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Volumn 103, Issue 2, 2010, Pages 180-188

Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice

Author keywords

ApoE deficient mice; Atherosclerotic lesions; Cysteine; Lupin protein

Indexed keywords

APOLIPOPROTEIN E; CALCIUM; CASEIN; COLLAGEN; CYSTEINE; FAT; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUPIN PROTEIN; MINERAL; OVALBUMIN; PHOSPHATE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; 5' NUCLEOTIDASE; AMINO ACID; CYSTINE; LIPID; NT5C3 PROTEIN, MOUSE; PRIMER DNA;

EID: 75549091197     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509991565     Document Type: Article
Times cited : (19)

References (50)
  • 2
    • 38449120846 scopus 로고    scopus 로고
    • Effect of soy proteins and isoflavones on lipid metabolism and involved gene expression
    • Xiao CW, Mei J & Wood CM (2008) Effect of soy proteins and isoflavones on lipid metabolism and involved gene expression. Front Biosci 13, 2660-2673.
    • (2008) Front Biosci , vol.13 , pp. 2660-2673
    • Xiao, C.W.1    Mei, J.2    Wood, C.M.3
  • 3
    • 0346726203 scopus 로고    scopus 로고
    • Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells
    • Sirtori CR, Lovati MR, Manzoni C, et al. (2004) Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells. J Nutr 134, 18-23.
    • (2004) J Nutr , vol.134 , pp. 18-23
    • Sirtori, C.R.1    Lovati, M.R.2    Manzoni, C.3
  • 4
    • 51749085387 scopus 로고    scopus 로고
    • Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model
    • Marchesi M, Parolini C, Diani E, et al. (2008) Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model. Br J Nutr 100, 707-710.
    • (2008) Br J Nutr , vol.100 , pp. 707-710
    • Marchesi, M.1    Parolini, C.2    Diani, E.3
  • 5
    • 53049089173 scopus 로고    scopus 로고
    • Lupin protein influences the expression of hepatic gene involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats
    • Bettzieche A, Brandsch C, Weisse K, et al. (2008) Lupin protein influences the expression of hepatic gene involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats. Br J Nutr 99, 952-962.
    • (2008) Br J Nutr , vol.99 , pp. 952-962
    • Bettzieche, A.1    Brandsch, C.2    Weisse, K.3
  • 6
    • 34548831359 scopus 로고    scopus 로고
    • Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c
    • Spielmann J, Shukla A, Brandsch C, et al. (2007) Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c. Ann Nutr Metab 51, 387-392.
    • (2007) Ann Nutr Metab , vol.51 , pp. 387-392
    • Spielmann, J.1    Shukla, A.2    Brandsch, C.3
  • 7
    • 0027958084 scopus 로고
    • ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    • Nakashima Y, Plump AS, Raines EW, et al. (1994) ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 14, 133-140.
    • (1994) Arterioscler Thromb , vol.14 , pp. 133-140
    • Nakashima, Y.1    Plump, A.S.2    Raines, E.W.3
  • 8
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • Zhang SH, Reddick RL, Piedrahita JA, et al. (1992) Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3
  • 9
    • 34247092771 scopus 로고    scopus 로고
    • Isoflavone-poor soy protein alters the lipid metabolism of rats by SREBP-mediated down-regulation of hepatic genes
    • Shukla A, Brandsch C, Bettzieche A, et al. (2007) Isoflavone-poor soy protein alters the lipid metabolism of rats by SREBP-mediated down-regulation of hepatic genes. J Nutr Biochem 18, 313-321.
    • (2007) J Nutr Biochem , vol.18 , pp. 313-321
    • Shukla, A.1    Brandsch, C.2    Bettzieche, A.3
  • 10
    • 33947602260 scopus 로고    scopus 로고
    • Effects of rice proteins from two cultivars, Koshihikari and Shunyo, on cholesterol and triglyceride metabolism in growing and adult rats
    • Yang L, Kumagai T, Kawamura H, et al. (2007) Effects of rice proteins from two cultivars, Koshihikari and Shunyo, on cholesterol and triglyceride metabolism in growing and adult rats. Biosci Biotechnol Biochem 71, 694-703.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 694-703
    • Yang, L.1    Kumagai, T.2    Kawamura, H.3
  • 11
    • 38949148974 scopus 로고    scopus 로고
    • Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipopro-tein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression
