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Volumn 14, Issue 4, 2009, Pages 565-573

Molecular diagnosis and monitoring of chronic myelogenous leukemia: BCR-Abl and more

Author keywords

Chronic myelogenous leukemia; Cytogenetic analysis; Imatinib; Molecular monitoring; Mutational analysis; Resistance

Indexed keywords

BCR ABL PROTEIN; MESSENGER RNA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 75149198771     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (110)
  • 1
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia-advances in biology and new approaches to treatment
    • Goldman JM, Melo JV. Chronic myeloid leukemia-advances in biology and new approaches to treatment. N Engl J Med 2003; 349: 1451-1464.
    • (2003) N Engl J Med , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 2
    • 0030757461 scopus 로고    scopus 로고
    • Cancer incidence and mortality in the European Union: Cancer registry data and estimates of national incidence for 1990
    • Black RJ, Bray F, Ferlay J, Parkin DM. Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990. Eur J Cancer 1997; 33: 1075-1107.
    • (1997) Eur J Cancer , vol.33 , pp. 1075-1107
    • Black, R.J.1    Bray, F.2    Ferlay, J.3    Parkin, D.M.4
  • 3
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell P. A minute chromosome in human chronic granulocytic leukemia. Science 1960; 142: 1497.
    • (1960) Science , vol.142 , pp. 1497
    • Nowell, P.1
  • 4
    • 0020972981 scopus 로고
    • Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
    • Bartram CR, de Klein A, Hagemeijer A et al. Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1983; 306: 277-280.
    • (1983) Nature , vol.306 , pp. 277-280
    • Bartram, C.R.1    de Klein, A.2    Hagemeijer, A.3
  • 5
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005; 5: 172-183.
    • (2005) Nat Rev Cancer , vol.5 , pp. 172-183
    • Ren, R.1
  • 6
    • 2542500611 scopus 로고    scopus 로고
    • The biology of CML blast crisis
    • Calabretta B, Perrotti D. The biology of CML blast crisis. Blood 2004; 103: 4010-4022.
    • (2004) Blood , vol.103 , pp. 4010-4022
    • Calabretta, B.1    Perrotti, D.2
  • 7
    • 0029796725 scopus 로고    scopus 로고
    • BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats
    • Frank DA, Varticovski L. BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 1996; 10: 1724-1730.
    • (1996) Leukemia , vol.10 , pp. 1724-1730
    • Frank, D.A.1    Varticovski, L.2
  • 8
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs DL, Hilton DJ. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 2001; 19: 378-387.
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 9
    • 0033959620 scopus 로고    scopus 로고
    • The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: Roles for phosphatidylinositol 3-kinase and Raf
    • Neshat MS, Raitano AB, Wang HG, Reed JC, Sawyers CL. The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol 2000; 20: 1179-1186.
    • (2000) Mol Cell Biol , vol.20 , pp. 1179-1186
    • Neshat, M.S.1    Raitano, A.B.2    Wang, H.G.3    Reed, J.C.4    Sawyers, C.L.5
  • 10
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental check-point in definitive hematopoiesis
    • Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental check-point in definitive hematopoiesis. Cell 1998; 93: 397-409.
    • (1998) Cell , vol.93 , pp. 397-409
    • Neubauer, H.1    Cumano, A.2    Muller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 11
    • 0028147448 scopus 로고
    • Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
    • Puil L, Liu J, Gish G et al. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J 1994; 13: 764-773.
    • (1994) EMBO J , vol.13 , pp. 764-773
    • Puil, L.1    Liu, J.2    Gish, G.3
  • 12
    • 19044372472 scopus 로고    scopus 로고
    • Critical role for Gab2 in transformation by BCR/ABL
    • Sattler M, Mohi MG, Pride YB et al. Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 2002; 1: 479-492.
    • (2002) Cancer Cell , vol.1 , pp. 479-492
    • Sattler, M.1    Mohi, M.G.2    Pride, Y.B.3
  • 13
    • 0032745240 scopus 로고    scopus 로고
    • BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis
    • Sattler M, Verma S, Byrne CH et al. BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis. Mol Cell Biol 1999; 19: 7473-7480.
