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Volumn 5, Issue 1, 2010, Pages 99-112

DNA microarrays to define and search for genes associated with obesity

Author keywords

Adipose tissue; Liver; Microarray; Obesity

Indexed keywords

ADHESION MOLECULES; ADIPOCYTE DIFFERENTIATION; ADIPOSE TISSUE; ANIMAL MODEL; DNA MICRO-ARRAY; FATTY ACID BIOSYNTHESIS; FATTY ACID OXIDATION; FREE FATTY ACID; GENE EXPRESSION PROFILES; HEPATIC TISSUE; IMMUNE RESPONSE; LIPID METABOLISMS; METABOLIC DISEASE; NON-ALCOHOLIC FATTY LIVER; OVER-EXPRESSION; PATHOGENIC MECHANISMS; RESPIRATORY ACTIVITY; STRESS RESPONSE; THERAPEUTIC TARGETS; WEALTH OF INFORMATION; WHITE ADIPOSE TISSUES;

EID: 75649148583     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200900228     Document Type: Review
Times cited : (32)

References (84)
  • 1
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena, M., Shalon, D., Davis, R.W., Brown, P. O., Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995, 270, 467-470.
    • (1995) Science , vol.270 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 2
    • 26844564069 scopus 로고    scopus 로고
    • Human tissue profiling with multidimensional protein identification technology
    • Cagney, G., Park, S., Chung, C., Tong, B. et al., Human tissue profiling with multidimensional protein identification technology. J. Proteome Res. 2005, 4, 1757-1767.
    • (2005) J. Proteome Res , vol.4 , pp. 1757-1767
    • Cagney, G.1    Park, S.2    Chung, C.3    Tong, B.4
  • 3
    • 0032958470 scopus 로고    scopus 로고
    • Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    • Aitman, T. J., Glazier, A. M., Wallace, C. A., Cooper, L.D. et al., Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat. Genet. 1999, 21, 76-83.
    • (1999) Nat. Genet , vol.21 , pp. 76-83
    • Aitman, T.J.1    Glazier, A.M.2    Wallace, C.A.3    Cooper, L.D.4
  • 4
    • 18344376704 scopus 로고    scopus 로고
    • Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays
    • Jiang, Y., Harlocker, S. L., Molesh, D. A., Dillon, D. C. et al., Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays. Oncogene 2002, 21, 2270-2282.
    • (2002) Oncogene , vol.21 , pp. 2270-2282
    • Jiang, Y.1    Harlocker, S.L.2    Molesh, D.A.3    Dillon, D.C.4
  • 5
    • 0034891712 scopus 로고    scopus 로고
    • A powerful technology for nutritional and obesity research
    • DNA hybridization arrays
    • Moreno-Aliaga, M. J., Marti, A., Garcia-Foncillas, J., Alfredo Martinez, J., DNA hybridization arrays: A powerful technology for nutritional and obesity research. Br. J. Nutr. 2001, 86, 119-122.
    • (2001) Br. J. Nutr , vol.86 , pp. 119-122
    • Moreno-Aliaga, M.J.1    Marti, A.2    Garcia-Foncillas, J.3    Alfredo Martinez, J.4
  • 6
    • 0031990657 scopus 로고    scopus 로고
    • Genomics and human disease - Variations on variation
    • Brown, P. O., Hartwell, L., Genomics and human disease - Variations on variation. Nat. Genet. 1998, 18, 91-93.
    • (1998) Nat. Genet , vol.18 , pp. 91-93
    • Brown, P.O.1    Hartwell, L.2
  • 7
    • 0029852580 scopus 로고    scopus 로고
    • Use of a cDNA microarray to analyse gene expression patterns in human cancer
    • DeRisi, J., Penland, L., Brown, P. O., Bittner, M. L. et al., Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat. Genet. 1996, 14, 457-460.
    • (1996) Nat. Genet , vol.14 , pp. 457-460
    • DeRisi, J.1    Penland, L.2    Brown, P.O.3    Bittner, M.L.4
  • 8
    • 0034471041 scopus 로고    scopus 로고
    • Obesity: Preventing and managing the global epidemic. Report of a WHO consultation.World Health Organ.Tech. Rep. Ser. 2000, 894, i-xii, 1-253.
