Biological reactive intermediates in drug discovery and development: A perspective from the pharmaceutical industry

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 45-51

  Baillie, Thomas A ^a   Kassahun, Kelem ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; ALKENE DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; FUROSEMIDE; HALOTHANE; TIENILIC ACID; TROGLITAZONE;

CONFERENCE PAPER; DRUG MANUFACTURE; DRUG METABOLISM; DRUG STRUCTURE; ENZYME STABILITY; HUMAN; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0035699829     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0667-6_5     Document Type: Conference Paper

References (9)

1. Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates. Studies with S-(N-methylcarbamoyl)glutathione, a metabolite of the antineoplastic agent N-methylformamide
2. Characterization of a halothane induced trifluoroacetylated 100 kDa neoantigen that is related to a glucose-regulated protein
3. Hepatotoxicity due to troglitazone: Report of two cases and review of adverse events reported to the United States Food and Drug Administration
4. Mass spectrometry in the analysis of glutathione conjugates
5. Protein targets of xenobiotic reactive intermediates
6. Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals
7. New concepts in immunology relevant to idiosyncratic drug reactions: The "danger hypothesis" and innate immune system