The Privileged Chemical Space Predictor (pcsp): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1338-1343

  Seedhouse, Steven J ^a   Labuda, Lucas P ^a   Disney, Matthew D ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Chemical biology; Chemical microarrays; Chemical space; Computer program; High throughput screening; RNA

Indexed keywords

ARTICLE; CANDIDA ALBICANS; COMBINATORIAL LIBRARY; COMPUTER PROGRAM; DRUG BINDING; DRUG TARGETING; HIGH THROUGHPUT SCREENING; INTRON; PRIVILEGED CHEMICAL SPACE PREDICTOR; RNA BINDING; STRUCTURE ACTIVITY RELATION;

CANDIDA ALBICANS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DNA; DRUG DESIGN; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA ALBICANS;

EID: 75449088319     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.017     Document Type: Article

References (19)

1. Geysen H.M., Schoenen F., Wagner D., and Wagner R. Nat. Rev. Drug Disc. 2 (2003) 222
2. Burke M.D., and Schreiber S.L. Angew. Chem., Int. Ed. 43 (2004) 46
3. Fergus S., Bender A., and Spring D.R. Curr. Opin. Chem. Biol. 9 (2005) 304
4. Schreiber S.L. Science 287 (2000) 1964
5. Simon R.J., Kania R.S., Zuckermann R.N., Huebner V.D., Jewell D.A., Banville S., Ng S., Wang L., Rosenberg S., Marlowe C.K., Spellmeyer D.C., Tan R.Y., Frankel A.D., Santi D.V., Cohen F.E., and Bartlett P.A. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 9367
6. Olivos H.J., Alluri P.G., Reddy M.M., Salony D., and Kodadek T. Org. Lett. 4 (2002) 4057
7. Liu Y., Palma A.S., and Feizi T. Biol. Chem. 390 (2009) 647
8. Ratner D.M., Adams E.W., Disney M.D., and Seeberger P.H. ChemBiochem 5 (2004) 1375
9. Winkler D.F., Hilpert K., Brandt O., and Hancock R.E. Methods Mol. Biol. 570 (2009) 157
10. Thomas J.R., and Hergenrother P.J. Chem. Rev. 108 (2008) 1171
11. Parsons J., Castaldi M.P., Dutta S., Dibrov S.M., Wyles D.L., and Hermann T. Nat. Chem. Biol. 5 (2009) 823
12. Marcheschi R.J., Mouzakis K.D., and Butcher S.E. ACS Chem. Biol. 4 (2009) 844
13. Labuda L.P., Pushechnikov A., and Disney M.D. ACS Chem. Biol. 4 (2009) 299
14. MacBeath G., Koehler A.N., and Schreiber S.L. J. Am. Chem. Soc. 121 (1999) 7967
15. Weiss, N. A.; Hassett, M. J. Introductory Statistics; Addison-Wesley Pub. Co.: Reading, Mass., 1982.
16. obs to a two-tailed p-value, standard statistics tables can be used. For example, see Table 1 in 15.
17. Lim H.S., Reddy M.M., Xiao X., Wilson J., Wilson R., Connell S., and Kodadek T. Bioorg. Med. Chem. Lett. 19 (2009) 3866
18. Udugamasooriya D.G., Dineen S.P., Brekken R.A., and Kodadek T. J. Am. Chem. Soc. 130 (2008) 5744
19. Zuckermann R.N., and Kodadek T. Curr. Opin. Mol. Ther. 11 (2009) 299