    • Obesity: Preventing and managing the global epidemic. Report of a WHO consultation.World Health Organ.Tech. Rep. Ser. 2000, 894, i-xii, 1-253.
  • 9
    • 0034655590 scopus 로고    scopus 로고
    • Leptinspecific patterns of gene expression in white adipose tissue
    • Soukas, A., Cohen, P., Socci, N. D., Friedman, J. M., Leptinspecific patterns of gene expression in white adipose tissue. Genes Dev. 2000, 14, 963-980.
    • (2000) Genes Dev , vol.14 , pp. 963-980
    • Soukas, A.1    Cohen, P.2    Socci, N.D.3    Friedman, J.M.4
  • 10
    • 0034633681 scopus 로고    scopus 로고
    • The expression of adipogenic genes is decreased in obesity and diabetes mellitus
    • Nadler, S. T., Stoehr, J. P., Schueler, K. L., Tanimoto, G. et al., The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc. Natl. Acad. Sci. USA 2000, 97, 11371-11376.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11371-11376
    • Nadler, S.T.1    Stoehr, J.P.2    Schueler, K.L.3    Tanimoto, G.4
  • 11
    • 0242636861 scopus 로고    scopus 로고
    • Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses
    • Moraes, R. C., Blondet, A., Birkenkamp-Demtroeder, K., Tirard, J. et al., Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology 2003, 144, 4773-4782.
    • (2003) Endocrinology , vol.144 , pp. 4773-4782
    • Moraes, R.C.1    Blondet, A.2    Birkenkamp-Demtroeder, K.3    Tirard, J.4
  • 12
    • 18344406192 scopus 로고    scopus 로고
    • DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats
    • Lopez, I. P., Marti, A., Milagro, F. I., Zulet Md Mde, L. et al., DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats. Obes. Res. 2003, 11, 188-194.
    • (2003) Obes. Res , vol.11 , pp. 188-194
    • Lopez, I.P.1    Marti, A.2    Milagro, F.I.3    Zulet Md Mde, L.4
  • 13
    • 0347123635 scopus 로고    scopus 로고
    • DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat
    • Application of genomic technologies
    • Middleton, F. A., Ramos, E. J. B., Xu, Y., Diab, H. et al., Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat. Nutrition 2004, 20, 14-25.
    • (2004) Nutrition , vol.20 , pp. 14-25
    • Middleton, F.A.1    Ramos, E.J.B.2    Xu, Y.3    Diab, H.4
  • 14
    • 22744456008 scopus 로고    scopus 로고
    • High-fat feeding period affects gene expression in rat white adipose tissue
    • Lopez, I.P., Milagro, F. I., Marti, A., Moreno-Aliaga, M.J. et al., High-fat feeding period affects gene expression in rat white adipose tissue. Mol. Cell. Biochem. 2005, 275, 109-115.
    • (2005) Mol. Cell. Biochem , vol.275 , pp. 109-115
    • Lopez, I.P.1    Milagro, F.I.2    Marti, A.3    Moreno-Aliaga, M.J.4
  • 15
    • 26944489280 scopus 로고    scopus 로고
    • Adipose gene expression patterns of weight gain suggest counteracting steroid hormone synthesis
    • Van Schothorst, E. M., Franssen-van Hal, N., Schaap, M. M., Pennings, J. et al., Adipose gene expression patterns of weight gain suggest counteracting steroid hormone synthesis. Obes. Res. 2005, 13, 1031-1041.
    • (2005) Obes. Res , vol.13 , pp. 1031-1041
    • Van Schothorst, E.M.1    Franssen-van Hal, N.2    Schaap, M.M.3    Pennings, J.4
  • 16
    • 33845520528 scopus 로고    scopus 로고
    • Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity
    • Campion, J., Milagro, F. I., Fernandez, D., Martinez, J. A., Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity. J. Physiol. Biochem. 2006, 62, 71-80.
    • (2006) J. Physiol. Biochem , vol.62 , pp. 71-80
    • Campion, J.1    Milagro, F.I.2    Fernandez, D.3    Martinez, J.A.4
  • 17
    • 44149086375 scopus 로고    scopus 로고
    • Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet
    • Kim, Y. J., Park, T., Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet. Nutr. Res. 2008, 28, 414-422.
