Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 461-468

  Zhu, X ^a   Sano, H ^a   Kwang Pyo Kim, ^a   Sano, A ^a   Boetticher, E ^a   Munoz N M ^a   Cho, W ^a   Leff, A R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (3 ACETAMIDE 1 BENZYL 2 ETHYLINDOYL 5 OXY)PROPANEPHOSPHONIC ACID; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARACHIDONIC ACID; ARACHIDONIC TRIFLUOROMETHYL KETONE; BROMOENOL LACTONE; CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LEUKOTRIENE C4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; RAS PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SUBUNIT; EOSINOPHIL; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOSTIMULATION; INHIBITION KINETICS; PRIORITY JOURNAL;

EID: 0035400144     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.461     Document Type: Article

References (60)

1. Phospholipases
2. 2
3. 2(s); comparison of arachidonoyl-selective and -nonselective enzymes
4. 2 (type IV) in isolated human peripheral blood eosinophils by sandwich-ELISA
5. 2
6. 4 induced stimulation of eosinophils
7. 2 contains a calcium-dependent translocation domain with homology to PKC and GAP
8. 2
9. 2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis
10. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocated to the nuclear envelope upon cell activation
11. 2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase
12. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C
13. 2 is phosphorylated and activated by MAP kinase
14. Parallel signal processing among mammalian MAPKs
15. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
16. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
17. The MAPK signaling cascade
18. 2 in regulating arachidonic acid release in macrophages
19. 1-adrenergic receptors in Madin-Darby canine kidney cells
20. 2
21. 2) in thrombin-stimulated platelets
22. 2 in human neutrophils stimulated with tumor necrosis factor-α
23. 2 by a mitogen-activated protein kinase-independent mechanism in the human astrocytoma cell line 1321N1
24. 2
25. Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin and VLA-4 on human eosinophils and neutrophils
26. 4 production and degranulation by human eosinophils
27. Pharmacology of the eosinophils
28. Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophils degranulation
29. Eosinophils do respond to fMLP
30. Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils
31. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils
32. 2
33. 2
34. 2 by bromoenol lactone and trifluoromethyl ketones
35. 2
36. 2
37. 2 production in lipopolysaccharide-stimulated monocytes
38. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
39. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
40. 4 generation, but not histamine release or IL-4 production from human basophils
41. 2 and the release of arachidonic acid in human neutrophils
42. Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells
43. FMLP activates Ras and Raf in human neutrophils: Potential role in activation of MAP kinase
44. Farnesyl diphosphate-based inhibitors of Ras farnesyl protein transferase
45. Identification of Ras farnesyltransferase inhibitors by microbial screening
46. 2 in allergic response and parturition
47. 2
48. 2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils
49. 4 release
50. 2 in protein kinase C-dependent arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cells
51. 2 is modulated by ATP: Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition
52. 2 enzymes present in P388D1 macrophages
53. 2 inhibitor
54. 2 in the human astrocytoma cell line 1321N1
55. 2 integrin-dependent adhesion of human eosinophils
56. 2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium
57. 2 activity by either FcγRIIA or FcγRIIIB in human neutrophils
58. Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF
59. Kinase pathways in chemoattractant-induced degranulation of neutrophils: The role of p38 mitogen-activated protein kinase activated by Src family kinases
60. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase