katzenellenbogen BS, Frasor J. Therapeutic targeting in the estrogen receptor hormonal pathway. Semin Oncol 2004;31(suppl 3):28-38.
    • (2004) Semin Oncol , vol.31 , Issue.3 SUPPL. , pp. 28-38
    • Katzenellenbogen, B.S.1    Frasor, J.2
  • 2
    • 0029870691 scopus 로고    scopus 로고
    • Oestrogen and progesterone receptors as prognostic variables in hormonally treated breast cancer
    • Robertson JFR, Cannon PM, Nicholson RI et al. Oestrogen and progesterone receptors as prognostic variables in hormonally treated breast cancer. Int J Biol Markers 1996;11:29-35.
    • (1996) Int J Biol Markers , vol.11 , pp. 29-35
    • Robertson, J.F.R.1    Cannon, P.M.2    Nicholson, R.I.3
  • 3
    • 0026557343 scopus 로고
    • Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 Randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women
    • Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 1992;339:71-85.
    • (1992) Lancet , vol.339 , pp. 71-85
  • 4
    • 0037240178 scopus 로고    scopus 로고
    • Endocrine therapy of advanced disease: Analysis and implications of the existing data
    • Pritchard KI. Endocrine therapy of advanced disease: analysis and implications of the existing data. Clin Cancer Res 2003;9:460S-467S.
    • (2003) Clin Cancer Res , vol.9
    • Pritchard, K.I.1
  • 5
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365:1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 6
    • 10744233578 scopus 로고    scopus 로고
    • Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status
    • Ellis MJ, Coop A, Singh B et al. Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status. Cancer Res 2003;63:6523-6531.
    • (2003) Cancer Res , vol.63 , pp. 6523-6531
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 7
    • 0032191125 scopus 로고    scopus 로고
    • Steroidal and nonsteroidal oestrogen antagonists in breast cancer: Basic and clinical appraisal
    • Favoni RE, de Cupis A. Steroidal and nonsteroidal oestrogen antagonists in breast cancer: basic and clinical appraisal. Trends Pharmacol Sci 1998;19:406-415.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 406-415
    • Favoni, R.E.1    De Cupis, A.2
  • 8
    • 0029566969 scopus 로고
    • Mechanisms of action of endocrine treatment in breast cancer
    • Lønning PE, Lien EA. Mechanisms of action of endocrine treatment in breast cancer. Crit Rev Oncol Hematol 1995;21:158-193.
    • (1995) Crit Rev Oncol Hematol , vol.21 , pp. 158-193
    • Lønning, P.E.1    Lien, E.A.2
  • 9
    • 0036892182 scopus 로고    scopus 로고
    • Estrogen receptor a and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells
    • Petz LN, Ziegler YS, Loven MA et al. Estrogen receptor a and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology 2002;143:4583-4591.
    • (2002) Endocrinology , vol.143 , pp. 4583-4591
    • Petz, L.N.1    Ziegler, Y.S.2    Loven, M.A.3
  • 11
    • 0242499440 scopus 로고    scopus 로고
    • Aromatase inhibitors for breast cancer: Lessons from the laboratory
    • Johnston SRD, Dowsett M. Aromatase inhibitors for breast cancer: lessons from the laboratory. Nat Rev Cancer 2003;3:821-831.
    • (2003) Nat Rev Cancer , vol.3 , pp. 821-831
    • Johnston, S.R.D.1    Dowsett, M.2
  • 12
    • 0022653964 scopus 로고
    • Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
    • Green S, Walter P, Kumar V et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986;320:134-139.
    • (1986) Nature , vol.320 , pp. 134-139
    • Green, S.1    Walter, P.2    Kumar, V.3
  • 13
    • 0026018572 scopus 로고
    • Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene
    • Keaveney M, Klug J, Dawson MT et al. Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene. J Mol Endocrinol 1991;6:111-115.
    • (1991) J Mol Endocrinol , vol.6 , pp. 111-115
    • Keaveney, M.1    Klug, J.2    Dawson, M.T.3
  • 14
    • 0027431263 scopus 로고
    • Sequencing of an RNA transcript of the human estrogen receptor gene: Evidence for a new transcriptional event
    • Piva R, Bianchi N, Aguiari GL et al. Sequencing of an RNA transcript of the human estrogen receptor gene: evidence for a new transcriptional event. J Steroid Biochem Mol Biol 1993;46:531-538.
    • (1993) J Steroid Biochem Mol Biol , vol.46 , pp. 531-538
    • Piva, R.1    Bianchi, N.2    Aguiari, G.L.3
  • 15
    • 0034828996 scopus 로고    scopus 로고
    • Suppression by estrogen receptor beta of AP-1 mediated transactivation through estrogen receptor alpha
    • Maruyama S, Fujimoto N, Asano K et al. Suppression by estrogen receptor beta of AP-1 mediated transactivation through estrogen receptor alpha. J Steroid Biochem Mol Biol 2001;78:177-184.