    • (1999) Mol Cell Biol , vol.19 , pp. 7473-7480
    • Sattler, M.1    Verma, S.2    Byrne, C.H.3
  • 14
    • 0029816460 scopus 로고    scopus 로고
    • The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype
    • Melo JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 1996; 88: 2375-2384.
    • (1996) Blood , vol.88 , pp. 2375-2384
    • Melo, J.V.1
  • 15
    • 3242804413 scopus 로고    scopus 로고
    • Biology of chronic myelogenous leukemia-signaling pathways of initiation and transformation
    • Melo JD, Deininger MW. Biology of chronic myelogenous leukemia-signaling pathways of initiation and transformation. Hematol Oncol Clin North Am 2004; 18: 545-568.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 545-568
    • Melo, J.D.1    Deininger, M.W.2
  • 16
    • 0023753576 scopus 로고
    • The molecular genetics of Philadelphia chromosome-positive leukemias
    • Kurzrock RG, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 1988; 319: 990-998.
    • (1988) N Engl J Med , vol.319 , pp. 990-998
    • Kurzrock, R.G.1    Gutterman, J.U.2    Talpaz, M.3
  • 18
    • 10144254429 scopus 로고    scopus 로고
    • Neutrophilic-chronic myeloid leukemia: A distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)
    • Pane F, Frigeri F, Sindona M et al. Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction). Blood 1996; 88: 2410-2414.
    • (1996) Blood , vol.88 , pp. 2410-2414
    • Pane, F.1    Frigeri, F.2    Sindona, M.3
  • 19
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 20
    • 0025187837 scopus 로고
    • Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
    • Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 1990; 87: 6649-6653.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6649-6653
    • Kelliher, M.A.1    McLaughlin, J.2    Witte, O.N.3    Rosenberg, N.4
  • 21
    • 33947224197 scopus 로고    scopus 로고
    • New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance
    • Kantarjian HM, Talpaz M, Giles F, O'Brien S, Cortes J. New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med 2006; 145: 913-923.
    • (2006) Ann Intern Med , vol.145 , pp. 913-923
    • Kantarjian, H.M.1    Talpaz, M.2    Giles, F.3    O'Brien, S.4    Cortes, J.5
  • 22
    • 34249664406 scopus 로고    scopus 로고
    • Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia
    • Hehlmann R, Berger U, Pfirrmann M et al. Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia. Blood 2007; 109: 4686-4692.
    • (2007) Blood , vol.109 , pp. 4686-4692
    • Hehlmann, R.1    Berger, U.2    Pfirrmann, M.3
  • 23
    • 70349326117 scopus 로고    scopus 로고
    • Kobayashi S, Kimura F, Ikeda T et al. BCR-ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression. Leukemia (advanced online publ 9 April 2009; doi: 10.1038/leu.2009.74).
    • Kobayashi S, Kimura F, Ikeda T et al. BCR-ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression. Leukemia (advanced online publ 9 April 2009; doi: 10.1038/leu.2009.74).
  • 24
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Chen Zhao AC, Jamieson CH, Fereshteh M et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009; 458: 776-780.
    • (2009) Nature , vol.458 , pp. 776-780
    • Chen Zhao, A.C.1    Jamieson, C.H.2    Fereshteh, M.3
  • 25
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C, Beigi R, Guo GR et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008; 14: 238-249.
    • (2008) Cancer Cell , vol.14 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3
  • 26
    • 46749084679 scopus 로고    scopus 로고
    • Ikaros and acute leukemia
    • Mullighan C, Downing J. Ikaros and acute leukemia. Leuk Lymphoma 2008; 49: 847-849.
    • (2008) Leuk Lymphoma , vol.49 , pp. 847-849
    • Mullighan, C.1    Downing, J.2
  • 27
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C, Beigi R, Guo GR et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008; 14: 238-249.
    • (2008) Cancer Cell , vol.14 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3
  • 28
    • 44449085896 scopus 로고    scopus 로고
    • Linking miRNA regulation to BCR-ABL expression: The next dimension
    • Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell 2008; 13: 467-469.
    • (2008) Cancer Cell , vol.13 , pp. 467-469
    • Faber, J.1    Gregory, R.I.2    Armstrong, S.A.3
  • 29
    • 22144461002 scopus 로고    scopus 로고
    • miRNAs, cancer, and stem cell division
    • Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122: 6-7.
