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1
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0032127443
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Frequency of clonal B lymphocytes in chronic myelogenous leukemia evaluated by fluorescence in situ hybridization
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Al-Amin A, Lennartz K, Runde V, Seeber S, Opalka B, Kloke O: Frequency of clonal B lymphocytes in chronic myelogenous leukemia evaluated by fluorescence in situ hybridization. Cancer Genet Cytogenet 1998, 104:45-47.
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Cancer Genet Cytogenet
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Al-Amin, A.1
Lennartz, K.2
Runde, V.3
Seeber, S.4
Opalka, B.5
Kloke, O.6
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4
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0032080097
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Inhibition of BCR-ABL expression with antisense oligodeoxynucleotides restores β-1 integrin-mediated adhesion and proliferation inhibition in chronic myelogenous leukemia hematopoietic progenitors
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+ cells with breakpoint-specific antisense oligonucleotides increased CML progenitor cell adhesion to stroma and decreased cell proliferation.
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(1998)
Blood
, vol.91
, pp. 3414-3422
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Bhatia, R.1
Verfaillie, C.M.2
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5
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0031905439
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The effect of interferon-α on β-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia
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Bhatia R, Verfaillie CM: The effect of interferon-α on β-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia. Leuk Lymphoma 1998, 28:241-254. This is an excellent overview of the topic.
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(1998)
Leuk Lymphoma
, vol.28
, pp. 241-254
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Bhatia, R.1
Verfaillie, C.M.2
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6
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0031881480
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L-selectin expression in CD34 positive cells in chronic myeloid leukemia
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Kimura A, Kawaishi K, Sasaki A, Hyodo H, Oguma N: L-selectin expression in CD34 positive cells in chronic myeloid leukemia. Leuk Lymphoma 1998, 28:389-404.
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(1998)
Leuk Lymphoma
, vol.28
, pp. 389-404
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Kimura, A.1
Kawaishi, K.2
Sasaki, A.3
Hyodo, H.4
Oguma, N.5
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7
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0032546266
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Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up regulation of Bcl-xL
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Amarante-Mendez GP, McGahon AJ, Nishioka WK, Afar DE, Witte ON, Green DR: Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL. Oncogene 1998, 16:1383-1390. These authors present evidence showing that the BCR-ABL gene product has powerful antiapoptotic properties that are independent of the phase of the cell cycle. BCR-ABL-specific antisense oligonucleotides restore sensitivity to apoptosis.
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(1998)
Oncogene
, vol.16
, pp. 1383-1390
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Amarante-Mendez, G.P.1
McGahon, A.J.2
Nishioka, W.K.3
Afar, D.E.4
Witte, O.N.5
Green, D.R.6
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8
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0032032270
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BCR-ABL gene products exert their antiapoptotic effects against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3
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Amarante-Mendez GP, Naekyung Kim C, Liu L, Huang Y, Perkins CL, Green DR, Bhalla K: BCR-ABL gene products exert their antiapoptotic effects against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3. Blood 1998, 91:1700-1705. This paper attempts to explain the mechanism of BCR-ABL-induced resistance to apoptosis. Resistance is mediated through prevention of cytosolic accumulation of cytochrome c and activation of caspase c, both of which occur upstream of the final common pathway to apoptosis.
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(1998)
Blood
, vol.91
, pp. 1700-1705
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Amarante-Mendez, G.P.1
Naekyung Kim, C.2
Liu, L.3
Huang, Y.4
Perkins, C.L.5
Green, D.R.6
Bhalla, K.7
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9
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0032510271
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Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 α
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Wark G, Heyworth CM, Spooncer E, Czaplewski L, Francis JM, Dexter TM, Whetton AD; Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 α. Oncogene 1998, 16:1319-1324.
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(1998)
Oncogene
, vol.16
, pp. 1319-1324
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Wark, G.1
Heyworth, C.M.2
Spooncer, E.3
Czaplewski, L.4
Francis, J.M.5
Dexter, T.M.6
Whetton, A.D.7
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10
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0031867876
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The growth inhibitory role and potential clinical value of macrophage inflammatory protein 1 alpha in myeloid leukaemias
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Owen-Lynch PJ, Czaplewski LG, Hunter MG, Whetton AD: The growth inhibitory role and potential clinical value of macrophage inflammatory protein 1 alpha in myeloid leukaemias. Leuk Lymphoma 1998, 30:41-53.