    • (2001) J Steroid Biochem Mol Biol , vol.78 , pp. 177-184
    • Maruyama, S.1    Fujimoto, N.2    Asano, K.3
  • 16
    • 0031024808 scopus 로고    scopus 로고
    • A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers
    • Tang Z, Treilleux I, Brown M. A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers. Mol Cell Biol 1997;17:1274-1280.
    • (1997) Mol Cell Biol , vol.17 , pp. 1274-1280
    • Tang, Z.1    Treilleux, I.2    Brown, M.3
  • 17
    • 0032920661 scopus 로고    scopus 로고
    • Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells
    • Daschner PJ, Ciolino HP, Plouzek CA et al. Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells. Breast Cancer Res Treat 1999;53:229-240.
    • (1999) Breast Cancer Res Treat , vol.53 , pp. 229-240
    • Daschner, P.J.1    Ciolino, H.P.2    Plouzek, C.A.3
  • 18
    • 0031561119 scopus 로고    scopus 로고
    • Agonistic effects of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: Functional difference between estrogen receptors alpha and beta
    • Watanabe T, Inoue S, Ogawa S et al. Agonistic effects of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: functional difference between estrogen receptors alpha and beta. Biochem Biophys Res Commun 1997;236:140-145.
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 140-145
    • Watanabe, T.1    Inoue, S.2    Ogawa, S.3
  • 19
    • 0029048753 scopus 로고
    • Gynecologic effects of tamoxifen and the association with endometrial carcinoma
    • Assikis VJ, Jordan VC. Gynecologic effects of tamoxifen and the association with endometrial carcinoma. Int J Gynaecol Obstet 1995;49:241-257.
    • (1995) Int J Gynaecol Obstet , vol.49 , pp. 241-257
    • Assikis, V.J.1    Jordan, V.C.2
  • 20
    • 0033870250 scopus 로고    scopus 로고
    • Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling
    • Badia E, Duchesne M-J, Semlali A et al. Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. Cancer Res 2000;60:4130-4138.
    • (2000) Cancer Res , vol.60 , pp. 4130-4138
    • Badia, E.1    Duchesne, M.-J.2    Semlali, A.3
  • 21
    • 10644274482 scopus 로고    scopus 로고
    • Estrogen receptor mutations in human disease
    • Herynk MH, Fuqua SAW. Estrogen receptor mutations in human disease. Endocr Rev 2004;25:869-898.
    • (2004) Endocr Rev , vol.25 , pp. 869-898
    • Herynk, M.H.1    Fuqua, S.A.W.2
  • 22
    • 0037506015 scopus 로고    scopus 로고
    • Estrogen receptor β protein in human breast cancer: Correlation with clinical tumor parameters
    • Fuqua SAW, Schiff R, Parra I et al. Estrogen receptor β protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res 2003;63:2434-2439.
    • (2003) Cancer Res , vol.63 , pp. 2434-2439
    • Fuqua, S.A.W.1    Schiff, R.2    Parra, I.3
  • 23
    • 14544283318 scopus 로고    scopus 로고
    • Expression of estrogen receptor-α and -β, glucocorticoid receptor, and progesterone receptor genes in human embryonic stem cells and embryoid bodies
    • Hong SH, Nah HY, Lee YJ et al. Expression of estrogen receptor-α and -β, glucocorticoid receptor, and progesterone receptor genes in human embryonic stem cells and embryoid bodies. Mol Cells 2004;18:320-325.
    • (2004) Mol Cells , vol.18 , pp. 320-325
    • Hong, S.H.1    Nah, H.Y.2    Lee, Y.J.3
  • 24
    • 3042525924 scopus 로고    scopus 로고
    • Breast cancer, stem/progenitor cells and the estrogen receptor
    • Dontu G, El-Ashry D, Wicha MS. Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab 2004;15:193-197.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 193-197
    • Dontu, G.1    El-Ashry, D.2    Wicha, M.S.3
  • 25
    • 0035900785 scopus 로고    scopus 로고
    • The tamoxifen-responsive estrogen receptor α Mutant D351Y shows reduced tamoxifen-dependent interaction with copressor complexes
    • Yamamoto Y, Wada O, Suzawa M et al. The tamoxifen-responsive estrogen receptor α Mutant D351Y shows reduced tamoxifen-dependent interaction with copressor complexes. J Biol Chem 2001;276:42684-42691.
    • (2001) J Biol Chem , vol.276 , pp. 42684-42691
    • Yamamoto, Y.1    Wada, O.2    Suzawa, M.3
  • 26
    • 0342601412 scopus 로고    scopus 로고
    • The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer
    • Tonetti DA, Jordan VC. The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer. J Steroid Biochem Mol Biol 1997;62:119-128.
