-
1
-
-
33644799866
-
Differential functions of ras for malignant phenotypic conversion
-
Moon A: Differential functions of ras for malignant phenotypic conversion. Arch. Pharm. Res. 29, 113-122 (2006).
-
(2006)
Arch. Pharm. Res
, vol.29
, pp. 113-122
-
-
Moon, A.1
-
2
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G: EGFR antagonists in cancer treatment. N. Engl. J. Med. 358, 1160-1174 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
3
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Includes an excellent summary of signaling through EGFR, plus a history of anti-EGFR therapies and a description of their clinical applications, ■
-
Downward J: Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22 (2003). ■ Includes an excellent summary of signaling through EGFR, plus a history of anti-EGFR therapies and a description of their clinical applications.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
4
-
-
50349086063
-
Tissue factor expression in non-small cell lung cancer: Relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation
-
Regina S, Rollin J, Blechet C, Iochmann S, Reverdiau P, Gruel Y: Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation. J. Thorac. Oncol. 3, 689-697 (2008).
-
(2008)
J. Thorac. Oncol
, vol.3
, pp. 689-697
-
-
Regina, S.1
Rollin, J.2
Blechet, C.3
Iochmann, S.4
Reverdiau, P.5
Gruel, Y.6
-
5
-
-
33750474485
-
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12
-
Cespedes MV, Sancho FJ, Guerrero S et al.: K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12. Carcinogenesis 27, 2190-2200 (2006).
-
(2006)
Carcinogenesis
, vol.27
, pp. 2190-2200
-
-
Cespedes, M.V.1
Sancho, F.J.2
Guerrero, S.3
-
6
-
-
28844463032
-
Moose models of K-ras-initiated carcinogenesis
-
Janssen KP, Abal M, El Marjou F, Loovard D, Robine S: Moose models of K-ras-initiated carcinogenesis. Biochim. Biophys. Acta 1756, 145-154 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, pp. 145-154
-
-
Janssen, K.P.1
Abal, M.2
El Marjou, F.3
Loovard, D.4
Robine, S.5
-
8
-
-
3242697688
-
High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform
-
Lilleberg SL, Durocher J, Sanders C, Walters K, Culver K: High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform. Ann. NY Acad. Sci. 1022, 250-256 (2004).
-
(2004)
Ann. NY Acad. Sci
, vol.1022
, pp. 250-256
-
-
Lilleberg, S.L.1
Durocher, J.2
Sanders, C.3
Walters, K.4
Culver, K.5
-
9
-
-
39049186213
-
Detection of a K-ras mutation in urine of patients with colorectal cancer
-
Su YH, Wang M, Aiamkitsumrit B, Brenner DE, Block TM: Detection of a K-ras mutation in urine of patients with colorectal cancer. Cancer Biomark. 1, 177-182 (2005).
-
(2005)
Cancer Biomark
, vol.1
, pp. 177-182
-
-
Su, Y.H.1
Wang, M.2
Aiamkitsumrit, B.3
Brenner, D.E.4
Block, T.M.5
-
10
-
-
48549105413
-
Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients
-
Describes a sensitive, quantitative approach for mutant status characterization, with the potential for broad application in clinical sample analysis, ■
-
Diehl F, Schmidt K, Durkee KH et al.: Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients. Gastroenterology 135, 489-498 (2008). ■ Describes a sensitive, quantitative approach for mutant status characterization, with the potential for broad application in clinical sample analysis.
-
(2008)
Gastroenterology
, vol.135
, pp. 489-498
-
-
Diehl, F.1
Schmidt, K.2
Durkee, K.H.3
-
11
-
-
3242709323
-
Mutant DNA in plasma of lung cancer patients: Potential for monitoring response to therapy
-
Kimura T, Holland WS, Kawaguchi T et al.: Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy. Ann. NY Acad. Sci. 1022, 55-60 (2004).
-
(2004)
Ann. NY Acad. Sci
, vol.1022
, pp. 55-60
-
-
Kimura, T.1
Holland, W.S.2
Kawaguchi, T.3
-
12
-
-
20444374483
-
Circulating tumour-derived DNA and RNA markers in blood: A tool for early detection, diagnostics, and follow-up?
-
Bremnes RM, Sirera R, Camps C: Circulating tumour-derived DNA and RNA markers in blood: a tool for early detection, diagnostics, and follow-up? Lung Cancer 49, 1-12 (2005).
-
(2005)
Lung Cancer
, vol.49
, pp. 1-12
-
-
Bremnes, R.M.1
Sirera, R.2
Camps, C.3
-
13
-
-
32644435012
-
Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe
-
Luo JD, Chan EC, Shih CL et al.: Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe. Nucleic Acids Res. 34, E12 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Luo, J.D.1
Chan, E.C.2
Shih, C.L.3
-
14
-
-
33846017682
-
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: In relation to cigarette smoking
-
Jiao L, Zhu J, Hassan MM, Evans DB, Abbruzzese JL, Li D: K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: In relation to cigarette smoking. Pancreas 34, 55-62 (2007).
-
(2007)
Pancreas
, vol.34
, pp. 55-62
-
-
Jiao, L.1
Zhu, J.2
Hassan, M.M.3
Evans, D.B.4
Abbruzzese, J.L.5
Li, D.6
-
15
-
-
3242724826
-
Transrenal DNA as a diagnostic tool: Important technical notes
-
Su YH, Wang M, Block TM et al.: Transrenal DNA as a diagnostic tool: Important technical notes. Ann. NY Acad. Sci. 1022, 81-89 (2004).
