-
1
-
-
41349099104
-
Cancer statistics, 2008
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96.
-
(2008)
CA Cancer J Clin
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
41949114641
-
Recent major improvement in long-term survival of younger patients with multiple myeloma
-
Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood. 2008;111:2521-2526.
-
(2008)
Blood
, vol.111
, pp. 2521-2526
-
-
Brenner, H.1
Gondos, A.2
Pulte, D.3
-
3
-
-
43749117945
-
Multicenter, randomized, doubleblind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
-
Rajkumar SV, Rosiñol L, Hussein M, et al. Multicenter, randomized, doubleblind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J Clin Oncol. 2008;26:2171-2177.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2171-2177
-
-
Rajkumar, S.V.1
Rosiñol, L.2
Hussein, M.3
-
4
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
VISTA Trial Investigators
-
San Miguel JF, Schlag R, Khuageva NK, et al; VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359:906-917.
-
(2008)
N Engl J Med
, vol.359
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
5
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003;348:2609-2617.
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
6
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators
-
Richardson PG, Sonneveld P, Schuster MW, et al; Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487-2498.
-
(2005)
N Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
-
7
-
-
70450230539
-
Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
-
In press
-
Dimopoulos MA, Chen C, Spencer A, et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia. In press.
-
Leukemia
-
-
Dimopoulos, M.A.1
Chen, C.2
Spencer, A.3
-
8
-
-
36349010285
-
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
-
Multiple Myeloma (009) Study Investigators
-
Weber DM, Chen C, Niesvizky R, et al; Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med. 2007;357:2133-2142.
-
(2007)
N Engl J Med
, vol.357
, pp. 2133-2142
-
-
Weber, D.M.1
Chen, C.2
Niesvizky, R.3
-
9
-
-
67649985917
-
Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma
-
Chen C, Reece DE, Siegel D, et al. Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma. Br J Haematol. 2009;146:164-170.
-
(2009)
Br J Haematol
, vol.146
, pp. 164-170
-
-
Chen, C.1
Reece, D.E.2
Siegel, D.3
-
10
-
-
34548539381
-
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
-
Orlowski RZ, Nagler A, Sonneveld P, et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol. 2007;25:3892-3901.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3892-3901
-
-
Orlowski, R.Z.1
Nagler, A.2
Sonneveld, P.3
-
11
-
-
36349023319
-
Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
-
Dimopoulos M, Spencer A, Attal M, et al; Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med. 2007;357:2123-2132.
-
(2007)
N Engl J Med
, vol.357
, pp. 2123-2132
-
-
Dimopoulos, M.1
Spencer, A.2
Attal, M.3
-
12
-
-
35048830443
-
Phase III trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma (E4A03): A trial coordinated by the Eastern Cooperative Oncology Group
-
Rajkumar SV, Jacobus S, Callander N, et al. Phase III trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma (E4A03): a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol. Annual Meeting Abstracts 2007;25(suppl 18):LBA8025.
-
(2007)
J Clin Oncol. Annual Meeting Abstracts
, vol.25
, Issue.SUPPL. 18
-
-
Rajkumar, S.V.1
Jacobus, S.2
Callander, N.3
-
13
-
-
41349095820
-
A randomized trial of lenalidomide plus high-dose dexamethasone (RD) versus lenalidomide plus low-dose dexamethasone (Rd) in newly diagnosed multiple myeloma (E4A03): A trial coordinated by the Eastern Cooperative Oncology Group
-
[Abstract 74]
-
Rajkumar SV, Jacobus S, Callander N, et al. A randomized trial of lenalidomide plus high-dose dexamethasone (RD) versus lenalidomide plus low-dose dexamethasone (Rd) in newly diagnosed multiple myeloma (E4A03): a trial coordinated by the Eastern Cooperative Oncology Group. Blood. 2007;110: 31a. [Abstract 74].
-
(2007)
Blood
, vol.110
-
-
Rajkumar, S.V.1
Jacobus, S.2
Callander, N.3
-
14
-
-
60849121199
-
Initial results of PX-171-003, an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM)
-
Abstract 864
-
Jagannath S, Vij R, Stewart AK, et al. Initial results of PX-171-003, an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM). Blood. 2008;112:Abstract 864.
