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Volumn 52, Issue 2, 2010, Pages 296-304

Liver cancer: From molecular pathogenesis to new therapies. Summary of the EASL single topic conference

Author keywords

Cancer; Liver transplantation; Local therapy; Multi kinase inhibitor

Indexed keywords

ALCOHOL; ALPHA INTERFERON; BEVACIZUMAB; BRIVANIB; CALCINEURIN INHIBITOR; DOXORUBICIN; ERLOTINIB; FLICE INHIBITORY PROTEIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS X PROTEIN; HEPATITIS B(E) ANTIGEN; INTERFERON; IRINOTECAN; LAMIVUDINE; MAMMALIAN TARGET OF RAPAMYCIN; PLACEBO; RAPAMYCIN; SORAFENIB; SUNITINIB; TRANSCRIPTOME; TUMOR MARKER; VIRUS DNA;

EID: 75349110931     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.11.010     Document Type: Conference Paper
Times cited : (44)

References (117)
  • 1
    • 0034856294 scopus 로고    scopus 로고
    • Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver
    • Bruix J., Sherman M., Llovet J.M., Beaugrand M., Lencioni R., Burroughs A.K., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35 (2001) 421-430
    • (2001) J Hepatol , vol.35 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3    Beaugrand, M.4    Lencioni, R.5    Burroughs, A.K.6
  • 2
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin D.M., Bray F., Ferlay J., and Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 94 (2001) 153-156
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 3
    • 46349101016 scopus 로고    scopus 로고
    • The influence of alcohol consumption and hepatitis B and C infections on the risk of liver cancer in Europe
    • Ribes J., Cleries R., Esteban L., Moreno V., and Bosch F.X. The influence of alcohol consumption and hepatitis B and C infections on the risk of liver cancer in Europe. J Hepatol 49 (2008) 233-242
    • (2008) J Hepatol , vol.49 , pp. 233-242
    • Ribes, J.1    Cleries, R.2    Esteban, L.3    Moreno, V.4    Bosch, F.X.5
  • 5
    • 0014607316 scopus 로고
    • Viral hepatitis, postnecrotic cirrhosis, and hepatocellular carcinoma
    • Smith J.B., and Blumberg B.S. Viral hepatitis, postnecrotic cirrhosis, and hepatocellular carcinoma. Lancet 2 (1969) 953
    • (1969) Lancet , vol.2 , pp. 953
    • Smith, J.B.1    Blumberg, B.S.2
  • 6
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan
    • Beasley R.P., Hwang L.Y., Lin C.C., and Chien C.S. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet 2 (1981) 1129-1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Hwang, L.Y.2    Lin, C.C.3    Chien, C.S.4
  • 7
    • 27744549862 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems
    • Chang M.H., Chen T.H., Hsu H.M., Wu T.C., Kong M.S., Liang D.C., et al. Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems. Clin Cancer Res 11 (2005) 7953-7957
    • (2005) Clin Cancer Res , vol.11 , pp. 7953-7957
    • Chang, M.H.1    Chen, T.H.2    Hsu, H.M.3    Wu, T.C.4    Kong, M.S.5    Liang, D.C.6
  • 8
    • 84984555343 scopus 로고    scopus 로고
    • Hepatitis Be antigen and the risk of hepatocellular carcinoma
    • Yang H.I., Lu S.N., Liaw Y.F., You S.L., Sun C.A., Wang L.Y., et al. Hepatitis Be antigen and the risk of hepatocellular carcinoma. N Engl J Med 347 (2002) 168-174
    • (2002) N Engl J Med , vol.347 , pp. 168-174
    • Yang, H.I.1    Lu, S.N.2    Liaw, Y.F.3    You, S.L.4    Sun, C.A.5    Wang, L.Y.6
  • 9
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen C.J., Yang H.I., Su J., Jen C.L., You S.L., Lu S.N., et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295 (2006) 65-73
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Lu, S.N.6
  • 10
    • 51049117284 scopus 로고    scopus 로고
    • Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    • Yang H.I., Yeh S.H., Chen P.J., Iloeje U.H., Jen C.L., Su J., et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 100 (2008) 1134-1143
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1134-1143
    • Yang, H.I.1    Yeh, S.H.2    Chen, P.J.3    Iloeje, U.H.4    Jen, C.L.5    Su, J.6
  • 11
    • 20444401583 scopus 로고    scopus 로고
    • Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in West Africa: a community-based intervention study
    • Turner P.C., Sylla A., Gong Y.Y., Diallo M.S., Sutcliffe A.E., Hall A.J., et al. Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in West Africa: a community-based intervention study. Lancet 365 (2005) 1950-1956
    • (2005) Lancet , vol.365 , pp. 1950-1956
    • Turner, P.C.1    Sylla, A.2    Gong, Y.Y.3    Diallo, M.S.4    Sutcliffe, A.E.5    Hall, A.J.6
  • 12
    • 22644435919 scopus 로고    scopus 로고
    • Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
    • Murakami Y., Saigo K., Takashima H., Minami M., Okanoue T., Brechot C., et al. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54 (2005) 1162-1168
    • (2005) Gut , vol.54 , pp. 1162-1168
    • Murakami, Y.1    Saigo, K.2    Takashima, H.3    Minami, M.4    Okanoue, T.5    Brechot, C.6
  • 13
    • 33947528120 scopus 로고    scopus 로고
    • The hepatitis B virus × protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription
    • Cougot D., Wu Y., Cairo S., Caramel J., Renard C.A., Levy L., et al. The hepatitis B virus × protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. J Biol Chem 282 (2007) 4277-4287
    • (2007) J Biol Chem , vol.282 , pp. 4277-4287
    • Cougot, D.1    Wu, Y.2    Cairo, S.3    Caramel, J.4    Renard, C.A.5    Levy, L.6
  • 14
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard M.J., Wang L.H., and Schneider R.J. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294 (2001) 2376-2378