    • (2008) Nutr. Res , vol.28 , pp. 414-422
    • Kim, Y.J.1    Park, T.2
  • 18
    • 44449149311 scopus 로고    scopus 로고
    • Adipocyte gene expression is altered in formerly obese mice and as a function of diet composition
    • Miller, R. S., Becker, K.G., Prabhu, V., Cooke, D.W., Adipocyte gene expression is altered in formerly obese mice and as a function of diet composition. J. Nutr. 2008, 138, 1033-1038.
    • (2008) J. Nutr , vol.138 , pp. 1033-1038
    • Miller, R.S.1    Becker, K.G.2    Prabhu, V.3    Cooke, D.W.4
  • 19
    • 0035490416 scopus 로고    scopus 로고
    • Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice
    • Ferrante, A.W., Jr., Thearle, M., Liao, T., Leibel, R. L., Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes 2001, 50, 2268-2278.
    • (2001) Diabetes , vol.50 , pp. 2268-2278
    • Ferrante Jr., A.W.1    Thearle, M.2    Liao, T.3    Leibel, R.L.4
  • 20
    • 0035966010 scopus 로고    scopus 로고
    • Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver
    • Liang, C.P., Tall, A. R., Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. J. Biol. Chem. 2001, 276, 49066-49076.
    • (2001) J. Biol. Chem , vol.276 , pp. 49066-49076
    • Liang, C.P.1    Tall, A.R.2
  • 21
    • 9444236888 scopus 로고    scopus 로고
    • LA-cp rats: Microarray analysis of lipid-related gene expression
    • Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR
    • Deng, X., Elam, M. B., Wilcox, H. G., Cagen, L. M. et al., Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: Microarray analysis of lipid-related gene expression. Endocrinology 2004, 145, 5847-5861.
    • (2004) Endocrinology , vol.145 , pp. 5847-5861
    • Deng, X.1    Elam, M.B.2    Wilcox, H.G.3    Cagen, L.M.4
  • 22
    • 5444240778 scopus 로고    scopus 로고
    • Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model
    • Kim, S., Sohn, I., Ahn, J. I., Lee, K. H., Lee, Y. S., Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Gene 2004, 340, 99-109.
    • (2004) Gene , vol.340 , pp. 99-109
    • Kim, S.1    Sohn, I.2    Ahn, J.I.3    Lee, K.H.4    Lee, Y.S.5
  • 23
    • 24344468717 scopus 로고    scopus 로고
    • Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
    • Inoue, M., Ohtake, T., Motomura, W., Takahashi, N. et al., Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem. Biophys. Res.Commun.2005, 336, 215-222.
    • (2005) Biochem. Biophys. Res.Commun , vol.336 , pp. 215-222
    • Inoue, M.1    Ohtake, T.2    Motomura, W.3    Takahashi, N.4
  • 24
    • 32644443742 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression
    • Patsouris, D., Reddy, J. K., Muller, M., Kersten, S., Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. Endocrinology 2006, 147, 1508-1516.
    • (2006) Endocrinology , vol.147 , pp. 1508-1516
    • Patsouris, D.1    Reddy, J.K.2    Muller, M.3    Kersten, S.4
  • 25
    • 42749093595 scopus 로고    scopus 로고
    • Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: A microarray analysis
    • Yang, R. L., Li, W., Shi, Y. H., Le, G.W., Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: A microarray analysis. Nutrition 2008, 24, 582-588.
    • (2008) Nutrition , vol.24 , pp. 582-588
    • Yang, R.L.1    Li, W.2    Shi, Y.H.3    Le, G.W.4
  • 26
    • 51249088146 scopus 로고    scopus 로고
    • The effects of high fat on central appetite genes in Wistar rats: A microarray analysis
    • Xu, R.Y., Wan, Y. P., Tang, Q.Y., Wu, J., Cai, W., The effects of high fat on central appetite genes in Wistar rats: A microarray analysis. Clin. Chim. Acta 2008, 397, 96-100.
    • (2008) Clin. Chim. Acta , vol.397 , pp. 96-100
    • Xu, R.Y.1    Wan, Y.P.2    Tang, Q.Y.3    Wu, J.4    Cai, W.5
  • 27
    • 0036081451 scopus 로고    scopus 로고
    • Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle
    • Sreekumar, R., Unnikrishnan, J., Fu, A., Nygren, J. et al., Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 2002, 282, E1055-1061.