-
(2008)
Blood
, vol.112
-
-
Jagannath, S.1
Vij, R.2
Stewart, A.K.3
-
15
-
-
70349643684
-
Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
-
Abstract 8504
-
Jagannath S, Vij R, Stewart AK, et al. Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J Clin Oncol. 2009;27(suppl 15):Abstract 8504.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL. 15
-
-
Jagannath, S.1
Vij, R.2
Stewart, A.K.3
-
16
-
-
75149115447
-
Initial results of PX-171-04, an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM)
-
Abstract 865
-
Vij R, Wang M, Orlowski R, et al. Initial results of PX-171-04, an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM). Blood. 2008;112:Abstract 865.
-
(2008)
Blood
, vol.112
-
-
Vij, R.1
Wang, M.2
Orlowski, R.3
-
17
-
-
70350682328
-
PX-171-006: Phase Ib multicenter dose escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) and low-dose dexamethasone (loDex) in relapsed and refractory multiple myeloma (MM): Preliminary results
-
(suppl; Abstract 8541)
-
Niesvizky R, Bensinger W, Vallone M, et al. PX-171-006: phase Ib multicenter dose escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) and low-dose dexamethasone (loDex) in relapsed and refractory multiple myeloma (MM): preliminary results. J Clin Oncol. 2009;27:15s (suppl; Abstract 8541).
-
(2009)
J Clin Oncol
, vol.27
-
-
Niesvizky, R.1
Bensinger, W.2
Vallone, M.3
-
18
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
DOI 10.1016/j.ccr.2005.10.013, PII S153561080500334X
-
Chauhan D, Catley L, Li G, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell. 2005;8:407-419. (Pubitemid 41579835)
-
(2005)
Cancer Cell
, vol.8
, Issue.5
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
Ovaa, H.11
Berkers, C.12
Nicholson, B.13
Chao, T.-H.14
Neuteboom, S.T.C.15
Richardson, P.16
Palladino, M.A.17
Anderson, K.C.18
-
19
-
-
41949110089
-
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
-
Piva R, Ruggeri B, Williams M, et al. CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood. 2008;111:2765-2775.
-
(2008)
Blood
, vol.111
, pp. 2765-2775
-
-
Piva, R.1
Ruggeri, B.2
Williams, M.3
-
20
-
-
77949432502
-
Clinical trial of the novel structure proteasome inhibitor NPI-0052 in patients with relapsed and relapsed/ refractory multiple myeloma (r/r MM)
-
(suppl; Abstract 8505)
-
Hofmeister CC, Richardson P, Zimmerman T, et al. Clinical trial of the novel structure proteasome inhibitor NPI-0052 in patients with relapsed and relapsed/ refractory multiple myeloma (r/r MM). J Clin Oncol. 2009;27:15s (suppl; Abstract 8505).
-
(2009)
J Clin Oncol
, vol.27
-
-
Hofmeister, C.C.1
Richardson, P.2
Zimmerman, T.3
-
21
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan D, Singh A, Brahmandam M, et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood. 2008;111:1654-1664.
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
-
22
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341:1565-1571.
-
(1999)
N Engl J Med
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
23
-
-
0036843032
-
Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma
-
Rajkumar SV, Hayman S, Gertz MA, et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J Clin Oncol. 2002;20:4319-4323.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4319-4323
-
-
Rajkumar, S.V.1
Hayman, S.2
Gertz, M.A.3
-
24
-
-
0037208595
-
Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
-
Weber D, Rankin K, Gavino M, et al. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol. 2003;21:16-19.
-
(2003)
J Clin Oncol
, vol.21
, pp. 16-19
-
-
Weber, D.1
Rankin, K.2
Gavino, M.3
-
25
-
-
3042735765
-
Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: Results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity
-
Richardson P, Schlossman R, Jagannath S, et al. Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity. Mayo Clin Proc. 2004;79:875-882.