    • (2005) Cell , vol.122 , pp. 6-7
    • Croce, C.M.1    Calin, G.A.2
  • 30
    • 58149398623 scopus 로고    scopus 로고
    • Translation of the Philadelphia chromosome into therapy for CML
    • Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112: 4808-4817.
    • (2008) Blood , vol.112 , pp. 4808-4817
    • Druker, B.J.1
  • 31
    • 10744220743 scopus 로고    scopus 로고
    • Approval summary: Imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
    • Johnson JR, Bross P, Cohen M et al. Approval summary: imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clin Cancer Res 2003; 9: 1972-1979.
    • (2003) Clin Cancer Res , vol.9 , pp. 1972-1979
    • Johnson, J.R.1    Bross, P.2    Cohen, M.3
  • 32
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F, Hughes TP, Iwasa Y et al. Dynamics of chronic myeloid leukaemia. Nature 2005; 435: 1267-1270.
    • (2005) Nature , vol.435 , pp. 1267-1270
    • Michor, F.1    Hughes, T.P.2    Iwasa, Y.3
  • 33
    • 76749096715 scopus 로고    scopus 로고
    • Ljungman P, Bregni M, Brune M et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (advanced online publ 6 July 2009; doi: 10.1038/bmt.2009.141).
    • Ljungman P, Bregni M, Brune M et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (advanced online publ 6 July 2009; doi: 10.1038/bmt.2009.141).
  • 34
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002; 99: 1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 35
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002; 99: 3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 36
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355: 2408-2417.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 37
    • 33748696341 scopus 로고    scopus 로고
    • Survival benefit with imatinib mesylate versus interferon-alpha-based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia
    • Kantarjian HM, Talpaz M, O'Brien S et al. Survival benefit with imatinib mesylate versus interferon-alpha-based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia. Blood 2006; 108: 1835-1840.
    • (2006) Blood , vol.108 , pp. 1835-1840
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 38
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 39
    • 39049161669 scopus 로고    scopus 로고
    • Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia: Need for new response definitions?
    • Kantarjian H, O'Brien S, Shan J et al. Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia: need for new response definitions? Cancer 2008; 112: 837-845.
    • (2008) Cancer , vol.112 , pp. 837-845
    • Kantarjian, H.1    O'Brien, S.2    Shan, J.3
  • 40
    • 20144388183 scopus 로고    scopus 로고
    • Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5-year follow-up
    • Lahaye T, Riehm B, Berger U et al. Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up. Cancer 2005; 103: 1659-1669.
    • (2005) Cancer , vol.103 , pp. 1659-1669
    • Lahaye, T.1    Riehm, B.2    Berger, U.3
  • 41
    • 10744228340 scopus 로고    scopus 로고
    • Imatinib mesylate therapy of chronic phase chronic myeloid leukemia resistant or intolerant to interferon: Results and prognostic factors for response and progression-free survival in 150 patients
    • Cervantes F, Hernandez-Boluda JC, Steegmann JL et al. Imatinib mesylate therapy of chronic phase chronic myeloid leukemia resistant or intolerant to interferon: results and prognostic factors for response and progression-free survival in 150 patients. Haematologica 2003; 88: 1117-1122.
    • (2003) Haematologica , vol.88 , pp. 1117-1122
    • Cervantes, F.1    Hernandez-Boluda, J.C.2    Steegmann, J.L.3
  • 42
    • 9144264829 scopus 로고    scopus 로고
    • Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • Branford S, Rudzki Z, Harper A et al. Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia 2003; 17: 2401-2409.
    • (2003) Leukemia , vol.17 , pp. 2401-2409
    • Branford, S.1    Rudzki, Z.2    Harper, A.3
  • 43
    • 30844433972 scopus 로고    scopus 로고
    • Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia
    • Hughes T, Branford S. Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia. Blood Rev 2006; 20: 29-41.
    • (2006) Blood Rev , vol.20 , pp. 29-41
    • Hughes, T.1    Branford, S.2
  • 44
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • Wang L, Pearson K, Ferguson JE, Clark RE. The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br J Haematol 2003; 120: 990-999.
    • (2003) Br J Haematol , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 45
    • 41349123259 scopus 로고    scopus 로고
    • Monitoring the response and course of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: Practical advice on the use and interpretation of monitoring methods
    • Kantarjian H, Schiffer C, Jones D, Cortes J. Monitoring the response and course of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: practical advice on the use and interpretation of monitoring methods. Blood 2008; 111: 1774-1780.