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 15
    • 33646193810 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication
    • Bouchard M.J., Wang L., and Schneider R.J. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol 80 (2006) 4406-4414
    • (2006) J Virol , vol.80 , pp. 4406-4414
    • Bouchard, M.J.1    Wang, L.2    Schneider, R.J.3
  • 16
    • 0038558163 scopus 로고    scopus 로고
    • Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
    • Kim K.H., and Seong B.L. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 22 (2003) 2104-2116
    • (2003) EMBO J , vol.22 , pp. 2104-2116
    • Kim, K.H.1    Seong, B.L.2
  • 17
    • 1442290121 scopus 로고    scopus 로고
    • Hepatitis B virus × protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alpha
    • Moon E.J., Jeong C.H., Jeong J.W., Kim K.R., Yu D.Y., Murakami S., et al. Hepatitis B virus × protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alpha. FASEB J 18 (2004) 382-384
    • (2004) FASEB J , vol.18 , pp. 382-384
    • Moon, E.J.1    Jeong, C.H.2    Jeong, J.W.3    Kim, K.R.4    Yu, D.Y.5    Murakami, S.6
  • 18
    • 33644854241 scopus 로고    scopus 로고
    • Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones
    • Pollicino T., Belloni L., Raffa G., Pediconi N., Squadrito G., Raimondo G., et al. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology 130 (2006) 823-837
    • (2006) Gastroenterology , vol.130 , pp. 823-837
    • Pollicino, T.1    Belloni, L.2    Raffa, G.3    Pediconi, N.4    Squadrito, G.5    Raimondo, G.6
  • 19
    • 0037299853 scopus 로고    scopus 로고
    • Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells
    • Kwon J.A., and Rho H.M. Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells. Biol Chem 384 (2003) 203-212
    • (2003) Biol Chem , vol.384 , pp. 203-212
    • Kwon, J.A.1    Rho, H.M.2
  • 20
    • 58249123434 scopus 로고    scopus 로고
    • Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression
    • Du J., Liang X., Liu Y., Qu Z., Gao L., Han L., et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell Death Differ 16 (2009) 219-229
    • (2009) Cell Death Differ , vol.16 , pp. 219-229
    • Du, J.1    Liang, X.2    Liu, Y.3    Qu, Z.4    Gao, L.5    Han, L.6
  • 21
    • 36348950196 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study
    • Bruno S., Crosignani A., Maisonneuve P., Rossi S., Silini E., and Mondelli M.U. Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study. Hepatology 46 (2007) 1350-1356
    • (2007) Hepatology , vol.46 , pp. 1350-1356
    • Bruno, S.1    Crosignani, A.2    Maisonneuve, P.3    Rossi, S.4    Silini, E.5    Mondelli, M.U.6
  • 22
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • Moriya K., Nakagawa K., Santa T., Shintani Y., Fujie H., Miyoshi H., et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 61 (2001) 4365-4370
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3    Shintani, Y.4    Fujie, H.5    Miyoshi, H.6
  • 23
    • 1842478144 scopus 로고    scopus 로고
    • The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade
    • Street A., Macdonald A., Crowder K., and Harris M. The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J Biol Chem 279 (2004) 12232-12241
    • (2004) J Biol Chem , vol.279 , pp. 12232-12241
    • Street, A.1    Macdonald, A.2    Crowder, K.3    Harris, M.4
  • 24
    • 16244364798 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription
    • Street A., Macdonald A., McCormick C., and Harris M. Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J Virol 79 (2005) 5006-5016
    • (2005) J Virol , vol.79 , pp. 5006-5016
    • Street, A.1    Macdonald, A.2    McCormick, C.3    Harris, M.4
  • 25
    • 33748114343 scopus 로고    scopus 로고
    • The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    • Perz J.F., Armstrong G.L., Farrington L.A., Hutin Y.J., and Bell B.P. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 45 (2006) 529-538
    • (2006) J Hepatol , vol.45 , pp. 529-538
    • Perz, J.F.1    Armstrong, G.L.2    Farrington, L.A.3    Hutin, Y.J.4    Bell, B.P.5
  • 26
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle E.E., Rodriguez C., Walker-Thurmond K., and Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348 (2003) 1625-1638
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 27
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    • Paradis V., Zalinski S., Chelbi E., Guedj N., Degos F., Vilgrain V., et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 49 (2009) 851-859
    • (2009) Hepatology , vol.49 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3    Guedj, N.4    Degos, F.5    Vilgrain, V.6
  • 28
    • 34848881905 scopus 로고    scopus 로고
    • Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
    • Calvisi D.F., Ladu S., Gorden A., Farina M., Lee J.S., Conner E.A., et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest 117 (2007) 2713-2722
    • (2007) J Clin Invest , vol.117 , pp. 2713-2722
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3    Farina, M.4    Lee, J.S.5    Conner, E.A.6
  • 29
    • 0032924622 scopus 로고    scopus 로고
    • p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • Matsuda Y., Ichida T., Matsuzawa J., Sugimura K., and Asakura H. p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116 (1999) 394-400
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 30
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S., Rickman D.S., de Reynies A., Balabaud C., Rebouissou S., Jeannot E., et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 45 (2007) 42-52