-
(2004)
Mayo Clin Proc
, vol.79
, pp. 875-882
-
-
Richardson, P.1
Schlossman, R.2
Jagannath, S.3
-
26
-
-
1942534043
-
The evolution of thalidomide and its IMiD derivatives as anticancer agents
-
Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer. 2004;4:314-322.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 314-322
-
-
Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
-
27
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood. 2002;99:4525-4530.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
28
-
-
0035195019
-
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
-
Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia. 2001;15:1950-1961.
-
(2001)
Leukemia
, vol.15
, pp. 1950-1961
-
-
Gupta, D.1
Treon, S.P.2
Shima, Y.3
-
29
-
-
60849097047
-
Pomalidomide (CC4047) plus low-dose dexamethasone (pom/dex) is highly effective therapy in relapsed multiple myeloma
-
Abstract 866
-
Lacy MQ, Hayman SR, Gertz MA, et al. Pomalidomide (CC4047) plus low-dose dexamethasone (pom/dex) is highly effective therapy in relapsed multiple myeloma. Blood. 2008;112:Abstract 866.
-
(2008)
Blood
, vol.112
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
30
-
-
9144220841
-
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications
-
Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc Natl Acad Sci USA. 2004;101:540-545.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 540-545
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
31
-
-
0141593496
-
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
-
Catley L, Weisberg E, Tai YT, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003;102:2615-2622.
-
(2003)
Blood
, vol.102
, pp. 2615-2622
-
-
Catley, L.1
Weisberg, E.2
Tai, Y.T.3
-
32
-
-
33644836549
-
Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies
-
O'Connor OA, Heaney ML, Schwartz L, et al. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J Clin Oncol. 2006;24:166-173.
-
(2006)
J Clin Oncol
, vol.24
, pp. 166-173
-
-
O'Connor, O.A.1
Heaney, M.L.2
Schwartz, L.3
-
33
-
-
39749103428
-
Phase i trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma
-
Richardson P, Mitsiades C, Colson K, et al. Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma. Leuk Lymphoma. 2008;49:502-507.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 502-507
-
-
Richardson, P.1
Mitsiades, C.2
Colson, K.3
-
34
-
-
67449125357
-
A phase II study of oral panobinostat (LBH589) in adult patients with advanced refractory multiple myeloma
-
Abstract 2774
-
Wolf JL, Siegel D, Matous J, et al. A phase II study of oral panobinostat (LBH589) in adult patients with advanced refractory multiple myeloma. Blood. 2008;112:Abstract 2774.
-
(2008)
Blood
, vol.112
-
-
Wolf, J.L.1
Siegel, D.2
Matous, J.3
-
35
-
-
67449109154
-
Phase IA/II study of oral panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies
-
Abstract 958
-
Ottmann OG, Spencer A, Prince HM, et al. Phase IA/II study of oral panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies. Blood. 2008;112:Abstract 958.
-
(2008)
Blood
, vol.112
-
-
Ottmann, O.G.1
Spencer, A.2
Prince, H.M.3
-
36
-
-
67650456888
-
Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: Effect on myeloma bone disease in the 5T2MM murine model of myeloma
-
Deleu S, Lemaire M, Arts J, et al. Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma. Cancer Res. 2009;69: 5307-5311.
-
(2009)
Cancer Res
, vol.69
, pp. 5307-5311
-
-
Deleu, S.1
Lemaire, M.2
Arts, J.3
-
37
-
-
67649179529
-
Phase i trial of vorinostat plus bortezomib (bort) in relapsed/refractory multiple myeloma (mm) patients (pts)
-
Abstract 8548
-
Badros AZ, Philip S, Niesvizk R, et al. Phase I trial of vorinostat plus bortezomib (bort) in relapsed/refractory multiple myeloma (mm) patients (pts). J Clin Oncol. 2008;26:Abstract 8548.
-
(2008)
J Clin Oncol
, vol.26
-
-
Badros, A.Z.1
Philip, S.2
Niesvizk, R.3
-
38
-
-
67449148094
-
High response rates with the combination of bortezomib, dexamethasone and the pan-histone deacetylase inhibitor romidepsin in patients with relapsed or refractory multiple myeloma in a phase I/II clinical trial
-
Abstract 3698
-
Harrison S, Quach H, Yuen K, et al. High response rates with the combination of bortezomib, dexamethasone and the pan-histone deacetylase inhibitor romidepsin in patients with relapsed or refractory multiple myeloma in a phase I/II clinical trial. Blood. 2008;112:Abstract 3698.
