Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells

Biological Chemistry

Volumn 384, Issue 2, 2003, Pages 203-212

  Kwon, Jin Ah ^a   Rho, Hyune Mo ^a,b  

^a Seoul National University   (South Korea)

^b Inje University   (South Korea)

Author keywords

E2F1; HBc; Human p53 gene; Transcriptional repression

Indexed keywords

GLUTATHIONE TRANSFERASE; HEPATITIS B CORE ANTIGEN; NUCLEOTIDE; PROTEIN P53; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR E2F; VIRUS FUSION PROTEIN;

ARTICLE; BINDING ASSAY; BINDING SITE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC ANALYSIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

BINDING SITES; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, P53; GLUTATHIONE TRANSFERASE; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE DELETION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; VIRAL CORE PROTEINS;

DNA VIRUSES; HEPATITIS B VIRUS;

EID: 0037299853     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.022     Document Type: Article

References (39)

1. Aguilar, F., Harris, C. C., Sun, T., Hollstein, M., and Cerutti, P. (1994). Geographic variation of p53 mutational profile in non-malignant human liver. Science 264, 1317-1319.
2. Andrews, N. C., and Faller, D. V. (1991). A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19, 2499.
3. Antonucci, T. K. and Rutter, W. J. (1989). Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner. J. Virol. 63, 579-583.
4. Bressac, B., Galvin, K. M., Liang, T. J., Isselbacher, K. J., Wands, J. R., and Ozturk, M. (1990). Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87, 1973-1977.
5. Choi, B. H., Park, G. T., and Rho, H. M. (1999). Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. J. Biol. Chem. 274, 2858-2865.
6. Choi, M., Lee, H., and Rho, H. M. (2002). E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis B viral X protein (HBx) on the p53 promoter. IUBMB Life 53, 1-9.
7. Eckhardt, S. G., Milich, D. R., and McLachlan, A. (1991). Hepatitis B virus core antigen has two nuclear localization sequences in the arginine-rich carboxyl terminus. J. Virol. 65, 575-582.
8. Flemington, E. K., Speck, S. H., and Kaelin, W. G. Jr. (1993). E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 90, 6914-6918.
9. Ganem, D., and Varmus, H. E. (1987). The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56, 651-693.
10. Gorman, C. M., Moffat, L. F., and Howard, B. H. (1982). Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
11. Hatton, T., Zhou, S., and Standring, D. N. (1992). RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J. Virol. 66, 5232-5241.
12. Hsu, I. C., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., and Harris, C. C. (1991). Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350, 427-428.
13. Johnson, D. G., and Schneider-Broussard (1998). Role of E2F in cell cycle control and cancer. Front. Biosci. 3, 447-448.
14. Kim, S. K., Jang, S. K., and Rho, H. M. (1994). Effect of frameshift mutation in the pre-C region of hepatitis B virus on the X and C genes. J. Gen. Virol. 75, 917-923.
15. Ko, L. J., and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
16. Kwon, J. A., and Rho, H. M. (2002). Hepatitis B viral core protein activates the hepatitis B viral enhancer II/pregenomic promoter through the nuclear factor κB binding site. Biochem. Cell Biol. 80, 445-455.
17. Lee, S. G., and Rho, H. M. (2000). Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 19, 468-471.
18. Lee, S. G., Lee, H., and Rho, H. M. (2001). Transcriptional repression of the human p53 gene by cobalt chloride mimicking hypoxia. FEBS Lett. 507, 259-263.
19. Levine, A. J. (1993). The tumor suppressor genes. Annu. Rev. Biochem. 62, 623-651.
20. Li, C. J., Wang, C., Friedman, D. J., and Pardee, A. B. (1995). Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 92, 5461-5464.
21. Liao, W., and Ou, J. H. (1995). Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J. Virol. 69, 1025-1029.
22. Massimi, P., and Banks, L. (1997). Repression of p53 transcriptional activity by the HPV E7 proteins. Virology 227, 255-259.
23. Megyeri, K., Berencsi, K., Halazonetis, T. D., Prendergast, G. C., Gri, G., Plotkin, S. A., Rovera, G., and Gonczol, E. (1999). Involvement of a p53-dependent pathway in rubella virus-induced apoptosis. Virology 259, 74-84.
24. Mondelli, M., Tedder, R. S., Ferns, B., Pontisso, P., Realdi, G., and Alberti, A. (1986). Differential distribution of hepatitis B core and E antigens in hepatocytes: analysis by monoclonal antibodies. Hepatology 6, 199-204.
25. Nevins, J. R. (1992). E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429.
26. Otsuka, M., Kato, N., Lan, K., Yoshida, H., Kato, J., Goto, T., Shiratori, Y., and Omata, M. (2000). Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J. Biol. Chem. 275, 34122-34130.
27. Pierce, A. M., Schneider-Broussard, R., Gimenez-Conti, I. B., Russell, J. L., Conti, C. J., and Johnson, D. G. (1999). E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model. Mol. Cell. Biol. 19, 6408-6414.
28. Proudfoot, N. J., Gil, A., and Maniatis, T. (1982). The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell 31, 553-563.
29. Ray, R. B., Steele, R., Meyer, K., and Ray, R. (1997). Transcriptional repression of p53 promoter by hepatitis C virus core protein. J. Biol. Chem. 272, 10983-10986.
30. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, NY USA: Cold Spring Harbor Laboratory Press).
31. Sheppard, H. M., Corneillie, S. I., Espiritu, C., Gatti, A., and Liu, X. (1999). New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen. Mol. Cell Biol. 19, 2746-2753.
32. Shin, H. J., and Rho, H. M. (1995). Release of the hepatitis B virus-associated DNA polymerase from the viral particle by the proteolytic cleavage. J. Biol. Chem. 270, 11047-11050.
33. Smith, D. B., and Johnson, K. S. (1988). Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40.
34. Summers, J., and Mason, W. S. (1982). Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29, 403-415.
35. Tiollais, P., Pourcel, C., and Dejean, A. (1985). The hepatitis B virus. Nature 317, 489-495.
36. Uittenbogaard, M. N., Giebler, H. A., Reisman, D., and Nyborg, J. K. (1995). Transcriptional repression of p53 by human T-cell leukemia virus type I Tax protein. J. Biol. Chem. 270, 28503-28506.
37. Wang, X. W., Gibson, M. K., Vermeulen, W., Yeh, H., Forrester, K., Sturzbecher, H. W., Hoeijmakers, J. H., and Harris, C. C. (1995). Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55, 6012-6016.
38. Whitten, T. M., Quets, A. T., and Schloemer, R. H. (1991). Identification of the hepatitis B virus factor that inhibits expression of the β interferon gene. J. Virol. 65, 4699-4704.
39. Yamasaki, L., Jacks, T., Bronson, R., Goillot, E., Harlow, E., and Dyson, N. J. (1996). Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-548.