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(1998)
Leuk Lymphoma
, vol.30
, pp. 41-53
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Owen-Lynch, P.J.1
Czaplewski, L.G.2
Hunter, M.G.3
Whetton, A.D.4
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11
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0031952303
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Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors
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Jonuleit T, Peschel C, Schwab R, van der Kuip H, Buchdunger E, Fischer T, et al.: Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors. Br J Haematol 1998, 100:295-303.
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(1998)
Br J Haematol
, vol.100
, pp. 295-303
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Jonuleit, T.1
Peschel, C.2
Schwab, R.3
Van der Kuip, H.4
Buchdunger, E.5
Fischer, T.6
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12
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0032556921
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BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner
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Cambier N, Chopra R, Strasser A, Metcalf D, Elefanty AG: BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner. Oncogene 1998, 16:335-348. This paper presents more evidence showing that BCR-ABL confers protection against apoptotic signals.
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(1998)
Oncogene
, vol.16
, pp. 335-348
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Cambier, N.1
Chopra, R.2
Strasser, A.3
Metcalf, D.4
Elefanty, A.G.5
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13
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0031951277
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Biology of chronic myelogenous leukemia
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Verfaillie CM: Biology of chronic myelogenous leukemia. Hematol Oncol Clin North Am 1998, 12:1-29. This is an excellent and comprehensive review of the BCR-ABL gene and the effects of its products on cell signaling.
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(1998)
Hematol Oncol Clin North Am
, vol.12
, pp. 1-29
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Verfaillie, C.M.1
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14
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0032055156
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High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase
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Wang JC, Lapidot T, Cashman JC, Doedens M, Addy L, Sutherland DR, et al.: High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood 1998, 91:2406-2414.
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(1998)
Blood
, vol.91
, pp. 2406-2414
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Wang, J.C.1
Lapidot, T.2
Cashman, J.C.3
Doedens, M.4
Addy, L.5
Sutherland, D.R.6
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15
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0032529306
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The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: An in vivo model of chronic myelogenous leukemia biology
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Dazzi F, Capelli D, Hasserjian R, Cotter F, Corbo M, Pletti A, et al.: The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: an in vivo model of chronic myelogenous leukemia biology. Blood 1998, 92:1390-1396. This paper details the engraftment characteristics and cell kinetics of a new murine model of CML
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(1998)
Blood
, vol.92
, pp. 1390-1396
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Dazzi, F.1
Capelli, D.2
Hasserjian, R.3
Cotter, F.4
Corbo, M.5
Pletti, A.6
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17
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0031806721
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Therapy-related chronic myeloid leukemia: An epidemiological, clinical and pathogenetic appraisal
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Aguiar RC: Therapy-related chronic myeloid leukemia: an epidemiological, clinical and pathogenetic appraisal. Leuk Lymphoma 1998, 29:17-26.
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(1998)
Leuk Lymphoma
, vol.29
, pp. 17-26
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Aguiar, R.C.1
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Chronic myeloid leukemia
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Goldman JM: Chronic myeloid leukemia. Curr Opin Hematol 1997, 4:277-285.
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Curr Opin Hematol
, vol.4
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Goldman, J.M.1
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19
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0031947727
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Importance of mixed chimerism to predict relapse in persistently BCR/ABL positive survivors after allogeneic bone marrow transplantation for chronic myeloid leukemia
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Roman J, Martin C, Torres A, Garcia A, Andres P, Garcia MJ, Baiget M: Importance of mixed chimerism to predict relapse in persistently BCR/ABL positive survivors after allogeneic bone marrow transplantation for chronic myeloid leukemia. Leuk Lymphoma 1998, 28:541-550.
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(1998)
Leuk Lymphoma
, vol.28
, pp. 541-550
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Roman, J.1
Martin, C.2
Torres, A.3
Garcia, A.4
Andres, P.5
Garcia, M.J.6
Baiget, M.7
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20
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0032190169
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A special fluorescent in situ hybridization technique to study peripheral blood and assess the effectiveness of interferon therapy in chronic myeloid leukemia
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Buno I, Wyatt WA, Zinsmeister AR, Dietz-Band J, Silver RT, Dewald GW: A special fluorescent in situ hybridization technique to study peripheral blood and assess the effectiveness of interferon therapy in chronic myeloid leukemia. Blood 1998, 92:2315-2321. This is an examination of the utility of fluorescent in situ hybridization done using probes for BCR and ABL1 on peripheral blood samples and marrow. Residual disease in patients in complete cytogenetic remission was equally identifiable in both types of samples. It may not be necessary to collect marrow samples so often to monitor therapy.
