메뉴 건너뛰기




Volumn 4, Issue 3, 2010, Pages 181-188

Role of 11β-hydroxysteroid-dehydrogenase type 1 in the metabolic risk associated with obesity;Rôle de l'enzyme 11β-hydroxystéroïde-déshydrogénase de type 1 dans le risque métabolique associé à l'obésité

Author keywords

11 hydroxystero d dehydrogenase type 1; Abdominal obesity; Cortisol; Glucocorticoids; Metabolic syndrome; Selective inhibition; Type 2 diabetes

Indexed keywords


EID: 76149111586     PISSN: 19515995     EISSN: 19516002     Source Type: Journal    
DOI: 10.1007/s11690-009-0204-2     Document Type: Article
Times cited : (2)

References (43)
  • 1
    • 68549139946 scopus 로고    scopus 로고
    • The pathogenetic role of cortisol in the metabolic syndrome: A hypothesis
    • Anagnostis P, Athyros VG, Tziomalos K, et al (2009) The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab 94: 2692-701.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2692-2701
    • Anagnostis, P.1    Athyros, V.G.2    Tziomalos, K.3
  • 2
  • 3
    • 4043077286 scopus 로고    scopus 로고
    • 11β-hydroxysteroïd-dehydrogenase type 1: A tissue-specific regulator of glucocorticoid response
    • Tomlinson JW, Walker EA, Bujalska IJ, et al (2004) 11β-hydroxysteroïd-dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 25: 831-66.
    • (2004) Endocr Rev , vol.25 , pp. 831-866
    • Tomlinson, J.W.1    Walker, E.A.2    Bujalska, I.J.3
  • 5
    • 71549157437 scopus 로고    scopus 로고
    • La 11β-hydroxystéroïde-déshydrogénase de type 1: Première partie: Rôle de l'exposition tissulaire au cortisol dans le risque métabolique lié à l'obésité
    • Iovino A, Scheen AJ (2009) La 11β-hydroxystéroïde-déshydrogénase de type 1: première partie: rôle de l'exposition tissulaire au cortisol dans le risque métabolique lié à l'obésité. Med Mal Metab (sous presse).
    • (2009) Med Mal Metab (Sous Presse)
    • Iovino, A.1    Scheen, A.J.2
  • 6
    • 77949386560 scopus 로고    scopus 로고
    • La 11β-hydroxystéroïde-déshydrogénase de type 1: Deuxième partie: Inhibition sélective pour traiter les anomalies métaboliques associées à l'obésité
    • Iovino A, Scheen AJ (2009) La 11β-hydroxystéroïde-déshydrogénase de type 1: deuxième partie: inhibition sélective pour traiter les anomalies métaboliques associées à l'obésité. Med Mal Metab (sous presse).
    • (2009) Med Mal Metab (Sous Presse)
    • Iovino, A.1    Scheen, A.J.2
  • 7
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum?
    • Bujalska IJ, Kumar S, Stewart PM (1997) Does central obesity reflect "Cushing's disease of the omentum?" Lancet 349: 1210-3.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 8
    • 1942520410 scopus 로고    scopus 로고
    • Cushing's disease of the omentum": Fact or fiction?
    • Tomlinson JW, Stewart PM (2004) "Cushing's disease of the omentum": fact or fiction? J Endocrinol Invest 27: 171-4.
    • (2004) J Endocrinol Invest , vol.27 , pp. 171-174
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 9
    • 33845644003 scopus 로고    scopus 로고
    • Tissue production of cortisol by 11β-hydroxysteroid dehydrogenase type 1 and metabolic disease
    • Walker BR, Andrew R (2006) Tissue production of cortisol by 11β-hydroxysteroid dehydrogenase type 1 and metabolic disease. Ann NY Acad Sci 1083: 165-84.
    • (2006) Ann NY Acad Sci , vol.1083 , pp. 165-184
    • Walker, B.R.1    Andrew, R.2
  • 10
    • 53549105499 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
    • Swali A, Walker EA, Lavery GG, et al (2008) 11β-hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia 51: 2003-11.