    • (1997) J Steroid Biochem Mol Biol , vol.62 , pp. 119-128
    • Tonetti, D.A.1    Jordan, V.C.2
  • 28
    • 0030940071 scopus 로고    scopus 로고
    • An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer
    • Zhang Q-X, Borg A, Wolf DM et al. An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Res 1997;57:1244-1249.
    • (1997) Cancer Res , vol.57 , pp. 1244-1249
    • Zhang, Q.-X.1    Borg, A.2    Wolf, D.M.3
  • 29
    • 0034663421 scopus 로고    scopus 로고
    • ICI 182,780 (Faslodex™): Development of a novel, "pure" antiestrogen
    • Howell A, Osborne CK, Morris C et al. ICI 182,780 (Faslodex™): development of a novel, "pure" antiestrogen. Cancer 2000;89:817-825.
    • (2000) Cancer , vol.89 , pp. 817-825
    • Howell, A.1    Osborne, C.K.2    Morris, C.3
  • 30
    • 0031471007 scopus 로고    scopus 로고
    • Acquired tamoxifen resistance in human breast cancer - Potential mechanisms and clinical implications
    • Johnston SRD. Acquired tamoxifen resistance in human breast cancer - potential mechanisms and clinical implications. Anticancer Drugs 1997;8:911-930.
    • (1997) Anticancer Drugs , vol.8 , pp. 911-930
    • Johnston, S.R.D.1
  • 31
    • 0026639108 scopus 로고
    • Prognostic factors and treatment decisions in axillary-node-negative breast cancer
    • McGuire WL, Clark GM. Prognostic factors and treatment decisions in axillary-node-negative breast cancer. N Engl J Med 1992;326:1756-1761.
    • (1992) N Engl J Med , vol.326 , pp. 1756-1761
    • McGuire, W.L.1    Clark, G.M.2
  • 32
    • 21244444556 scopus 로고    scopus 로고
    • Endocrine responsiveness: Understanding how progesterone receptor can be used to select endocrine therapy
    • Osborne CK, Schiff R, Arpino G et al. Endocrine responsiveness: understanding how progesterone receptor can be used to select endocrine therapy. Breast 2005;14:458-465.
    • (2005) Breast , vol.14 , pp. 458-465
    • Osborne, C.K.1    Schiff, R.2    Arpino, G.3
  • 33
    • 32944457272 scopus 로고    scopus 로고
    • Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: An hypothesis-generating study
    • Dowsett M, Cuzick J, Wale C et al. Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: an hypothesis-generating study. J Clin Oncol 2005;23:7512-7517.
    • (2005) J Clin Oncol , vol.23 , pp. 7512-7517
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3
  • 34
    • 32944482243 scopus 로고    scopus 로고
    • Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
    • Cui X, Schiff R, Arpino G et al. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 2005;23:7721-7735.
    • (2005) J Clin Oncol , vol.23 , pp. 7721-7735
    • Cui, X.1    Schiff, R.2    Arpino, G.3
  • 35
    • 0036862696 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer: An update
    • Lake DE, Hudis C. Aromatase inhibitors in breast cancer: an update. Cancer Control 2002;9:490-498.
    • (2002) Cancer Control , vol.9 , pp. 490-498
    • Lake, D.E.1    Hudis, C.2
  • 36
    • 0036777549 scopus 로고    scopus 로고
    • Sequencing of endocrine therapies in breast cancer-integration of recent data
    • Carlson RW. Sequencing of endocrine therapies in breast cancer-integration of recent data. Breast Cancer Res Treat 2002;75(suppl 1):S27-S32; discussion S33-S35.
    • (2002) Breast Cancer Res Treat , vol.75 , Issue.1 SUPPL.
    • Carlson, R.W.1
  • 37
    • 13244275242 scopus 로고    scopus 로고
    • The choice of systemic adjuvant therapy in receptor-positive early breast cancer
    • Dellapasqua S, Castiglione-Gertsch M. The choice of systemic adjuvant therapy in receptor-positive early breast cancer. Eur J Cancer 2005;41:357-364.
    • (2005) Eur J Cancer , vol.41 , pp. 357-364
    • Dellapasqua, S.1    Castiglione-Gertsch, M.2
  • 38
    • 0028084758 scopus 로고
    • Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer
    • DeFriend DJ, Howell A, Nicholson RI et al. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer. Cancer Res 1994;54:408-414.
    • (1994) Cancer Res , vol.54 , pp. 408-414
    • DeFriend, D.J.1    Howell, A.2    Nicholson, R.I.3
  • 39
    • 10244278009 scopus 로고    scopus 로고
    • Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes
    • McClelland RA, Manning DL, Gee JMM et al. Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes. Breast Cancer Res Treat 1996;41:31-41.