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reynies, A.3    Balabaud, C.4    Rebouissou, S.5    Jeannot, E.6
  • 31
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P., Legoix P., Bluteau O., Belghiti J., Franco D., Binot F., et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120 (2001) 1763-1773
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3    Belghiti, J.4    Franco, D.5    Binot, F.6
  • 32
    • 0037443891 scopus 로고    scopus 로고
    • Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
    • Iizuka N., Oka M., Yamada-Okabe H., Nishida M., Maeda Y., Mori N., et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 361 (2003) 923-929
    • (2003) Lancet , vol.361 , pp. 923-929
    • Iizuka, N.1    Oka, M.2    Yamada-Okabe, H.3    Nishida, M.4    Maeda, Y.5    Mori, N.6
  • 33
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • Ye Q.H., Qin L.X., Forgues M., He P., Kim J.W., Peng A.C., et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 9 (2003) 416-423
    • (2003) Nat Med , vol.9 , pp. 416-423
    • Ye, Q.H.1    Qin, L.X.2    Forgues, M.3    He, P.4    Kim, J.W.5    Peng, A.C.6
  • 34
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee J.S., Chu I.S., Heo J., Calvisi D.F., Sun Z., Roskams T., et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40 (2004) 667-676
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3    Calvisi, D.F.4    Sun, Z.5    Roskams, T.6
  • 35
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • Lee J.S., and Thorgeirsson S.S. Comparative and integrative functional genomics of HCC. Oncogene 25 (2006) 3801-3809
    • (2006) Oncogene , vol.25 , pp. 3801-3809
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 36
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang D.Y., Villanueva A., Hoshida Y., Peix J., Newell P., Minguez B., et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 68 (2008) 6779-6788
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3    Peix, J.4    Newell, P.5    Minguez, B.6
  • 37
    • 46249083024 scopus 로고    scopus 로고
    • MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    • Ladeiro Y., Couchy G., Balabaud C., Bioulac-Sage P., Pelletier L., Rebouissou S., et al. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47 (2008) 1955-1963
    • (2008) Hepatology , vol.47 , pp. 1955-1963
    • Ladeiro, Y.1    Couchy, G.2    Balabaud, C.3    Bioulac-Sage, P.4    Pelletier, L.5    Rebouissou, S.6
  • 38
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet J.M., and Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48 (2008) 1312-1327
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 39
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A., Forgues M., Ye Q.H., Jia H.L., He P., Zanetti K.A., et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10 (2006) 99-111
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    Jia, H.L.4    He, P.5    Zanetti, K.A.6
  • 43
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng A.L., Kang Y.K., Chen Z., Tsao C.J., Qin S., Kim J.S., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10 (2009) 25-34
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 44
    • 67651165187 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study
    • Faivre S., Raymond E., Boucher E., Douillard J., Lim H.Y., Kim J.S., et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol 10 (2009) 794-800
    • (2009) Lancet Oncol , vol.10 , pp. 794-800
    • Faivre, S.1    Raymond, E.2    Boucher, E.3    Douillard, J.4    Lim, H.Y.5    Kim, J.S.6
  • 45
    • 67649946279 scopus 로고    scopus 로고
    • Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
    • Zhu A.X., Sahani D.V., Duda D.G., di Tomaso E., Ancukiewicz M., Catalano O.A., et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol 27 (2009) 3027-3035
    • (2009) J Clin Oncol , vol.27 , pp. 3027-3035
    • Zhu, A.X.1    Sahani, D.V.2    Duda, D.G.3    di Tomaso, E.4    Ancukiewicz, M.5    Catalano, O.A.6
  • 46
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • Semela D., and Dufour J.F. Angiogenesis and hepatocellular carcinoma. J Hepatol 41 (2004) 864-880
    • (2004) J Hepatol , vol.41 , pp. 864-880
    • Semela, D.1    Dufour, J.F.2
  • 47
    • 65549105393 scopus 로고    scopus 로고
    • Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis
    • Schoenleber S.J., Kurtz D.M., Talwalkar J.A., Roberts L.R., and Gores G.J. Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis. Br J Cancer 100 (2009) 1385-1392
    • (2009) Br J Cancer , vol.100 , pp. 1385-1392
    • Schoenleber, S.J.1    Kurtz, D.M.2    Talwalkar, J.A.3    Roberts, L.R.4    Gores, G.J.5
  • 48
    • 60849124241 scopus 로고    scopus 로고
    • Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
    • Thomas M.B., Morris J.S., Chadha R., Iwasaki M., Kaur H., Lin E., et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 27 (2009) 843-850
    • (2009) J Clin Oncol , vol.27 , pp. 843-850
    • Thomas, M.B.1    Morris, J.S.2    Chadha, R.3    Iwasaki, M.4    Kaur, H.5    Lin, E.6
  • 50
    • 33947501692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
    • Sieghart W., Fuereder T., Schmid K., Cejka D., Werzowa J., Wrba F., et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 83 (2007) 425-432
    • (2007) Transplantation , vol.83 , pp. 425-432
    • Sieghart, W.1    Fuereder, T.2    Schmid, K.3    Cejka, D.4    Werzowa, J.5    Wrba, F.6
  • 51
    • 59849095780 scopus 로고    scopus 로고
    • Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma