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(1998)
Blood
, vol.92
, pp. 2315-2321
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Buno, I.1
Wyatt, W.A.2
Zinsmeister, A.R.3
Dietz-Band, J.4
Silver, R.T.5
Dewald, G.W.6
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21
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0345487506
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Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: A new strategy for remission assessment
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Muhlmann J, Thaler J, Hilbe W, Bechter O, Erdel M, Utermann G, Duba HC: Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: a new strategy for remission assessment. Genes Chromosom Cancer 1998, 21:90-100.
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Genes Chromosom Cancer
, vol.21
, pp. 90-100
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Muhlmann, J.1
Thaler, J.2
Hilbe, W.3
Bechter, O.4
Erdel, M.5
Utermann, G.6
Duba, H.C.7
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22
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0031846124
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Leg ulcers associated with long-term hydroxyurea therapy
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Weinlich G, Schuler G, Greil R, Kofler H, Fritsch P: Leg ulcers associated with long-term hydroxyurea therapy. J Am Acad Dermatol 1998, 39:372-374.
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J Am Acad Dermatol
, vol.39
, pp. 372-374
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Weinlich, G.1
Schuler, G.2
Greil, R.3
Kofler, H.4
Fritsch, P.5
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23
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0031974586
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Hydroxyurea-induced leg ulceration in 14 patients
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Best PJ, Daoud MS, Pittelkow MR, Petitt RM: Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 1998, 128:29-32.
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(1998)
Ann Intern Med
, vol.128
, pp. 29-32
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Best, P.J.1
Daoud, M.S.2
Pittelkow, M.R.3
Petitt, R.M.4
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24
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17344371806
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Alltrans retinoic acid (ATRA) in patients with chronic myeloid leukemia in the chronic phase
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Russo D, Regazzi M, Sacchi S, Visani G, Lazzarino M, Avvisati G, et al.: Alltrans retinoic acid (ATRA) in patients with chronic myeloid leukemia in the chronic phase. Leukemia 1998, 12:449-454.
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(1998)
Leukemia
, vol.12
, pp. 449-454
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Russo, D.1
Regazzi, M.2
Sacchi, S.3
Visani, G.4
Lazzarino, M.5
Avvisati, G.6
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25
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0031948594
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Anagrelide for treatment of patients with chronic myelogenous leukemia and a high platelet count
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Trapp OM, Beykirch MK, Petrides PE: Anagrelide for treatment of patients with chronic myelogenous leukemia and a high platelet count. Blood Cells Mol Dis 1998, 24:9-13.
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(1998)
Blood Cells Mol Dis
, vol.24
, pp. 9-13
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Trapp, O.M.1
Beykirch, M.K.2
Petrides, P.E.3
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26
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0345696854
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Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia
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Guilhot F, Chastang C, Michallet M, Guerci A, Harousseau J, Maloisel F, et al.: Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia, N Engl J Med 1997, 337:223-229.
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N Engl J Med
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, pp. 223-229
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Guilhot, F.1
Chastang, C.2
Michallet, M.3
Guerci, A.4
Harousseau, J.5
Maloisel, F.6
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27
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0031833734
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GM. CSF can improve the cytogenetic response obtained with interferon-alpha therapy in patients with chronic myelogenous leukemia
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Cortes J, Kantarjian H, O'Brien S, Kurzrock R, Keating M, Talpaz M: GM. CSF can improve the cytogenetic response obtained with interferon-alpha therapy in patients with chronic myelogenous leukemia. Leukemia 1998, 12:860-864.
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(1998)
Leukemia
, vol.12
, pp. 860-864
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Cortes, J.1
Kantarjian, H.2
O'Brien, S.3
Kurzrock, R.4
Keating, M.5
Talpaz, M.6
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28
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0032522945
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Randomized study on hydroxyurea alone versus hydroxyurea combined with low-dose interferon-α 2b for chronic myeloid leukemia
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The Benelux CML Study Group: Randomized study on hydroxyurea alone versus hydroxyurea combined with low-dose interferon-α 2b for chronic myeloid leukemia. Blood 1998, 91:2713-2721.
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(1998)
Blood
, vol.91
, pp. 2713-2721
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29
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0031962954
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Effect of interferon-alpha therapy on bone marrow fibrosis in chronic myelogenous leukemia
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Wilhelm M, Bueso-Ramos C, O'Brien S, Pierce S, Keating M, Talpaz M, Kantarjian HM: Effect of interferon-alpha therapy on bone marrow fibrosis in chronic myelogenous leukemia. Leukemia 1998, 12:65-70.