    • (2008) Diabetologia , vol.51 , pp. 2003-2011
    • Swali, A.1    Walker, E.A.2    Lavery, G.G.3
  • 11
    • 0036959901 scopus 로고    scopus 로고
    • A switch in dehydrogenase to reductase activity of 11β-hydroxysteroid-dehydrogenase type 1 upon differentiation of human omental adipose stromal cells
    • Bujalska IJ, Walker EA, Hewison M, et al (2002) A switch in dehydrogenase to reductase activity of 11β-hydroxysteroid-dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab 87: 1205-10.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1205-1210
    • Bujalska, I.J.1    Walker, E.A.2    Hewison, M.3
  • 12
    • 18844438379 scopus 로고    scopus 로고
    • Hexose-6-phosphate dehydrogenase confers oxoreductase activity upon 11β-hydoxysteroid-dehydrogenase type 1
    • Bujalska IJ, Draper N, Michailidou Z, et al (2005) Hexose-6-phosphate dehydrogenase confers oxoreductase activity upon 11β-hydoxysteroid-dehydrogenase type 1. J Mol Endocrinol 34: 675-84.
    • (2005) J Mol Endocrinol , vol.34 , pp. 675-684
    • Bujalska, I.J.1    Draper, N.2    Michailidou, Z.3
  • 13
    • 0942290504 scopus 로고    scopus 로고
    • 11β-hydroxysteroid-dehydrogenase type 1 in obesity and type 2 diabetes
    • Stulnig TM, Waldhäusl W (2004) 11β-hydroxysteroid-dehydrogenase type 1 in obesity and type 2 diabetes. Diabetologia 47: 1-11.
    • (2004) Diabetologia , vol.47 , pp. 1-11
    • Stulnig, T.M.1    Waldhäusl, W.2
  • 14
    • 63249083541 scopus 로고    scopus 로고
    • Cortisol release from adipose tissue by 11β-hydroxysteroid-dehydrogenase type 1 in humans
    • Stimson RH, Andersson J, Andrew R, et al (2009) Cortisol release from adipose tissue by 11β-hydroxysteroid-dehydrogenase type 1 in humans. Diabetes 58: 46-53.
    • (2009) Diabetes , vol.58 , pp. 46-53
    • Stimson, R.H.1    Andersson, J.2    Andrew, R.3
  • 15
    • 39849090597 scopus 로고    scopus 로고
    • Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11β-hydroxysteroid-dehydrogenase type 1) gene
    • Iwasaki Y, Takayasu S, Nishiyama M, et al (2008) Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11β-hydroxysteroid-dehydrogenase type 1) gene. Mol Cell Endocrinol 285: 10-8.
    • (2008) Mol Cell Endocrinol , vol.285 , pp. 10-18
    • Iwasaki, Y.1    Takayasu, S.2    Nishiyama, M.3
  • 16
    • 67651015402 scopus 로고    scopus 로고
    • Diet and the role of 11β-hydroxysteroid-dehydrogenase-1 on obesity
    • London E, Castonguay TW (2009) Diet and the role of 11β-hydroxysteroid-dehydrogenase-1 on obesity. J Nutr Biochem 20: 485-93.
    • (2009) J Nutr Biochem , vol.20 , pp. 485-493
    • London, E.1    Castonguay, T.W.2
  • 17
    • 42949100803 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenal axis in the regulation of energy balance
    • Nieuwenhuizen AG, Rutters F (2008) The hypothalamic-pituitary-adrenal axis in the regulation of energy balance. Physiol Behav 94: 169-77.
    • (2008) Physiol Behav , vol.94 , pp. 169-177
    • Nieuwenhuizen, A.G.1    Rutters, F.2
  • 18
    • 34248148124 scopus 로고    scopus 로고
    • Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid-dehydrogenase type 1: Physiological regulator and pharmacological target for energy partitioning
    • Walker BR (2007) Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid-dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning. Proc Nutr Soc 66: 1-8.