    • (2002) Am. J. Physiol. Endocrinol. Metab , vol.282
    • Sreekumar, R.1    Unnikrishnan, J.2    Fu, A.3    Nygren, J.4
  • 28
    • 75649130306 scopus 로고    scopus 로고
    • de Wit, N. J., Bosch-Vermeulen, H., de Groot, P. J., Hooiveld, G. J. et al., The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med. Genomics 2008, 1, 14.
    • de Wit, N. J., Bosch-Vermeulen, H., de Groot, P. J., Hooiveld, G. J. et al., The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med. Genomics 2008, 1, 14.
  • 29
    • 34547614847 scopus 로고    scopus 로고
    • Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: A nutrigenomic approach
    • Naito, Y., Uchiyama, K., Mizushima, K., Kuroda, M. et al., Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: A nutrigenomic approach. Int. J. Mol. Med. 2006, 18, 685-695.
    • (2006) Int. J. Mol. Med , vol.18 , pp. 685-695
    • Naito, Y.1    Uchiyama, K.2    Mizushima, K.3    Kuroda, M.4
  • 30
  • 31
    • 21344454651 scopus 로고    scopus 로고
    • Obesity-related differential gene expression in the visceral adipose tissue
    • Baranova, A., Collantes, R., Gowder, S. J., Elariny, H. et al., Obesity-related differential gene expression in the visceral adipose tissue. Obes. Surg. 2005, 15, 758-765.
    • (2005) Obes. Surg , vol.15 , pp. 758-765
    • Baranova, A.1    Collantes, R.2    Gowder, S.J.3    Elariny, H.4
  • 32
    • 24944489239 scopus 로고    scopus 로고
    • Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: Increased expression of inflammation-related genes
    • Lee, Y. H., Nair, S., Rousseau, E., Allison, D. B. et al., Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: Increased expression of inflammation-related genes. Diabetologia 2005, 48, 1776-1783.
    • (2005) Diabetologia , vol.48 , pp. 1776-1783
    • Lee, Y.H.1    Nair, S.2    Rousseau, E.3    Allison, D.B.4
  • 33
    • 28844502670 scopus 로고    scopus 로고
    • Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers
    • Marrades, M. P., Milagro, F. I., Martinez, J. A., Moreno-Aliaga, M. J., Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. Biochem. Biophys. Res. Commun. 2006, 339, 785-789.
    • (2006) Biochem. Biophys. Res. Commun , vol.339 , pp. 785-789
    • Marrades, M.P.1    Milagro, F.I.2    Martinez, J.A.3    Moreno-Aliaga, M.J.4
  • 34
    • 30944453514 scopus 로고    scopus 로고
    • Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray
    • Chiappini, F., Barrier, A., Saffroy, R., Domart, M. C. et al., Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab. Invest. 2006, 86, 154-165.
    • (2006) Lab. Invest , vol.86 , pp. 154-165
    • Chiappini, F.1    Barrier, A.2    Saffroy, R.3    Domart, M.C.4
  • 35
    • 22844439963 scopus 로고    scopus 로고
    • Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis
    • Younossi, Z. M., Gorreta, F., Ong, J. P., Schlauch, K. et al., Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. Liver Int. 2005, 25, 760-771.
    • (2005) Liver Int , vol.25 , pp. 760-771
    • Younossi, Z.M.1    Gorreta, F.2    Ong, J.P.3    Schlauch, K.4
  • 36
    • 0041668152 scopus 로고    scopus 로고
    • Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: Development of an ELISA system for quantification of resistin
    • Maebuchi, M., Machidori, M., Urade, R., Ogawa, T., Moriyama, T., Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: Development of an ELISA system for quantification of resistin. Arch. Biochem. Biophys. 2003, 416, 164-170.
    • (2003) Arch. Biochem. Biophys , vol.416 , pp. 164-170
    • Maebuchi, M.1    Machidori, M.2    Urade, R.3    Ogawa, T.4    Moriyama, T.5
  • 37
    • 33746681910 scopus 로고    scopus 로고
    • Tissue-specific expression and regulation of sexually dimorphic genes in mice
    • Yang, X., Schadt, E. E., Wang, S., Wang, H. et al., Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res. 2006, 16, 995-1004.