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(1998)
Leukemia
, vol.12
, pp. 65-70
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Wilhelm, M.1
Bueso-Ramos, C.2
O'Brien, S.3
Pierce, S.4
Keating, M.5
Talpaz, M.6
Kantarjian, H.M.7
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30
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0031811933
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Collection of Ph-negative progenitor cells with granulocyte-colony stimulating factor in patients with chronic myeloid leukaemia who respond to recombinant α-interferon
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Reiffers J, Taylor K, Gluckman E, Gorin NC, Mahon FX, Miclea JM, et al.: Collection of Ph-negative progenitor cells with granulocyte-colony stimulating factor in patients with chronic myeloid leukaemia who respond to recombinant α-interferon. Br J Haematol 1998, 102:639-646.
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(1998)
Br J Haematol
, vol.102
, pp. 639-646
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Reiffers, J.1
Taylor, K.2
Gluckman, E.3
Gorin, N.C.4
Mahon, F.X.5
Miclea, J.M.6
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31
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2642680046
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Absence of influence of prior treatment with interferon on the outcome of allogoneic bone marrow transplantation for chronic myeloid leukemia
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Tomas JF, Lopez-Lorenzo JL, Requena MJ, Agular R, Steegmann JL, Camara R, et al.: Absence of influence of prior treatment with interferon on the outcome of allogoneic bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant 1998, 22:47-51.
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(1998)
Bone Marrow Transplant
, vol.22
, pp. 47-51
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Tomas, J.F.1
Lopez-Lorenzo, J.L.2
Requena, M.J.3
Agular, R.4
Steegmann, J.L.5
Camara, R.6
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32
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2642643774
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Association between pretransplant interferon-alpha and outcome after unrelated donor marrow transplantation for chronic myelogenous leukemia in chronic phase
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Morton AJ, Gooley T, Hansen JA, Appelbaum FR, Bruemmer B, Bjerke JW, et al.: Association between pretransplant interferon-alpha and outcome after unrelated donor marrow transplantation for chronic myelogenous leukemia in chronic phase. Blood 1998, 92:394-401.
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(1998)
Blood
, vol.92
, pp. 394-401
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Morton, A.J.1
Gooley, T.2
Hansen, J.A.3
Appelbaum, F.R.4
Bruemmer, B.5
Bjerke, J.W.6
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33
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0032478962
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A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa
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Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC, et al.: A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst 1998, 90:850-858. This meta-analysis of 14 studies (P = 1573) is an attempt to develop a system with which to predict responses to interferon on the basis of initial clinical and with which to predict responses to interferon on the basis of initial clinical and hematologic criteria.
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(1998)
J Natl Cancer Inst
, vol.90
, pp. 850-858
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Hasford, J.1
Pfirrmann, M.2
Hehlmann, R.3
Allan, N.C.4
Baccarani, M.5
Kluin-Nelemans, J.C.6
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Early treatment decisions with interferon-alfa therapy in early chronic-phase chronic myelogenous leukemia
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Sacchi S, Kantarjian HM, Smithe TL, O'Brien S, Pierce S, Kornblau S, et al.: Early treatment decisions with interferon-alfa therapy in early chronic-phase chronic myelogenous leukemia. J Clin Oncol 1998, 16:882-889. This retrospective analysis of 274 patients treated with interferon was done to identify early predictors of nonresponse. Such predictors could be used to support consideration of alternative, investigational therapy.
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(1998)
J Clin Oncol
, vol.16
, pp. 882-889
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Sacchi, S.1
Kantarjian, H.M.2
Smithe, T.L.3
O'Brien, S.4
Pierce, S.5
Kornblau, S.6
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35
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0032168729
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An in vitro model for cytogenetic conversion in CML, Interferon-α preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture
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Cornelissen JJ, Ploemacher RE, Wognum BW, Borsboom A, Kluin-Nelemans HC, Hagemeijer A, Lowenberg B: An in vitro model for cytogenetic conversion in CML, Interferon-α preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture. J Clin Invest 1998, 102:976-983.
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(1998)
J Clin Invest
, vol.102
, pp. 976-983
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Cornelissen, J.J.1
Ploemacher, R.E.2
Wognum, B.W.3
Borsboom, A.4
Kluin-Nelemans, H.C.5
Hagemeijer, A.6
Lowenberg, B.7
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36
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0032529110
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Treatment with interferon-α preferentially reduces the Ä-capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM
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Gordon MY, Marley SB, Lewis JL, Davidson RJ, Nguyen DX, Grand FH, et al.: Treatment with interferon-α preferentially reduces the Ä-capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM. J Clin Invest 1998, 102:710-715. This is an attempt to predict responses to interferon with an in vitro sensitivity assay. The ability to amplify granulocyte-macrophage colony forming units and suppression of this ability by interferon predicted responsiveness to interferon in 86% of cases.