    • (2008) Blood , vol.111 , pp. 1774-1780
    • Kantarjian, H.1    Schiffer, C.2    Jones, D.3    Cortes, J.4
  • 46
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T, Deininger M, Hochhaus A et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108: 28-37.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3
  • 47
    • 0032797040 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia
    • Osarogiagbon UR MP. Chronic myelogenous leukemia. Curr Opin Hematol 1999; 6: 241-246.
    • (1999) Curr Opin Hematol , vol.6 , pp. 241-246
    • Osarogiagbon, U.M.1
  • 48
    • 33947356622 scopus 로고    scopus 로고
    • Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes
    • Haferlach C, Rieder H, Lillington DM et al. Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes. Genes Chromosomes Cancer 2007; 46: 494-499.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 494-499
    • Haferlach, C.1    Rieder, H.2    Lillington, D.M.3
  • 49
    • 41449106741 scopus 로고    scopus 로고
    • Monitoring treatment of chronic myeloid leukemia
    • Baccarani M, Pane F, Saglio G. Monitoring treatment of chronic myeloid leukemia. Haematologica 2008; 93: 161-169.
    • (2008) Haematologica , vol.93 , pp. 161-169
    • Baccarani, M.1    Pane, F.2    Saglio, G.3
  • 50
    • 0033991906 scopus 로고    scopus 로고
    • A multicenter investigation with D-FISH BCR/ABL1 probes
    • Dewald G, Stallard R, Alsaadi A et al. A multicenter investigation with D-FISH BCR/ABL1 probes. Cancer Genet Cytogenet 2000; 116: 97-104.
    • (2000) Cancer Genet Cytogenet , vol.116 , pp. 97-104
    • Dewald, G.1    Stallard, R.2    Alsaadi, A.3
  • 52
    • 30844457778 scopus 로고    scopus 로고
    • Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia
    • Landstrom AP, Tefferi A. Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia. Leuk Lymphoma 2006; 47: 397-402.
    • (2006) Leuk Lymphoma , vol.47 , pp. 397-402
    • Landstrom, A.P.1    Tefferi, A.2
  • 53
    • 0030749221 scopus 로고    scopus 로고
    • Improved sensitivity of BCR-ABL detection: A triple-probe three-color fluorescence in situ hybridization system
    • Sinclair PB, Green AR, Grace C, Nacheva EP. Improved sensitivity of BCR-ABL detection: a triple-probe three-color fluorescence in situ hybridization system. Blood 1997; 90: 1395-1402.
    • (1997) Blood , vol.90 , pp. 1395-1402
    • Sinclair, P.B.1    Green, A.R.2    Grace, C.3    Nacheva, E.P.4
  • 54
    • 0032079490 scopus 로고    scopus 로고
    • Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia
    • Dewald GW, Wyatt WA, Juneau AL et al. Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia. Blood 1998; 91: 3357-3365.
    • (1998) Blood , vol.91 , pp. 3357-3365
    • Dewald, G.W.1    Wyatt, W.A.2    Juneau, A.L.3
  • 55
    • 0029098199 scopus 로고
    • Hypermetaphase fluorescence in situ hybridization for quantitative monitoring of Philadelphia chromosome-positive cells in patients with chronic myelogenous leukemia during treatment
    • Seong DC, Kantarjian HM, Ro JY et al. Hypermetaphase fluorescence in situ hybridization for quantitative monitoring of Philadelphia chromosome-positive cells in patients with chronic myelogenous leukemia during treatment. Blood 1995; 86: 2343-2349.
    • (1995) Blood , vol.86 , pp. 2343-2349
    • Seong, D.C.1    Kantarjian, H.M.2    Ro, J.Y.3
  • 56
    • 0011689252 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: Comparison with metaphase banding analysis
    • Cuneo A, Bigoni R, Emmanuel B et al. Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: comparison with metaphase banding analysis. Leukemia 1998; 12: 1718-1723.
    • (1998) Leukemia , vol.12 , pp. 1718-1723
    • Cuneo, A.1    Bigoni, R.2    Emmanuel, B.3
  • 57
    • 0034119298 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization on peripheral-blood specimens is a reliable method to evaluate cytogenetic response in chronic myeloid leukemia
    • Le Gouill S, Milpied N, Daviet A et al. Fluorescence in situ hybridization on peripheral-blood specimens is a reliable method to evaluate cytogenetic response in chronic myeloid leukemia. J Clin Oncol 2000; 18: 1533-1538.
