Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures

Journal of Neuroscience

Volumn 27, Issue 24, 2007, Pages 6590-6599

  Polack, Pierre Olivier ^a   Guillemain, Isabelle ^b   Hu, Emilie ^a,c   Deransart, Colin ^b   Depaulis, Antoine ^b   Charpier, Stéphane ^a,c  

^a INSERM   (France)

^b GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Absence epilepsy; Cortical synchronization; Focal epilepsy; In vivo; Somatosensory cortex; Thalamus

Indexed keywords

ABSENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; EPILEPTIC DISCHARGE; EPILEPTIC FOCUS; FEMALE; GENETIC MODEL; INTRACELLULAR RECORDING; MALE; NERVE CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; BIOTIN; BRAIN MAPPING; EPILEPSY, ABSENCE; FACE; MODELS, GENETIC; NEURONS; PERIODICITY; RATS; RATS, WISTAR; SOMATOSENSORY CORTEX; WAKEFULNESS;

EID: 34250308414     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0753-07.2007     Document Type: Article

References (54)

1. Amitai Y (1994) Membrane potential oscillations underlying firing patterns in neocortical neurons. Neuroscience 63:151-161.
2. Amitai Y, Connors BW (1994) The barrel cortex of rodents. In: Cerebral cortex (Jones EG, Diamond I, eds), pp 299-331. New York: Plenum.
3. Avanzini G, Panzica F, de Curtis M (2000) The role of the thalamus in vigilance and epileptogenic mechanisms. Clin Neurophysiol 111 [Suppl 2]:S19-S26.
4. Bal T, von Krosigk M, McCormick DA (1995) Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. J Physiol (Lond) 483:665-685.
5. Blumenfeld H, McCormick DA (2000) Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J Neurosci 20:5153-5162.
6. Brecht M, Roth A, Sakmann B (2003) Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex. J Physiol (Lond) 553:243-265.
7. Buzsaki G (1991) The thalamic clock: emergent network properties. Neuroscience 41:351-364.
8. Chapin JK, Lin CS (1984) Mapping the body representation in the SI cortex of anesthetized and awake rats. J Comp Neurol 229:199-213.
9. Charpier S, Leresche N, Deniau JM, Mahon S, Hughes SW, Crunelli V (1999) On the putative contribution of GABA(B) receptors to the electrical events occurring during spontaneous spike and wave discharges. Neuropharmacology 38:1699-1706.
10. Coenen AM, van Luijtelaar EL (2003) Genetic animal models for absence epilepsy: a review of the WAG/Rijstrain of rats. Behav Genet 33:635-655.
11. Crill WE (1996) Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58:349-362.
12. D'Antuono M, Inaba Y, Biagini G, D'Arcangelo G, Tancredi V, Avoli M (2006) Synaptic hyperexcitability of deep layer neocortical cells in a genetic model of absence seizures. Genes Brain Behav 5:73-84.
13. Depaulis A, Van Luijtelaar EL (2005) Genetic models of absence epilepsy in the rat. In: Models of seizures and epilepsy (Pitkänen A, Schwartzkroin PA, Moshé SL, eds), pp 233-248. London: Elsevier.
14. Feldman MD (1984) Morphology of the neocortical pyramidal neuron. In: Cerebral cortex (Peters A, Jones EG, eds), pp 123-200. New York: Plenum.
15. Feldmeyer D, Egger V, Lubke J, Sakmann B (1999) Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single "barrel" of developing rat somatosensory cortex. J Physiol (Lond) 521:169-190.
16. Fricker D, Verheugen JA, Miles R (1999) Cell-attached measurements of the firing threshold of rat hippocampal neurones. J Physiol (Lond) 517:791-804.
17. Holmes MD, Brown M, Tucker DM (2004) Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence. Epilepsia 45:1568-1579.
18. Jasper HH, Kershman J (1941) Electroencephalographic classification of the epilepsies. Arch Neurol Psychiatry 45:903-943.
19. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H (2004) Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res 1000:102-109.
20. h channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. J Neurosci 26:1677-1687.
21. Le Van Quyen M, Foucher J, Lachaux J, Rodriguez E, Lutz A, Martinerie J, Varela FJ (2001) Comparison of Hilbert transform and wavelet methods for the analysis of neuronal synchrony. J Neurosci Methods 111:83-98.
22. Manning JP, Richards DA, Leresche N, Crunelli V, Bowery NG (2004) Cortical-area specific block of genetically determined absence seizures by ethosuximide. Neuroscience 123:5-9.
23. Manns ID, Sakmann B, Brecht M (2004) Sub- and suprathreshold receptive field properties of pyramidal neurones in layers 5A and 5B of rat somatosensory barrel cortex. J Physiol (Lond) 556:601-622.