    • Nagarajan S, Burris RL, Stewart BW, et al. (2008) Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipopro-tein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression. J Nutr 138, 332-337.
    • (2008) J Nutr , vol.138 , pp. 332-337
    • Nagarajan, S.1    Burris, R.L.2    Stewart, B.W.3
  • 12
    • 0025951819 scopus 로고
    • Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis
    • Sanchez A & Hubbard RW (1991) Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis. Med Hypotheses 36, 27-32.
    • (1991) Med Hypotheses , vol.36 , pp. 27-32
    • Sanchez, A.1    Hubbard, R.W.2
  • 13
    • 0028821534 scopus 로고
    • Overview of proposed mechanisms for the hypocholesterolemic effect of soy
    • Potter SM (1995) Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 125, 606S-611S.
    • (1995) J Nutr , vol.125
    • Potter, S.M.1
  • 14
    • 33947543879 scopus 로고    scopus 로고
    • Dietary fish protein alters blood lipid concentrations and hepatic genes involved in cholesterol homeostasis in the rat model
    • Shukla A, Bettzieche A, Hirche F, et al. (2006) Dietary fish protein alters blood lipid concentrations and hepatic genes involved in cholesterol homeostasis in the rat model. Br J Nutr 96, 674-682.
    • (2006) Br J Nutr , vol.96 , pp. 674-682
    • Shukla, A.1    Bettzieche, A.2    Hirche, F.3
  • 15
    • 11144353056 scopus 로고    scopus 로고
    • Effect of five cysteine-containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet
    • Lin CC, Yin MC, Hsu CC, et al. (2004) Effect of five cysteine-containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet. Lipids 39, 843-848.
    • (2004) Lipids , vol.39 , pp. 843-848
    • Lin, C.C.1    Yin, M.C.2    Hsu, C.C.3
  • 16
    • 37349073710 scopus 로고    scopus 로고
    • Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet
    • Lin CC & Yin MC (2008) Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet. Br J Nutr 99, 37-43.
    • (2008) Br J Nutr , vol.99 , pp. 37-43
    • Lin, C.C.1    Yin, M.C.2
  • 17
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
    • Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J Nutr 123, 1939-1951.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr., G.C.3
  • 18
    • 18044400534 scopus 로고    scopus 로고
    • New processing of lupin protein isolates and functional properties
    • Wäsche A, Müller K & Knauf U (2001) New processing of lupin protein isolates and functional properties. Nahrung 45, 393-395.
    • (2001) Nahrung , vol.45 , pp. 393-395
    • Wäsche, A.1    Müller, K.2    Knauf, U.3
  • 19
    • 4544254660 scopus 로고    scopus 로고
    • Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Sung JH, Choi SJ, Lee SW, et al. (2004) Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Biosci Biotechnol Biochem 68, 1051-1058.
    • (2004) Biosci Biotechnol Biochem , vol.68 , pp. 1051-1058
    • Sung, J.H.1    Choi, S.J.2    Lee, S.W.3
  • 20
    • 0141988889 scopus 로고    scopus 로고
    • Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: Comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)
    • Teupser D, Persky AD & Breslow JL (2003) Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement). Arterioscler Thromb Vasc Biol 23, 1907-1913.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1907-1913
    • Teupser, D.1    Persky, A.D.2    Breslow, J.L.3
  • 22
    • 84944001028 scopus 로고
    • High performance liquid chro-matography method for rapid and accurate determination of homocysteine in plasma and serum
    • Vester B & Rasmussen K (1991) High performance liquid chro-matography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Bio-chem 29, 549-554.
    • (1991) Eur J Clin Chem Clin Bio-chem , vol.29 , pp. 549-554
    • Vester, B.1    Rasmussen, K.2
  • 23
    • 0020526811 scopus 로고
    • Platelet glutathione peroxidase activity as an index of selenium status in rats
    • Levander OA, Deloach DP, Morris VC, et al. (1983) Platelet glutathione peroxidase activity as an index of selenium status in rats. J Nutr 113, 55-63.
    • (1983) J Nutr , vol.113 , pp. 55-63
    • Levander, O.A.1    Deloach, D.P.2    Morris, V.C.3
  • 24
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 25
    • 14944348447 scopus 로고    scopus 로고
