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Volumn 121, Issue 8, 1997, Pages 1613-1618

Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat

Author keywords

1 adrenoceptors; 1 adrenoceptors; 5 HT receptors; 5 hydroxytryptamine; Food intake; Monoamine reuptake inhibition; Noradrenaline; Serotonin noradrenaline reuptake inhibitor (SNRI); Sibutramine

Indexed keywords

1 (1 METHYL 5 INDOLYL) 3 (3 PYRIDYL)UREA; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ALPHA 1 ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; BETA 1 ADRENERGIC RECEPTOR; METERGOLINE; METOPROLOL; NORADRENALIN; PRAZOSIN; RITANSERIN; SEROTONIN; SEROTONIN RECEPTOR; SIBUTRAMINE;

EID: 0030759773     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701311     Document Type: Article
Times cited : (148)

References (40)
  • 2
    • 0022607286 scopus 로고
    • Further evidence of the inhibitory role of perifornical hypothalamic β-adrenergic receptors in the feeding behaviour of hungry rats
    • BENDOTTI, C., VILLA, M. & SAMANIN, R. (1986). Further evidence of the inhibitory role of perifornical hypothalamic β-adrenergic receptors in the feeding behaviour of hungry rats. Life Sci., 38, 259-266.
    • (1986) Life Sci. , vol.38 , pp. 259-266
    • Bendotti, C.1    Villa, M.2    Samanin, R.3
  • 4
    • 0023814888 scopus 로고
    • The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation
    • BUCKETT, W.R., THOMAS, P.C. & LUSCOMBE, G.P. (1988). The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog. Neuro-Psychopharmacol. Biol. Psychiat., 12, 575-584.
    • (1988) Prog. Neuro-Psychopharmacol. Biol. Psychiat. , vol.12 , pp. 575-584
    • Buckett, W.R.1    Thomas, P.C.2    Luscombe, G.P.3
  • 5
    • 0018088673 scopus 로고
    • A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212)
    • CLINESCHMIDT, B.V., MCGUFFIN, J.C., PFLUEGER, A.B. & TOTARO, J.A. (1978). A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212). Br. J. Pharmacol., 62, 579-589.
    • (1978) Br. J. Pharmacol. , vol.62 , pp. 579-589
    • Clineschmidt, B.V.1    McGuffin, J.C.2    Pflueger, A.B.3    Totaro, J.A.4
  • 7
    • 0001090721 scopus 로고
    • 5-HT receptor subtypes and feeding behaviour
    • ed. Bradley, P.B., Handley, S.L., Cooper, S.J., Key, B.J., Barnes, N.M. & Coote, J. Oxford: Pergamon Press
    • DOURISH, C.T. (1992). 5-HT receptor subtypes and feeding behaviour. In 5-Hydroxytryptamine-CNS Receptors and Brain Function. ed. Bradley, P.B., Handley, S.L., Cooper, S.J., Key, B.J., Barnes, N.M. & Coote, J. pp. 179-202. Oxford: Pergamon Press.
    • (1992) 5-Hydroxytryptamine-CNS Receptors and Brain Function , pp. 179-202
    • Dourish, C.T.1
  • 8
    • 0029400158 scopus 로고
    • Multiple serotonin receptors: Opportunities for new treatments for obesity?
    • DOURISH, C.T. (1995). Multiple serotonin receptors: Opportunities for new treatments for obesity? Obesity Res., 3, 449S-462S.
    • (1995) Obesity Res. , vol.3
    • Dourish, C.T.1
  • 10
    • 0000197205 scopus 로고
    • Effects of Metabolites 1 and 2 of sibutramine on the short-term control of food intake in the rat
    • FANTINO, M. & SOUQUET, A.-M. (1995). Effects of Metabolites 1 and 2 of sibutramine on the short-term control of food intake in the rat. Int. J. Obesity, 19, 145.
    • (1995) Int. J. Obesity , vol.19 , pp. 145
    • Fantino, M.1    Souquet, A.-M.2
  • 11
    • 0022378491 scopus 로고
    • 2-noradrenergic receptors mediate feeding induced by paraventricular nucleus injection of norepinephrine and clonidine
    • 2-noradrenergic receptors mediate feeding induced by paraventricular nucleus injection of norepinephrine and clonidine. Eur. J. Pharmacol., 115, 11-19.
    • (1985) Eur. J. Pharmacol. , vol.115 , pp. 11-19
    • Goldman, C.K.1    Marino, L.2    Leibowitz, S.F.3
  • 12
    • 8544264752 scopus 로고    scopus 로고
    • In vivo criteria to differentiate monoamine uptake inhibitors (MARIs) from serotonin releasing drugs: Sibutramine is a MAR1
