메뉴 건너뛰기




Volumn , Issue , 2007, Pages 261-285

Role of Drug Metabolism in Drug Development

Author keywords

Drug drug interaction; Genetic polymorphisms and drug metabolizing enzymes; Human liver microsomes and hepatocytes

Indexed keywords


EID: 75749134257     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470191699.ch9     Document Type: Chapter
Times cited : (5)

References (62)
  • 3
    • 0035699829 scopus 로고    scopus 로고
    • Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry
    • Baillie TA, Kassahun K. Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry. Adv Exp Med Biol 2001;500:45-51.
    • (2001) Adv Exp Med Biol , vol.500 , pp. 45-51
    • Baillie, T.A.1    Kassahun, K.2
  • 5
    • 0043027104 scopus 로고    scopus 로고
    • In vitro drug interactions of cytochrome P450: an evaluation of fluorogenic to conventional substrates
    • Cohen LH, Remley MJ, Raunig D, Vaz AD. In vitro drug interactions of cytochrome P450: an evaluation of fluorogenic to conventional substrates. Drug Metab Dispos 2003;31:1005-1015.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1005-1015
    • Cohen, L.H.1    Remley, M.J.2    Raunig, D.3    Vaz, A.D.4
  • 7
    • 0036784476 scopus 로고    scopus 로고
    • Comparison of in vitro preparations for semiquantitative prediction of in vivo drug metabolism
    • DOI:10.1124/dmd.30.10.1129
    • de Graaf IAM, van Meijeren CE, Pektas F, Koster HJ. Comparison of in vitro preparations for semiquantitative prediction of in vivo drug metabolism. Drug Metab Dispos 2002;30:1129-1136. DOI:10.1124/dmd.30.10.1129.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1129-1136
    • de Graaf, I.A.M.1    van Meijeren, C.E.2    Pektas, F.3    Koster, H.J.4
  • 8
    • 0033972441 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
    • Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet 2000;38:41-57.
    • (2000) Clin Pharmacokinet , vol.38 , pp. 41-57
    • Dresser, G.K.1    Spence, J.D.2    Bailey, D.G.3
  • 9
    • 0029788511 scopus 로고    scopus 로고
    • Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices
    • Ekins S, Williams JA, Murray GI, Burke MD, Marchant NC, Engeset J, Hawksworth GM. Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. Drug Metab Dispos 1996;24:990-995.
    • (1996) Drug Metab Dispos , vol.24 , pp. 990-995
    • Ekins, S.1    Williams, J.A.2    Murray, G.I.3    Burke, M.D.4    Marchant, N.C.5    Engeset, J.6    Hawksworth, G.M.7
  • 10
    • 1642281756 scopus 로고    scopus 로고
    • Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
    • Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem Res Toxicol 2004;17:3-16.
    • (2004) Chem Res Toxicol , vol.17 , pp. 3-16
    • Evans, D.C.1    Watt, A.P.2    Nicoll-Griffith, D.A.3    Baillie, T.A.4
  • 11
    • 0025880861 scopus 로고
    • Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy
    • Fennell TR, Kedderis GL, Sumner SCJ. Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy. Chem Res Toxicol 1991;4:678-687.
    • (1991) Chem Res Toxicol , vol.4 , pp. 678-687
    • Fennell, T.R.1    Kedderis, G.L.2    Sumner, S.C.J.3
  • 12
    • 0028303338 scopus 로고
    • Identification of metabolites of carcinogens by 13C NMR spectroscopy
    • Fennell TR, Sumner SCJ. Identification of metabolites of carcinogens by 13C NMR spectroscopy. Drug Metab Rev 1994;26:469-481.
    • (1994) Drug Metab Rev , vol.26 , pp. 469-481
    • Fennell, T.R.1    Sumner, S.C.J.2
  • 13
    • 33745798151 scopus 로고    scopus 로고
    • Methods to evaluate biliary excretion of drugs in humans: an updated review
    • Ghibellini G, Leslie EM, Brouwer KL. Methods to evaluate biliary excretion of drugs in humans: an updated review. Mol Pharmacol 2006;3:198-211.