    • (2007) Proc Nutr Soc , vol.66 , pp. 1-8
    • Walker, B.R.1
  • 19
    • 0035918143 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor gamma ligands inhibit adipocyte 11β-hydroxysteroid-dehydrogenase type 1 expression and activity
    • Beger J, Tanen M, Elbrecht A, et al (2001) Peroxisome proliferator activated receptor gamma ligands inhibit adipocyte 11β-hydroxysteroid-dehydrogenase type 1 expression and activity. J Biol Chem 276: 12629-35.
    • (2001) J Biol Chem , vol.276 , pp. 12629-12635
    • Beger, J.1    Tanen, M.2    Elbrecht, A.3
  • 20
    • 34249845549 scopus 로고    scopus 로고
    • Effects of peroxysome proliferator activated receptor-α and-γ agonists on 11β-hydroxysteroid-dehydrogenase type 1 in sub-cutaneous adipose tissue in men
    • Wake DJ, Stimson RH, Tan GD, et al (2007) Effects of peroxysome proliferator activated receptor-α and-γ agonists on 11β-hydroxysteroid-dehydrogenase type 1 in sub-cutaneous adipose tissue in men. J Clin Endocrinol Metab 92: 1848-56.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1848-1856
    • Wake, D.J.1    Stimson, R.H.2    Tan, G.D.3
  • 21
    • 43049122505 scopus 로고    scopus 로고
    • 11β-hydroxysteroid-dehydrogenase type 1 and obesity
    • Morton NM, Seckl JR (2008) 11β-hydroxysteroid-dehydrogenase type 1 and obesity. Front Horm Res 36: 146-64.
    • (2008) Front Horm Res , vol.36 , pp. 146-164
    • Morton, N.M.1    Seckl, J.R.2
  • 22
    • 70449473618 scopus 로고    scopus 로고
    • Anti-diabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis
    • Lloyd DJ, Helmering J, Cordover D, et al (2009) Anti-diabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis. Diabetes Obes Metab 11: 688-99.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 688-699
    • Lloyd, D.J.1    Helmering, J.2    Cordover, D.3
  • 23
    • 67649362287 scopus 로고    scopus 로고
    • 11β-hydroxysteroid-dehydrogenase type 1 inhibitors: A review of recent patents
    • Boyle CD, Kowalski TJ (2009) 11β-hydroxysteroid-dehydrogenase type 1 inhibitors: a review of recent patents. Exp Opin Ther Pat 19: 801-25.
    • (2009) Exp Opin Ther Pat , vol.19 , pp. 801-825
    • Boyle, C.D.1    Kowalski, T.J.2
  • 24
    • 67349178689 scopus 로고    scopus 로고
    • Additive action of 11β-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats
    • Berthiaume M, Laplante M, Festuccia WT, et al (2009) Additive action of 11β-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int J Obes 33: 601-4.
    • (2009) Int J Obes , vol.33 , pp. 601-604
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3
  • 25
    • 23044460294 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans
    • Basu R, Singh RJ, Basu A, et al (2005) Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans. J Clin Endocrinol Metab 90: 3919-26.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3919-3926
    • Basu, R.1    Singh, R.J.2    Basu, A.3
  • 26
    • 14644388141 scopus 로고    scopus 로고
    • Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor carbenoxolone
    • Sandeep TC, Andrew R, Homer NZM, et al (2005) Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 54: 872-9.
    • (2005) Diabetes , vol.54 , pp. 872-879
    • Sandeep, T.C.1    Andrew, R.2    Homer, N.Z.M.3
  • 27
    • 17844363297 scopus 로고    scopus 로고
    • The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans
    • Andrew R, Westerbacka J, Wahren J, et al (2005) The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes 54: 1364-70.