-
(2008)
Blood
, vol.112
-
-
Harrison, S.1
Quach, H.2
Yuen, K.3
-
39
-
-
70349301166
-
A phase i study of vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma
-
Abstract 3705
-
Siegel D, Weber D, Mitsiades CS, et al. A phase I study of vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma. Blood. 2008;112:Abstract 3705.
-
(2008)
Blood
, vol.112
-
-
Siegel, D.1
Weber, D.2
Mitsiades, C.S.3
-
40
-
-
51049121251
-
Phase i trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in combination with bortezomib in patients with advanced multiple myeloma
-
Abstract 1172
-
Weber D, Jagannath S, Mazumder A, et al. Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in combination with bortezomib in patients with advanced multiple myeloma. Blood. 2007;110:Abstract 1172.
-
(2007)
Blood
, vol.110
-
-
Weber, D.1
Jagannath, S.2
Mazumder, A.3
-
41
-
-
73849152317
-
Vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma: A phase i study
-
(suppl; Abstract 8586)
-
Siegel DS, Weber DM, Mitsiades CS, et al. Vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma: a phase I study. J Clin Oncol. 2009;27:15s (suppl; Abstract 8586).
-
(2009)
J Clin Oncol
, vol.27
-
-
Siegel, D.S.1
Weber, D.M.2
Mitsiades, C.S.3
-
42
-
-
73849120547
-
Panobinostat plus lenalidomide and dexamethasone phase i trial in multiple myeloma (MM)
-
(suppl; Abstract 8542)
-
Spencer A, Taylor K, Lonial S, et al. Panobinostat plus lenalidomide and dexamethasone phase I trial in multiple myeloma (MM). J Clin Oncol. 2009;27:15s (suppl; Abstract 8542).
-
(2009)
J Clin Oncol
, vol.27
-
-
Spencer, A.1
Taylor, K.2
Lonial, S.3
-
43
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA. 2002;99:14374-14379.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
44
-
-
33748938280
-
Phase 1 clinical trial of KOS-953 + bortezomib (BZ) in relapsed refractory multiple myeloma (MM)
-
(suppl; Abstract 3066)
-
Chanan-Khan A, Richardson P, Alsina M, et al. Phase 1 clinical trial of KOS-953 + bortezomib (BZ) in relapsed refractory multiple myeloma (MM). J Clin Oncol. 2006;24:18S (suppl; Abstract 3066).
-
(2006)
J Clin Oncol
, vol.24
-
-
Chanan-Khan, A.1
Richardson, P.2
Alsina, M.3
-
45
-
-
34548181762
-
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
-
Hideshima T, Catley L, Raje N, et al. Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol. 2007;138:783-791.
-
(2007)
Br J Haematol
, vol.138
, pp. 783-791
-
-
Hideshima, T.1
Catley, L.2
Raje, N.3
-
46
-
-
0141731299
-
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3+-kinase/AKT signaling
-
Tai YT, Podar K, Catley L, et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3+-kinase/AKT signaling. Cancer Res. 2003;63:5850-5858.
-
(2003)
Cancer Res
, vol.63
, pp. 5850-5858
-
-
Tai, Y.T.1
Podar, K.2
Catley, L.3
-
47
-
-
0035525792
-
The AKT kinase is activated in multiple myeloma tumor cells
-
Hsu J, Shi Y, Krajewski S, et al. The AKT kinase is activated in multiple myeloma tumor cells. Blood. 2001;98:2853-2855.
-
(2001)
Blood
, vol.98
, pp. 2853-2855
-
-
Hsu, J.1
Shi, Y.2
Krajewski, S.3
-
48
-
-
33646577479
-
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood. 2006;107:4053-4062.
-
(2006)
Blood
, vol.107
, pp. 4053-4062
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
-
49
-
-
33846243705
-
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
-
Gajate C, Mollinedo F. Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood. 2007;109:711-719.