    • (1996) Breast Cancer Res Treat , vol.41 , pp. 31-41
    • McClelland, R.A.1    Manning, D.L.2    Gee, J.M.M.3
  • 40
    • 0037534310 scopus 로고    scopus 로고
    • Studies on the development of resistance to the pure antiestrogen Faslodex™ in three human breast cancer cell lines
    • Sommer A, Hoffmann J, Lichtner RB et al. Studies on the development of resistance to the pure antiestrogen Faslodex™ in three human breast cancer cell lines. Steroid Biochem Mol Biol 2003;85:33-47.
    • (2003) Steroid Biochem Mol Biol , vol.85 , pp. 33-47
    • Sommer, A.1    Hoffmann, J.2    Lichtner, R.B.3
  • 41
    • 1842784776 scopus 로고    scopus 로고
    • Fulvestrant and the sequential endocrine cascade for advanced breast cancer
    • Johnston S. Fulvestrant and the sequential endocrine cascade for advanced breast cancer. Br J Cancer 2004;90(suppl 1):S15-S18.
    • (2004) Br J Cancer , vol.90 , Issue.1 SUPPL.
    • Johnston, S.1
  • 42
    • 33746612280 scopus 로고    scopus 로고
    • Plasma membrane for steroid hormones in cell signaling and nuclear function
    • Melmed S, Conn PM, eds. Totowa, NJ: Humana Press
    • Pietras RJ, Szego CM. Plasma membrane for steroid hormones in cell signaling and nuclear function. In: Melmed S, Conn PM, eds. Endocrinology: Basic and Clinical Principles, Second Edition. Totowa, NJ: Humana Press, 2005:67-84.
    • (2005) Endocrinology: Basic and Clinical Principles, Second Edition , pp. 67-84
    • Pietras, R.J.1    Szego, C.M.2
  • 43
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab 2005;16:273-279.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 273-279
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 44
    • 0028853923 scopus 로고
    • Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells
    • Masamura S, Santner SJ, Heitjan DF et al. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J Clin Endocrinol Metab 1995;80:2918-2925.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2918-2925
    • Masamura, S.1    Santner, S.J.2    Heitjan, D.F.3
  • 45
    • 9144270449 scopus 로고    scopus 로고
    • Adaptive hypersensitivity to estrogen: Mechanism for sequential responses to hormonal therapy in breast cancer
    • Santen RJ, Song RX, Zhang Z et al. Adaptive hypersensitivity to estrogen: mechanism for sequential responses to hormonal therapy in breast cancer. Clin Cancer Res 2004;10:337S-345S.
    • (2004) Clin Cancer Res , vol.10
    • Santen, R.J.1    Song, R.X.2    Zhang, Z.3
  • 46
    • 0035714726 scopus 로고    scopus 로고
    • Adaptive hypersensitivity to estradiol: Potential mechanism for secondary hormonal responses in breast cancer patients
    • Santen R, Jeng MH, Wang JP et al. Adaptive hypersensitivity to estradiol: potential mechanism for secondary hormonal responses in breast cancer patients. J Steroid Biochem Mol Biol 2001;79:115-125.
    • (2001) J Steroid Biochem Mol Biol , vol.79 , pp. 115-125
    • Santen, R.1    Jeng, M.H.2    Wang, J.P.3
  • 48
    • 0037903066 scopus 로고    scopus 로고
    • New approaches to the understanding of tamoxifen action and resistance
    • Berstein LM, Zheng H, Yue W et al. New approaches to the understanding of tamoxifen action and resistance. Endocr Relat Cancer 2003;10:267-277.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 267-277
    • Berstein, L.M.1    Zheng, H.2    Yue, W.3
  • 49
    • 0034464912 scopus 로고    scopus 로고
    • Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo
    • Shim WS, Conaway M, Masamura S et al. Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo. Endocrinology 2000;141:396-405.
    • (2000) Endocrinology , vol.141 , pp. 396-405
    • Shim, W.S.1    Conaway, M.2    Masamura, S.3
  • 50
    • 0028886694 scopus 로고
    • Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
    • Kato S, Endoh H, Masuhiro Y et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-1494.
    • (1995) Science , vol.270 , pp. 1491-1494
    • Kato, S.1    Endoh, H.2    Masuhiro, Y.3
  • 51
    • 0038418382 scopus 로고    scopus 로고
    • Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor α
    • Kinoshita Y, Chen S. Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor α. Cancer Res 2003;63:3546-3555.
    • (2003) Cancer Res , vol.63 , pp. 3546-3555
    • Kinoshita, Y.1    Chen, S.2
  • 52
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand P-A, Miksicek RJ et al. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-2183.