    • (2005) Diabetes , vol.54 , pp. 1364-1370
    • Andrew, R.1    Westerbacka, J.2    Wahren, J.3
  • 28
    • 63249128191 scopus 로고    scopus 로고
    • Liver is the site of splanchnic cortisol production in obese non-diabetic humans
    • Basu R, Basu A, Grudzien M, et al (2009) Liver is the site of splanchnic cortisol production in obese non-diabetic humans. Diabetes 58: 39-45.
    • (2009) Diabetes , vol.58 , pp. 39-45
    • Basu, R.1    Basu, A.2    Grudzien, M.3
  • 29
    • 0035051205 scopus 로고    scopus 로고
    • Tissue-specific dysregulation of cortisol metabolism in human obesity
    • Rask E, Olsson T, Söderberg S, et al (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86: 1418-21.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1418-1421
    • Rask, E.1    Olsson, T.2    Söderberg, S.3
  • 30
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: Impaired cortisone→cortisol conversion in subjects with central adiposity
    • Stewart PM, Boulton A, Kumar S, et al (1999) Cortisol metabolism in human obesity: Impaired cortisone→cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84: 1022-7.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3
  • 31
    • 0036324073 scopus 로고    scopus 로고
    • Tissue-specific changes in peripheral cortisol metabolism in obese women: Increased adipose 11β-hydroxysteroid-dehydrogenase type 1 activity
    • Rask E, Walker BR, Söderberg S, et al (2002) Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid-dehydrogenase type 1 activity. J Clin Endocrinol Metab 87: 3330-6.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3330-3336
    • Rask, E.1    Walker, B.R.2    Söderberg, S.3
  • 32
    • 63249113536 scopus 로고    scopus 로고
    • Selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1 for patients with metabolic syndrome, is the target liver, fat, or both?
    • Stewart PM, Tomlinson JW (2009) Selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1 for patients with metabolic syndrome, is the target liver, fat, or both? (commentary). Diabetes 58: 14-5.
    • (2009) Diabetes , vol.58 , pp. 14-15
    • Stewart, P.M.1    Tomlinson, J.W.2
  • 33
    • 58149330675 scopus 로고    scopus 로고
    • Impaired glucose tolerance and insulin resistance are associated with increased adipose 11β-hydroxysteroid-dehydrogenase type 1 expression and elevated hepatic 5-alpha-reductase activity
    • Tomlinson JW, Finney J, Gay C, et al (2008) Impaired glucose tolerance and insulin resistance are associated with increased adipose 11β-hydroxysteroid-dehydrogenase type 1 expression and elevated hepatic 5-alpha-reductase activity. Diabetes 57: 2652-60.
    • (2008) Diabetes , vol.57 , pp. 2652-2660
    • Tomlinson, J.W.1    Finney, J.2    Gay, C.3
  • 34
    • 69949092969 scopus 로고    scopus 로고
    • Omental adipose tissue 11β-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women
    • Veilleux A, Rhéaume C, Daris M, et al (2009) Omental adipose tissue 11β-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women. J Clin Endocrinol Metab 94: 3550-7.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3550-3557
    • Veilleux, A.1    Rhéaume, C.2    Daris, M.3
  • 35
    • 60849127882 scopus 로고    scopus 로고
    • Enhanced cortisol production rates, free cortisol, and 11β-HSD1 expression correlate with visceral fat and insulin resistance in men: Effect of weight loss
    • Purnell JQ, Kahn SE, Samuels MH, et al (2009) Enhanced cortisol production rates, free cortisol, and 11β-HSD1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. Am J Physiol Endocrinol Metab 296: E351-7.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Purnell, J.Q.1    Kahn, S.E.2    Samuels, M.H.3
  • 36
    • 4544263736 scopus 로고    scopus 로고
    • 11β-hydroxysteroid-dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus
    • Valsamakis G, Anwar A, Tomlinson JW, et al (2004) 11β-hydroxysteroid-dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus. J Clin Endocrinol Metab 89: 4755-61.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4755-4761
    • Valsamakis, G.1    Anwar, A.2    Tomlinson, J.W.3
  • 37
    • 36549073576 scopus 로고    scopus 로고
    • Modulation of glucocorticoid action and the treatment of type 2 diabetes
    • Tomlinson JW, Stewart PM (2007) Modulation of glucocorticoid action and the treatment of type 2 diabetes. Best Pract Res Clin Endocrinol Metab 21: 607-19.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , pp. 607-619
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 38
    • 34447105433 scopus 로고    scopus 로고
    • Inhibition of 11β-hydroxysteroid-dehydrogenase type 1 as a promising therapeutic target
    • Wamil M, Seckl JR (2007) Inhibition of 11β-hydroxysteroid-dehydrogenase type 1 as a promising therapeutic target. Drug Discov Today 12: 504-20.
