-
2
-
-
0033579163
-
Mutational spectra ofPTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
-
Ali IU, Schriml LM, Dean M (1999) Mutational spectra ofPTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91: 1922-1932.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1922-1932
-
-
Ali, I.U.1
Schriml, L.M.2
Dean, M.3
-
3
-
-
0029127042
-
Molecular alterations ofthe AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, (1995) Molecular alterations ofthe AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 64: 280-285.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
de Feo, D.2
Godwin, A.K.3
Bell, D.W.4
Cheng, J.Q.5
-
4
-
-
33744832614
-
An Integrated in Silico 3D Model-Driven Discovery of a Novel, Potent, and Selective Amidosulfonamide 5-HT1A Agonist (PRX-00023) for the Treatment of Anxiety and Depression
-
Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, (2006) An Integrated in Silico 3D Model-Driven Discovery of a Novel, Potent, and Selective Amidosulfonamide 5-HT1A Agonist (PRX-00023) for the Treatment of Anxiety and Depression. J Med Chem 49:3116-3135.
-
(2006)
J Med Chem
, vol.49
, pp. 3116-3135
-
-
Becker, O.M.1
Dhanoa, D.S.2
Marantz, Y.3
Chen, D.4
Shacham, S.5
-
6
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF (2008) The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8: 187-98.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 187-98
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.5
-
7
-
-
0025911006
-
Dehydroandrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus
-
Chang RS, Ding L, Chen GQ, Pan QC, Zhao ZL, (1991) Dehydroandrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus. Proc Soc Exp Biol Med 197: 59-66.
-
(1991)
Proc Soc Exp Biol Med
, vol.197
, pp. 59-66
-
-
Chang, R.S.1
Ding, L.2
Chen, G.Q.3
Pan, Q.C.4
Zhao, Z.L.5
-
9
-
-
39649087113
-
Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity
-
Fang XK, Gao J, Zhu DN (2008) Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci 82: 615-22.
-
(2008)
Life Sci
, vol.82
, pp. 615-22
-
-
Fang, X.K.1
Gao, J.2
Zhu, D.N.3
-
10
-
-
0029294584
-
Molecular Recognition of the Inhibitor AG-1343 by HIV-1 Protease: Conformationally Flexible Docking by Evolutionary Programming
-
Gehlhaar DK, Verkhivker GM, Rejto PA, Sherman CJ, Fogel DB, (1995) Molecular Recognition of the Inhibitor AG-1343 by HIV-1 Protease: Conformationally Flexible Docking by Evolutionary Programming. Chemistry & Biology 2: 317.
-
(1995)
Chemistry & Biology
, vol.2
, pp. 317
-
-
Gehlhaar, D.K.1
Verkhivker, G.M.2
Rejto, P.A.3
Sherman, C.J.4
Fogel, D.B.5
-
11
-
-
0032971463
-
Flavonoids and the inhibition of PKC and PI 3-kinase
-
Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, et al. (1999) Flavonoids and the inhibition of PKC and PI 3-kinase. General Pharmacology 32: 279-286.
-
(1999)
General Pharmacology
, vol.32
, pp. 279-286
-
-
Gamet-Payrastre, L.1
Manenti, S.2
Gratacap, M.P.3
Tulliez, J.4
Chap, H.5
-
14
-
-
0030255303
-
Scoring noncovalent protein-ligand interactions: A continuous differentiable function tuned to compute binding affinities
-
Jain AN (1996) Scoring noncovalent protein-ligand interactions: A continuous differentiable function tuned to compute binding affinities. J Comput Aided Mol Design 10: 427-440.
-
(1996)
J Comput Aided Mol Design
, vol.10
, pp. 427-440
-
-
Jain, A.N.1
-
15
-
-
67349190889
-
Kaempferol induces cell death through ERK and Aktdependent down-regulation of XIAP and survivin in human glioma cells
-
Jeong JC, Kim MS, Kim TH, Kim YK (2009) Kaempferol induces cell death through ERK and Aktdependent down-regulation of XIAP and survivin in human glioma cells. Neurochem Res May 34: 991-1001.
-
(2009)
Neurochem Res May
, vol.34
, pp. 991-1001
-
-
Jeong, J.C.1
Kim, M.S.2
Kim, T.H.3
Kim, Y.K.4
-
16
-
-
15244346501
-
LigScore: A novel scoring function for predicting binding affinities
-
Krammer A, Kirchhoff PD, Jiang X, Venkatachalam CM, Waldman M (2005) LigScore: a novel scoring function for predicting binding affinities. J Mol Graph Model 23: 395-407.