    • (1996) EMBO J , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.-A.2    Miksicek, R.J.3
  • 53
    • 0035721850 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor
    • Marquez DC, Lee J, Lin T et al. Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor. Endocrine 2001;16:73-81.
    • (2001) Endocrine , vol.16 , pp. 73-81
    • Marquez, D.C.1    Lee, J.2    Lin, T.3
  • 54
    • 0033542402 scopus 로고    scopus 로고
    • The protective effects of estrogen on the cardiovascular system
    • Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801-1811.
    • (1999) N Engl J Med , vol.340 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 55
    • 0141455509 scopus 로고    scopus 로고
    • Interactions between estrogen and growth factor receptors in human breast cancers and the tumor-associated vasculature
    • Pietras RJ. Interactions between estrogen and growth factor receptors in human breast cancers and the tumor-associated vasculature. Breast J 2003;9:361-373.
    • (2003) Breast J , vol.9 , pp. 361-373
    • Pietras, R.J.1
  • 56
    • 15544379599 scopus 로고    scopus 로고
    • Estrogen-receptor biology: Continuing progress and therapeutic implications
    • Osborne CK, Schiff R. Estrogen-receptor biology: continuing progress and therapeutic implications. J Clin Oncol 2005;23:1616-1622.
    • (2005) J Clin Oncol , vol.23 , pp. 1616-1622
    • Osborne, C.K.1    Schiff, R.2
  • 57
    • 23744447497 scopus 로고    scopus 로고
    • Integration of the extranuclear and nuclear actions of estrogen
    • Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19:1951-1959.
    • (2005) Mol Endocrinol , vol.19 , pp. 1951-1959
    • Levin, E.R.1
  • 58
    • 0032890051 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Molecular and biological aspects
    • Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 1999;237:1-30.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 1-30
    • Ferrara, N.1
  • 59
    • 0034086611 scopus 로고    scopus 로고
    • Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
    • Hyder SM, Nawaz Z, Chiappetta C et al. Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor. Cancer Res 2000;60:3183-3190.
    • (2000) Cancer Res , vol.60 , pp. 3183-3190
    • Hyder, S.M.1    Nawaz, Z.2    Chiappetta, C.3
  • 60
    • 0033602501 scopus 로고    scopus 로고
    • Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells
    • Ruohola JK, Valve EM, Karkkainen MJ et al. Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol Cell Endocrinol 1999;149:29-40.
    • (1999) Mol Cell Endocrinol , vol.149 , pp. 29-40
    • Ruohola, J.K.1    Valve, E.M.2    Karkkainen, M.J.3
  • 61
    • 23044463773 scopus 로고    scopus 로고
    • Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer
    • Rydén L, Jirström K, Bendahl P-O et al. Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer. J Clin Oncol 2005;23:4695-4704.
    • (2005) J Clin Oncol , vol.23 , pp. 4695-4704
    • Rydén, L.1    Jirström, K.2    Bendahl, P.-O.3
  • 62
    • 0037087535 scopus 로고    scopus 로고
    • Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
    • Lipton A, Ali SM, Leitzel K et al. Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol 2002;20:1467-1472.
    • (2002) J Clin Oncol , vol.20 , pp. 1467-1472
    • Lipton, A.1    Ali, S.M.2    Leitzel, K.3
  • 63
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-1/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-1/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 64
    • 1842830729 scopus 로고    scopus 로고
    • Improved antitumor therapy with Herceptin and Faslodex for dual targeting of HER-2 and estrogen receptor signaling pathways in human breast cancers with overexpression of HER-2/neu gene
    • Pietras RJ, Marquez DC, Chen H-W et al. Improved antitumor therapy with Herceptin and Faslodex for dual targeting of HER-2 and estrogen receptor signaling pathways in human breast cancers with overexpression of HER-2/neu gene. Breast Cancer Res Treat 2003;82(suppl 1):12-13.
    • (2003) Breast Cancer Res Treat , vol.82 , Issue.1 SUPPL. , pp. 12-13
    • Pietras, R.J.1    Marquez, D.C.2    Chen, H.-W.3
  • 65
    • 0028997307 scopus 로고
    • HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells
    • Pietras RJ, Arboleda J, Reese DM et al. HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells. Oncogene 1995;10:2435-2446.
    • (1995) Oncogene , vol.10 , pp. 2435-2446
    • Pietras, R.J.1    Arboleda, J.2    Reese, D.M.3
  • 66
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • Baum M, Buzdar AU, Cuzick J et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002;359:2131-2139.
    • (2002) Lancet , vol.359 , pp. 2131-2139
    • Baum, M.1    Buzdar, A.U.2    Cuzick, J.3
  • 67
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Howell A, Cuzick J, Baum M et al. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 2005;365:60-62.