-
(2007)
Blood
, vol.109
, pp. 711-719
-
-
Gajate, C.1
Mollinedo, F.2
-
50
-
-
66149107150
-
Phase I/II results of a multicenter trial of perifosine (KRX-0401) + bortezomib in patients with relapsed or relapsed/refractory multiple myeloma who were previously relapsed from or refractory to bortezomib
-
Abstract 870
-
Richardson P, Wolf J, Jakubowiak A, et al. Phase I/II results of a multicenter trial of perifosine (KRX-0401) - bortezomib in patients with relapsed or relapsed/refractory multiple myeloma who were previously relapsed from or refractory to bortezomib. Blood. 2008;112:Abstract 870.
-
(2008)
Blood
, vol.112
-
-
Richardson, P.1
Wolf, J.2
Jakubowiak, A.3
-
51
-
-
64749112000
-
Phase i results of perifosine (KRX-0401) in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma (MM)
-
Abstract 3691
-
Jakubowiak A, Richardson P, Zimmerman TM, et al. Phase I results of perifosine (KRX-0401) in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma (MM). Blood. 2008;112:Abstract 3691.
-
(2008)
Blood
, vol.112
-
-
Jakubowiak, A.1
Richardson, P.2
Zimmerman, T.M.3
-
52
-
-
33846914141
-
Targeting PKC in multiple myeloma: In vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
-
Podar K, Raab MS, Zhang J, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood. 2007;109:1669-1677.
-
(2007)
Blood
, vol.109
, pp. 1669-1677
-
-
Podar, K.1
Raab, M.S.2
Zhang, J.3
-
53
-
-
27244434182
-
Identification and validation of novel therapeutic targets for multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, et al. Identification and validation of novel therapeutic targets for multiple myeloma. J Clin Oncol. 2005;23:6345-6350.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6345-6350
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
-
54
-
-
77950810666
-
Akt as a therapeutic target in multiple myeloma
-
abstract n. S8.3
-
Hideshima T, Raje N. Akt as a therapeutic target in multiple myeloma. Haematologica. 2007;92[suppl 2]:abstract n. S8.3.
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 2
-
-
Hideshima, T.1
Raje, N.2
-
55
-
-
75149167181
-
Future perspectives in the management of myeloma
-
abstract n.S13.4
-
Anderson KC. Future perspectives in the management of myeloma. Haematologica. 2007;92[suppl. 2]:abstract n.S13.4.
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 2
-
-
Anderson, K.C.1
-
56
-
-
0037013205
-
Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6
-
Shi Y, Hsu JH, Hu L, et al. Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6. J Biol Chem. 2002;277:15712-15720.
-
(2002)
J Biol Chem
, vol.277
, pp. 15712-15720
-
-
Shi, Y.1
Hsu, J.H.2
Hu, L.3
-
57
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L, et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res. 2002;62:5027-5034.
-
(2002)
Cancer Res
, vol.62
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
-
58
-
-
0038281345
-
Downstream effectors of oncogenic ras in multiple myeloma cells
-
Hu L, Shi Y, Hsu JH, et al. Downstream effectors of oncogenic ras in multiple myeloma cells. Blood. 2003;101:3126-3135.
-
(2003)
Blood
, vol.101
, pp. 3126-3135
-
-
Hu, L.1
Shi, Y.2
Hsu, J.H.3
-
59
-
-
10244260355
-
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma
-
Raje N, Kumar S, Hideshima T, et al. Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma. Blood. 2004;104:4188-4193.
-
(2004)
Blood
, vol.104
, pp. 4188-4193
-
-
Raje, N.1
Kumar, S.2
Hideshima, T.3
-
60
-
-
17444440115
-
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
-
Strömberg T, Dimberg A, Hammarberg A, et al. Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004;103:3138-3147.
-
(2004)
Blood
, vol.103
, pp. 3138-3147
-
-
Strömberg, T.1
Dimberg, A.2
Hammarberg, A.3
-
61
-
-
33644516582
-
Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasoneinduced apoptosis
-
Yan H, Frost P, Shi Y, et al. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasoneinduced apoptosis. Cancer Res. 2006;66:2305-2313.
-
(2006)
Cancer Res
, vol.66
, pp. 2305-2313
-
-
Yan, H.1
Frost, P.2
Shi, Y.3
-
62
-
-
10244229652
-
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
-
Frost P, Moatamed F, Hoang B, et al. In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood. 2004;104:4181-4187.