    • (2006) Genome Res , vol.16 , pp. 995-1004
    • Yang, X.1    Schadt, E.E.2    Wang, S.3    Wang, H.4
  • 38
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal, K.T., Wiesbrock, S. M., Marino, M.W., Hotamisligil, G. S., Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 39
    • 55849114349 scopus 로고    scopus 로고
    • Adipocytokines and the metabolic complications of obesity
    • Rasouli, N., Kern, P. A., Adipocytokines and the metabolic complications of obesity. J. Clin. Endocrinol. Metab. 2008, 93, S64-73.
    • (2008) J. Clin. Endocrinol. Metab , vol.93
    • Rasouli, N.1    Kern, P.A.2
  • 40
    • 0034900072 scopus 로고    scopus 로고
    • Please pass the chips: Genomic insights into obesity and diabetes
    • Nadler, S.T., Attie, A. D., Please pass the chips: Genomic insights into obesity and diabetes. J. Nutr. 2001, 131, 2078-2081.
    • (2001) J. Nutr , vol.131 , pp. 2078-2081
    • Nadler, S.T.1    Attie, A.D.2
  • 41
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
    • Ashburner, M., Ball, C.A., Blake, J.A., Botstein, D. et al., Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 2000, 25, 25-29.
    • (2000) Nat. Genet , vol.25 , pp. 25-29
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3    Botstein, D.4
  • 42
    • 0842328001 scopus 로고    scopus 로고
    • Update on adipocyte hormones: Regulation of energy balance and carbohydrate/lipid metabolism
    • Havel, P. J., Update on adipocyte hormones: Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 2004, 53 Suppl 1, S143-151.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Havel, P.J.1
  • 43
    • 33746156977 scopus 로고    scopus 로고
    • Chronic inflammation: Role of adipose tissue and modulation by weight loss
    • You, T., Nicklas, B. J., Chronic inflammation: Role of adipose tissue and modulation by weight loss. Curr. Diabetes Rev. 2006, 2, 29-37.
    • (2006) Curr. Diabetes Rev , vol.2 , pp. 29-37
    • You, T.1    Nicklas, B.J.2
  • 44
    • 46249083328 scopus 로고    scopus 로고
    • Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    • Henegar, C., Tordjman, J., Achard, V., Lacasa, D. et al., Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008, 9, R14.
    • (2008) Genome Biol , vol.9
    • Henegar, C.1    Tordjman, J.2    Achard, V.3    Lacasa, D.4
  • 45
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M. et al., Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4
  • 46
    • 0035514934 scopus 로고    scopus 로고
    • Partial leptin deficiency and human adiposity
    • Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S. et al., Partial leptin deficiency and human adiposity. Nature 2001, 414, 34-35.
    • (2001) Nature , vol.414 , pp. 34-35
    • Farooqi, I.S.1    Keogh, J.M.2    Kamath, S.3    Jones, S.4
  • 47
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel, A., Issad, T., Camoin, L., Ozata, M., Strosberg, A. D., A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 1998, 18, 213-215.
    • (1998) Nat. Genet , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 48
    • 0036963628 scopus 로고    scopus 로고
    • Leptin - From a signal of adiposity to a hormonal mediator in peripheral tissues
    • Baratta, M., Leptin - From a signal of adiposity to a hormonal mediator in peripheral tissues. Med. Sci. Monit. 2002, 8, RA282-292.
    • (2002) Med. Sci. Monit , vol.8
    • Baratta, M.1
  • 49
    • 0037329602 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle
    • Minokoshi, Y., Kahn, B.B., Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem. Soc.Trans. 2003, 31, 196-201.
    • (2003) Biochem. Soc.Trans , vol.31 , pp. 196-201
    • Minokoshi, Y.1    Kahn, B.B.2
  • 50
    • 0030821976 scopus 로고    scopus 로고
    • Is leptin the link between obesity and insulin resistance?
    • Girard, J., Is leptin the link between obesity and insulin resistance? Diabetes Metab. 1997, 23 Suppl 3, 16-24.