    • (2000) J Clin Oncol , vol.18 , pp. 1533-1538
    • Le Gouill, S.1    Milpied, N.2    Daviet, A.3
  • 58
    • 0036752111 scopus 로고    scopus 로고
    • Correlation of three methods of measuring cytogenetic response in chronic myelocytic leukemia
    • Lesser ML, Dewald GW, Sison CP, Silver RT. Correlation of three methods of measuring cytogenetic response in chronic myelocytic leukemia. Cancer Genet Cytogenet 2002; 137: 79-84.
    • (2002) Cancer Genet Cytogenet , vol.137 , pp. 79-84
    • Lesser, M.L.1    Dewald, G.W.2    Sison, C.P.3    Silver, R.T.4
  • 59
    • 20844444924 scopus 로고    scopus 로고
    • Assessment of the response to imatinib in chronic myeloid leukemia patients-comparison between the FISH, multiplex and RT-PCR methods
    • Raanani P, Ben-Bassat I, Gan S et al. Assessment of the response to imatinib in chronic myeloid leukemia patients-comparison between the FISH, multiplex and RT-PCR methods. Eur J Haematol 2004; 73: 243-250.
    • (2004) Eur J Haematol , vol.73 , pp. 243-250
    • Raanani, P.1    Ben-Bassat, I.2    Gan, S.3
  • 60
    • 85009854501 scopus 로고    scopus 로고
    • Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: A study on 350 cases
    • Schoch C, Schnittger S, Bursch S et al. Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: a study on 350 cases. Leukemia 2002; 16: 53-59.
    • (2002) Leukemia , vol.16 , pp. 53-59
    • Schoch, C.1    Schnittger, S.2    Bursch, S.3
  • 61
    • 33845946457 scopus 로고    scopus 로고
    • Monitoring minimal residual disease and controlling drug resistance in chronic myeloid leukaemia patients in treatment with imatinib as a guide to clinical management
    • Martinelli G II, Soverini S, Cilloni D et al. Monitoring minimal residual disease and controlling drug resistance in chronic myeloid leukaemia patients in treatment with imatinib as a guide to clinical management. Hematol Oncol 2006; 24: 196-204.
    • (2006) Hematol Oncol , vol.24 , pp. 196-204
    • Martinelli II, G.1    Soverini, S.2    Cilloni, D.3
  • 62
    • 19244366937 scopus 로고    scopus 로고
    • Minimal residual disease in chronic myeloid leukemia
    • Lowenberg B. Minimal residual disease in chronic myeloid leukemia. N Engl J Med 2003; 349: 1399-1401.
    • (2003) N Engl J Med , vol.349 , pp. 1399-1401
    • Lowenberg, B.1
  • 63
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349: 1423-1432.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 64
    • 22544459376 scopus 로고    scopus 로고
    • Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation
    • Merante S, Orlandi E, Bernasconi P et al. Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation. Haematologica 2005: 979-981.
    • (2005) Haematologica , pp. 979-981
    • Merante, S.1    Orlandi, E.2    Bernasconi, P.3
  • 65
    • 1342343034 scopus 로고    scopus 로고
    • Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission
    • Mauro MJ, Druker BJ, Maziarz RT. Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission. Leuk Res 2004; 28 (Suppl 1): S71-73.
    • (2004) Leuk Res , vol.28 , Issue.SUPPL. 1
    • Mauro, M.J.1    Druker, B.J.2    Maziarz, R.T.3
  • 66
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • Cortes J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a molecular response. Blood 2004; 104: 2204-2205.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 67
    • 45149091617 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: ESMO clinical recommendations for the diagnosis, treatment and follow-up
    • ii63-64
    • Hochhaus A, Dreyling M. Chronic myelogenous leukemia: ESMO clinical recommendations for the diagnosis, treatment and follow-up. Ann Oncol 2008; 19 (Suppl 2): ii63-64.
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 2
    • Hochhaus, A.1    Dreyling, M.2
  • 68
    • 13344250478 scopus 로고    scopus 로고
    • Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction
    • Hochhaus A, Lin F, Reiter A et al. Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction. Blood 1996; 87: 1549-1555.