-
(2004)
Blood
, vol.104
, pp. 4181-4187
-
-
Frost, P.1
Moatamed, F.2
Hoang, B.3
-
63
-
-
33947643303
-
The mTOR inhibitor RAD001 (everolimus) is active against multiple myeloma cells in vitro and in vivo
-
Mitsiades N, McMullan C, Poulaki V, et al. The mTOR inhibitor RAD001 (everolimus) is active against multiple myeloma cells in vitro and in vivo. ASH Annual Meeting Abstracts. 2004;104:1496.
-
(2004)
ASH Annual Meeting Abstracts
, vol.104
, pp. 1496
-
-
Mitsiades, N.1
McMullan, C.2
Poulaki, V.3
-
64
-
-
33750072949
-
MTOR and cancer therapy
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene. 2006;25: 6436-6446.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
65
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov. 2006;5:671-688.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
66
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
67
-
-
68649117850
-
Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
-
Farag SS, Zhang S, Jansak BS, et al. Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma. Leuk Res. 2009;33:1475-1480.
-
(2009)
Leuk Res
, vol.33
, pp. 1475-1480
-
-
Farag, S.S.1
Zhang, S.2
Jansak, B.S.3
-
68
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan X, Harkavy B, Shen N, et al. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene. 2007; 26:1932-1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
-
69
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 2005;65:7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
-
70
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006;66: 1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
71
-
-
75149181089
-
Combination of Nab-rapamycin and perifosine induces synergistic cytotoxicity and antitumor activity via autophagy and apoptosis in multiple myeloma (MM)
-
Abstract 3663
-
Cirstea D, Hideshima T, Pozzi S, et al. Combination of Nab-rapamycin and perifosine induces synergistic cytotoxicity and antitumor activity via autophagy and apoptosis in multiple myeloma (MM). Blood. 2008;112:Abstract 3663.
-
(2008)
Blood
, vol.112
-
-
Cirstea, D.1
Hideshima, T.2
Pozzi, S.3
-
72
-
-
75149134465
-
Phase i trial of CCI-779 (temsirolimus) and weekly bortezomib in relapsed and/or refractory multiple myeloma
-
Abstract 3696
-
Ghobrial IM, Munshi N, Schlossman R, et al. Phase I trial of CCI-779 (temsirolimus) and weekly bortezomib in relapsed and/or refractory multiple myeloma. Blood. 2008;112:Abstract 3696.
-
(2008)
Blood
, vol.112
-
-
Ghobrial, I.M.1
Munshi, N.2
Schlossman, R.3
-
73
-
-
27244445489
-
Molecular pathogenesis and a consequent classification of multiple myeloma
-
Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol. 2005;23:6333-6338.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6333-6338
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
-
74
-
-
33747872306
-
A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
-
Baughn LB, Di Liberto M, Wu K, et al. A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res. 2006;66:7661-7667.
-
(2006)
Cancer Res
, vol.66
, pp. 7661-7667
-
-
Baughn, L.B.1
Di Liberto, M.2
Wu, K.3
-
75
-
-
23044439051
-
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
-
Raje N, Kumar S, Hideshima T, et al. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood. 2005;106:1042-1047.
-
(2005)
Blood
, vol.106
, pp. 1042-1047
-
-
Raje, N.1
Kumar, S.2
Hideshima, T.3
-
76
-
-
67349099081
-
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
-
Raje N, Hideshima T, Mukherjee S, et al. Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma. Leukemia. 2009;23:961-970.
-
(2009)
Leukemia
, vol.23
, pp. 961-970
-
-
Raje, N.1
Hideshima, T.2
Mukherjee, S.3
-
77
-
-
0032711250
-
IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
-
Puthier D, Bataille R, Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol. 1999;29:3945-3950.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3945-3950
-
-
Puthier, D.1
Bataille, R.2
Amiot, M.3
-
78
-
-
0032750492
-
Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells
-
Puthier D, Derenne S, Barillé S, et al. Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells. Br J Haematol. 1999;107:392-395.