    • GUNDLAH, C., MARTIN, K.F., HEAL, D.J., SCHJOTT, J. & AUERBACH, S.B. (1996). In vivo criteria to differentiate monoamine uptake inhibitors (MARIs) from serotonin releasing drugs: Sibutramine is a MAR1. Soc. Neurosci. Abs., 22, 612.
    • (1996) Soc. Neurosci. Abs. , vol.22 , pp. 612
    • Gundlah, C.1    Martin, K.F.2    Heal, D.J.3    Schjott, J.4    Auerbach, S.B.5
  • 13
    • 0001612783 scopus 로고
    • Effects in the rat of sibutramine on food intake and the behavioral satiety sequence
    • HALFORD, J.C.G., HEAL, D.J. & BLUNDELL, J.E. (1995). Effects in the rat of sibutramine on food intake and the behavioral satiety sequence. Br. J. Pharmacol., 114, 387P.
    • (1995) Br. J. Pharmacol. , vol.114
    • Halford, J.C.G.1    Heal, D.J.2    Blundell, J.E.3
  • 14
    • 0023895447 scopus 로고
    • 1 recognition sites
    • 1 recognition sites. J. Receptor Res., 8, 59-81.
    • (1988) J. Receptor Res. , vol.8 , pp. 59-81
    • Hoyer, D.1
  • 17
    • 0013469753 scopus 로고    scopus 로고
    • Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and NA reuptake inhibitor sibutramine in the rat
    • JACKSON, H.C., BEARHAM, M.C., MAZURKIEWICZ, S.E., HEAL, D.J. & BUCKETT, W.R. (1996a). Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and NA reuptake inhibitor sibutramine in the rat. Br. J. Pharmacol., 117, 168P.
    • (1996) Br. J. Pharmacol. , vol.117
    • Jackson, H.C.1    Bearham, M.C.2    Mazurkiewicz, S.E.3    Heal, D.J.4    Buckett, W.R.5
  • 18
    • 0013505918 scopus 로고    scopus 로고
    • Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat
    • JACKSON, H.C., HUTCHINS, L.J., MAZURKIEWICZ, S.E., HEAL, D.J. & BUCKETT, W.R. (1996b). Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br. J. Pharmacol., 117, 323P.
    • (1996) Br. J. Pharmacol. , vol.117
    • Jackson, H.C.1    Hutchins, L.J.2    Mazurkiewicz, S.E.3    Heal, D.J.4    Buckett, W.R.5
  • 20
    • 0025827064 scopus 로고
    • 1C receptors mediate 1-2(chlorophenyl)piperazine-induced hypophagia
    • 1C receptors mediate 1-2(chlorophenyl)piperazine-induced hypophagia. Br. J. Pharmacol., 103, 2016-2020.
    • (1991) Br. J. Pharmacol. , vol.103 , pp. 2016-2020
    • Kennett, G.A.1    Curzon, G.2
  • 22
    • 8544251834 scopus 로고
    • Antagonist studies on the overt behavioural effects of MK-212 and mCPP in the rat
    • KNIGHT, M. & FLETCHER, A. (1989). Antagonist studies on the overt behavioural effects of MK-212 and mCPP in the rat. Br. J. Pharmacol., 97, 46IP.
    • (1989) Br. J. Pharmacol. , vol.97
    • Knight, M.1    Fletcher, A.2
  • 23
    • 0020082265 scopus 로고
    • Distribution of alpha-adrenergic, beta-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat
    • LEIBOWITZ, S.F., JHANWAR-UNIYAL, M., DVORKIN, B. & MAKMAN, M.H. (1982). Distribution of alpha-adrenergic, beta-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res., 233, 97-114.
    • (1982) Brain Res. , vol.233 , pp. 97-114
    • Leibowitz, S.F.1    Jhanwar-Uniyal, M.2    Dvorkin, B.3    Makman, M.H.4
  • 24
    • 0018081182 scopus 로고
    • Pharmacological characterization of perifornical hypothalamic β-adrenergic receptors mediating feeding inhibition in the rat
    • LEIBOWITZ, S.F. & ROSSAKIS, C. (1978). Pharmacological characterization of perifornical hypothalamic β-adrenergic receptors mediating feeding inhibition in the rat. Neuropharmacology, 17, 691-702.
    • (1978) Neuropharmacology , vol.17 , pp. 691-702
    • Leibowitz, S.F.1    Rossakis, C.2
  • 27
    • 0024503310 scopus 로고
    • The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride
    • LUSCOMBE, G.P., HOPCROFT, R.H., THOMAS, P.C. & BUCKETT, W.R. (1989). The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology, 28, 129-134.
    • (1989) Neuropharmacology , vol.28 , pp. 129-134
    • Luscombe, G.P.1    Hopcroft, R.H.2    Thomas, P.C.3    Buckett, W.R.4
  • 28
    • 0021164310 scopus 로고
    • Clonidine-induced feeding: Analysis of central sites of action and fiber projections mediating this response
