Cathepsin K regulates adipocyte differentiation: Possible involvement of type i collagen degradation

Endocrine Journal

Volumn 56, Issue 1, 2009, Pages 55-63

  Han, Junfeng ^a   Luo, Tianhong ^a   Gu, Yanyun ^a   Li, Guo ^a   Jai, Weiping ^a   Luo, Min ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Adipocyte differentiation; C ebp ; Cathepsin k; Obesity; Ppar ; Type i collagen

Indexed keywords

CATHEPSIN K; CCAAT ENHANCER BINDING PROTEIN ALPHA; COLLAGEN TYPE 1; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OBESITY; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CATHEPSINS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; COLLAGEN TYPE I; CYSTEINE PROTEINASE INHIBITORS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; LEUCINE; MICE; PPAR GAMMA; PROTEIN PROCESSING, POST-TRANSLATIONAL; TIME FACTORS;

EID: 62549136587     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K08E-143     Document Type: Article

References (23)

1. MacDougald OA, Mandrup S (2002) Adipogenesis: forces that tip the scales. Trends Endocrinol Metab 13: 5-11.
2. Kubo Y, Kaidzu S, Nakajima I, Takenouchi K, Nakamura F (2000) Organization of extracellular matrix components during differentiation of adipocytes in long-term culture. In Vitro Cell Dev Biol Anim 36: 38-44.
3. Sang QX (1998) Complex role of matrix metalloproteinases in angiogenesis. Cell Res 8: 171-177.
4. Soukas A, Cohen P, Socci ND, Friedman JM (2000) Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 14: 963-980.
5. Chiellini C, Costa M, Novelli SE, Amri EZ, Benzi L, Bertacca A, Cohen P, Del Prato S, Friedman JM, Maffei M (2003) Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol 195(2): 309-321.
6. Xiao Y, Junfeng H, Tianhong L, Lu W, Shulin C (2006) Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of obesity. J Clin Endocrinol Metab 91: 4520-4527.
7. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4): 402-408.
8. Culp LA, Murray BA, Rollins BJ (1979) Fibronectin and proteoglycans as determinants of cell-substratum adhesion. J Supramol Struct 11: 401-427.
9. Spiegelman BM, Ginty CA (1983) Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell 35: 657-666.
10. Chun TH, Hotary KB, Weiss SJ (2006) A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125(3): 577-591.
11. Dodds RA, Connor JR, Drake FH, Gowen M (1999) Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues. Arthritis Rheum 42: 1588-1593.
12. Grabowskal U, Chambers TJ, Shiroo M (2005) Recent developments in cathepsin K inhibitor design. Curr Opin Drug Discov Devel 8: 619-630.
13. Littlewood-Evans AJ, Bilbe G, Bowler WB, Farley D, Wlodarski B (1997) The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma. Cancer Res 57: 5386-5390.
14. Spiegelman BM, Flier JS (1996) Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-380.
15. Christy RJ, Yang VW, Ntambi JM, Geiman DE, Landschulz WH, Friedman AD, Nakabeppu Y, Kelly TJ, Lane MD (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev 3: 1323-1335.
16. Kaestner KH, Christry RJ, Lane, MD (1990) Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAATV enhancer binding protein. Proc Natl Acad Sci USA 87: 251-255.
17. MacDougald OM, Lane MD (1995) Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 64: 345-373.
18. Cowherd RM, Lyle RE, McGehee Jr (1999) Molecular regulation of adipocyte differentiation. Semin Cell Dev Biol 10: 3-10.
19. John R. Harrison, Yu-Feng Huang, Stephen H. Clark (2005) Collal promoter-targeted expression of p20 CCAAT enhancer binding protein β (C/EBPP), a truncated C/EBPβ isoform, causes osteopenia in transgenic mice. The Journal of Biological Chemisitry 280(9): 8117-8124.
20. Lai Wang, Yvonne Y. Shao, and R. Tracy Ballock (2006) Peroxisome proliferator-activated receptor-γ promotes adipogenic changes in growth plate chondrocytes in vitro. PPAR Res 2006: 67297.
21. Funicello M, Novelli M, Maffei M (2007) Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores. PLoS ONE 2(1): e683.
22. Chavey C, Mari B, Monthouel MN, Anglard P (2003) Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278: 11888-11896.
23. Soraya Taleb, Raffaella Cancello, Daniele Lacasa (2006) Cathepsin S Promotes Human Preadipocyte Differentiation: Possible Involvement of Fibronectin Degradation. Endocrinology 147(10): 4950-4959.