    • (1996) Blood , vol.87 , pp. 1549-1555
    • Hochhaus, A.1    Lin, F.2    Reiter, A.3
  • 69
    • 0029953648 scopus 로고    scopus 로고
    • Quantitative molecular methods to monitor the response of CML patients to interferon-alpha
    • Hochhaus A, Lin F, Reiter A et al. Quantitative molecular methods to monitor the response of CML patients to interferon-alpha. Bone Marrow Transplant 1996; 17 (Suppl 3): S41-44.
    • (1996) Bone Marrow Transplant , vol.17 , Issue.SUPPL. 3
    • Hochhaus, A.1    Lin, F.2    Reiter, A.3
  • 70
    • 33750327903 scopus 로고    scopus 로고
    • Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia
    • Branford S, Cross NC, Hochhaus A et al. Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia. Leukemia 2006; 20: 1925-1930.
    • (2006) Leukemia , vol.20 , pp. 1925-1930
    • Branford, S.1    Cross, N.C.2    Hochhaus, A.3
  • 71
    • 34548793961 scopus 로고    scopus 로고
    • An international study to standardize the detection and quantitation of BCR-ABL transcripts from stabilized peripheral blood preparations by quantitative RT-PCR
    • Muller MC, Saglio G, Lin F et al. An international study to standardize the detection and quantitation of BCR-ABL transcripts from stabilized peripheral blood preparations by quantitative RT-PCR. Haematologica 2007; 92: 970-973.
    • (2007) Haematologica , vol.92 , pp. 970-973
    • Muller, M.C.1    Saglio, G.2    Lin, F.3
  • 72
    • 38349081290 scopus 로고    scopus 로고
    • Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories
    • Muller MC, Erben P, Saglio G et al. Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories. Leukemia 2008; 22: 96-102.
    • (2008) Leukemia , vol.22 , pp. 96-102
    • Muller, M.C.1    Erben, P.2    Saglio, G.3
  • 73
    • 0034693878 scopus 로고    scopus 로고
    • Regulation of cell death by the Abl tyrosine kinase
    • Wang JY. Regulation of cell death by the Abl tyrosine kinase. Oncogene 2000; 19: 5643-5650.
    • (2000) Oncogene , vol.19 , pp. 5643-5650
    • Wang, J.Y.1
  • 74
    • 33744463354 scopus 로고    scopus 로고
    • BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML
    • Press RD, Love Z, Tronnes AA et al. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML. Blood 2006; 107: 4250-4256.
    • (2006) Blood , vol.107 , pp. 4250-4256
    • Press, R.D.1    Love, Z.2    Tronnes, A.A.3
  • 75
    • 0037093061 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) in the treatment of relapse of chronic myeloid leukemia after allogeneic stem cell transplantation
    • Olavarria E, Craddock C, Dazzi F et al. Imatinib mesylate (STI571) in the treatment of relapse of chronic myeloid leukemia after allogeneic stem cell transplantation. Blood 2002; 99: 3861-3862.
    • (2002) Blood , vol.99 , pp. 3861-3862
    • Olavarria, E.1    Craddock, C.2    Dazzi, F.3
  • 76
    • 4444364014 scopus 로고    scopus 로고
    • BCR-ABL transcripts are early predictors for hematological relapse in chronic myeloid leukemia after hematopoietic cell transplantation with reduced intensity conditioning
    • Lange T, Deininger M, Brand R et al. BCR-ABL transcripts are early predictors for hematological relapse in chronic myeloid leukemia after hematopoietic cell transplantation with reduced intensity conditioning. Leukemia 2004; 18: 1468-1475.
    • (2004) Leukemia , vol.18 , pp. 1468-1475
    • Lange, T.1    Deininger, M.2    Brand, R.3
  • 77
    • 33646127175 scopus 로고    scopus 로고
    • Prediction of relapse by day 100 BCR-ABL quantification after allogeneic stem cell transplantation for chronic myeloid leukemia
    • Asnafi V, Rubio MT, Delabesse E et al. Prediction of relapse by day 100 BCR-ABL quantification after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia 2006; 20: 793-799.