    • (1997) Diabetes Metab , vol.23 , Issue.SUPPL. 3 , pp. 16-24
    • Girard, J.1
  • 51
    • 0029909389 scopus 로고    scopus 로고
    • Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women
    • Larsson, H., Elmstahl, S., Ahren, B., Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women. Diabetes 1996, 45, 1580-1584.
    • (1996) Diabetes , vol.45 , pp. 1580-1584
    • Larsson, H.1    Elmstahl, S.2    Ahren, B.3
  • 52
    • 0033830448 scopus 로고    scopus 로고
    • Regulation of metabolism and body fat mass by leptin
    • Baile, C.A., Della-Fera, M.A., Martin, R. J., Regulation of metabolism and body fat mass by leptin. Annu. Rev. Nutr. 2000, 20, 105-127.
    • (2000) Annu. Rev. Nutr , vol.20 , pp. 105-127
    • Baile, C.A.1    Della-Fera, M.A.2    Martin, R.J.3
  • 53
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • Caro, J. F., Kolaczynski, J.W., Nyce, M. R., Ohannesian, J. P. et al., Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance. Lancet 1996, 348, 159-161.
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3    Ohannesian, J.P.4
  • 54
    • 0034110038 scopus 로고    scopus 로고
    • Organization of extracellular matrix components during differentiation of adipocytes in long-term culture
    • Kubo, Y., Kaidzu, S., Nakajima, I., Takenouchi, K., Nakamura, F., Organization of extracellular matrix components during differentiation of adipocytes in long-term culture. In Vitro Cell Dev. Biol. Anim. 2000, 36, 38-44.
    • (2000) In Vitro Cell Dev. Biol. Anim , vol.36 , pp. 38-44
    • Kubo, Y.1    Kaidzu, S.2    Nakajima, I.3    Takenouchi, K.4    Nakamura, F.5
  • 55
    • 62549136587 scopus 로고    scopus 로고
    • Cathepsin K regulates adipocyte differentiation: Possible involvement of type I collagen degradation
    • Han, J., Luo, T., Gu, Y., Li, G. et al., Cathepsin K regulates adipocyte differentiation: Possible involvement of type I collagen degradation. Endocr. J. 2009, 56, 55-63.
    • (2009) Endocr. J , vol.56 , pp. 55-63
    • Han, J.1    Luo, T.2    Gu, Y.3    Li, G.4
  • 56
    • 0035209720 scopus 로고    scopus 로고
    • Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals
    • van Dielen, F. M., van't Veer, C., Schols, A. M., Soeters, P. B. et al., Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int. J. Obes. Relat. Metab. Disord. 2001, 25, 1759-1766.
    • (2001) Int. J. Obes. Relat. Metab. Disord , vol.25 , pp. 1759-1766
    • van Dielen, F.M.1    van't Veer, C.2    Schols, A.M.3    Soeters, P.B.4
  • 57
    • 67650531437 scopus 로고    scopus 로고
    • Serum amyloid A3 does not contribute to circulating SAA levels
    • Chiba, T., Han, C. Y., Vaisar, T., Shimokado, K. et al., Serum amyloid A3 does not contribute to circulating SAA levels. J. Lipid Res. 2009, 50, 1353-1362.
    • (2009) J. Lipid Res , vol.50 , pp. 1353-1362
    • Chiba, T.1    Han, C.Y.2    Vaisar, T.3    Shimokado, K.4
  • 58
    • 24644518893 scopus 로고    scopus 로고
    • Cathepsin S, a novel biomarker of adiposity: Relevance to atherogenesis
    • Taleb, S., Lacasa, D., Bastard, J. P., Poitou, C. et al., Cathepsin S, a novel biomarker of adiposity: Relevance to atherogenesis. FASEB J. 2005, 19, 1540-1542.
    • (2005) FASEB J , vol.19 , pp. 1540-1542
    • Taleb, S.1    Lacasa, D.2    Bastard, J.P.3    Poitou, C.4
  • 59
    • 33745584354 scopus 로고    scopus 로고
    • Acute-phase serum amyloid A: An inflammatory adipokine and potential link between obesity and its metabolic complications
    • Yang, R. Z., Lee, M. J., Hu, H., Pollin, T. I. et al., Acute-phase serum amyloid A: An inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med. 2006, 3, e287.