    • Baba H.A., Wohlschlaeger J., Cicinnati V.R., Hilgard P., Lang H., Sotiropoulos G.C., et al. Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma. Liver Int 29 (2009) 399-405
    • (2009) Liver Int , vol.29 , pp. 399-405
    • Baba, H.A.1    Wohlschlaeger, J.2    Cicinnati, V.R.3    Hilgard, P.4    Lang, H.5    Sotiropoulos, G.C.6
  • 52
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz K.J., Wohlschlaeger J., Lang H., Sotiropoulos G.C., Malago M., Steveling K., et al. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 48 (2008) 83-90
    • (2008) J Hepatol , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6
  • 53
    • 34047118033 scopus 로고    scopus 로고
    • Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
    • Semela D., Piguet A.C., Kolev M., Schmitter K., Hlushchuk R., Djonov V., et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 46 (2007) 840-848
    • (2007) J Hepatol , vol.46 , pp. 840-848
    • Semela, D.1    Piguet, A.C.2    Kolev, M.3    Schmitter, K.4    Hlushchuk, R.5    Djonov, V.6
  • 54
    • 44649105082 scopus 로고    scopus 로고
    • Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma
    • Piguet A.C., Semela D., Keogh A., Wilkens L., Stroka D., Stoupis C., et al. Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. J Hepatol 49 (2008) 78-87
    • (2008) J Hepatol , vol.49 , pp. 78-87
    • Piguet, A.C.1    Semela, D.2    Keogh, A.3    Wilkens, L.4    Stroka, D.5    Stoupis, C.6
  • 55
    • 34248327483 scopus 로고    scopus 로고
    • De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects
    • Toso C., Meeberg G.A., Bigam D.L., Oberholzer J., Shapiro A.M., Gutfreund K., et al. De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects. Transplantation 83 (2007) 1162-1168
    • (2007) Transplantation , vol.83 , pp. 1162-1168
    • Toso, C.1    Meeberg, G.A.2    Bigam, D.L.3    Oberholzer, J.4    Shapiro, A.M.5    Gutfreund, K.6
  • 56
    • 43849095466 scopus 로고    scopus 로고
    • Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma
    • Zimmerman M.A., Trotter J.F., Wachs M., Bak T., Campsen J., Skibba A., et al. Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma. Liver Transpl 14 (2008) 633-638
    • (2008) Liver Transpl , vol.14 , pp. 633-638
    • Zimmerman, M.A.1    Trotter, J.F.2    Wachs, M.3    Bak, T.4    Campsen, J.5    Skibba, A.6
  • 58
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa G.K., Schwartz L., Ricci S., Amadori D., Santoro A., Figer A., et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 24 (2006) 4293-4300
    • (2006) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3    Amadori, D.4    Santoro, A.5    Figer, A.6
  • 59
    • 33750455106 scopus 로고    scopus 로고
    • Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm phase II design
    • Taylor J.M., Braun T.M., and Li Z. Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm phase II design. Clin Trials 3 (2006) 335-348
    • (2006) Clin Trials , vol.3 , pp. 335-348
    • Taylor, J.M.1    Braun, T.M.2    Li, Z.3
  • 61
    • 0034142193 scopus 로고    scopus 로고
    • Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma
    • Koda M., Murawaki Y., Mitsuda A., Ohyama K., Horie Y., Suou T., et al. Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma. Cancer 88 (2000) 529-537
    • (2000) Cancer , vol.88 , pp. 529-537
    • Koda, M.1    Murawaki, Y.2    Mitsuda, A.3    Ohyama, K.4    Horie, Y.5    Suou, T.6
  • 62
    • 0033953406 scopus 로고    scopus 로고
    • Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection
    • Khan K.N., Yatsuhashi H., Yamasaki K., Yamasaki M., Inoue O., Koga M., et al. Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection. J Hepatol 32 (2000) 269-278
    • (2000) J Hepatol , vol.32 , pp. 269-278
    • Khan, K.N.1    Yatsuhashi, H.2    Yamasaki, K.3    Yamasaki, M.4    Inoue, O.5    Koga, M.6
  • 63
    • 12344315670 scopus 로고    scopus 로고
    • Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma
    • Sasaki A., Kai S., Iwashita Y., Hirano S., Ohta M., and Kitano S. Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma. Cancer 103 (2005) 299-306
    • (2005) Cancer , vol.103 , pp. 299-306
    • Sasaki, A.1    Kai, S.2    Iwashita, Y.3    Hirano, S.4    Ohta, M.5    Kitano, S.6
  • 64
    • 0038714350 scopus 로고    scopus 로고
    • Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection
    • Lencioni R.A., Allgaier H.P., Cioni D., Olschewski M., Deibert P., Crocetti L., et al. Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology 228 (2003) 235-240
    • (2003) Radiology , vol.228 , pp. 235-240
    • Lencioni, R.A.1    Allgaier, H.P.2    Cioni, D.3    Olschewski, M.4    Deibert, P.5    Crocetti, L.6
  • 65
    • 61949290827 scopus 로고    scopus 로고
    • Systematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapies
    • Cho Y.K., Kim J.K., Kim M.Y., Rhim H., and Han J.K. Systematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapies. Hepatology 49 (2009) 453-459
    • (2009) Hepatology , vol.49 , pp. 453-459
    • Cho, Y.K.1    Kim, J.K.2    Kim, M.Y.3    Rhim, H.4    Han, J.K.5
  • 66
    • 33644662778 scopus 로고    scopus 로고
    • A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma
    • Chen M.S., Li J.Q., Zheng Y., Guo R.P., Liang H.H., Zhang Y.Q., et al. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg 243 (2006) 321-328
    • (2006) Ann Surg , vol.243 , pp. 321-328
    • Chen, M.S.1    Li, J.Q.2    Zheng, Y.3    Guo, R.P.4    Liang, H.H.5    Zhang, Y.Q.6
  • 67
    • 38649141497 scopus 로고    scopus 로고
    • Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?