    • A new LC/APCI-MS method for the determination of cholesterol oxidation products in food
    • Raith K, Brunner C, Farwanah H, et al. (2005) A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. J Chromatogr A 1067, 207-211.
    • (2005) J Chromatogr A , vol.1067 , pp. 207-211
    • Raith, K.1    Brunner, C.2    Farwanah, H.3
  • 26
    • 1642547028 scopus 로고    scopus 로고
    • Determination of 24S-and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry
    • Burkhard I, Rentsch KM & von Eckardstein A (2004) Determination of 24S-and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J Lipid Res 45, 776-781.
    • (2004) J Lipid Res , vol.45 , pp. 776-781
    • Burkhard, I.1    Rentsch, K.M.2    Von Eckardstein, A.3
  • 28
    • 33751576769 scopus 로고    scopus 로고
    • Novel insights into vascular calcification
    • Ketteler M & Giachelli C (2006) Novel insights into vascular calcification. Kidney Int Suppl. 105, S5-S9.
    • (2006) Kidney Int , Issue.SUPPL. 105
    • Ketteler, M.1    Giachelli, C.2
  • 29
    • 33846670534 scopus 로고    scopus 로고
    • Ageing of the conduit arteries
    • Greenwald SE (2007) Ageing of the conduit arteries. J Pathol 211, 157-172.
    • (2007) J Pathol , vol.211 , pp. 157-172
    • Greenwald, S.E.1
  • 30
    • 3042856482 scopus 로고    scopus 로고
    • Vascular calcification: Mechanisms and clinical ramifications
    • Abedin M, Tintut Y & Demer LL (2004) Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol 24, 1161-1170.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1161-1170
    • Abedin, M.1    Tintut, Y.2    Demer, L.L.3
  • 31
    • 0028354771 scopus 로고
    • Coronary arterial calcification as an active process: A new perspective on an old problem
    • Doherty TM & Detrano RC (1994) Coronary arterial calcification as an active process: a new perspective on an old problem. Calcif Tissue Int 54, 224-230.
    • (1994) Calcif Tissue Int , vol.54 , pp. 224-230
    • Doherty, T.M.1    Detrano, R.C.2
  • 32
    • 0038201864 scopus 로고    scopus 로고
    • Pathology of the thin-cap fibroatheroma: A type of vulnerable plaque
    • Virmani R, Burke AP, Kolodgie FD, et al. (2003) Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque. J Interv Cardiol 16, 267-272.
    • (2003) J Interv Cardiol , vol.16 , pp. 267-272
    • Virmani, R.1    Burke, A.P.2    Kolodgie, F.D.3
  • 33
    • 20844451175 scopus 로고    scopus 로고
    • Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: An intravascular ultrasound study
    • Ehara S, Kobayashi Y, Yoshiyama M, et al. (2004) Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation 110, 3424-3429.
    • (2004) Circulation , vol.110 , pp. 3424-3429
    • Ehara, S.1    Kobayashi, Y.2    Yoshiyama, M.3
  • 34
    • 33749514279 scopus 로고    scopus 로고
    • A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps
    • Vengrenyuk Y, Carlier S, Xanthos S, et al. (2006) A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci USA 103, 14678-14683.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14678-14683
    • Vengrenyuk, Y.1    Carlier, S.2    Xanthos, S.3
  • 35
    • 33744741007 scopus 로고    scopus 로고
    • Osteogenic regulation of vascular calcification
    • Towler DA, Shao JS, Cheng SL, et al. (2006) Osteogenic regulation of vascular calcification. Ann N Y Acad Sci 1068, 327-333.
    • (2006) Ann N y Acad Sci , vol.1068 , pp. 327-333
    • Towler, D.A.1    Shao, J.S.2    Cheng, S.L.3
  • 36
    • 47249157776 scopus 로고    scopus 로고
    • Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor runx-2 by akt signaling
    • Byon CH, Javed A, Dai Q, et al. (2008) Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor runx-2 by akt signaling. J Biol Chem 283, 15319-15327.
    • (2008) J Biol Chem , vol.283 , pp. 15319-15327
    • Byon, C.H.1    Javed, A.2    Dai, Q.3
  • 37
    • 0035749974 scopus 로고    scopus 로고
    • Association of mild hyperhomocysteinemia with aortic calcification in hypercholes-terolemic patients
    • Hirose N, Arai Y, Ishii T, et al. (2001) Association of mild hyperhomocysteinemia with aortic calcification in hypercholes-terolemic patients. J Atheroscler Thromb 8, 91-94.
    • (2001) J Atheroscler Thromb , vol.8 , pp. 91-94
    • Hirose, N.1    Arai, Y.2    Ishii, T.3
  • 38
