Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

Trends in Endocrinology and Metabolism

Volumn 21, Issue 2, 2010, Pages 96-103

  Reddy, Pradeep ^a   Zheng, Wenjing ^a   Liu, Kui ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN; MUELLERIAN INHIBITING FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN P27; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXL2; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

CELLULAR DISTRIBUTION; DOWN REGULATION; FEMALE; FEMALE INFERTILITY; GENE EXPRESSION; GRANULOSA CELL; HUMAN; IN VITRO STUDY; MAMMAL; MOLECULAR MECHANICS; NONHUMAN; OOCYTE; OVARY FOLLICLE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL;

ANIMALS; CELL CYCLE; CELL SURVIVAL; FEMALE; GENES, CDC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; OVARIAN FOLLICLE; SIGNAL TRANSDUCTION;

EID: 75249093941     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2009.10.001     Document Type: Review

References (83)

1. McGee E.A., and Hsueh A.J. Initial and cyclic recruitment of ovarian follicles. Endocr. Rev. 21 (2000) 200-214
2. Broekmans F.J., et al. Female reproductive ageing: current knowledge and future trends. Trends Endocrinol. Metab. 18 (2007) 58-65
3. Hansen K.R., et al. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum. Reprod. 23 (2008) 699-708
4. Faddy M.J., and Gosden R.G. A model conforming the decline in follicle numbers to the age of menopause in women. Hum. Reprod. 11 (1996) 1484-1486
5. McNatty K.P., et al. Growth and paracrine factors regulating follicular formation and cellular function. Mol. Cell Endocrinol. 163 (2000) 11-20
6. Pepling M.E., and Spradling A.C. Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles. Dev. Biol. 234 (2001) 339-351
7. Wassarman P.M., and Albertini D.F. The mammalian ovum. In: Knobil E., and Neill J.D. (Eds). The Physiology of Reproduction (1994), Raven Press 79-122
8. Castrillon D.H., et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301 (2003) 215-218
9. John G.B., et al. Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev. Biol. 321 (2008) 197-204
10. Reddy P., et al. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319 (2008) 611-613
11. Reddy P., et al. PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Hum. Mol. Genet. 18 (2009) 2813-2824
12. Wandji S.A., et al. Initiation in vitro of growth of bovine primordial follicles. Biol. Reprod. 55 (1996) 942-948
13. O'Brien M.J., et al. A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence. Biol. Reprod. 68 (2003) 1682-1686
14. Fortune J.E., et al. Activation of bovine and baboon primordial follicles in vitro. Theriogenology 49 (1998) 441-449
15. Wandji S.A., et al. Initiation of growth of baboon primordial follicles in vitro. Hum. Reprod. 12 (1997) 1993-2001
16. Fortune J.E., et al. The primordial to primary follicle transition. Mol. Cell Endocrinol. 163 (2000) 53-60
17. Crisponi L., et al. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat. Genet. 27 (2001) 159-166
18. Uda M., et al. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum. Mol. Genet. 13 (2004) 1171-1181
19. De Baere E., et al. FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation. Am. J. Hum. Genet. 72 (2003) 478-487
20. Udar N., et al. Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients. Hum. Mutat. 22 (2003) 222-228
21. Schmidt D., et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131 (2004) 933-942
22. Baarends W.M., et al. Anti-mullerian hormone and anti-mullerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induced follicle growth. Endocrinology 136 (1995) 4951-4962
23. Durlinger A.L., et al. Regulation of ovarian function: the role of anti-Mullerian hormone. Reproduction 124 (2002) 601-609
24. Hirobe S., et al. Mullerian inhibiting substance messenger ribonucleic acid expression in granulosa and Sertoli cells coincides with their mitotic activity. Endocrinology 131 (1992) 854-862
25. Takahashi M., et al. The ontogeny of mullerian inhibiting substance in granulosa cells of the bovine ovarian follicle. Biol. Reprod. 35 (1986) 447-453
26. Vigier B., et al. Production of anti-Mullerian hormone: another homology between Sertoli and granulosa cells. Endocrinology 114 (1984) 1315-1320
27. Weenen C., et al. Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol. Hum. Reprod. 10 (2004) 77-83
28. Durlinger A.L., et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 140 (1999) 5789-5796
29. Carlsson I.B., et al. Anti-Mullerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro. Hum. Reprod. 21 (2006) 2223-2227
30. Cicenas J., et al. Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. Breast Cancer Res. 7 (2005) R394-R401
31. Robertson G.P. Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev. 24 (2005) 273-285
32. Salmena L., et al. Tenets of PTEN tumor suppression. Cell 133 (2008) 403-414
33. Stocker H., et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295 (2002) 2088-2091
34. Lan Z.J., et al. Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice. Biol. Reprod. 71 (2004) 1469-1474
35. Crino P.B., et al. The tuberous sclerosis complex. N. Engl. J. Med. 355 (2006) 1345-1356