    • (2006) PLoS Med , vol.3
    • Yang, R.Z.1    Lee, M.J.2    Hu, H.3    Pollin, T.I.4
  • 60
    • 0033960533 scopus 로고    scopus 로고
    • Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids
    • Gao, J., Ye, H., Serrero, G., Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. J. Cell. Physiol. 2000, 182, 297-302.
    • (2000) J. Cell. Physiol , vol.182 , pp. 297-302
    • Gao, J.1    Ye, H.2    Serrero, G.3
  • 61
    • 33745942915 scopus 로고    scopus 로고
    • Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very lowdensity lipoproteins
    • Magnusson, B., Asp, L., Bostrom, P., Ruiz, M. et al., Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very lowdensity lipoproteins. Arterioscler. Thromb. Vasc. Biol. 2006, 26, 1566-1571.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 1566-1571
    • Magnusson, B.1    Asp, L.2    Bostrom, P.3    Ruiz, M.4
  • 62
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang, S. H., Reddick, R. L., Piedrahita, J. A., Maeda, N., Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992, 258, 468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 63
    • 0017069533 scopus 로고
    • Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts
    • Bersot, T. P., Mahley, R.W., Brown, M. S., Goldstein, J. L., Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. J. Biol. Chem. 1976, 251, 2395-2398.
    • (1976) J. Biol. Chem , vol.251 , pp. 2395-2398
    • Bersot, T.P.1    Mahley, R.W.2    Brown, M.S.3    Goldstein, J.L.4
  • 64
    • 0028961832 scopus 로고
    • Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity
    • Pullinger, C. R., Hennessy, L. K., Chatterton, J. E., Liu, W. et al., Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity. J. Clin. Invest. 1995, 95, 1225-1234.
    • (1995) J. Clin. Invest , vol.95 , pp. 1225-1234
    • Pullinger, C.R.1    Hennessy, L.K.2    Chatterton, J.E.3    Liu, W.4
  • 67
    • 0035075872 scopus 로고    scopus 로고
    • A preliminary report
    • Genetic deletions of glutathione-S-transferase as a risk factor in squamous cell carcinoma of the larynx
    • Hanna, E., MacLeod, S., Vural, E., Lang, N., Genetic deletions of glutathione-S-transferase as a risk factor in squamous cell carcinoma of the larynx: A preliminary report. Am. J. Otolaryngol. 2001, 22, 121-123.
    • (2001) Am. J. Otolaryngol , vol.22 , pp. 121-123
    • Hanna, E.1    MacLeod, S.2    Vural, E.3    Lang, N.4
  • 68
    • 58249103063 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes
    • Widberg, C. H., Newell, F. S., Bachmann, A.W., Ramnoruth, S. N. et al., Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes. Am. J. Physiol. Endocrinol. Metab. 2009, 296, E121-131.
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.296
    • Widberg, C.H.1    Newell, F.S.2    Bachmann, A.W.3    Ramnoruth, S.N.4
  • 69
    • 0035099602 scopus 로고    scopus 로고
    • Obesity, overnutrition and the immune system
    • Samartin, S., Chandra, R. K., Obesity, overnutrition and the immune system. Nutr. Res. 2001, 21, 243-262.
    • (2001) Nutr. Res , vol.21 , pp. 243-262
    • Samartin, S.1    Chandra, R.K.2
  • 71
    • 0038660699 scopus 로고    scopus 로고
    • Preadipocyte conversion to macrophage. Evidence of plasticity
    • Charriere, G., Cousin, B., Arnaud, E., Andre, M. et al., Preadipocyte conversion to macrophage. Evidence of plasticity. J. Biol. Chem. 2003, 278, 9850-9855.
    • (2003) J. Biol. Chem , vol.278 , pp. 9850-9855
    • Charriere, G.1    Cousin, B.2    Arnaud, E.3    Andre, M.4
  • 72
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I. et al., TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 2006, 116, 3015-3025.
    • (2006) J. Clin. Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4
  • 73
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen, K. E., Hotamisligil, G. S., Inflammation, stress, and diabetes. J. Clin. Invest. 2005, 115, 1111-1119.