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(1998)
J Clin Invest
, vol.102
, pp. 710-715
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Gordon, M.Y.1
Marley, S.B.2
Lewis, J.L.3
Davidson, R.J.4
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Grand, F.H.6
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0032147137
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Fas-mediated modulation of Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis
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Selleri C, Maciejewski JP, Pane F, Luciano L, Raiola AM, Mostarda I, et al.: Fas-mediated modulation of Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis. Blood 1998, 92:981-989. This paper presents more evidence of the antiapoptotic effect of BCR-ABL. One effect of interferon in CML is to increase sensitivity to Fas-triggered apoptosis.
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(1998)
Blood
, vol.92
, pp. 981-989
-
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Selleri, C.1
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Pane, F.3
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Mostarda, I.6
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Association of HLA phenotype and response to interferon-alpha in patients with chronic myelogenous leukemia
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Cortes J, Fayad L, Kantarjian H, O'Brien S, Lee MS, Talpaz M: Association of HLA phenotype and response to interferon-alpha in patients with chronic myelogenous leukemia. Leukemia 1998, 12:455-462.
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(1998)
Leukemia
, vol.12
, pp. 455-462
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Cortes, J.1
Fayad, L.2
Kantarjian, H.3
O'Brien, S.4
Lee, M.S.5
Talpaz, M.6
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40
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0031932054
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Interferon-α restores β 1-integrin-dependent, collagen-mediated platelet aggregation in a patient with chronic myelogenous leukemia
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Verfaillie CM, Bhatia R, Browne P, Key NS: Interferon-α restores β 1-integrin-dependent, collagen-mediated platelet aggregation in a patient with chronic myelogenous leukemia. J Lab Clin Med 1998, 131:163-169.
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(1998)
J Lab Clin Med
, vol.131
, pp. 163-169
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Verfaillie, C.M.1
Bhatia, R.2
Browne, P.3
Key, N.S.4
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41
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Conversion of interferon-induced, long-term cytogenetic remissions in chronic myelogenous leukemia to polymerase chain reaction negativity
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Kurzrock R, Estrov Z, Kantarjian H, Talpaz M: Conversion of interferon-induced, long-term cytogenetic remissions in chronic myelogenous leukemia to polymerase chain reaction negativity. J Clin Oncol 1998, 16:1526-1531.
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J Clin Oncol
, vol.16
, pp. 1526-1531
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Kurzrock, R.1
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Kantarjian, H.3
Talpaz, M.4
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0031854819
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Does BCR-ABL genomic rearrangement persist in CML patients in complete remission after interferon-α therapy?
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Brizard F, Chomel JC, Veinstein A, Rivet J, Giraud C, Kitzis A, et al.: Does BCR-ABL genomic rearrangement persist in CML patients in complete remission after interferon-α therapy? Leukemia 1998, 12:1076-1080.
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(1998)
Leukemia
, vol.12
, pp. 1076-1080
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Brizard, F.1
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Veinstein, A.3
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Kitzis, A.6
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Clinical course and therapy of chronic myelogenous leukemia with interferon-α and chemotherapy
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Kantarjian HM, Giles FJ, O'Brien SM, Talpaz M: Clinical course and therapy of chronic myelogenous leukemia with interferon-α and chemotherapy. Hematol Oncol Clin North Am 1998, 12:31-80. This is a comprehensive review of the history and current use of interferon in CML therapy.
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(1998)
Hematol Oncol Clin North Am
, vol.12
, pp. 31-80
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Kantarjian, H.M.1
Giles, F.J.2
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44
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0032170989
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Comparative analysis of autografting in chronic myelogenous leukemia: Effects of priming regimen and marrow or blood origin of stem cells
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Verfaillie CM, Bhatia R, Steinbuch M, Defor T, Hirsch B, Miller JS, et al.: Comparative analysis of autografting in chronic myelogenous leukemia: effects of priming regimen and marrow or blood origin of stem cells. Blood 1998, 92:1820-1831.
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(1998)
Blood
, vol.92
, pp. 1820-1831
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Verfaillie, C.M.1
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Miller, J.S.6
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Bhatia R, Forman SJ: Autologous transplant for the treatment of chronic myelogenous leukemia. Hematol Oncol Clin North Am 1998, 12:151-172. This is a good review of an increasingly important therapy.
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