-
(1999)
Br J Haematol
, vol.107
, pp. 392-395
-
-
Puthier, D.1
Derenne, S.2
Barillé, S.3
-
79
-
-
75149156715
-
RGB 286638 a novel multi-targeted small molecule inhibitor induces multiple myeloma (MM) cell death through abrogation of CDK-dependent and independent survival mechanisms
-
Abstract 2759
-
Cirstea D, Hideshima T, Pozzi S, et al. RGB 286638, a novel multi-targeted small molecule inhibitor, induces multiple myeloma (MM) cell death through abrogation of CDK-dependent and independent survival mechanisms. Blood. 2008:112:Abstract 2759.
-
(2008)
Blood
, vol.112
-
-
Cirstea, D.1
Hideshima, T.2
Pozzi, S.3
-
80
-
-
75149146138
-
2008-AT7519, a novel small molecule multi-cyclin dependent kinase inhibitor, induces apoptosis in multiple myeloma VIA GSK3+
-
Abstract 251
-
Santo L, Vallet S, Hideshima T, et al. ASH 2008-AT7519, a novel small molecule multi-cyclin dependent kinase inhibitor, induces apoptosis in multiple myeloma VIA GSK3+. Blood. 2008;112:Abstract 251.
-
(2008)
Blood
, vol.112
-
-
Santo, L.1
Vallet, S.2
Hideshima, T.3
Ash, E.4
-
81
-
-
0025313227
-
IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
-
Kurihara N, Bertolini D, Suda T, et al. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol. 1990;144:4226-4230.
-
(1990)
J Immunol
, vol.144
, pp. 4226-4230
-
-
Kurihara, N.1
Bertolini, D.2
Suda, T.3
-
82
-
-
35948943113
-
Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
-
Voorhees PM, Chen Q, Kuhn DJ, et al. Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Clin Cancer Res. 2007;13:6469-6478.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6469-6478
-
-
Voorhees, P.M.1
Chen, Q.2
Kuhn, D.J.3
-
83
-
-
51649083849
-
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
-
Tai YT, Dillon M, Song W, et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood. 2008;112:1329-1337.
-
(2008)
Blood
, vol.112
, pp. 1329-1337
-
-
Tai, Y.T.1
Dillon, M.2
Song, W.3
-
84
-
-
35348915408
-
Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model
-
Neri P, Kumar S, Fulciniti MT, et al. Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model. Clin Cancer Res. 2007;13:5903-5909.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5903-5909
-
-
Neri, P.1
Kumar, S.2
Fulciniti, M.T.3
-
85
-
-
33746122751
-
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment
-
Tai YT, Li XF, Breitkreutz I, et al. Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Cancer Res. 2006;66:6675-6682.
-
(2006)
Cancer Res
, vol.66
, pp. 6675-6682
-
-
Tai, Y.T.1
Li, X.F.2
Breitkreutz, I.3
-
86
-
-
47549118123
-
Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
-
Shammas MA, Koley H, Bertheau RC, et al. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia. 2008;22:1410-1418.
-
(2008)
Leukemia
, vol.22
, pp. 1410-1418
-
-
Shammas, M.A.1
Koley, H.2
Bertheau, R.C.3
-
87
-
-
75149137094
-
Results of a phase i study of GRN163L a direct inhibitor of telomerase in patients with relapsed and refractory multiple myeloma (MM)
-
Abstract 3701
-
Chanan-Khan AA, Munshi NC, Hussein MA, et al. Results of a phase I study of GRN163L, a direct inhibitor of telomerase, in patients with relapsed and refractory multiple myeloma (MM). Blood. 2008;112:Abstract 3701.
-
(2008)
Blood
, vol.112
-
-
Chanan-Khan, A.A.1
Munshi, N.C.2
Hussein, M.A.3
-
88
-
-
0034876702
-
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis
-
Bezieau S, Devilder MC, Avet-Loiseau H, et al. High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. Hum Mutat. 2001;18:212-224.
-
(2001)
Hum Mutat
, vol.18
, pp. 212-224
-
-
Bezieau, S.1
Devilder, M.C.2
Avet-Loiseau, H.3
-
89
-
-
11144358447
-
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Alsina M, Fonseca R, Wilson EF, et al. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood. 2004;103:3271-3277.