    • (2006) Mol Pharmacol , vol.3 , pp. 198-211
    • Ghibellini, G.1    Leslie, E.M.2    Brouwer, K.L.3
  • 14
    • 0346656878 scopus 로고    scopus 로고
    • Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes
    • Ghosal A, Hapangama N, Yuan Y, Lu X, Horne D, Patrick JE, Zbaida S. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes. Biopharm Drug Dispos 2003;24:375-384.
    • (2003) Biopharm Drug Dispos , vol.24 , pp. 375-384
    • Ghosal, A.1    Hapangama, N.2    Yuan, Y.3    Lu, X.4    Horne, D.5    Patrick, J.E.6    Zbaida, S.7
  • 16
    • 0038680172 scopus 로고    scopus 로고
    • Drug-drug interactions: clinical perspective
    • In:Rodrigues AD, editor. Drug-Drug Interactions. New York: Marcel Dekker
    • Greenblatt DJ, von Moltke LL. Drug-drug interactions: clinical perspective. In:Rodrigues AD, editor. Drug-Drug Interactions. New York: Marcel Dekker; 2002. p 565-584.
    • (2002) , pp. 565-584
    • Greenblatt, D.J.1    von Moltke, L.L.2
  • 17
    • 0003605672 scopus 로고
    • Radiobiology for the Radiologist
    • JB Lippincott Company
    • Hall EJ. Radiobiology for the Radiologist. JB Lippincott Company; 1994.
    • (1994)
    • Hall, E.J.1
  • 18
    • 4043117632 scopus 로고    scopus 로고
    • Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures
    • Hewitt NJ, Utesch D. Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures. Hum Exp Toxicol 2004;23:307-316.
    • (2004) Hum Exp Toxicol , vol.23 , pp. 307-316
    • Hewitt, N.J.1    Utesch, D.2
  • 19
    • 2442700486 scopus 로고    scopus 로고
    • Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned?
    • Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-569.
    • (2004) J Clin Pharmacol , vol.44 , pp. 559-569
    • Huang, S.M.1    Lesko, L.J.2
  • 20
    • 0038685771 scopus 로고    scopus 로고
    • Comparative biotransformation of radiolabeled [14C]omapatrilat and stable-labeled [13C2]omapatrilat after oral administration to rats, dogs, and humans
    • Iyer RA, Malhotra B, Sanaullah K, Mitroka J, Bonacorsi SJ, Waller SC, Rinehart JK, Kripalani K. Comparative biotransformation of radiolabeled [14C]omapatrilat and stable-labeled [13C2]omapatrilat after oral administration to rats, dogs, and humans. Drug Metab Dispos 2003;31:67-75.
    • (2003) Drug Metab Dispos , vol.31 , pp. 67-75
    • Iyer, R.A.1    Malhotra, B.2    Sanaullah, K.3    Mitroka, J.4    Bonacorsi, S.J.5    Waller, S.C.6    Rinehart, J.K.7    Kripalani, K.8
  • 22
    • 19144370649 scopus 로고    scopus 로고
    • Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone
    • Jaakkola T, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther 2005;77:404-414.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 404-414
    • Jaakkola, T.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 23
    • 0034885012 scopus 로고    scopus 로고
    • Role of drug metabolism in drug discovery and development
    • Kumar GN, Surapaneni S. Role of drug metabolism in drug discovery and development. Med Res Rev 2001;21:397-411.
    • (2001) Med Res Rev , vol.21 , pp. 397-411
    • Kumar, G.N.1    Surapaneni, S.2
  • 24
    • 17144423884 scopus 로고    scopus 로고
    • Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects
    • Lilja JJ, Backman JT, Neuvonen PJ. Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:433-439.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 433-439
    • Lilja, J.J.1    Backman, J.T.2    Neuvonen, P.J.3
  • 25
    • 0037379318 scopus 로고    scopus 로고
    • Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification
    • Lu AY, Wang RW, Lin JH. Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification. Drug Metab Dispos 2003;31:345-350.