    • (2007) Drug Discov Today , vol.12 , pp. 504-520
    • Wamil, M.1    Seckl, J.R.2
  • 39
    • 43849098723 scopus 로고    scopus 로고
    • A novel selective 11β-hydroxysteroid-dehydrogenase type 1 inhibitor prevents human adipogenesis
    • Bujalska IJ, Gathercole LL, Tomlinson JW, et al (2008) A novel selective 11β-hydroxysteroid-dehydrogenase type 1 inhibitor prevents human adipogenesis. J Endocrinol 197: 297-307.
    • (2008) J Endocrinol , vol.197 , pp. 297-307
    • Bujalska, I.J.1    Gathercole, L.L.2    Tomlinson, J.W.3
  • 40
    • 39049131253 scopus 로고    scopus 로고
    • Modulation of 11β-hydroxysteroid-dehydrogenase (11β-HSD) activity biomarkers and pharmacokinetics of PF-00915275: A selective 11β-HSD1 inhibitor
    • Courtney R, Stewart PM, Toh M, et al (2008) Modulation of 11β-hydroxysteroid-dehydrogenase (11β-HSD) activity biomarkers and pharmacokinetics of PF-00915275: a selective 11β-HSD1 inhibitor. J Clin Endocrinol Metab 93: 550-6.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 550-556
    • Courtney, R.1    Stewart, P.M.2    Toh, M.3
  • 41
    • 64549162134 scopus 로고    scopus 로고
    • INCB013739, a selective inhibitor of 11β-hydroxysteroid-dehydrogenase type 1 (11β-HSD1), improves insulin sensitivity and lowers plasma cholesterol over 28 days in patients with type 2 diabetes mellitus
    • Hawkins M, Hunter D, Kishore P, et al (2008) INCB013739, a selective inhibitor of 11β-hydroxysteroid-dehydrogenase type 1 (11β-HSD1), improves insulin sensitivity and lowers plasma cholesterol over 28 days in patients with type 2 diabetes mellitus (Abstract). Diabetes 57 (Suppl. 1): A99-A100.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Hawkins, M.1    Hunter, D.2    Kishore, P.3
  • 42
    • 73249122496 scopus 로고    scopus 로고
    • Efficacy and safety of the 11β-HSD1 inhibitor, INCB13739, added to metformin therapy in patients with type 2 diabetes (abstract)
    • late breaking abstract 7-LB
    • Rosenstock J, Banarer S, Fonseca V, et al (2009) Efficacy and safety of the 11β-HSD1 inhibitor, INCB13739, added to metformin therapy in patients with type 2 diabetes (abstract). Diabetes 59(Suppl. 1): late breaking abstract 7-LB.
    • (2009) Diabetes , vol.59 , Issue.SUPPL. 1
    • Rosenstock, J.1    Banarer, S.2    Fonseca, V.3
  • 43
    • 67651094103 scopus 로고    scopus 로고
    • Discovery of novel dual functional agent as PPARgamma agonist and 11β-HSD1 inhibitor for the treatment of diabetes
    • Ye YL, Zhou Z, Zou HJ, et al (2009) Discovery of novel dual functional agent as PPARgamma agonist and 11β-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem 17: 5722-32.
    • (2009) Bioorg Med Chem , vol.17 , pp. 5722-5732
    • Ye, Y.L.1    Zhou, Z.2    Zou, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.