Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12629-12635

  Berger, Joel ^a   Tanen, Michael ^b   Elbrecht, Alex ^b   Hermanowski Vosatka, Anne ^a   Moller, David E ^b   Wright, Samuel D ^a   Thieringer, Rolf ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Research Laboratories ^*

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENETIC ENGINEERING; INSULIN; RNA; TISSUE CULTURE;

GENE EXPRESSIONS;

BIOCHEMISTRY;

11BETA HYDROXYSTEROID DEHYDROGENASE; 2 [2 (4 PHENOXY 2 PROPYLPHENOXY)ETHYL]INDOLE 5 ACETIC ACID; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL) 2 HYDROXYETHOXY]BENZYL] 2,4 THIAZOLIDINEDIONE; CELL PROTEIN; CORTISONE; GLUCOCORTICOID; HYDROCORTISONE; INSULIN; L 805643; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); ROSIGLITAZONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE; 2,4-THIAZOLIDINEDIONE; CELL RECEPTOR; CYCLOHEXIMIDE; DNA BINDING PROTEIN; HYDROXYSTEROID DEHYDROGENASE; LIGAND; MESSENGER RNA; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOSTEROID METABOLISM; DIABETES MELLITUS; DOWN REGULATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; HORMONAL REGULATION; HYPERADRENOCORTICISM; INHIBITION KINETICS; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; C57BL MOUSE; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; KINETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALIA;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3 CELLS; ADIPOCYTES; ANIMALS; CYCLOHEXIMIDE; DIABETES MELLITUS, EXPERIMENTAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYSTEROID DEHYDROGENASES; KINETICS; LEPTIN; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035918143     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M003592200     Document Type: Article

References (47)