    • (2003) Drug Metab Dispos , vol.31 , pp. 345-350
    • Lu, A.Y.1    Wang, R.W.2    Lin, J.H.3
  • 27
    • 8844286879 scopus 로고    scopus 로고
    • CYP3A4 induction by xenobiotics:biochemistry, experimental methods and impact on drug discovery and development
    • Luo G, Guenthner T, Gan LS, Humphreys WG. CYP3A4 induction by xenobiotics:biochemistry, experimental methods and impact on drug discovery and development. Curr Drug Metab 2004;5:483-505.
    • (2004) Curr Drug Metab , vol.5 , pp. 483-505
    • Luo, G.1    Guenthner, T.2    Gan, L.S.3    Humphreys, W.G.4
  • 28
    • 4544295323 scopus 로고    scopus 로고
    • The use of radiolabeled compounds for ADME studies in discovery and exploratory development
    • Marathe PH, Shyu WC, Humphreys WG. The use of radiolabeled compounds for ADME studies in discovery and exploratory development. Curr Pharm Des 2004;10:2991-3008.
    • (2004) Curr Pharm Des , vol.10 , pp. 2991-3008
    • Marathe, P.H.1    Shyu, W.C.2    Humphreys, W.G.3
  • 29
    • 0036082463 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
    • Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP, Ducharme MP. Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 2002;302:369-373.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 369-373
    • Marier, J.F.1    Vachon, P.2    Gritsas, A.3    Zhang, J.4    Moreau, J.P.5    Ducharme, M.P.6
  • 30
    • 0242657450 scopus 로고    scopus 로고
    • Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation
    • Martignoni M, Monshouwer M, de Kanter R, Pezzetta D, Moscone A, Grossi P. Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. Toxicol In Vitro 2004;18:121-128.
    • (2004) Toxicol In Vitro , vol.18 , pp. 121-128
    • Martignoni, M.1    Monshouwer, M.2    de Kanter, R.3    Pezzetta, D.4    Moscone, A.5    Grossi, P.6
  • 31
    • 6944226371 scopus 로고    scopus 로고
    • Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance
    • McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos 2004;32:1247-1253.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1247-1253
    • McGinnity, D.F.1    Soars, M.G.2    Urbanowicz, R.A.3    Riley, R.J.4
  • 33
    • 0032589627 scopus 로고    scopus 로고
    • Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz
    • Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD. Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Drug Metab Dispos 1999;27:1319-1333.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1319-1333
    • Mutlib, A.E.1    Chen, H.2    Nemeth, G.A.3    Markwalder, J.A.4    Seitz, S.P.5    Gan, L.S.6    Christ, D.D.7
  • 36
    • 0037627707 scopus 로고    scopus 로고
    • Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide
    • Niemi M, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Diabetologia 2003b;46:347-351.
    • (2003) Diabetologia , vol.46 , pp. 347-351
    • Niemi, M.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 37
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolismdependent inhibitor of CYP2C8: implications for drug-drug interactions
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolismdependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos 2006;34:191-197.
    • (2006) Drug Metab Dispos , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 38
    • 0018951018 scopus 로고
    • Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat
    • Parker RJ, Hirom PC, Millburn P. Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat. Hydrolysis of glucuronic acid conjugates in the gut lumen. Xenobiotica 1980;10:689-703.
    • (1980) Xenobiotica , vol.10 , pp. 689-703
    • Parker, R.J.1    Hirom, P.C.2    Millburn, P.3
  • 39
    • 0000889408 scopus 로고    scopus 로고
    • Biotransformation of xenobiotics
    • In: Klassen CD, editor. Casarett & Doull's Toxicology: The Basic Science of Poisons McGraw-Hill
    • Parkinson A. Biotransformation of xenobiotics. In: Klassen CD, editor. Casarett & Doull's Toxicology: The Basic Science of Poisons McGraw-Hill; 2001. p 133-224.
