Deletion of phospholipase C β4 in thalamocortical relay nucleus leads to absence seizures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 51, 2009, Pages 21912-21917

  Cheong, Eunji ^a   Zheng, Yihong ^a,b   Lee, Kyoobin ^a   Lee, Jungryun ^a   Kim, Seongwook ^a,b   Sanati, Maryam ^a,b   Lee, Sukyung ^c   Kim, Yeon Soo ^c   Shin, Hee Sup ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Inje University   (South Korea)

Author keywords

Epilepsy; Gene knockdown; Knockout mice; Thalamus

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYSTEINE; ETHOSUXIMIDE; GAMMA BUTYROLACTONE; PHORBOL DIDECANOATE; PHOSPHOLIPASE C BETA4;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DIMERIZATION; GENE DELETION; GENE SILENCING; HYPERPOLARIZATION; KNOCKOUT GENE; MOUSE; NERVE CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMOCORTICAL TRACT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; ELECTROENCEPHALOGRAPHY; ENZYME ACTIVATORS; EPILEPSY, ABSENCE; GABA AGONISTS; GENE SILENCING; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; PHOSPHOLIPASE C BETA; THALAMUS;

ANIMALIA; MUS;

EID: 76049101652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912204106     Document Type: Article

References (39)

1. McCormick DA, Contreras D (2001) On the cellular and network bases of epileptic seizures. Ann Rev Physiol 63:815-846.
2. Snead OC, 3rd (1995) Basic mechanisms of generalized absence seizures. Ann Neurol 37:146-157.
3. Beenhakker MP, Huguenard JR (2009) Neurons that fire together also conspire together: Is normal sleep circuitry hijacked to generate epilepsy? Neuron 62:612-632.
4. Crunelli V, Leresche N (2002) Childhood absence epilepsy: Genes, channels, neurons and networks. Nat Rev 3:371-382.
5. WilliamsD(1953)Astudy of thalamic and cortical rhythms in petit mal. Brain 76:50-69.
6. Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C (1998) Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol 55:27-57.
7. Timofeev I, Steriade M (2004) Neocortical seizures: Initiation, development and cessation. Neuroscience 123:299-336.
8. Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci 30:350-356.
9. Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 283:541-543.
10. Meeren HK, Pijn JP, Van Luijtelaar EL, Coenen AM, Lopes da Silva FH (2002) Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci 22:1480-1495.
11. Tan HO, et al. (2007) Reduced cortical inhibition in amouse model of familial childhood absence epilepsy. Proc Natl Acad Sci USA 104:17536-17541.
12. Polack PO, et al. (2007) Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci 27:6590-6599.
13. Manning JP, Richards DA, Leresche N, Crunelli V, Bowery NG (2004) Cortical-area specific block of genetically determined absence seizures by ethosuximide. Neuroscience 123:5-9.
14. McCormick DA, Bal T (1997) Sleep and arousal: Thalamocortical mechanisms. Annu Rev Neurosci 20:185-215.
15. Avanzini G, Panzica F, de Curtis M (2000) The role of the thalamus in vigilance and epileptogenic mechanisms. Clin Neurophysiol 111:S19-S26.
16. Llinas RR, Steriade M (2006) Bursting of thalamic neurons and states of vigilance. J Neurophysiol 95:3297-3308.
17. Kim D, et al. (2001) Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron 31:35-45.
18. Steriade M, Contreras D (1995) Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J Neurosci 15:623-642.
19. Noebels JL, Sidman RL (1979) Inherited epilepsy: Spike-wave and focal motor seizures in the mutant mouse tottering. Science 204:1334-1336.
20. Pinault D, et al. (1998) Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsy. J Physiol 509:449-456.
21. Frankel WN (1999) Detecting genes in new and old mouse models for epilepsy: A prospectus through the magnifying glass. Epilepsy Res 36:97-110.
22. 2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell 88:385-392.
23. Barclay J, Rees M (1999) Mouse models of spike-wave epilepsy. Epilepsia 40:17-22.
24. Noebels JL, Qiao X, Bronson RT, Spencer C, Davisson MT (1990) Stargazer: A new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res 7:129-135.
25. Zhang Y, Mori M, Burgess DL, Noebels JL (2002) Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci 22:6362-6371.
26. Zhang Y, Vilaythong AP, Yoshor D, Noebels JL (2004) Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci 24:5239-5248.
27. Song I, et al. (2004) Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J Neurosci 24:5249-5257.
28. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL (2009) Genetic enhancement of thalamocortical network activity by elevating alpha1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci 29:1615-1625.
29. Miyata M, et al. (2003) Role of thalamic phospholipase Cβ4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. J Neurosci 23:8098-8108.
30. Watanabe M, et al. (1998) Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain. Eur J Neurosci 10:2016-2025.
31. 2+ channels controls pain sensory gating in the thalamus. J Neurosci 28:13331-13340.
32. Hu RQ, Banerjee PK, Snead OC, 3rd (2000) Regulation of gamma-aminobutyric acid (GABA) release in cerebral cortex in the gamma-hydroxybutyric acid (GHB) model of absence seizures in rat. Neuropharmacology 39:427-439.
33. Wong CG, Gibson KM, Snead OC, 3rd (2004) From the street to the brain: Neurobiology of the recreational drug gamma-hydroxybutyric acid. Trends Pharmacol Sci 25:29-34.
34. Bowery NG (2006) GABAB receptor: A site of therapeutic benefit. Curr Opin Pharmacol 6:37-43.
35. Shin J, et al. (2009) Phospholipase C β4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. J Neurosci In Press
36. Charpier S, et al. (1999) On the putative contribution of GABA(B) receptors to the electrical events occurring during spontaneous spike and wave discharges. Neuropharmacology 38:1699-1706.
37. Strege PR, Bernard CE, Ou Y, Gibbons SJ, Farrugia G (2005) Effect of mibefradil on sodium and calcium currents. Am J Physiol Gastrointest Liver Physiol 289:G249-G253.
38. Iftinca MC, Zamponi GW (2009) Regulation of neuronal T-type calcium channels. Trends Pharmacol Sci 30:32-40.
39. Kang SJ, et al. (2008) Expression of Kir2.1 channels in astrocytes under pathophysiological conditions. Mol Cells 25:124-130.