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3
  • 68
    • 29544433211 scopus 로고    scopus 로고
    • A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer
    • Thürlimann B, Keshaviah A, Coates AS et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med 2005;353:2747-2757.
    • (2005) N Engl J Med , vol.353 , pp. 2747-2757
    • Thürlimann, B.1    Keshaviah, A.2    Coates, A.S.3
  • 69
    • 33845296200 scopus 로고    scopus 로고
    • Central review of ER, PgR and HER-2 in BIG 1-98 evaluating letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer
    • Viale G, Regan M, Dell'Orto P et al. Central review of ER, PgR and HER-2 in BIG 1-98 evaluating letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer. Breast Cancer Res Treat 2005;94(suppl 1):S13.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 SUPPL.
    • Viale, G.1    Regan, M.2    Dell'Orto, P.3
  • 70
    • 33645503063 scopus 로고    scopus 로고
    • Letrozole or tamoxifen in early breast cancer
    • Buzdar AU, Baum M, Cuzick J. Letrozole or tamoxifen in early breast cancer. N Engl J Med 2006;354:1528.
    • (2006) N Engl J Med , vol.354 , pp. 1528
    • Buzdar, A.U.1    Baum, M.2    Cuzick, J.3
  • 71
    • 33645518217 scopus 로고    scopus 로고
    • Letrozole or tamoxifen in early breast cancer
    • Chlebowski RT. Letrozole or tamoxifen in early breast cancer. N Engl J Med 2006;354:1529.
    • (2006) N Engl J Med , vol.354 , pp. 1529
    • Chlebowski, R.T.1
  • 72
    • 33645530354 scopus 로고    scopus 로고
    • Letrozole or tamoxifen in early breast cancer
    • Coates AS, Mouridsen H, Mauriac L et al. Letrozole or tamoxifen in early breast cancer. N Engl J Med 2006;354:1529.
    • (2006) N Engl J Med , vol.354 , pp. 1529
    • Coates, A.S.1    Mouridsen, H.2    Mauriac, L.3
  • 73
    • 33645518217 scopus 로고    scopus 로고
    • Letrozole or tamoxifen in early breast cancer
    • Erban JK. Letrozole or tamoxifen in early breast cancer. N Engl J Med 2006;354:1529.
    • (2006) N Engl J Med , vol.354 , pp. 1529
    • Erban, J.K.1
  • 74
    • 10744223655 scopus 로고    scopus 로고
    • A randomized trial of exemestane after two or three years of tamoxifen therapy in postmenopausal women with primary breast cancer
    • Coombes RC, Hall E, Gibson LJ et al. A randomized trial of exemestane after two or three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med 2004;350:1081-1092.
    • (2004) N Engl J Med , vol.350 , pp. 1081-1092
    • Coombes, R.C.1    Hall, E.2    Gibson, L.J.3
  • 75
    • 24644519961 scopus 로고    scopus 로고
    • Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: Preliminary results of the Italian Tamoxifen Anastrozole Trial
    • Boccardo F, Rubagotti A, Puntoni M et al. Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: preliminary results of the Italian Tamoxifen Anastrozole Trial. J Clin Oncol 2005;23:5138-5147.
    • (2005) J Clin Oncol , vol.23 , pp. 5138-5147
    • Boccardo, F.1    Rubagotti, A.2    Puntoni, M.3
  • 76
    • 14544273687 scopus 로고    scopus 로고
    • Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years of adjuvant tamoxifen: Combined results from 3,123 women enrolled in the ABCSG Trial 8 and the ARNO 95 Trial
    • Jakesz R, Kaufmann M, Gnant M et al. Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years of adjuvant tamoxifen: combined results from 3,123 women enrolled in the ABCSG Trial 8 and the ARNO 95 Trial. Breast Cancer Res Treat 2004;88(suppl 1):S7.
    • (2004) Breast Cancer Res Treat , vol.88 , Issue.1 SUPPL.
    • Jakesz, R.1    Kaufmann, M.2    Gnant, M.3
  • 77
    • 33845348985 scopus 로고    scopus 로고
    • Switching from adjuvant tamoxifen to anastrozole in postmenopausal women with hormone-responsive early breast cancer: A meta-analysis of the ARNO 95 Trial, ABCSG Trial 8, and the ITA Trial
    • Jonat W, Gnant M, Bocccardo F et al. Switching from adjuvant tamoxifen to anastrozole in postmenopausal women with hormone-responsive early breast cancer: a meta-analysis of the ARNO 95 Trial, ABCSG Trial 8, and the ITA Trial. Breast Cancer Res Treat 2005;94(suppl 1):S11.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 SUPPL.
    • Jonat, W.1    Gnant, M.2    Bocccardo, F.3
  • 78
    • 7444259675 scopus 로고    scopus 로고
    • A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    • Goss PE, Ingle JN, Martino S et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 2003;349:1793-1802.