24. Meeren H, van Luijtelaar G, Lopes da Silva F, Coenen A (2005) Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory. Arch Neurol 62:371-376.
25. Meeren HK, Pijn JP, van Luijtelaar EL, Coenen AM, Lopes da Silva FH (2002) Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci 22:1480-1495.
26. Neckelmann D, Amzica F, Steriade M (1998) Spike-wave complexes and fast components of cortically generated seizures. III. Synchronizing mechanisms. J Neurophysiol 80:1480-1494.
27. Neckelmann D, Amzica F, Steriade M (2000) Changes in neuronal conductance during different components of cortically generated spike-wave seizures. Neuroscience 96:475-485.
28. Nersesyan H, Hyder F, Rothman DL, Blumenfeld H (2004) Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. J Cereb Blood Flow Metab 24:589-599.
29. Nicolelis MA, Fanselow EE (2002) Thalamocortical [correction of Thalamcortical] optimization of tactile processing according to behavioral state. Nat Neurosci 5:517-523.
30. Panayiotopoulos CP (1997) Absence epilepsies. In: Epilepsy: a comprehensive textbook (Engel J, Pedley TA, eds), pp 2327-2346. Philadelphia: Lippincot-Raven.
31. Parri HR, Crunelli V (1998) Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing. J Neurosci 18:854-867.
32. Paxinos G, Watson C (1986) The brain in stereotaxic coordinates. Sydney: Academic.
33. Penfield WG, Jasper HH (1954) Epilepsy and the functional anatomy of the human brain. Boston: Little Brown.
34. Petsche H (1962) Pathophysiology and clinical aspects of petitmal. Toposcopic studies on the phenomenology of the spike wave pattern. Wien Z Nervenheilkd Grenzgeb 19:345-442.
35. Pinault D, Lereshe N, Charpier S, Deniau JM, Marescaux C, Vergnes M, Crunelli V (1998) Intracellular recordings in thalamic neurones during spike and waves discharges in rats with absence epilepsy. J Physiol (Lond) 509:449-456.
36. Rall W (1969) Time constants and electrotonic length of membrane cylinders and neurons. Biophys J 9:1483-1508.
37. Sadleir LG, Farrell K, Smith S, Connolly MB, Scheffer IE (2006) Electroclinical features of absence seizures in childhood absence epilepsy. Neurology 67:413-418.
38. Silva LR, Amitai Y, Connors BW (1991) Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science 251:432-435.
39. Simons DJ, Woolsey TA (1984) Morphology of Golgi-Cox-impregnated barrel neurons in rat SmI cortex. J Comp Neurol 230:119-132.
40. Sitnikova E, van Luijtelaar G (2004) Cortical control of generalized absence seizures: effect of lidocaine applied to the somatosensory cortex in WAG/Rij rats. Brain Res 1012:127-137.
41. Slaght SJ, Paz T, Chavez M, Deniau JM, Mahon S, Charpier S (2004) On the activity of the corticostriatal networks during spike-and-wave discharges in a genetic model of absence epilepsy. J Neurosci 24:6816-6825.
42. Snead III OC (1992) Pharmacological models of generalized absence seizures in rodents. J Neural Transm Suppl 35:7-19.
43. Steriade M, Amzica F (1994) Dynamic coupling among neocortical neurons during evoked and spontaneous spike-wave seizure activity. J Neurophysiol 72:2051-2069.
44. Steriade M, Contreras D (1995) Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J Neurosci 15:623-642.
45. Steriade M, Contreras D (1998) Spike-wave complexes and fast components of cortically generated seizures. I. Role of neocortex and thalamus. J Neurophysiol 80:1439-1455.
46. Strauss U, Kole MH, Brauer AU, Pahnke J, Bajorat R, Rolfs A, Nitsch R, Deisz RA (2004) An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci 19:3048-3058.
47. Svoboda K, Helmchen F, Denk W, Tank DW (1999) Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nat Neurosci 2:65-73.
48. Timofeev I, Steriade M (2004) Neocortical seizures: initiation, development and cessation. Neuroscience 123:299-336.
49. van Luijtelaar G, Sitnikova E (2006) Global and focal aspects of absence epilepsy: The contribution of genetic models. Neurosci Biobehav Rev 30:983-1003.
50. Vergnes M, Marescaux C, Depaulis A (1990) Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy. Brain Res 523:87-91.
51. Watts J, Thomson AM (2005) Excitatory and inhibitory connections show selectivity in the neocortex. J Physiol (Lond) 562:89 -97.
52. Williams SR, Stuart GJ (1999) Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons. J Physiol (Lond) 521:467-482.
53. Williams SR, Stuart GJ (2000) Site independence of EPSP time course is mediated by dendritic I (h) in neocortical pyramidal neurons. J Neurophysiol 83:3177-3182.
54. Zilles K (1985) The cortex of the rat: a stereotaxic atlas. Berlin: Springer.