Metabolism of [14C]omapatrilat, a sulfhydryl-containing vasopeptidase inhibitor in humans

Drug Metabolism and Disposition

Volumn 29, Issue 1, 2001, Pages 60-69

  Iyer, Ramaswamy A ^a   Mitroka, James ^a   Malhotra, Bimal ^a   Bonacorsi Jr , Samuel ^a   Waller, Stephen C ^a   Rinehart, J Kent ^a   Roongta, Vikram A ^a   Kripalani, Kishin ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 THIO 3 PHENYLPROPIONIC ACID; AMIDE; DRUG METABOLITE; OMAPATRILAT; PROPIONIC ACID DERIVATIVE; S METHYL 2 THIO 3 PHENYLPROPIONIC ACID; UNCLASSIFIED DRUG; VASOPEPTIDASE INHIBITOR;

ARTICLE; BLOOD SAMPLING; CONGESTIVE HEART FAILURE; DISULFIDE BOND; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; HUMAN; HYPERTENSION; PRIORITY JOURNAL; RADIOACTIVITY; REACTION ANALYSIS; STEREOISOMERISM; STRUCTURE ANALYSIS;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PYRIDINES; THIAZEPINES;

EID: 0035153195     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Dual metalloprotease inhibitors. IV. Utilization of thiazepines and thiazines as constrained peptidomimetic surrogates in mercaptoacyl dipeptides
2. Mercaptoacyl dipeptides as dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Preliminary structure-activity studies
3. Captopril disulfide: Conjugates may act as prodrugs; Disposition of the disulfide dimer of captopril in the rat
4. Thiol/disulfide exchange equilibria and disulfide bond stability
5. Quantitative determination of BMS-186716, a thiol compound, in dog plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after formation of the methyl acrylate adduct
6. Quantitative determination of BMS-186716, a thiol compound, in rat plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after hydrolysis of the methyl acrylate adduct by the native esterases
7. Metabolism of captopril-L-cysteine, a captopril metabolite, in rats and dogs
8. New and emerging drug treatments for hypertension
9. Biotransformation of the disulfide of captopril in subcellular fractions of rat tissue
10. Captopril: Pharmacology, metabolism and disposition
11. S-Oxidative cleavage of farnesylcysteine and farnesylcysteine methyl ester by the flavin-containing monooxygenase
12. Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates
13. Dual metalloprotease inhihitors: Mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and endopeptidase
14. Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptidic surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors
15. Dual metalloprotease inhibitors. I. Constrained peptodomimetics of mercaptoacyl dipeptides
16. Vasopeptidase inhibitors: Incorporation of geminal and spirocylcic substituted azepinones in mercaptoacyl dipeptides
17. The safety and 24-hour antihypertensive efficacy of the vasopeptidase inhibitor omaptrilat: A pilot study
18. Stereoselective sulfoxidation by human flavin-containing monoxygenase
19. Repression of angiotensin II and potential of bradykinin to contribute to the synergistic effects of dual metalloprotease inhibition in heart failure
20. Effects of omapatrilat in low, normal, and high renin experimental hypertension
21. Omapatrilat, a vasopeptidase inhibitor, is an effective antihypertensive agent in mild to moderate hypertension
22. The metabolism of 35S-D-penicillamine in man
23. Antihypertensive dose response of omapatrilat, a vasopeptidase inhibitor, in mild to moderate hypertension
24. Efficacy and safety of omapatrilat, a vasopeptidase inhibitor