The fate of free radicals in a cellulose based hydrogel: Detection by electron paramagnetic resonance spectroscopy

Journal of Pharmaceutical Sciences

Volumn 98, Issue 7, 2009, Pages 2464-2471

  Basumallick, Lipika ^a,c   Ji, J Andrea ^a   Naber, Nariman ^b   Wang, Y John ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Trinity Biosystems   (United States)

Author keywords

Electron paramagnetic resonance; Free radicals; Hydroxypropyl methylcellulose; Spin trapping

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CELLULOSE; EDETIC ACID; FREE RADICAL; HYDROXYPROPYLMETHYLCELLULOSE; METAL ION; METHIONINE; METHYLCELLULOSE; TEMPOL;

ARTICLE; AUTOCLAVE; DRUG DEGRADATION; DRUG FORMULATION; ELECTRON SPIN RESONANCE; HYDROGEL; OXIDATION; QUANTITATIVE ANALYSIS; SPIN TRAPPING; VISCOSITY;

EID: 67650119674     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21632     Document Type: Article

References (21)

1. Li C, Martini L, Ford J, Roberts M. 2005. The use of hypromellose in oral drug delivery. J Pharm Pharmacol 57:533-546. (Pubitemid 40562392)
2. Siepmann J, Peppas NA. 2001. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 48:139-157. (Pubitemid 32434400)
3. Pham AT, Lee PI. 1994. Probing the mechanisms of drug-release from hydroxypropyl methylcellulose matrices. Pharm Res 11:1379-1384. (Pubitemid 24339641)
4. Guay DF, Cole BJWRCF, Jr, Hausman MC, Genco J. 2002. Mechanisms of oxidative degradation of carbohydrates during oxygen delignification. III. Reaction of photochemically generated hydroxyl radicals with 1,5-anhydrocellobitol and cellulose. J Pulp Paper Sci 28:217-226. (Pubitemid 34945383)
5. McBurney LF. 1954. In: Ott E, Spurlin HM, Grafflin MW, editors. Cellulose and cellulose derivatives, Vol.I. New York: Interscience.
6. Nguyen TH. 1994. Formulation and delivery of proteins and peptides. In: Cleland JL, Langer R, editors. ACS symposium series. Washington: American Chemical Society. pp. 59-71.
7. Calucci L, Pinzino C, Zandomeneghi M, Capocchi A, Ghiringhelli S, Saviozzi F, Tozzi S, Galleschi L. 2003. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices. J Agric Food Chem 51:927-934.
8. Polovka M, Brezova V, Simko P. 2007. EPR spectroscopy: A tool to characterize gamma-irradiated foods. J Food Nutr Res 46:75-83. (Pubitemid 46982231)
9. Williams HE, Loades VC, Claybourn M, Murphy DM. 2006. Electron paramagnetic resonance spectroscopy studies of oxidative degradation of an active pharmaceutical ingredient and quantitative analysis of the organic radical intermediates using partial least-squares regression. Anal Chem 78: 604-608. (Pubitemid 43100395)
10. Basly J-P, Basly I, Bernard M. 1998. Electron spin resonance detection of radiosterilization of pharmaceuticals: Application to four nitrofurans. Analyst 123:1753-1756. (Pubitemid 28408602)
11. Alderman D. 1984. Review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms. Int J Pharm Tech Prod Mfr 5:1-9. (Pubitemid 15105124)
12. Buettner GR. 1987. Spin trapping: ESR parameters of spin adducts. Free Radic Biol Med 3:259-303.
13. Schaich KM, Borg DC. 1988. Fenton reactions in lipid phases. Lipids 23:570-579.
14. Dahl T, He GX, Samuels G. 1998. Effect of hydrogen peroxide on the viscosity of a hydroxyethylcellulosebased gel. Pharm Res 15:1137-1140. (Pubitemid 28356935)
15. Kuzina SI, Mikhailov AI. 2005. Formation of free radicals during the photolysis and radiolysis of cellulose photochemistry and magnetochemistry. Russ J Phy Chem 79:1115-1123.
16. Baertschi S, Jansen P. 2005. Stress testing: A predictive tool. New York: Taylor & Francis. pp. 13-44.
17. Boccardi G. 2005. Oxidative susceptibility testing. New York: Talyor & Francis. pp. 205-230.
18. Johnson D, Gu L. 1988. Autoxidation and antioxidants. New York: Wiley. pp. 415-450.
19. Barr D, Heiss A, Kamlowski A, Maier D, Erstling J, Meling H. 2001. Shelf-life analysis of beer using an automated lag-time EPR system. Spectroscopy 16: 16-19.
20. Ha E, Wang W, Wang YJ. 2002. Peroxide formation in polysorbate 80 and protein stability. J Pharm Sci 91:2252-2264. (Pubitemid 35050710)
21. Wasylaschuk WR, Harmon PA, Wagner G, Harman AB, Templeton AC, Xu H, Reed RA. 2007. Evaluation of hydroperoxides in common pharmaceutical excipients. J Pharm Sci 96:106-116. (Pubitemid 46087343)