-
(2005)
J Mol Graph Model
, vol.23
, pp. 395-407
-
-
Krammer, A.1
Kirchhoff, P.D.2
Jiang, X.3
Venkatachalam, C.M.4
Waldman, M.5
-
17
-
-
42149151524
-
Underlying mechanism of quercetin-induced cell death in human glioma cells
-
Kim EJ, Choi CH, Park JY, Kang SK, Kim YK (2008) Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem Res 33: 971-9.
-
(2008)
Neurochem Res
, vol.33
, pp. 971-9
-
-
Kim, E.J.1
Choi, C.H.2
Park, J.Y.3
Kang, S.K.4
Kim, Y.K.5
-
18
-
-
64049102516
-
The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration
-
Labbé D, Provençal M, Lamy S, Boivin D, Gingras D, (2009) The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration. J Nutr 139: 646-52.
-
(2009)
J Nutr
, vol.139
, pp. 646-52
-
-
Labbé, D.1
Provençal, M.2
Lamy, S.3
Boivin, D.4
Gingras, D.5
-
19
-
-
40749083585
-
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells
-
Lee SH, Cekanova M, Baek SJ (2008) Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol Carcino 47: 197-208.
-
(2008)
Mol Carcino
, vol.47
, pp. 197-208
-
-
Lee, S.H.1
Cekanova, M.2
Baek, S.J.3
-
20
-
-
62749165351
-
Distribution and biological activities of the flavonoid luteolin
-
López-Lázaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 9: 31-59.
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 31-59
-
-
López-Lázaro, M.1
-
21
-
-
67650133615
-
Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide
-
Lin FL, Wu SJ, Lee SC, (2009) Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide. Phytother Res.
-
(2009)
Phytother Res
-
-
Lin, F.L.1
Wu, S.J.2
Lee, S.C.3
-
22
-
-
16444377544
-
Antioxidant properties of gingerol related compounds from ginger
-
Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N (2004) Antioxidant properties of gingerol related compounds from ginger. Biofactors 21: 293-6.
-
(2004)
Biofactors
, vol.21
, pp. 293-6
-
-
Masuda, Y.1
Kikuzaki, H.2
Hisamoto, M.3
Nakatani, N.4
-
23
-
-
0032534025
-
The presence of a constitutively-active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway
-
Moore SM, Rintoul RC, Walker TR, Chilvers ER, Haslett C, (1998) The presence of a constitutively-active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res 58: 5239-5247.
-
(1998)
Cancer Res
, vol.58
, pp. 5239-5247
-
-
Moore, S.M.1
Rintoul, R.C.2
Walker, T.R.3
Chilvers, E.R.4
Haslett, C.5
-
24
-
-
0033545622
-
A General and Fast Scoring Function for Protein-Ligand Interactions: A Simplified Potential Approach
-
Muegge I and Martin YC (1999) A General and Fast Scoring Function for Protein-Ligand Interactions: A Simplified Potential Approach. J Med Chem 42: 791.
-
(1999)
J Med Chem
, vol.42
, pp. 791
-
-
Muegge, I.1
Martin, Y.C.2
-
25
-
-
33749242403
-
PMF Scoring Revisited
-
Muegge I (2006) PMF Scoring Revisited. J Med Chem 49: 5895-5902.
-
(2006)
J Med Chem
, vol.49
, pp. 5895-5902
-
-
Muegge, I.1
-
26
-
-
0033618371
-
Up-regulation ofAkt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, (1999) Up-regulation ofAkt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 274: 21528-21532.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
-
27
-
-
75649113641
-
-
NCBI-PubChem Compound database
-
NCBI-PubChem Compound database. [http:// pubchem.ncbi.nlm.nih.gov/]
-
-
-
-
28
-
-
49049110784
-
PI3K-AKT network roles in infectious diseases
-
Noguchi M and Kinowaki K (2008) PI3K-AKT network roles in infectious diseases Kansenshogaku Zasshi 82: 161-7.
-
(2008)
Kansenshogaku Zasshi
, vol.82
, pp. 161-7
-
-
Noguchi, M.1
Kinowaki, K.2
-
29
-
-
57349152569
-
Nov Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria
-
Park M, Bae J, Lee DS (2008) Nov Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res 22: 1446-9.
-
(2008)
Phytother Res
, vol.22
, pp. 1446-1449
-
-
Park, M.1
Bae, J.2
Lee, D.S.3
-
30
-
-
8444240824
-
Early Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Lung Cancer Progression
-
Pierre PM, Peter MT, Yu S, Rahman SMJ, Yildiz P, (2004) Early Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Lung Cancer Progression. Am J Respir Crit Care Med 170: 1088-1094.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 1088-1094
-
-
Pierre, P.M.1
Peter, M.T.2
Yu, S.3
Rahman, S.M.J.4
Yildiz, P.5
-
31
-
-
0028217223
-
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase
-
Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res 54: 2419-2423.
