Very-high-dose α-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats

Journal of Neuroscience Research

Volumn 87, Issue 2, 2009, Pages 556-566

  Miyamoto, Kaori ^a,b   Shiozaki, Motoko ^a,c   Shibata, Masahiro ^d   Koike, Masato ^e   Uchiyama, Yasuo ^e   Gotow, Takahiro ^a  

^a KOSHIEN UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^e JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell death associated protein; Cytoskeleton; Lysosome; Neurodegeneration; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CATHEPSIN D; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOFUSCIN; NEUROFILAMENT PROTEIN; PROTEIN BCL XL; SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; NEUROFILAMENT PROTEIN H; PROTEIN BCL X;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD PRESSURE MEASUREMENT; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; HIPPOCAMPUS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LYSOSOME; MALE; MICROGLIA; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; PYRAMIDAL NERVE CELL; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; VITAMIN SUPPLEMENTATION; ANIMAL; BLOOD PRESSURE; BRAIN; DRUG EFFECT; GENETICS; GLIA; METABOLISM; NERVE CELL; PATHOLOGY; STROKE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ALPHA-TOCOPHEROL; ANIMALS; BCL-X PROTEIN; BLOOD PRESSURE; BLOTTING, WESTERN; BRAIN; CATHEPSIN D; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERTENSION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEUROFILAMENT PROTEINS; NEUROGLIA; NEURONS; RATS; STROKE; SUPEROXIDE DISMUTASE;

EID: 62849099321     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21851     Document Type: Article

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