    • (2003) N Engl J Med , vol.349 , pp. 1793-1802
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 79
    • 24744450378 scopus 로고    scopus 로고
    • Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: Updated findings from NCIC CTG MA.17
    • Goss PE, Ingle JN, Martino S et al. Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst 2005;97:1262-1271.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1262-1271
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 80
    • 33845590953 scopus 로고    scopus 로고
    • Updated analysis of NCIC CTG MA.17 (letrozole vs. placebo to letrozole vs placebo) post unblinding
    • Goss PE, Ingle JN, Palmer MJ et al. Updated analysis of NCIC CTG MA.17 (letrozole vs. placebo to letrozole vs placebo) post unblinding. Breast Cancer Res Treat 2005;94(suppl 1):S10.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 SUPPL.
    • Goss, P.E.1    Ingle, J.N.2    Palmer, M.J.3
  • 81
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma. Results of a survival update based on a combined analysis of data from two mature phase III trials
    • Buzdar AU, Jonat W, Howell A et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma. Results of a survival update based on a combined analysis of data from two mature phase III trials. Cancer 1998;83:1142-1152.
    • (1998) Cancer , vol.83 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3
  • 82
    • 0031943424 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor for advanced breast cancer: Double-blind, randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate
    • Dombernowsky P, Smith I, Falkson G et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind, randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol 1998;16:453-461.
    • (1998) J Clin Oncol , vol.16 , pp. 453-461
    • Dombernowsky, P.1    Smith, I.2    Falkson, G.3
  • 83
    • 0034128928 scopus 로고    scopus 로고
    • Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a phase III randomized double-blind trial
    • Kaufmann M, Bajetta E, Dirix LY et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. J Clin Oncol 2000;18:1399-1411.
    • (2000) J Clin Oncol , vol.18 , pp. 1399-1411
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3
  • 84
    • 17144472154 scopus 로고    scopus 로고
    • Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: A phase II trial
    • Lønning PE, Bajetta E, Murray R et al. Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a phase II trial. J Clin Oncol 2000;18:2234-2244.
    • (2000) J Clin Oncol , vol.18 , pp. 2234-2244
    • Lønning, P.E.1    Bajetta, E.2    Murray, R.3
  • 85
    • 0035498544 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma
    • Bonneterre J, Buzdar A, Nabholtz JM et al. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer 2001;92:2247-2258.
    • (2001) Cancer , vol.92 , pp. 2247-2258
    • Bonneterre, J.1    Buzdar, A.2    Nabholtz, J.M.3
  • 86
    • 0343584508 scopus 로고    scopus 로고
    • Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: Results of a phase III study of the International Letrozole Breast Cancer Group
    • Mourisden H, Gershanovich M, Sun Y et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol 2001;19:2596-2606.
    • (2001) J Clin Oncol , vol.19 , pp. 2596-2606
    • Mourisden, H.1    Gershanovich, M.2    Sun, Y.3
  • 87
    • 22244449598 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: A prospectively planned combined survival analysis of two multicenter trials
    • Howell A, Pippen J, Elledge RM et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials. Cancer 2005;104:236-239.
    • (2005) Cancer , vol.104 , pp. 236-239
    • Howell, A.1    Pippen, J.2    Elledge, R.M.3
  • 88
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JFR, Quaresma Albano J et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002;20:3396-3403.
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.R.2    Quaresma Albano, J.3
  • 89
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • Osborne CK, Pippen J, Jones SE et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002;20:3386-3395.
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3
  • 90
    • 0038683988 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: A prospective combined analysis of two multicenter trials
    • Robertson JFR, Osborne CK, Howell A et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 2003;98:229-238.
    • (2003) Cancer , vol.98 , pp. 229-238
    • Robertson, J.F.R.1    Osborne, C.K.2    Howell, A.3
  • 91
    • 0042236493 scopus 로고    scopus 로고
    • Sequential hormonal therapy for metastatic breast cancer after adjuvant tamoxifen or anastrozole
    • Carlson RW, Henderson IC. Sequential hormonal therapy for metastatic breast cancer after adjuvant tamoxifen or anastrozole. Breast Cancer Res Treat 2003;80(suppl 1):S19-S26; discussion S27-S28.
    • (2003) Breast Cancer Res Treat , vol.80 , Issue.1 SUPPL.
    • Carlson, R.W.1    Henderson, I.C.2
  • 92
    • 18044398983 scopus 로고    scopus 로고
    • Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy
    • Osipo C, Gajdos C, Cheng D et al. Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy. J Steroid Biochem Mol Biol 2005;93:249-256.