    • Livraghi T., Meloni F., Di Stasi M., Rolle E., Solbiati L., Tinelli C., et al. Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?. Hepatology 47 (2008) 82-89
    • (2008) Hepatology , vol.47 , pp. 82-89
    • Livraghi, T.1    Meloni, F.2    Di Stasi, M.3    Rolle, E.4    Solbiati, L.5    Tinelli, C.6
  • 68
    • 20944442423 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation
    • Lu D.S., Yu N.C., Raman S.S., Lassman C., Tong M.J., Britten C., et al. Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation. Hepatology 41 (2005) 1130-1137
    • (2005) Hepatology , vol.41 , pp. 1130-1137
    • Lu, D.S.1    Yu, N.C.2    Raman, S.S.3    Lassman, C.4    Tong, M.J.5    Britten, C.6
  • 69
    • 46249116195 scopus 로고    scopus 로고
    • Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: a pilot clinical study
    • Lencioni R., Crocetti L., Petruzzi P., Vignali C., Bozzi E., Della Pina C., et al. Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: a pilot clinical study. J Hepatol 49 (2008) 217-222
    • (2008) J Hepatol , vol.49 , pp. 217-222
    • Lencioni, R.1    Crocetti, L.2    Petruzzi, P.3    Vignali, C.4    Bozzi, E.5    Della Pina, C.6
  • 70
    • 23444458554 scopus 로고    scopus 로고
    • Percutaneous ethanol injection for hepatocellular carcinoma: alive or dead?
    • Lencioni R., and Llovet J.M. Percutaneous ethanol injection for hepatocellular carcinoma: alive or dead?. J Hepatol 43 (2005) 377-380
    • (2005) J Hepatol , vol.43 , pp. 377-380
    • Lencioni, R.1    Llovet, J.M.2
  • 71
    • 33845402644 scopus 로고    scopus 로고
    • Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies
    • Marelli L., Stigliano R., Triantos C., Senzolo M., Cholongitas E., Davies N., et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 30 (2007) 6-25
    • (2007) Cardiovasc Intervent Radiol , vol.30 , pp. 6-25
    • Marelli, L.1    Stigliano, R.2    Triantos, C.3    Senzolo, M.4    Cholongitas, E.5    Davies, N.6
  • 72
    • 0036085956 scopus 로고    scopus 로고
    • Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials
    • Camma C., Schepis F., Orlando A., Albanese M., Shahied L., Trevisani F., et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology 224 (2002) 47-54
    • (2002) Radiology , vol.224 , pp. 47-54
    • Camma, C.1    Schepis, F.2    Orlando, A.3    Albanese, M.4    Shahied, L.5    Trevisani, F.6
  • 73
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
    • Llovet J.M., and Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37 (2003) 429-442
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 74
    • 33846847728 scopus 로고    scopus 로고
    • Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics
    • Varela M., Real M.I., Burrel M., Forner A., Sala M., Brunet M., et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 46 (2007) 474-481
    • (2007) J Hepatol , vol.46 , pp. 474-481
    • Varela, M.1    Real, M.I.2    Burrel, M.3    Forner, A.4    Sala, M.5    Brunet, M.6
  • 75
    • 41049116317 scopus 로고    scopus 로고
    • Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients
    • Malagari K., Chatzimichael K., Alexopoulou E., Kelekis A., Hall B., Dourakis S., et al. Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients. Cardiovasc Intervent Radiol 31 (2008) 269-280
    • (2008) Cardiovasc Intervent Radiol , vol.31 , pp. 269-280
    • Malagari, K.1    Chatzimichael, K.2    Alexopoulou, E.3    Kelekis, A.4    Hall, B.5    Dourakis, S.6
  • 78
    • 60849136064 scopus 로고    scopus 로고
    • Combined approach to hepatocellular carcinoma: a new treatment concept for nonresectable disease
    • Strebel B.M., and Dufour J.F. Combined approach to hepatocellular carcinoma: a new treatment concept for nonresectable disease. Expert Rev Anticancer Ther 8 (2008) 1743-1749
    • (2008) Expert Rev Anticancer Ther , vol.8 , pp. 1743-1749
    • Strebel, B.M.1    Dufour, J.F.2
  • 79
    • 0642307263 scopus 로고    scopus 로고
    • The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988 and 2001: 5-year survival has improved significantly with time
    • Yoo H.Y., Patt C.H., Geschwind J.F., and Thuluvath P.J. The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988 and 2001: 5-year survival has improved significantly with time. J Clin Oncol 21 (2003) 4329-4335
    • (2003) J Clin Oncol , vol.21 , pp. 4329-4335
    • Yoo, H.Y.1    Patt, C.H.2    Geschwind, J.F.3    Thuluvath, P.J.4
  • 80
    • 57749191711 scopus 로고    scopus 로고
    • Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis
    • Mazzaferro V., Llovet J.M., Miceli R., Bhoori S., Schiavo M., Mariani L., et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol 10 (2009) 35-43
    • (2009) Lancet Oncol , vol.10 , pp. 35-43
    • Mazzaferro, V.1    Llovet, J.M.2    Miceli, R.3    Bhoori, S.4    Schiavo, M.5    Mariani, L.6
  • 81
    • 33745820881 scopus 로고    scopus 로고
    • Waiting list removal rates among patients with chronic and malignant liver diseases
    • Freeman R.B., Edwards E.B., and Harper A.M. Waiting list removal rates among patients with chronic and malignant liver diseases. Am J Transplant 6 (2006) 1416-1421
    • (2006) Am J Transplant , vol.6 , pp. 1416-1421
    • Freeman, R.B.1    Edwards, E.B.2    Harper, A.M.3
  • 82
    • 34250785170 scopus 로고    scopus 로고
    • A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system
    • Piscaglia F., Camaggi V., Ravaioli M., Grazi G.L., Zanello M., Leoni S., et al. A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system. Liver Transpl 13 (2007) 857-866
    • (2007) Liver Transpl , vol.13 , pp. 857-866
    • Piscaglia, F.1    Camaggi, V.2    Ravaioli, M.3    Grazi, G.L.4    Zanello, M.5    Leoni, S.6
  • 83