    • (2001) , pp. 133-224
    • Parkinson, A.1
  • 40
    • 84889417445 scopus 로고    scopus 로고
    • Product Note for guidance on the investigation of drug interactions (CPMP/EWP/560/95)
    • Available at
    • Product Note for guidance on the investigation of drug interactions (CPMP/EWP/560/95). Available atwww.eudra.org/humandocs/humans/EWP.html.
  • 41
    • 0033105118 scopus 로고    scopus 로고
    • Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Hydrolysis of glucuronic acid conjugates in the gut lumen
    • Rodrigues AD. Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Biochem Pharmacol 1999;57:465-480.
    • (1999) Biochem Pharmacol , vol.57 , pp. 465-480
    • Rodrigues, A.D.1
  • 42
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara Y, Hirano M, Sato H, Sugiyama Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther 2004;311:228-236.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 43
    • 33646517938 scopus 로고    scopus 로고
    • Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
    • Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K, Rodrigues AD. Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Curr Drug Metab 2006;7:375-388.
    • (2006) Curr Drug Metab , vol.7 , pp. 375-388
    • Sinz, M.1    Kim, S.2    Zhu, Z.3    Chen, T.4    Anthony, M.5    Dickinson, K.6    Rodrigues, A.D.7
  • 44
    • 0036783401 scopus 로고    scopus 로고
    • Whole-body autoradiography in drug discovery
    • Solon EG, Balani SK, Lee FW. Whole-body autoradiography in drug discovery. Curr Drug Metab 2002;3:451-462.
    • (2002) Curr Drug Metab , vol.3 , pp. 451-462
    • Solon, E.G.1    Balani, S.K.2    Lee, F.W.3
  • 45
    • 0035527670 scopus 로고    scopus 로고
    • Quantitative whole-body autoradiography in the pharmaceutical industry. Survey results on study design, methods, and regulatory compliance
    • Solon EG, Kraus L. Quantitative whole-body autoradiography in the pharmaceutical industry. Survey results on study design, methods, and regulatory compliance. J Pharmacol Toxicol Methods 2001;46:73-81.
    • (2001) J Pharmacol Toxicol Methods , vol.46 , pp. 73-81
    • Solon, E.G.1    Kraus, L.2
  • 46
    • 0026723146 scopus 로고
    • Characterization of urinary metabolites from [1,2,methoxy-13C]-2-methoxyethanol in mice using 13C nuclear magnetic resonance spectroscopy
    • Sumner SCJ, Stedman DB, Clarke DO, Welsch F, Fennell TR. Characterization of urinary metabolites from [1,2,methoxy-13C]-2-methoxyethanol in mice using 13C nuclear magnetic resonance spectroscopy. Chem Res Toxicol 1992;5:553-560.
    • (1992) Chem Res Toxicol , vol.5 , pp. 553-560
    • Sumner, S.C.J.1    Stedman, D.B.2    Clarke, D.O.3    Welsch, F.4    Fennell, T.R.5
  • 47
    • 84889309204 scopus 로고    scopus 로고
    • US Food and Drug Administration Guidance for industry: drug metabolism/drug interaction studies in the drug development process: studies in vitro
    • Available at
    • US Food and Drug Administration Guidance for industry: drug metabolism/drug interaction studies in the drug development process: studies in vitro. Available at www.fda.gov/cder/guidance.html.
  • 48
    • 0038413486 scopus 로고    scopus 로고
    • Basic anatomical and physiological data for use in radiological protection:reference values: ICRP Publication 89
    • Valentin J. Basic anatomical and physiological data for use in radiological protection:reference values: ICRP Publication 89. Annals of the ICRP 2002;32:1-277.
    • (2002) Annals of the ICRP , vol.32 , pp. 1-277
    • Valentin, J.1
  • 50
    • 33344472326 scopus 로고    scopus 로고
    • Glucuronidation as a major metabolic clearance pathway of 14C-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection
    • Epub 2005 Dec 20-28
    • Wang L, Zhang D, Swaminathan A, Xue Y, Cheng PT, Wu S, Mosqueda-Garcia R, Aurang C, Everett DW, Humphreys WG. Glucuronidation as a major metabolic clearance pathway of 14C-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection. Drug Metab Dispos 2006;34:427-439. Epub 2005 Dec 20-28.