    • (2006) Leukemia , vol.20 , pp. 793-799
    • Asnafi, V.1    Rubio, M.T.2    Delabesse, E.3
  • 78
    • 75149113290 scopus 로고    scopus 로고
    • Ballestrero A, Cirmena G, Dominietto A et al. Peripheral blood vs. bone marrow for molecular monitoring of BCR-ABL levels in chronic myelogenous leukemia; a retrospective analysis in allogeneic bone marrow recipients. Int J Clin Lab 2009; in press.
    • Ballestrero A, Cirmena G, Dominietto A et al. Peripheral blood vs. bone marrow for molecular monitoring of BCR-ABL levels in chronic myelogenous leukemia; a retrospective analysis in allogeneic bone marrow recipients. Int J Clin Lab 2009; in press.
  • 79
    • 35448967331 scopus 로고    scopus 로고
    • I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 2007; 8: 1018-1029.
    • (2007) Lancet Oncol , vol.8 , pp. 1018-1029
    • Part, A.J.F.1
  • 80
    • 0036874198 scopus 로고    scopus 로고
    • Campbell LJ, Patsouris C, Rayeroux KC, Somana K, Januszewicz EH, Szer J. BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration. Cancer Genet Cytogenet 2002; 139: 30-33.
    • Campbell LJ, Patsouris C, Rayeroux KC, Somana K, Januszewicz EH, Szer J. BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration. Cancer Genet Cytogenet 2002; 139: 30-33.
  • 81
    • 0344177196 scopus 로고    scopus 로고
    • Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib
    • Morel F, Bris MJ, Herry A et al. Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib. Eur J Haematol 2003; 70: 235-239.
    • (2003) Eur J Haematol , vol.70 , pp. 235-239
    • Morel, F.1    Bris, M.J.2    Herry, A.3
  • 82
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16: 2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 83
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST1571: Diverse mechanisms of resistance
    • Mahon FX, Deininger MW, Schultheis B et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST1571: diverse mechanisms of resistance. Blood 2000; 96: 1070-1079.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 84
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 2000; 95: 1758-1766.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 85
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104: 3739-3745.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3    Pirmohamed, M.4
  • 86
    • 0036720397 scopus 로고    scopus 로고
    • The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML
    • O'Dwyer ME, Mauro MJ, Kurilik G et al. The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Blood 2002; 100: 1628-1633.
    • (2002) Blood , vol.100 , pp. 1628-1633
    • O'Dwyer, M.E.1    Mauro, M.J.2    Kurilik, G.3
  • 87
    • 0942287753 scopus 로고    scopus 로고
    • Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate
    • O'Dwyer ME, Mauro MJ, Blasdel C et al. Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate. Blood 2004; 103: 451-455.
    • (2004) Blood , vol.103 , pp. 451-455
    • O'Dwyer, M.E.1    Mauro, M.J.2    Blasdel, C.3
  • 88
    • 0037330989 scopus 로고    scopus 로고
    • Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate
    • Schoch C, Haferlach T, Kern W et al. Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate. Leukemia 2003; 17: 461-463.
    • (2003) Leukemia , vol.17 , pp. 461-463
    • Schoch, C.1    Haferlach, T.2    Kern, W.3
  • 89
    • 24744443720 scopus 로고    scopus 로고
    • High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
    • Willis SG, Lange T, Demehri S et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005; 106: 2128-2137.
    • (2005) Blood , vol.106 , pp. 2128-2137
    • Willis, S.G.1    Lange, T.2    Demehri, S.3
  • 90
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E, Kantarjian H, Jones D et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006; 20: 1767-1773.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 91
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2: 117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 92
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S, Rudzki Z, Walsh S et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002; 99: 3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 93
    • 0036493544 scopus 로고    scopus 로고
    • Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann WK, Jones LC, Lemp NA et al. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 2002; 99: 1860-1862.
    • (2002) Blood , vol.99 , pp. 1860-1862
    • Hofmann, W.K.1    Jones, L.C.2    Lemp, N.A.3
  • 94
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 2002; 100: 1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3
  • 95
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deninger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000; 96: 3343-3356.
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deninger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 96
    • 3042612211 scopus 로고    scopus 로고
    • Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib
    • Soverini S, Martinelli G, Amabile M et al. Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib. Clin Chem 2004; 50: 1205-1213.