    • MCCABE, J.T., DE BELLIS, M. & LEIBOWITZ, S.F. (1984). Clonidine-induced feeding: Analysis of central sites of action and fiber projections mediating this response. Brain Res., 309, 85-104.
    • (1984) Brain Res. , vol.309 , pp. 85-104
    • McCabe, J.T.1    De Bellis, M.2    Leibowitz, S.F.3
  • 30
    • 0027993093 scopus 로고
    • Involvement of beta-1 and beta-2 adrenergic receptors in the antidepressant-like effects of centrally administered isoproterenol
    • O'DONNELL, J.M., FRITH, S. & WILKINS, J. (1994). Involvement of beta-1 and beta-2 adrenergic receptors in the antidepressant-like effects of centrally administered isoproterenol. J. Pharmacol. Exp. Ther., 271, 246-254.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 246-254
    • O'Donnell, J.M.1    Frith, S.2    Wilkins, J.3
  • 31
    • 0007570575 scopus 로고    scopus 로고
    • Comparison of the effects of sibutramine, fluoxetine and d-fenflurarnine on extracellular 5-HT in rat anterior hypothalamus: An in vivo microdialysis study
    • PROW, M.R., HANNON, S.D., ASPLEY, S., MARTIN, K.F. & HEAL, D.J. (1996). Comparison of the effects of sibutramine, fluoxetine and d-fenflurarnine on extracellular 5-HT in rat anterior hypothalamus: an in vivo microdialysis study. Br. J. Pharmacol., 120, 351P.
    • (1996) Br. J. Pharmacol. , vol.120
    • Prow, M.R.1    Hannon, S.D.2    Aspley, S.3    Martin, K.F.4    Heal, D.J.5
  • 32
    • 0030249204 scopus 로고    scopus 로고
    • The physiology and brain mechanisms of feeding
    • ROWLAND, N.E., MORIEN, A. & LI, B.-H. (1996). The physiology and brain mechanisms of feeding. Nutrition, 12, 626-639.
    • (1996) Nutrition , vol.12 , pp. 626-639
    • Rowland, N.E.1    Morien, A.2    Li, B.-H.3
  • 33
    • 0029399534 scopus 로고
    • Sibutramine: A novel new agent for obesity treatment
    • RYAN, D.H., KAISER, P. & BRAY, G.A. (1995). Sibutramine: a novel new agent for obesity treatment. Obesity Res., 3, 553S-559S.
    • (1995) Obesity Res. , vol.3
    • Ryan, D.H.1    Kaiser, P.2    Bray, G.A.3
  • 34
    • 0020656558 scopus 로고
    • An analysis of the effects of systemically administered clonidine on the food and water intake of rats
    • SANGER, D.J. (1983). An analysis of the effects of systemically administered clonidine on the food and water intake of rats. Br. J. Pharmacol., 78, 159-164.
    • (1983) Br. J. Pharmacol. , vol.78 , pp. 159-164
    • Sanger, D.J.1
  • 36
    • 8544251835 scopus 로고    scopus 로고
    • Comparison of the effects of systemic administration of sibutramine (BTS 54 524) and d-amphetamine on noradrenaline (NA) efflux in rat frontal cortex
    • in press
    • STANFORD, S.C., HUGHES, Z.A., MASON, K. & HEAL, D.J. (1997). Comparison of the effects of systemic administration of sibutramine (BTS 54 524) and d-amphetamine on noradrenaline (NA) efflux in rat frontal cortex. Exp. Neurol., (in press).
    • (1997) Exp. Neurol.
    • Stanford, S.C.1    Hughes, Z.A.2    Mason, K.3    Heal, D.J.4
  • 37
    • 0000197204 scopus 로고
    • Effects of sibutramine on feeding behaviour in obese and lean Zucker rats
    • STRICKER-KRONGRAD, A., SOUQUET, A.-M. & BURLET, C. (1995). Effects of sibutramine on feeding behaviour in obese and lean Zucker rats. Int. J. Obesity, 19, 145.
    • (1995) Int. J. Obesity , vol.19 , pp. 145
    • Stricker-Krongrad, A.1    Souquet, A.-M.2    Burlet, C.3
  • 38
    • 0000979242 scopus 로고    scopus 로고
    • Effect of various monoamine receptor antagonists on the decrease in food intake induced by sibutramine in the rat
    • STRICKER-KRONGRAD, A., SOUQUET, A-M., JACKSON, H.C. & BURLET, C. (1996). Effect of various monoamine receptor antagonists on the decrease in food intake induced by sibutramine in the rat. Br. J. Pharmacol., 117, 167P.
    • (1996) Br. J. Pharmacol. , vol.117
    • Stricker-Krongrad, A.1    Souquet, A.-M.2    Jackson, H.C.3    Burlet, C.4


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