-
(2004)
Blood
, vol.103
, pp. 3271-3277
-
-
Alsina, M.1
Fonseca, R.2
Wilson, E.F.3
-
90
-
-
31544482800
-
Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
-
Yanamandra N, Colaco NM, Parquet NA, et al. Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin Cancer Res. 2006;12:591-599.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 591-599
-
-
Yanamandra, N.1
Colaco, N.M.2
Parquet, N.A.3
-
91
-
-
75149158621
-
A phase i mmrc clinical trial testing the combination of bortezomib and tipifarnib in relapsed/refractory multiple myeloma
-
Abstract 3706
-
Lonial S, Francis D, Karanes C, et al. A phase i mmrc clinical trial testing the combination of bortezomib and tipifarnib in relapsed/refractory multiple myeloma. Blood. 2008;112:Abstract 3706.
-
(2008)
Blood
, vol.112
-
-
Lonial, S.1
Francis, D.2
Karanes, C.3
-
92
-
-
75149161130
-
A phase II trial of sorafenib in patients with relapsing and resistant multiple myeloma (MM) previously treated with bortezomib (S0434)
-
Abstract e19517
-
Srkalovic G, Hussein M, Bolejack V, et al. A phase II trial of sorafenib in patients with relapsing and resistant multiple myeloma (MM) previously treated with bortezomib (S0434). J Clin Oncol. 2009;27(suppl):Abstract e19517.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Srkalovic, G.1
Hussein, M.2
Bolejack, V.3
-
93
-
-
50249138003
-
Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: Phase 1 results
-
Orlowski RZ, Stewart K, Vallone M, et al. Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: phase 1 results. Blood (ASH Annual Meeting Abstracts). 2007;110:409.
-
(2007)
Blood (ASH Annual Meeting Abstracts)
, vol.110
, pp. 409
-
-
Orlowski, R.Z.1
Stewart, K.2
Vallone, M.3
-
94
-
-
50249150555
-
Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
-
Alsina M, Trudel S, Vallone M, et al. Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood (ASH Annual Meeting Abstracts). 2007;110:411.
-
(2007)
Blood (ASH Annual Meeting Abstracts)
, vol.110
, pp. 411
-
-
Alsina, M.1
Trudel, S.2
Vallone, M.3
-
95
-
-
34447130992
-
A multicenter phase 1 clinical trial of tanespimycin (KOS-953) + bortezomib (BZ): Encouraging activity and manageable toxicity in heavily pre-treated patients with relapsed refractory multiple myeloma (MM)
-
Richardson P, Chanan-Khan AA, Lonial S, et al. A multicenter phase 1 clinical trial of tanespimycin (KOS-953) - bortezomib (BZ): encouraging activity and manageable toxicity in heavily pre-treated patients with relapsed refractory multiple myeloma (MM). Blood (ASH Annual Meeting Abstracts). 2006;108:406.
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
, pp. 406
-
-
Richardson, P.1
Chanan-Khan, A.A.2
Lonial, S.3
-
96
-
-
64749110754
-
Vorinostat plus bortezomib for the treatment of relapsed/refractory multiple myeloma: Early clinical experience
-
Abstract 871
-
Weber D, Badros AZ, Jagannath S, et al. Vorinostat plus bortezomib for the treatment of relapsed/refractory multiple myeloma: early clinical experience. Blood. 2008;112:Abstract 871.
-
(2008)
Blood
, vol.112
-
-
Weber, D.1
Badros, A.Z.2
Jagannath, S.3
-
97
-
-
67449140087
-
A phase IB, multicenter, open-label, dose-escalation study of oral panobinostat (LBH589) and I.V. bortezomib in patients with relapsed multiple myeloma
-
Abstract 2781
-
Siegel D, Sezer O, San Miguel JF, et al. A phase IB, multicenter, open-label, dose-escalation study of oral panobinostat (LBH589) and I.V. bortezomib in patients with relapsed multiple myeloma. Blood. 2008;112:Abstract 2781.
-
(2008)
Blood
, vol.112
-
-
Siegel, D.1
Sezer, O.2
San Miguel, J.F.3
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