    • (2004) Clin Chem , vol.50 , pp. 1205-1213
    • Soverini, S.1    Martinelli, G.2    Amabile, M.3
  • 97
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Martinelli G, Rosti G et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005; 23: 4100-4109.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3
  • 98
    • 14944367962 scopus 로고    scopus 로고
    • Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment
    • Chu S, Xu H, Shah NP et al. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood 2005; 105: 2093-2098.
    • (2005) Blood , vol.105 , pp. 2093-2098
    • Chu, S.1    Xu, H.2    Shah, N.P.3
  • 99
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP)
    • Nicolini FE, Corm S, Le QH et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia 2006; 20: 1061-1066.
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm, S.2    Le, Q.H.3
  • 100
    • 0036398414 scopus 로고    scopus 로고
    • Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571
    • Barthe C, Gharbi MJ, Lagarde V et al. Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571. Br J Haematol 2002; 119: 109-111.
    • (2002) Br J Haematol , vol.119 , pp. 109-111
    • Barthe, C.1    Gharbi, M.J.2    Lagarde, V.3
  • 101
    • 3042614056 scopus 로고    scopus 로고
    • Use of denaturing HPLC for detection of mutations in the BCR-ABL kinase domain in patients resistant to Imatinib
    • Irving JA, O'Brien S, Lennard AL, Minto L, Lin F, Hall AG. Use of denaturing HPLC for detection of mutations in the BCR-ABL kinase domain in patients resistant to Imatinib. Clin Chem 2004; 50: 1233-1237.
    • (2004) Clin Chem , vol.50 , pp. 1233-1237
    • Irving, J.A.1    O'Brien, S.2    Lennard, A.L.3    Minto, L.4    Lin, F.5    Hall, A.G.6
  • 102
    • 33750132881 scopus 로고    scopus 로고
    • Not all imatinib resistance in CML are BCR-ABL kinase domain mutations
    • Wei Y, Hardling M, Olsson B et al. Not all imatinib resistance in CML are BCR-ABL kinase domain mutations. Ann Hematol 2006; 85: 841-847.
    • (2006) Ann Hematol , vol.85 , pp. 841-847
    • Wei, Y.1    Hardling, M.2    Olsson, B.3
  • 103
    • 33644516935 scopus 로고    scopus 로고
    • The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia
    • Wang L, Knight K, Lucas C, Clark RE. The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia. Haematologica 2006; 91: 235-239.
    • (2006) Haematologica , vol.91 , pp. 235-239
    • Wang, L.1    Knight, K.2    Lucas, C.3    Clark, R.E.4
  • 104
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes J, Rousselot P, Kim DW et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 2007; 109: 3207-3213.
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3
  • 106
    • 75149147303 scopus 로고    scopus 로고
    • Chronic Myelogenous
    • NCCN Clinical Practice Guidelines in Oncology
    • NCCN Clinical Practice Guidelines in Oncology. Chronic Myelogenous Leukemia. V.l. 2010. www.nccn.org
    • Leukemia , vol.50 , pp. 2010
  • 107
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Baccarani M, Saglio G, Goldman J et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006; 108: 1809-1820.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 108
    • 33745592518 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Diagnosis and treatment
    • Quintas-Cardama A, Cortes JE. Chronic myeloid leukemia: diagnosis and treatment. Mayo Clin Proc 2006; 81: 973-988.
    • (2006) Mayo Clin Proc , vol.81 , pp. 973-988
    • Quintas-Cardama, A.1    Cortes, J.E.2
  • 109
    • 33644523280 scopus 로고    scopus 로고
    • Deininger MW Management of early stage disease. Hematology Am Soc Hematol Educ Program 2005: 174-182.
    • Deininger MW Management of early stage disease. Hematology Am Soc Hematol Educ Program 2005: 174-182.
  • 110
    • 61449090494 scopus 로고    scopus 로고
    • Suboptimal response to or failure of imatinib treatment for chronic myeloid leukemia: What is the optimal strategy?
    • Jabbour E, Cortes JE, Kantarjian HM. Suboptimal response to or failure of imatinib treatment for chronic myeloid leukemia: what is the optimal strategy? Mayo Clin Proc 2009; 84: 161-169.
    • (2009) Mayo Clin Proc , vol.84 , pp. 161-169
    • Jabbour, E.1    Cortes, J.E.2    Kantarjian, H.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.