    • 33845466968 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress
    • Tang FT, Chen SR, Wu XQ, et al. (2006) Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress. Calcif Tissue Int 79, 326-339.
    • (2006) Calcif Tissue Int , vol.79 , pp. 326-339
    • Tang, F.T.1    Chen, S.R.2    Wu, X.Q.3
  • 39
    • 17644373136 scopus 로고    scopus 로고
    • Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    • Tankó LB, Bagger YZ, Qin G, et al. (2005) Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation 111, 1883-1890.
    • (2005) Circulation , vol.111 , pp. 1883-1890
    • Tankó, L.B.1    Bagger, Y.Z.2    Qin, G.3
  • 40
    • 0031738457 scopus 로고    scopus 로고
    • Dietary soy protein isolate, compared with casein, reduces atherosclerotic lesion area in apolipoprotein E-deficient mice
    • Ni W, Tsuda Y, Sakono M, et al. (1998) Dietary soy protein isolate, compared with casein, reduces atherosclerotic lesion area in apolipoprotein E-deficient mice. J Nutr 128, 1884-1889.
    • (1998) J Nutr , vol.128 , pp. 1884-1889
    • Ni, W.1    Tsuda, Y.2    Sakono, M.3
  • 41
    • 57149095250 scopus 로고    scopus 로고
    • Aortic calcifications in familial hypercholesterolemia: Potential role of the low-density lipoprotein receptor gene
    • Alrasadi K, Alwaili K, Awan Z, et al. (2009) Aortic calcifications in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene. Am Heart J 157, 170-176.
    • (2009) Am Heart J , vol.157 , pp. 170-176
    • Alrasadi, K.1    Alwaili, K.2    Awan, Z.3
  • 42
    • 38449089009 scopus 로고    scopus 로고
    • Hyperphospha-temia: Effects on bone metabolism and cardiovascular risk
    • Caudarella R, Vescini F, Buffa A, et al. (2007) Hyperphospha-temia: effects on bone metabolism and cardiovascular risk. J Endocrinol Invest 30, 29-34.
    • (2007) J Endocrinol Invest , vol.30 , pp. 29-34
    • Caudarella, R.1    Vescini, F.2    Buffa, A.3
  • 43
    • 63849220348 scopus 로고    scopus 로고
    • Roles of hyperphosphatemia in vascular calcification
    • Shioi A & Nishizawa Y (2009) Roles of hyperphosphatemia in vascular calcification. Clin Calcium 19, 180-185.
    • (2009) Clin Calcium , vol.19 , pp. 180-185
    • Shioi, A.1    Nishizawa, Y.2
  • 44
    • 0030888183 scopus 로고    scopus 로고
    • Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease
    • Duell PB & Malinow MR (1997) Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol 8, 28-34.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 28-34
    • Duell, P.B.1    Malinow, M.R.2
  • 46
    • 0032421171 scopus 로고    scopus 로고
    • Role of the liver in interor-gan homeostasis of glutathione and cyst(e)ine
    • Ookhtens M & Kaplowitz N (1998) Role of the liver in interor-gan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis 18, 313-329.
    • (1998) Semin Liver Dis , vol.18 , pp. 313-329
    • Ookhtens, M.1    Kaplowitz, N.2
  • 47
    • 0034711007 scopus 로고    scopus 로고
    • The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes
    • Mosharov E, Cranford MR & Banerjee T (2000) The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry 39, 13005-13011.
    • (2000) Biochemistry , vol.39 , pp. 13005-13011
    • Mosharov, E.1    Cranford, M.R.2    Banerjee, T.3
  • 48
    • 0028180137 scopus 로고
    • TGF-b1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify
    • Watson KE, Boström K, Ravindranath R, et al. (1994) TGF-b1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest 93, 2106-2113.
    • (1994) J Clin Invest , vol.93 , pp. 2106-2113
    • Watson, K.E.1    Boström, K.2    Ravindranath, R.3
  • 49
    • 36549023457 scopus 로고    scopus 로고
    • Vascular Bmp Msx2 Wnt signalling and oxidative stress in arterial calcification
    • Shao JS, Aly ZA, Lai CF, et al. (2007) Vascular Bmp Msx2 Wnt signalling and oxidative stress in arterial calcification. Ann N Y Acad Sci 1117, 40-50.
    • (2007) Ann N y Acad Sci , vol.1117 , pp. 40-50
    • Shao, J.S.1    Aly, Z.A.2    Lai, C.F.3
  • 50
    • 0032890337 scopus 로고    scopus 로고
    • Oxysterols and atherosclerosis
    • Brown AJ & Jessup W (1999) Oxysterols and atherosclerosis. Atherosclerosis 142, 1-28.
    • (1999) Atherosclerosis , vol.142 , pp. 1-28
    • Brown, A.J.1    Jessup, W.2


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