Is human hibernation possible?

Annual Review of Medicine

Volumn 59, Issue , 2008, Pages 177-186

  Cheng, Chi Lee ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

5 AMP; Hypometabolism; Hypothermia; Torpor

Indexed keywords

ADENOSINE PHOSPHATE;

HEART ARREST; HIBERNATION; HUMAN; HYPOTHERMIA; INDUCED HYPOTHERMIA; MAMMAL; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ADENOSINE MONOPHOSPHATE; HIBERNATION; HUMANS; HYPOTHERMIA, INDUCED;

EID: 39649106917     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.59.061506.110403     Document Type: Review

References (33)

1. Heldmaier G, Ortmann S, Elvert R. 2004. Natural hypometabolism during hibernation and daily torpor in mammals. Respir. Physiol. Neurobiol. 141:317-29
2. Wu X, Kochanek PM, Cochran K, et al. 2005. Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J. Trauma 59:291-99
3. Kabon B, Bacher A, Spiss CK. 2003. Therapeutic hypothermia. Best Pract. Res. Clin. Anaesthesiol. 17:551-68
4. Moon PF, Ilkiw JE. 1993. Surface-induced hypothermia in dogs: 19 cases (1987-1989). J. Am. Vet. Med. Assoc. 202:437-44
5. Zhang J, Kaasik K, Blackburn MR, et al. 2006. Constant darkness is a circadian metabolic signal in mammals. Nature. 439:340-43
6. Stamper JL, Dark J, Zucker I. 1999. Photoperiod modulates torpor and food intake in Siberian hamsters challenged with metabolic inhibitors. Physiol. Behav. 66:113-18
7. Heller HC, Ruby NF. 2004. Sleep and circadian rhythms in mammalian torpor. Annu. Rev. Physiol. 66:275-89
8. Dark J, Miller DR, Zucker I. 1994. Reduced glucose availability induces torpor in Siberian hamsters. Am. J. Physiol. 267:496-501
9. Blackstone E, Morrison M, Roth MB. 2005. H2S induces a suspended animation-like state in mice. Science 308:518
10. Johansson BW. 1996. The hibernator heart - nature's model of resistance to ventricular fibrillation. Cardiovasc. Res. 31:826-32
11. Doherty JC, Kronon MT, Rotermund AJ Jr. 1993. The effects of short term cold storage upon ATP and 2,3-BPG levels in the blood of euthermic and hibernating thirteen-lined ground squirrels Spermophilus tridecemlineatus. Comp. Biochem. Physiol. Comp. Physiol. 1104:87-91
12. English TE, Storey KB. 2000. Enzymes of adenylate metabolism and their role in hibernation of the white-tailed prairie dog, Cynomys leucurus. Arch. Biochem. Biophys. 376:91-100
13. Boulant JA. 2006. Neuronal basis of Hammel's model for set-point thermoregulation. J. Appl. Physiol. 100:1347-54
14. Churchill TA, Simpkin S, Wang LC, et al. 1996. Metabolic effects of cold storage on livers from euthermic and hibernating Columbian ground squirrels. Cryobiology 33:34-40
15. Lowe ME. 1977. Molecular mechanisms of rat and human pancreatic triglyceride lipases. J. Nutr. 127:549-57
16. Squire TL, Lowe ME, Bauer VW, et al. 2003. Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol. Genom. 16:131-40
17. Barnes BM. 1989. Freeze avoidance in a mammal: body temperatures below 0°C in an Arctic hibernator. Science 244:1593-95
18. Lehninger AL. 1977. Biochemistry: The Molecular Bast of Cell Structure and Function, pp. 623-57. New York: Worth. 2nd ed.
19. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413-92
20. Loffler M, Morote-Garcia JC, Eltzschig SA, et al. 2007. Physiological roles of vascular nucleoside transporters. Arterioscler. Thromb. Vasc. Biol. 27:1004-13
21. King AE, Ackley MA, Cass CE, et al. 2006. Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol. Sci. 27:416-25
22. Inbe H, Watanabe S, Miyawaki M, et al. 2004. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. J. Biol. Chem. 279:19790-99
23. Abbracchio MP, Burnstock G, Boeynaems JM, et al. 2005. The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Trends Pharmacol. Sci. 26:8-9
24. Holman GD. 1979. Infinite cis influx of cyclic AMP into human erythrocyte ghosts. Biochim. Biophys. Acta 553:489-94
25. DeBari VA, Novak NA, Bennun A. 1984. Cyclic nucleotide metabolism in the human erythrocyte. Clin. Physiol. Biochem. 2:227-38
26. He Y, Chu SH, Walker WA. 1993. Nucleotide supplements alter proliferation and differentiation of cultured human (Caco-2) and rat (IEC-6) intestinal epithelial cells. J. Nutr. 123:1017-27
27. Visser WF, van Roermund CW, Ijlst L, et al. 2007. Metabolite transport across the peroxisomal membrane. Biochem. J. 401:365-75
28. Sharer JD. 2005. The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life 57:607-14
29. Frederiks WM, Marx F, Bosch KS, et al. 1987. Diurnal variation in 5′-nucleotidase activity in rat liver. A quantitative histochemical study. Histochemistry 87:439-43
30. Uchiyama Y. 1983. A histochemical study of variations in the localization of 5′-nucleotidase activity in the acinar cell of the rat exocrine pancreas over the twenty-four hour period. Cell Tissue Res. 230:411-20
31. 1 adenosine receptors. Mol. Cell Biol. 24:2710-19
32. Arch JR, Newsholme EA. 1978. Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem. J. 174:965-77
33. Lindsley JE, Rutter J. 2004. Nutrient sensing and metabolic decisions. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 139:543-59