36. Kwiatkowski D.J., et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 11 (2002) 525-534
37. Yang Q., and Guan K.L. Expanding mTOR signaling. Cell Res. 17 (2007) 666-681
38. Chong-Kopera H., et al. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J. Biol. Chem. 281 (2006) 8313-8316
39. Adhikari, D. et al. (2009) Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum. Mol. Genet. (In press), PMID: 19843540
40. Liu L., et al. Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a. Development 134 (2007) 199-209
41. Hosaka T., et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 2975-2980
42. Lin L., et al. Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21 (2004) 203-213
43. John G.B., et al. Specificity of the requirement for Foxo3 in primordial follicle activation. Reproduction 133 (2007) 855-863
44. Kaldis P. Another piece of the p27Kip1 puzzle. Cell 128 (2007) 241-244
45. Rajareddy S., et al. p27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice. Mol. Endocrinol. 21 (2007) 2189-2202
46. Fero M.L., et al. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85 (1996) 733-744
47. Kiyokawa H., et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85 (1996) 721-732
48. Tong W., et al. The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition. Cell Growth Differ. 9 (1998) 787-794
49. Mora A., et al. PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Dev. Biol. 15 (2004) 161-170
50. Vanhaesebroeck B., and Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346 (2000) 561-576
51. Wullschleger S., et al. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
52. Thomas G. The S6 kinase signaling pathway in the control of development and growth. Biol. Res. 35 (2002) 305-313
53. Pullen N., et al. Phosphorylation and activation of p70s6k by PDK1. Science 279 (1998) 707-710
54. Hovatta O. Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Eur. J. Obstet. Gynecol. Reprod. Biol. 113 Suppl 1 (2004) S50-S54
55. Telfer E.E., et al. A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum. Reprod. 23 (2008) 1151-1158
56. Jeruss J.S., and Woodruff T.K. Preservation of fertility in patients with cancer. N. Engl. J. Med. 360 (2009) 902-911
57. Fan H.Y., et al. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Mol. Endocrinol. 22 (2008) 2128-2140
58. Gougeon A. Dynamics for human follicular growth: morphologic, dynamic, and functional aspects. In: Leung P.C.K., and Adashi E.Y. (Eds). The Ovary (2nd edn) (2004), Elsevier Academic Press 25-43
59. Hirshfield A.N. Relationship between the supply of primordial follicles and the onset of follicular growth in rats. Biol. Reprod. 50 (1994) 421-428
60. Elvin J.A., and Matzuk M.M. Mouse models of ovarian failure. Rev. Reprod. 3 (1998) 183-195
61. Matzuk M.M., et al. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 296 (2002) 2178-2180
62. Richards J.S., et al. Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog. Horm. Res. 57 (2002) 195-220
63. Vanderhyden B. Molecular basis of ovarian development and function. Front. Biosci. 7 (2002) d2006-d2022
64. Adhikari D., and Liu K. Molecular mechanisms underlying the activation of Mammalian primordial follicles. Endocr. Rev. 30 (2009) 438-464
65. Liu K., et al. Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. Dev. Biol. 299 (2006) 1-11
66. Reddy P., et al. Activation of Akt (PKB) and suppression of FKHRL1 in mouse and rat oocytes by stem cell factor during follicular activation and development. Dev. Biol. 281 (2005) 160-170
67. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
68. Engelman J.A., et al. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7 (2006) 606-619
69. Barber D.F., et al. PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3-kinase. Sci. STKE 2006 (2006) e49
70. Carracedo A., and Pandolfi P.P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27 (2008) 5527-5541
71. Maehama T., and Dixon J.E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9 (1999) 125-128
72. Sarbassov D.D., et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
73. Accili D., and Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117 (2004) 421-426
74. Brunet A., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
75. Tran H., et al. The many forks in FOXO's road. Sci. STKE 2003 (2003) RE5
76. Burgering B.M., and Medema R.H. Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J. Leukoc. Biol. 73 (2003) 689-701
77. Datta S.R., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
78. Inoki K., et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4 (2002) 648-657
79. Manning B.D., et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10 (2002) 151-162
80. Potter C.J., et al. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4 (2002) 658-665
81. Wang L., et al. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J. Biol. Chem. 282 (2007) 20036-20044
82. Vanhaesebroeck B., et al. Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem. Sci. 30 (2005) 194-204
83. Adhikari, D. et al. (2009) Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Mol. Hum. Reprod (In press), PMID: 19843635.