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Volumn 315, Issue 5818, 2007, Pages 1565-1568

A cytochrome c oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; CYTOCHROME C OXIDASE; IRON; OXYGEN; PHENOL; REACTIVE OXYGEN METABOLITE; TYROSINE; WATER;

EID: 33947379088     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135844     Document Type: Article
Times cited : (479)

References (44)
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    • T. Tsukihara et al., Science 269, 1069 (1995).
    • (1995) Science , vol.269 , pp. 1069
    • Tsukihara, T.1
  • 29
    • 33947415043 scopus 로고    scopus 로고
    • Materials and methods are available as supporting material on Science Online.
    • Materials and methods are available as supporting material on Science Online.
  • 38
    • 33947405886 scopus 로고    scopus 로고
    • The peroxide detected at the ring electrode could arise either from direct release of peroxide during the catalytic cycle or from release and rapid disproportionation of superoxide (42, The hydrolytic autoxidation of heme oxygen complexes in aqueous solution is a well-documented phenomenon (39, 43, This process is known to be catalyzed by protons, and preliminary results indicate that the selectivity of all of our catalysts can be markedly improved by raising the pH (to the range of 8 to 12, Furthermore, our prior work with CcO models on edge-plane graphite provided evidence that superoxide is a substantial source of PROS 30
    • The peroxide detected at the ring electrode could arise either from direct release of peroxide during the catalytic cycle or from release and rapid disproportionation of superoxide (42). The hydrolytic autoxidation of heme oxygen complexes in aqueous solution is a well-documented phenomenon (39, 43). This process is known to be catalyzed by protons, and preliminary results indicate that the selectivity of all of our catalysts can be markedly improved by raising the pH (to the range of 8 to 12). Furthermore, our prior work with CcO models on edge-plane graphite provided evidence that superoxide is a substantial source of PROS (30).
  • 44
    • 33947396230 scopus 로고    scopus 로고
    • We dedicate this scientific contribution to the memory of the late H. Taube. We thank J. I. Brauman, T. D. P. Stack, C. C. Cummins, R. Boulatov, and P. H. Dinolfo for helpful discussions. N.K.D, R.A.D, and W.E. acknowledge a Stanford graduate fellowship, a Lavoisier fellowship, and a Dreyfus undergraduate fellowship, respectively. This material has its basis in work supported by the NIH under grant GM-17880-35
    • We dedicate this scientific contribution to the memory of the late H. Taube. We thank J. I. Brauman, T. D. P. Stack, C. C. Cummins, R. Boulatov, and P. H. Dinolfo for helpful discussions. N.K.D., R.A.D., and W.E. acknowledge a Stanford graduate fellowship, a Lavoisier fellowship, and a Dreyfus undergraduate fellowship, respectively. This material has its basis in work supported by the NIH under grant GM-17880-35.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.