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T., Forgues M., Wang W., Kim J.W., Ye Q., Jia H., et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 68 (2008) 1451-1461
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3    Kim, J.W.4    Ye, Q.5    Jia, H.6
  • 84
    • 44649095311 scopus 로고    scopus 로고
    • Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation
    • quiz 2155
    • Faria L.C., Gigou M., Roque-Afonso A.M., Sebagh M., Roche B., Fallot G., et al. Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. Gastroenterology 134 (2008) 1890-1899 quiz 2155
    • (2008) Gastroenterology , vol.134 , pp. 1890-1899
    • Faria, L.C.1    Gigou, M.2    Roque-Afonso, A.M.3    Sebagh, M.4    Roche, B.5    Fallot, G.6
  • 85
    • 33645345123 scopus 로고    scopus 로고
    • A prospective, randomized, multi-centre trial of systemic adjuvant chemotherapy versus no additional treatment in liver transplantation for hepatocellular carcinoma
    • Soderdahl G., Backman L., Isoniemi H., Cahlin C., Hockerstedt K., Broome U., et al. A prospective, randomized, multi-centre trial of systemic adjuvant chemotherapy versus no additional treatment in liver transplantation for hepatocellular carcinoma. Transpl Int 19 (2006) 288-294
    • (2006) Transpl Int , vol.19 , pp. 288-294
    • Soderdahl, G.1    Backman, L.2    Isoniemi, H.3    Cahlin, C.4    Hockerstedt, K.5    Broome, U.6
  • 86
    • 1642399031 scopus 로고    scopus 로고
    • Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization
    • Maddala Y.K., Stadheim L., Andrews J.C., Burgart L.J., Rosen C.B., Kremers W.K., et al. Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization. Liver Transpl 10 (2004) 449-455
    • (2004) Liver Transpl , vol.10 , pp. 449-455
    • Maddala, Y.K.1    Stadheim, L.2    Andrews, J.C.3    Burgart, L.J.4    Rosen, C.B.5    Kremers, W.K.6
  • 87
    • 33847644031 scopus 로고    scopus 로고
    • Response to preoperative chemoembolization correlates with outcome after liver transplantation in patients with hepatocellular carcinoma
    • Millonig G., Graziadei I.W., Freund M.C., Jaschke W., Stadlmann S., Ladurner R., et al. Response to preoperative chemoembolization correlates with outcome after liver transplantation in patients with hepatocellular carcinoma. Liver Transpl 13 (2007) 272-279
    • (2007) Liver Transpl , vol.13 , pp. 272-279
    • Millonig, G.1    Graziadei, I.W.2    Freund, M.C.3    Jaschke, W.4    Stadlmann, S.5    Ladurner, R.6
  • 88
    • 7044239577 scopus 로고    scopus 로고
    • Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study
    • Mazzaferro V., Battiston C., Perrone S., Pulvirenti A., Regalia E., Romito R., et al. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study. Ann Surg 240 (2004) 900-909
    • (2004) Ann Surg , vol.240 , pp. 900-909
    • Mazzaferro, V.1    Battiston, C.2    Perrone, S.3    Pulvirenti, A.4    Regalia, E.5    Romito, R.6
  • 89
    • 34548584062 scopus 로고    scopus 로고
    • A decision analysis model identifies the interval of efficacy for transarterial chemoembolization (TACE) in cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation
    • Aloia T.A., Adam R., Samuel D., Azoulay D., and Castaing D. A decision analysis model identifies the interval of efficacy for transarterial chemoembolization (TACE) in cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation. J Gastrointest Surg 11 (2007) 1328-1332
    • (2007) J Gastrointest Surg , vol.11 , pp. 1328-1332
    • Aloia, T.A.1    Adam, R.2    Samuel, D.3    Azoulay, D.4    Castaing, D.5
  • 90
    • 3843125293 scopus 로고    scopus 로고
    • Randomized controlled trial of screening for hepatocellular carcinoma
    • Zhang B.H., Yang B.H., and Tang Z.Y. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 130 (2004) 417-422
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 417-422
    • Zhang, B.H.1    Yang, B.H.2    Tang, Z.Y.3
  • 91
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 1208-1236
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 92
    • 67651002089 scopus 로고    scopus 로고
    • Semiannual surveillance for hepatocellular carcinoma improved patient survival compared to annual surveillance (Korean experience)
    • Kim D.Y., Han K.H., Ahn S.H., Paik Y.H., Lee K.S., and Chon C.Y. Semiannual surveillance for hepatocellular carcinoma improved patient survival compared to annual surveillance (Korean experience). Hepatology 46 (2007) 403A
    • (2007) Hepatology , vol.46
    • Kim, D.Y.1    Han, K.H.2    Ahn, S.H.3    Paik, Y.H.4    Lee, K.S.5    Chon, C.Y.6
  • 93
    • 33947575209 scopus 로고    scopus 로고
    • Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma
    • Hagiwara S., Kudo M., Kawasaki T., Nagashima M., Minami Y., Chung H., et al. Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma. J Gastroenterol 41 (2006) 1214-1219
    • (2006) J Gastroenterol , vol.41 , pp. 1214-1219
    • Hagiwara, S.1    Kudo, M.2    Kawasaki, T.3    Nagashima, M.4    Minami, Y.5    Chung, H.6
  • 94
    • 33748366782 scopus 로고    scopus 로고
    • Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size
    • Nakamura S., Nouso K., Sakaguchi K., Ito Y.M., Ohashi Y., Kobayashi Y., et al. Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. Am J Gastroenterol 101 (2006) 2038-2043
    • (2006) Am J Gastroenterol , vol.101 , pp. 2038-2043
    • Nakamura, S.1    Nouso, K.2    Sakaguchi, K.3    Ito, Y.M.4    Ohashi, Y.5    Kobayashi, Y.6
  • 95
    • 33847209203 scopus 로고    scopus 로고
    • The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma - with special reference to the serum levels of des-gamma-carboxy prothrombin
    • Shirabe K., Itoh S., Yoshizumi T., Soejima Y., Taketomi A., Aishima S., et al. The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma - with special reference to the serum levels of des-gamma-carboxy prothrombin. J Surg Oncol 95 (2007) 235-240