-
(1994)
Cancer Res
, vol.54
, pp. 2419-2423
-
-
Powis, G.1
Bonjouklian, R.2
Berggren, M.M.3
Gallegos, A.4
Abraham, R.5
-
32
-
-
75649106314
-
-
Protein Data Bank
-
Protein Data Bank. [http://www.rcsb.org/pdb/home/home.do]
-
-
-
-
33
-
-
75649127496
-
-
Pubmed
-
Pubmed
-
-
-
-
34
-
-
0141457852
-
Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata
-
Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R (2003) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 147-58.
-
(2003)
J Exp Ther Oncol
, pp. 147-58
-
-
Rajagopal, S.1
Kumar, R.A.2
Deevi, D.S.3
Satyanarayana, C.4
Rajagopalan, R.5
-
35
-
-
0037620888
-
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain
-
Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, (2003) Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem 46: 3953-3956.
-
(2003)
J Med Chem
, vol.46
, pp. 3953-3956
-
-
Sawyer, J.S.1
Anderson, B.D.2
Beight, D.W.3
Campbell, R.M.4
Jones, M.L.5
-
36
-
-
0034794639
-
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
-
Stein RC (2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. Endocr Relat Cancer 8: 237-248.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 237-248
-
-
Stein, R.C.1
-
38
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo W, Baldocchi R, Godfrey T, (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21: 99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.3
Baldocchi, R.4
Godfrey, T.5
-
39
-
-
0344496021
-
Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)
-
Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, (2003) Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett 13: 4355-4359.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4355-4359
-
-
Singh, J.1
Chuaqui, C.E.2
Boriack-Sjodin, P.A.3
Lee, W.C.4
Pontz, T.5
-
41
-
-
4444376879
-
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration
-
Tsai HR, Yang LM, Tsai WJ, Chiou WF (2004) Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. Eur J Pharmacol 498: 45-52.
-
(2004)
Eur J Pharmacol
, vol.498
, pp. 45-52
-
-
Tsai, H.R.1
Yang, L.M.2
Tsai, W.J.3
Chiou, W.F.4
-
42
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
Vanhaesebroeck B, Waterfield MD (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253: 239-254.
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
43
-
-
0037212102
-
LigandFit: A Novel Method for the Shape-Directed Rapid Docking of Ligands to Protein Active Sites
-
Venkatachalam CM, Jiang X, Oldfield T, Waldman M (2003) LigandFit: A Novel Method for the Shape-Directed Rapid Docking of Ligands to Protein Active Sites. J Mol Graph Modell 21: 289-307.
-
(2003)
J Mol Graph Modell
, vol.21
, pp. 289-307
-
-
Venkatachalam, C.M.1
Jiang, X.2
Oldfield, T.3
Waldman, M.4
-
44
-
-
67949104877
-
In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves
-
Verma AR, Vijayakumar M, Mathela CS, Rao CV (2009) In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves. Food Chem Toxicol.
-
(2009)
Food Chem Toxicol
-
-
Verma, A.R.1
Vijayakumar, M.2
Mathela, C.S.3
Rao, C.V.4
-
45
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
46
-
-
0028197377
-
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase
-
Woscholski R, Kodaki T, McKinnona M, Waterfield MD, Parker PJ (1994) A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS Letters 342: 109-114.
-
(1994)
Febs Letters
, vol.342
, pp. 109-114
-
-
Woscholski, R.1
Kodaki, T.2
McKinnona, M.3
Waterfield, M.D.4
Parker, P.J.5
-
47
-
-
1242329231
-
Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats
-
Yu BC, Hung CR, Chen WC, Cheng JT (2003) Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med 69: 1075-9.
-
(2003)
Planta Med
, vol.69
, pp. 1075-1079
-
-
Yu, B.C.1
Hung, C.R.2
Chen, W.C.3
Cheng, J.T.4
-
48
-
-
0034604067
-
Frequent activation ofAKT2 and induction ofapoptosis by inhibition Of phosphoinositide-3-OH kinase/ Akt pathway in human ovarian cancer
-
Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, (2000) Frequent activation ofAKT2 and induction ofapoptosis by inhibition Of phosphoinositide-3-OH kinase/ Akt pathway in human ovarian cancer. Oncogene 19: 2324-2330.
-
(2000)
Oncogene
, vol.19
, pp. 2324-2330
-
-
Yuan, Z.Q.1
Sun, M.2
Feldman, R.I.3
Wang, G.4
Ma, X.5
-
49
-
-
33746827428
-
Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit
-
Zhong YC (2006) Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit 29: 33-6.
-
(2006)
, vol.29
, pp. 33-36
-
-
Zhong, Y.C.1
|