    • (2005) J. Clin. Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 74
    • 67650502739 scopus 로고    scopus 로고
    • Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    • Midwood, K., Sacre, S., Piccinini, A. M., Inglis, J. et al., Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat. Med. 2009, 15, 774-780.
    • (2009) Nat. Med , vol.15 , pp. 774-780
    • Midwood, K.1    Sacre, S.2    Piccinini, A.M.3    Inglis, J.4
  • 75
    • 33751436631 scopus 로고    scopus 로고
    • Fat uses a TOLL-road to connect inflammation and diabetes
    • Kim, J. K., Fat uses a TOLL-road to connect inflammation and diabetes. Cell Metab. 2006, 4, 417-419.
    • (2006) Cell Metab , vol.4 , pp. 417-419
    • Kim, J.K.1
  • 76
    • 0033588229 scopus 로고    scopus 로고
    • Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner
    • Jain, N., Zhang, T., Kee, W. H., Li, W., Cao, X., Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. J. Biol. Chem. 1999, 274, 24392-24400.
    • (1999) J. Biol. Chem , vol.274 , pp. 24392-24400
    • Jain, N.1    Zhang, T.2    Kee, W.H.3    Li, W.4    Cao, X.5
  • 77
    • 0347419304 scopus 로고    scopus 로고
    • Fatty acid recycling in adipocytes: A role for glyceroneogenesis and phosphoenolpyruvate carboxykinase
    • Forest, C., Tordjman, J., Glorian, M., Duplus, E. et al., Fatty acid recycling in adipocytes: A role for glyceroneogenesis and phosphoenolpyruvate carboxykinase. Biochem. Soc. Trans. 2003, 31, 1125-1129.
    • (2003) Biochem. Soc. Trans , vol.31 , pp. 1125-1129
    • Forest, C.1    Tordjman, J.2    Glorian, M.3    Duplus, E.4
  • 78
    • 0034659814 scopus 로고    scopus 로고
    • Mitochondrial adaptations to obesity-related oxidant stress
    • Yang, S., Zhu, H., Li, Y., Lin, H. et al., Mitochondrial adaptations to obesity-related oxidant stress. Arch. Biochem. Biophys. 2000, 378, 259-268.
    • (2000) Arch. Biochem. Biophys , vol.378 , pp. 259-268
    • Yang, S.1    Zhu, H.2    Li, Y.3    Lin, H.4
  • 79
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein, J. L., Brown, M. S., Regulation of the mevalonate pathway. Nature 1990, 343, 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 80
    • 36849037401 scopus 로고    scopus 로고
    • Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    • Koonen, D. P., Jacobs, R. L., Febbraio, M., Young, M. E. et al., Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 2007, 56, 2863-2871.
    • (2007) Diabetes , vol.56 , pp. 2863-2871
    • Koonen, D.P.1    Jacobs, R.L.2    Febbraio, M.3    Young, M.E.4
  • 81
    • 0035798670 scopus 로고    scopus 로고
    • Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats
    • Luiken, J. J., Arumugam, Y., Dyck, D. J., Bell, R. C. et al., Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats. J. Biol. Chem. 2001, 276, 40567-40573.
    • (2001) J. Biol. Chem , vol.276 , pp. 40567-40573
    • Luiken, J.J.1    Arumugam, Y.2    Dyck, D.J.3    Bell, R.C.4
  • 82
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    • Zhou, J., Febbraio, M., Wada, T., Zhai, Y. et al., Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology 2008, 134, 556-567.
    • (2008) Gastroenterology , vol.134 , pp. 556-567
    • Zhou, J.1    Febbraio, M.2    Wada, T.3    Zhai, Y.4
  • 83
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
    • Ishii, T., Itoh, K., Takahashi, S., Sato, H. et al., Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 2000, 275, 16023-16029.
    • (2000) J. Biol. Chem , vol.275 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4
  • 84
    • 64749116935 scopus 로고    scopus 로고
    • Uncoupling proteins and non-alcoholic fatty liver disease
    • Cortez-Pinto, H., Machado, M. V., Uncoupling proteins and non-alcoholic fatty liver disease. J. Hepatol. 2009, 50, 857-860.
    • (2009) J. Hepatol , vol.50 , pp. 857-860
    • Cortez-Pinto, H.1    Machado, M.V.2


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