    • (2007) J Surg Oncol , vol.95 , pp. 235-240
    • Shirabe, K.1    Itoh, S.2    Yoshizumi, T.3    Soejima, Y.4    Taketomi, A.5    Aishima, S.6
  • 96
    • 33847231604 scopus 로고    scopus 로고
    • Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    • Carr B.I., Kanke F., Wise M., and Satomura S. Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States. Dig Dis Sci 52 (2007) 776-782
    • (2007) Dig Dis Sci , vol.52 , pp. 776-782
    • Carr, B.I.1    Kanke, F.2    Wise, M.3    Satomura, S.4
  • 97
    • 36348983813 scopus 로고    scopus 로고
    • N-Glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus
    • Liu X.E., Desmyter L., Gao C.F., Laroy W., Dewaele S., Vanhooren V., et al. N-Glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus. Hepatology 46 (2007) 1426-1435
    • (2007) Hepatology , vol.46 , pp. 1426-1435
    • Liu, X.E.1    Desmyter, L.2    Gao, C.F.3    Laroy, W.4    Dewaele, S.5    Vanhooren, V.6
  • 98
    • 0038786861 scopus 로고    scopus 로고
    • Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma
    • Capurro M., Wanless I.R., Sherman M., Deboer G., Shi W., Miyoshi E., et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 125 (2003) 89-97
    • (2003) Gastroenterology , vol.125 , pp. 89-97
    • Capurro, M.1    Wanless, I.R.2    Sherman, M.3    Deboer, G.4    Shi, W.5    Miyoshi, E.6
  • 99
    • 27744539432 scopus 로고    scopus 로고
    • GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma
    • Marrero J.A., Romano P.R., Nikolaeva O., Steel L., Mehta A., Fimmel C.J., et al. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma. J Hepatol 43 (2005) 1007-1012
    • (2005) J Hepatol , vol.43 , pp. 1007-1012
    • Marrero, J.A.1    Romano, P.R.2    Nikolaeva, O.3    Steel, L.4    Mehta, A.5    Fimmel, C.J.6
  • 100
    • 41149096402 scopus 로고    scopus 로고
    • Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening
    • Chan A.C., Poon R.T., Ng K.K., Lo C.M., Fan S.T., and Wong J. Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening. Ann Surg 247 (2008) 666-673
    • (2008) Ann Surg , vol.247 , pp. 666-673
    • Chan, A.C.1    Poon, R.T.2    Ng, K.K.3    Lo, C.M.4    Fan, S.T.5    Wong, J.6
  • 101
    • 33748134214 scopus 로고    scopus 로고
    • Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan
    • Toyoda H., Kumada T., Kiriyama S., Sone Y., Tanikawa M., Hisanaga Y., et al. Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan. Clin Gastroenterol Hepatol 4 (2006) 1170-1176
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1170-1176
    • Toyoda, H.1    Kumada, T.2    Kiriyama, S.3    Sone, Y.4    Tanikawa, M.5    Hisanaga, Y.6
  • 102
    • 0033960899 scopus 로고    scopus 로고
    • Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience
    • Yuen M.F., Cheng C.C., Lauder I.J., Lam S.K., Ooi C.G., and Lai C.L. Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience. Hepatology 31 (2000) 330-335
    • (2000) Hepatology , vol.31 , pp. 330-335
    • Yuen, M.F.1    Cheng, C.C.2    Lauder, I.J.3    Lam, S.K.4    Ooi, C.G.5    Lai, C.L.6
  • 103
    • 0035128185 scopus 로고    scopus 로고
    • Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
    • Bolondi L., Sofia S., Siringo S., Gaiani S., Casali A., Zironi G., et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut 48 (2001) 251-259
    • (2001) Gut , vol.48 , pp. 251-259
    • Bolondi, L.1    Sofia, S.2    Siringo, S.3    Gaiani, S.4    Casali, A.5    Zironi, G.6
  • 104
    • 1842426695 scopus 로고    scopus 로고
    • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance
    • Sangiovanni A., Del Ninno E., Fasani P., De Fazio C., Ronchi G., Romeo R., et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 126 (2004) 1005-1014
    • (2004) Gastroenterology , vol.126 , pp. 1005-1014
    • Sangiovanni, A.1    Del Ninno, E.2    Fasani, P.3    De Fazio, C.4    Ronchi, G.5    Romeo, R.6
  • 105
    • 38649114052 scopus 로고    scopus 로고
    • Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma
    • Forner A., Vilana R., Ayuso C., Bianchi L., Sole M., Ayuso J.R., et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 47 (2008) 97-104
    • (2008) Hepatology , vol.47 , pp. 97-104
    • Forner, A.1    Vilana, R.2    Ayuso, C.3    Bianchi, L.4    Sole, M.5    Ayuso, J.R.6
  • 106
    • 0034868879 scopus 로고    scopus 로고
    • Assessment of the benefits and risks of percutaneous biopsy before surgical resection of hepatocellular carcinoma
    • Durand F., Regimbeau J.M., Belghiti J., Sauvanet A., Vilgrain V., Terris B., et al. Assessment of the benefits and risks of percutaneous biopsy before surgical resection of hepatocellular carcinoma. J Hepatol 35 (2001) 254-258
    • (2001) J Hepatol , vol.35 , pp. 254-258
    • Durand, F.1    Regimbeau, J.M.2    Belghiti, J.3    Sauvanet, A.4    Vilgrain, V.5    Terris, B.6
  • 107
    • 34548093337 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with indeterminate or false-negative findings at initial MR imaging: effect on eligibility for curative treatment initial observations
    • Choi D., Mitchell D.G., Verma S.K., Bergin D., Navarro V.J., Malliah A.B., et al. Hepatocellular carcinoma with indeterminate or false-negative findings at initial MR imaging: effect on eligibility for curative treatment initial observations. Radiology 244 (2007) 776-783
    • (2007) Radiology , vol.244 , pp. 776-783
    • Choi, D.1    Mitchell, D.G.2    Verma, S.K.3    Bergin, D.4    Navarro, V.J.5    Malliah, A.B.6
  • 108
    • 29544451015 scopus 로고    scopus 로고
    • Does preoperative fine needle aspiration-biopsy produce tumor recurrence in patients following liver transplantation for hepatocellular carcinoma?