1. Bjorntorp, P. (1991) J. Intern. Med. 230, 195-201
2. Reaven, G. M., and Hoffman, B. B. (1987) Lancet 2, 435-437
3. Despres, J.-P., and Marette, A. (1999) in Insulin Resistance: The Metabolic Syndrome (Reaven, G. M., and Laws, A., eds) pp. 51-82, Humana Press Inc., Totowa, NJ
4. Lowell, B. B. (1999) Cell 99, 239-242
5. Chapman, A. B., Knight, D. M., and Ringold, G. M. (1985) J. Cell Biol. 101, 1227-1235
6. Ringold, G. M., Chapman, A. B., Knight, D. M., and Torti, F. M. (1986) Ann. N. Y. Acad. Sci. 478, 109-119
7. Hauner, H., Entenmann, G., Wabitsch, M., Gaillard, D., Ailhaud, G., Negrel, R., and Pfeiffer, E. F. (1989) J. Clin. Invest. 84, 1663-1670
8. Rebuffe-Scrive, M., Krotkiewski, M., Elfverson, J., and Bjorntorp, P. (1988) J. Clin. Endocrinol. & Metab. 67, 1122-1128
9. Mayo-Smith, W., Hayes, C. W., Biller, B. M., Klibanski, A., Rosenthal, H., and Rosenthal, D. I. (1989) Radiology 170, 515-518
10. Peeke, P. M., and Chrousos, G. P. (1995) Ann. N. Y. Acad. Sci. 771, 665-676
11. Stewart, P. M., and Krozowski, Z. S. (1999) Vitam. Horm. 57, 249-324
12. Bujalska, I. J., Kumar, S., and Stewart, P. M. (1997) Lancet 349, 1210-1213
13. Kotelevtsev, Y., Holmes, M. C., Burchell, A., Houston, P. M., Schmoll, D., Jamieson, P., Best, R., Brown, R., Edwards, C. R., Seckl, J. R., and Mullins, J. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14924-14929
14. Andrews, R. C., and Walker, B. R. (1999) Clin. Sci. (Lond.) 96, 513-523
15. Schoonjans, K., Marin, G., Staels, B., and Auwerx, J. (1997) Curr. Opin. Lipid. 8, 159-165
16. Keller, H., and Wahli, W. (1993) Trends Endocrinol. Metab. 4, 291-296
17. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7355-7359
18. Chinetti, G., Griglio, S., Antonucci, M., Torra, I. P., Delerive, P., Majd, Z., Fruchart, J. C., Chapman, J., Najib, J., and Staels, B. (1998) J. Biol. Chem. 273, 25573-25580
19. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Mol. Cell. Biol. 15, 3012-3022
20. Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., and Kelly, D. P. (1998) J. Clin. Invest. 102, 1083-1091
21. Staels, B., Koenig, W., Habib, A., Merval, R., Lebret, M., Torra, I. P., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J. C., Najib, J., Maclouf, J., and Tedgui, A. (1998) Nature 393, 790-793
22. Jones, P. S., Savory, R., Barratt, P., Bell, A. R., Gray, T. J., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Bell, D. R. (1995) Eur. J. Biochem. 233, 219-226
23. Xing, G., Zhang, L., Heynen, T., Yoshikawa, T., Smith, M., Weiss, S., and Detera-Wadleigh, S. (1995) Biochem. Biophys. Res. Commun. 217, 1015-1025
24. Tontonoz, P., Erding, H., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) Genes Dev. 8, 1224-1234
25. Elbrecht, A., Chen, Y., Cullinan, C. A., Hayes, N., Leibowitz, M. D., Moller, D. E., and Berger, J. (1996) Biochem. Biophys. Res. Commun. 224, 431-437
26. Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D., Sambasiva Rao, M., and Reddy, J. K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7921-7925
27. Brun, R. P., Tontonoz, P., Forman, B. M., Ellis, R., Chen, J., Evans, R. M., and Spiegelman, B. M. (1996) Genes Dev. 10, 974-984
28. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156
29. Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D. S., Spiegelman, B. M., and Mortensen, R. M. (1999) Mol. Cell 4, 611-617
30. Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y. Z., Ruiz-Lozano, P., Chien, K. R., Koder, A., and Evans, R. M. (1999) Mol. Cell 4, 585-595
31. Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kitamura, T., Fujita, T., Ezaki, O., Aizawa, S., Nagai, R., Tobe, K., Kimura, S., and Kadowaki, T. (1999) Mol. Cell 4, 597-609
32. Miles, P. D., Barak, Y., He, W., Evans, R. M., and Olefsky, J. M. (2000) J. Clin. Invest. 105, 287-292
33. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) J. Biol. Chem. 270, 12953-12956
34. Berger, J., Leibowitz, M. D., Doebber, T. W., Elbrecht, A., Zhang, B., Zhou, G., Biswas, C., Cullinan, C. A., Hayes, N. S., Li, Y., Tanen, M., Ventre, J., Wu, M. S., Berger, G. D., Mosley, R., Marquis, R., Santini, C., Sahoo, S. P., Tolman, R. L., Smith, R. G., and Moller, D. E. (1999) J. Biol. Chem. 274, 6718-6725
35. Berger, J., Bailey, P., Biswas, C., Cullinan, C. A., Doebber, T. W., Hayes, N. S., Saperstein, R., Smith, R. G., and Leibowitz, M. D. (1996) Endocrinology 137, 4189-4195
36. Tontonoz, P., Hu, E., Devine, J., Geale, E. G., and Spiegelman, B. M. (1995) Mol. Cell. Biol. 15, 351-357
37. Kallen, C. B., and Lazar, M. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5793-5796
38. Hollenberg, A. N., Susulic, V. S., Madura, J. P., Zhang, B., Moller, D. E., Tontonoz, P., Sarraf, P., Spiegelman, B. M., and Lowell, B. B. (1997) J. Biol. Chem. 272, 5283-5290
39. Napolitano, A., Voice, M. W., Edwards, C. R., Seckl, J. R., and Chapman, K. E. (1998) J. Steroid. Biochem. Mol. Biol. 64, 251-260
40. Zhang, B., Berger, J., Hu, E., Szalkowski, D., White-Carrington, S., Spiegelman, B., and Moller, D. E. (1996) Mol. Endocrinol. 10, 1457-1466
41. Zhang, B., MacNaul, K., Szalkowski, D., Li, Z., Berger, J., and Moller, D. E. (1999) J. Clin. Endocrinol. & Metab. 84, 4274-4277
42. Kawai, T., Takei, I., Oguma, Y., Ohashi, N., Tokui, M., Oguchi, S., Katsukawa, F., Shimada, A., Watanbe, K., and Saruta, T. (1999) Metabolism 48, 1102-1107
43. Mori, Y., Murakawa, Y., Okada, K., Horikoshi, H., Yokoyama, J., Tajima, N., and Ikeda, Y. (1999) Diabetes Care 22, 908-912
44. Kissebah, A. H. (1997) Diabetes Rev. 5, 8-20
45. Walker, R. W., Connacher, A. A., Lindsay, R. M., Webb, D. J., and Edwards, C. R. W. (1995) J. Clin. Endocrinol. & Metab. 80, 3155-3159
46. Wang, Q., Dryden, S., Frankish, H. M., Bing, C., Pickavance, L., Hopkins, D., Buckingham, R., and Williams, G. (1997) Br. J. Pharmacol. 122, 1405-1410
47. Hermanowski-Vosatka, A., Gerhold, D., Mundt, S. S., Loving, V. A., Lu, M., Chen, Y., Elbrecht, A., Wu, M., Doebber, T., Kelly, L., Milot, D., Guo, Q., Wang, P. R., Ippolito, M., Chao, Y. S., Wright, S. D., and Theiringer, R. (2000) Biochem. Biophys. Res. Commun. 279, 330-336