    • (2006) Drug Metab Dispos , vol.34 , pp. 427-439
    • Wang, L.1    Zhang, D.2    Swaminathan, A.3    Xue, Y.4    Cheng, P.T.5    Wu, S.6    Mosqueda-Garcia, R.7    Aurang, C.8    Everett, D.W.9    Humphreys, W.G.10
  • 52
    • 85042555751 scopus 로고
    • Use of ionizing radiation and radionuclides on human beings for medical research, training and nonmedical purpose
    • WHO
    • WHO.Use of ionizing radiation and radionuclides on human beings for medical research, training and nonmedical purpose. WHO Publication 611;1977.
    • (1977) WHO Publication , pp. 611
  • 54
    • 6944221357 scopus 로고    scopus 로고
    • Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE. Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos 2004;32:1201-1208.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3    Smith, D.A.4    Hurst, S.5    Goosen, T.C.6    Peterkin, V.7    Koup, J.R.8    Ball, S.E.9
  • 55
    • 84966310143 scopus 로고    scopus 로고
    • Application of microtiter plate assay to evaluate inhibitory effects of various compounds on nine cytochrome P450 isoforms and to estimate their inhibition patterns
    • Yamamoto T, Suzuki A, Kohno Y. Application of microtiter plate assay to evaluate inhibitory effects of various compounds on nine cytochrome P450 isoforms and to estimate their inhibition patterns. Drug Metab Pharmacokinet 2002;17:437-448.
    • (2002) Drug Metab Pharmacokinet , vol.17 , pp. 437-448
    • Yamamoto, T.1    Suzuki, A.2    Kohno, Y.3
  • 56
    • 27544468948 scopus 로고    scopus 로고
    • In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation
    • Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG. In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos 2005;33:1729-1739.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1729-1739
    • Zhang, D.1    Chando, T.J.2    Everett, D.W.3    Patten, C.J.4    Dehal, S.S.5    Humphreys, W.G.6
  • 57
    • 33845961553 scopus 로고    scopus 로고
    • Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar
    • Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos 2007;35:139-149.
    • (2007) Drug Metab Dispos , vol.35 , pp. 139-149
    • Zhang, D.1    Wang, L.2    Chandrasena, G.3    Ma, L.4    Zhu, M.5    Zhang, H.6    Davis, C.D.7    Humphreys, W.G.8
  • 58
    • 65249125136 scopus 로고    scopus 로고
    • LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials by using radioactive metabolites as reference standards
    • in print
    • Zhang D, Raghavan N, Chando T, Gambardella J, Fu Y, Zhang DX, Unger S, Humphreys WG. LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials by using radioactive metabolites as reference standards. Drug Metab Lett 2007a; in print.
    • (2007) Drug Metab Lett
    • Zhang, D.1    Raghavan, N.2    Chando, T.3    Gambardella, J.4    Fu, Y.5    Zhang, D.X.6    Unger, S.7    Humphreys, W.G.8
  • 59
    • 0242521617 scopus 로고    scopus 로고
    • A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analysis
    • Zhang H, Zhang D, Ray K. A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analysis. J Mass Spectrom 2003;38:1110-1112.
    • (2003) J Mass Spectrom , vol.38 , pp. 1110-1112
    • Zhang, H.1    Zhang, D.2    Ray, K.3
  • 60
    • 19944393579 scopus 로고    scopus 로고
    • Enzyme kinetics for clinically relevant CYP inhibition
    • Zhang ZY, Wong YN. Enzyme kinetics for clinically relevant CYP inhibition. Curr Drug Metab 2005;6:241-257.
    • (2005) Curr Drug Metab , vol.6 , pp. 241-257
    • Zhang, Z.Y.1    Wong, Y.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.