    • Saborido B.P., Diaz J.C., de Los Galanes S.J., Segurola C.L., de Usera M.A., Garrido M.D., et al. Does preoperative fine needle aspiration-biopsy produce tumor recurrence in patients following liver transplantation for hepatocellular carcinoma?. Transplant Proc 37 (2005) 3874-3877
    • (2005) Transplant Proc , vol.37 , pp. 3874-3877
    • Saborido, B.P.1    Diaz, J.C.2    de Los Galanes, S.J.3    Segurola, C.L.4    de Usera, M.A.5    Garrido, M.D.6
  • 109
    • 0035061788 scopus 로고    scopus 로고
    • Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach
    • Camma C., Giunta M., Andreone P., and Craxi A. Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach. J Hepatol 34 (2001) 593-602
    • (2001) J Hepatol , vol.34 , pp. 593-602
    • Camma, C.1    Giunta, M.2    Andreone, P.3    Craxi, A.4
  • 110
    • 33947360829 scopus 로고    scopus 로고
    • Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study
    • Bruno S., Stroffolini T., Colombo M., Bollani S., Benvegnu L., Mazzella G., et al. Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology 45 (2007) 579-587
    • (2007) Hepatology , vol.45 , pp. 579-587
    • Bruno, S.1    Stroffolini, T.2    Colombo, M.3    Bollani, S.4    Benvegnu, L.5    Mazzella, G.6
  • 111
    • 38449091418 scopus 로고    scopus 로고
    • Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
    • Veldt B.J., Heathcote E.J., Wedemeyer H., Reichen J., Hofmann W.P., Zeuzem S., et al. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 147 (2007) 677-684
    • (2007) Ann Intern Med , vol.147 , pp. 677-684
    • Veldt, B.J.1    Heathcote, E.J.2    Wedemeyer, H.3    Reichen, J.4    Hofmann, W.P.5    Zeuzem, S.6
  • 112
    • 59849093175 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease
    • Lok A.S., Seeff L.B., Morgan T.R., di Bisceglie A.M., Sterling R.K., Curto T.M., et al. Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease. Gastroenterology 136 (2009) 138-148
    • (2009) Gastroenterology , vol.136 , pp. 138-148
    • Lok, A.S.1    Seeff, L.B.2    Morgan, T.R.3    di Bisceglie, A.M.4    Sterling, R.K.5    Curto, T.M.6
  • 113
    • 33845760039 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis
    • Mazzaferro V., Romito R., Schiavo M., Mariani L., Camerini T., Bhoori S., et al. Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis. Hepatology 44 (2006) 1543-1554
    • (2006) Hepatology , vol.44 , pp. 1543-1554
    • Mazzaferro, V.1    Romito, R.2    Schiavo, M.3    Mariani, L.4    Camerini, T.5    Bhoori, S.6
  • 114
    • 33751514752 scopus 로고    scopus 로고
    • Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma
    • Lin S.M., Yu M.L., Lee C.M., Chien R.N., Sheen I.S., Chu C.M., et al. Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma. J Hepatol 46 (2007) 45-52
    • (2007) J Hepatol , vol.46 , pp. 45-52
    • Lin, S.M.1    Yu, M.L.2    Lee, C.M.3    Chien, R.N.4    Sheen, I.S.5    Chu, C.M.6
  • 115
    • 23044471083 scopus 로고    scopus 로고
    • Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: a multicenter retrospective study of 2795 patients
    • Matsumoto A., Tanaka E., Rokuhara A., Kiyosawa K., Kumada H., Omata M., et al. Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: a multicenter retrospective study of 2795 patients. Hepatol Res 32 (2005) 173-184
    • (2005) Hepatol Res , vol.32 , pp. 173-184
    • Matsumoto, A.1    Tanaka, E.2    Rokuhara, A.3    Kiyosawa, K.4    Kumada, H.5    Omata, M.6
  • 116
    • 19544391413 scopus 로고    scopus 로고
    • Lamivudine for patients with chronic hepatitis B and advanced liver disease
    • Liaw Y.F., Sung J.J., Chow W.C., Farrell G., Lee C.Z., Yuen H., et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 351 (2004) 1521-1531
    • (2004) N Engl J Med , vol.351 , pp. 1521-1531
    • Liaw, Y.F.1    Sung, J.J.2    Chow, W.C.3    Farrell, G.4    Lee, C.Z.5    Yuen, H.6
  • 117
    • 4644295202 scopus 로고    scopus 로고
    • Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine
    • Di Marco V., Marzano A., Lampertico P., Andreone P., Santantonio T., Almasio P.L., et al. Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine. Hepatology 40 (2004) 883-891
    • (2004) Hepatology , vol.40 , pp. 883-891
    • Di Marco, V.1    Marzano, A.2    Lampertico, P.3    Andreone, P.4    Santantonio, T.5    Almasio, P.L.6


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