    • (2005) J Steroid Biochem Mol Biol , vol.93 , pp. 249-256
    • Osipo, C.1    Gajdos, C.2    Cheng, D.3
  • 93
    • 33644984327 scopus 로고    scopus 로고
    • Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032
    • Ingle JN, Suman VJ, Rowland KM et al. Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032. J Clin Oncol 2006;24:1052-1056.
    • (2006) J Clin Oncol , vol.24 , pp. 1052-1056
    • Ingle, J.N.1    Suman, V.J.2    Rowland, K.M.3
  • 94
    • 18944402975 scopus 로고    scopus 로고
    • Fulvestrant (Faslodex®) as hormonal treatment in postmenopausal patients with advanced breast cancer (ABC) progressing after treatment with tamoxifen and aromatase inhibitors: Update of a phase II SAKK trial
    • Perey L, Paridaens R, Nolé F et al. Fulvestrant (Faslodex®) as hormonal treatment in postmenopausal patients with advanced breast cancer (ABC) progressing after treatment with tamoxifen and aromatase inhibitors: update of a phase II SAKK trial. Breast Cancer Res Treat 2004;88(suppl 1):S236.
    • (2004) Breast Cancer Res Treat , vol.88 , Issue.1 SUPPL.
    • Perey, L.1    Paridaens, R.2    Nolé, F.3
  • 95
    • 0034891355 scopus 로고    scopus 로고
    • High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy
    • Lønning PE, Taylor PD, Anker G et al. High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy. Breast Cancer Res Treat 2001;67:111-116.
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 111-116
    • Lønning, P.E.1    Taylor, P.D.2    Anker, G.3
  • 96
    • 28944444552 scopus 로고    scopus 로고
    • Intrinsic mechanism of estradiolinduced apoptosis in breast cancer cells resistant to estrogen deprivation
    • Lewis JS, Meeke K, Osipo C et al. Intrinsic mechanism of estradiolinduced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst 2005;97:1746-1759.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1746-1759
    • Lewis, J.S.1    Meeke, K.2    Osipo, C.3
  • 97
    • 0035930095 scopus 로고    scopus 로고
    • Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17β-estradiol
    • Song RX-D, Mor G, Naftolin F et al. Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17β-estradiol. J Natl Cancer Inst 2001;93:1714-1723.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1714-1723
    • Song, R.X.-D.1    Mor, G.2    Naftolin, F.3
  • 98
    • 0034066141 scopus 로고    scopus 로고
    • Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice
    • Yao K, Lee E-S, Bentrem DJ, et al. Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice. Clin Cancer Res 2000;6:2028-2036.
    • (2000) Clin Cancer Res , vol.6 , pp. 2028-2036
    • Yao, K.1    Lee, E.-S.2    Bentrem, D.J.3
  • 99
    • 21744434395 scopus 로고    scopus 로고
    • Role of fulvestrant in sequential hormonal therapy for advanced, hormone receptor-positive breast cancer in postmenopausal women
    • Come SE, Borges VF. Role of fulvestrant in sequential hormonal therapy for advanced, hormone receptor-positive breast cancer in postmenopausal women. Clin Breast Cancer 2005;6(suppl 1):S15-S22.
    • (2005) Clin Breast Cancer , vol.6 , Issue.1 SUPPL.
    • Come, S.E.1    Borges, V.F.2
  • 100
    • 0033058968 scopus 로고    scopus 로고
    • Randomized trial of diethylstilbestrol vs. tamoxifen in postmenopausal women with metastatic breast cancer: An updated analysis
    • Peethambaram PP, Ingle JN, Suman VJ et al. Randomized trial of diethylstilbestrol vs. tamoxifen in postmenopausal women with metastatic breast cancer: an updated analysis. Breast Cancer Res Treat 1999;54:117-122.
    • (1999) Breast Cancer Res Treat , vol.54 , pp. 117-122
    • Peethambaram, P.P.1    Ingle, J.N.2    Suman, V.J.3
  • 101
    • 33746614128 scopus 로고    scopus 로고
    • Fulvestrant (Faslodex): Current and future perspectives
    • Chicago, Illinois, October 28
    • Sahmoud T. Fulvestrant (Faslodex): current and future perspectives. Presented at the Lynn Sage Breast Cancer Symposium, Chicago, Illinois, October 28, 2004.
    • (2004) Lynn Sage Breast Cancer Symposium
    • Sahmoud, T.1
  • 102
    • 23744473720 scopus 로고    scopus 로고
    • Aromatase inhibitors: Combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistance
    • Johnston SRD, Martin L-A, Head J et al. Aromatase inhibitors: combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistance. J Steroid Biochem Mol Biol 2005;95:173-181.
    • (2005) J Steroid Biochem Mol Biol , vol.95 , pp. 173-181
    • Johnston, S.R.D.1    Martin, L.-A.2    Head, J.3


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