-
(2004)
Ann. NY Acad. Sci
, vol.1022
, pp. 81-89
-
-
Su, Y.H.1
Wang, M.2
Block, T.M.3
-
16
-
-
33749060720
-
Novel applications of polymerase chain reaction to urinary nucleic acid analysis
-
Lichtenstein AV, Melkonyan HS, Tomei LD, Umansky SR: Novel applications of polymerase chain reaction to urinary nucleic acid analysis. Methods Mol. Biol. 336, 145-154 (2006).
-
(2006)
Methods Mol. Biol
, vol.336
, pp. 145-154
-
-
Lichtenstein, A.V.1
Melkonyan, H.S.2
Tomei, L.D.3
Umansky, S.R.4
-
17
-
-
2342642789
-
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer
-
Su YH, Wang M, Brenner DE et al.: Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. J. Mol. Diagn. 6, 101-107 (2004).
-
(2004)
J. Mol. Diagn
, vol.6
, pp. 101-107
-
-
Su, Y.H.1
Wang, M.2
Brenner, D.E.3
-
18
-
-
12144291697
-
K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers
-
Destro A, Bianchi P, Alloisio M et al.: K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers. Lung Cancer 44, 23-32 (2004).
-
(2004)
Lung Cancer
, vol.44
, pp. 23-32
-
-
Destro, A.1
Bianchi, P.2
Alloisio, M.3
-
19
-
-
0344062858
-
Detection of K-ras and p53 motations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis
-
Keohavong P, Gao WM, Zheng KC et al.: Detection of K-ras and p53 motations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis. Anal. Biochem. 324, 92-99 (2004).
-
(2004)
Anal. Biochem
, vol.324
, pp. 92-99
-
-
Keohavong, P.1
Gao, W.M.2
Zheng, K.C.3
-
20
-
-
33746155812
-
TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: A prospective study
-
Gormally E, Vineis P, Matullo G et al.: TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Cancer Res. 66, 6871-6876 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 6871-6876
-
-
Gormally, E.1
Vineis, P.2
Matullo, G.3
-
21
-
-
14644405525
-
Molecular diagnosis of solid and cystic lesions of the pancreas
-
Khalid A, Finkelstein S, Mcgrath K: Molecular diagnosis of solid and cystic lesions of the pancreas. Clin. Lab. Med. 25, 101-116 (2005).
-
(2005)
Clin. Lab. Med
, vol.25
, pp. 101-116
-
-
Khalid, A.1
Finkelstein, S.2
Mcgrath, K.3
-
22
-
-
34247345257
-
Cell exfoliation in the human colon: Myth, reality and implications for colorectal cancer screening
-
Loktionov A: Cell exfoliation in the human colon: myth, reality and implications for colorectal cancer screening. Int. J. Cancer 120, 2281-2289 (2007).
-
(2007)
Int. J. Cancer
, vol.120
, pp. 2281-2289
-
-
Loktionov, A.1
-
23
-
-
10844281210
-
Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population
-
Imperiale TF, Ransohoff DF, Itzkowitz SH, Turnbull BA, Ross ME: Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N. Engl. J. Med. 351, 2704-2714 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 2704-2714
-
-
Imperiale, T.F.1
Ransohoff, D.F.2
Itzkowitz, S.H.3
Turnbull, B.A.4
Ross, M.E.5
-
24
-
-
21344459038
-
Noninvasive testing for colorectal cancer: A review
-
Ouyang DL, Chen JJ, Getzenberg RH, Schoen RE: Noninvasive testing for colorectal cancer: a review. Am. J. Gastroenterol. 100, 1393-1403 (2005).
-
(2005)
Am. J. Gastroenterol
, vol.100
, pp. 1393-1403
-
-
Ouyang, D.L.1
Chen, J.J.2
Getzenberg, R.H.3
Schoen, R.E.4
-
25
-
-
15244360703
-
Common gene polymorphisms, cancer progression and prognosis
-
Loktionov A: Common gene polymorphisms, cancer progression and prognosis. Cancer Lett. 208, 1-33 (2004).
-
(2004)
Cancer Lett
, vol.208
, pp. 1-33
-
-
Loktionov, A.1
-
26
-
-
34347355254
-
Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer
-
Rennert G, Kislitsin D, Brenner DE, Rennert HS, Lev Z: Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer. Cancer Lett. 253, 258-264 (2007).
-
(2007)
Cancer Lett
, vol.253
, pp. 258-264
-
-
Rennert, G.1
Kislitsin, D.2
Brenner, D.E.3
Rennert, H.S.4
Lev, Z.5
-
27
-
-
8744251241
-
Enhanced retrieval of DNA from human fecal samples results in improved performance of colorectal cancer screening test
-
Whitney D, Skoletsky J, Moore K et al.: Enhanced retrieval of DNA from human fecal samples results in improved performance of colorectal cancer screening test. J. Mol. Diagn. 6, 386-395 (2004).
-
(2004)
J. Mol. Diagn
, vol.6
, pp. 386-395
-
-
Whitney, D.1
Skoletsky, J.2
Moore, K.3
-
28
-
-
25844481536
-
DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests
-
Olson J, Whitney DH, Durkee K, Shuber AP: DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests. Diagn. Mol. Pathol. 14, 183-191 (2005).
-
(2005)
Diagn. Mol. Pathol
, vol.14
, pp. 183-191
-
-
Olson, J.1
Whitney, D.H.2
Durkee, K.3
Shuber, A.P.4
-
29
-
-
33746866363
-
-
Neri M, Cesario A, Granone P et al.: Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate. Lung Cancer 53, 393-395; author reply 397-398 (2006).
-
Neri M, Cesario A, Granone P et al.: Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate. Lung Cancer 53, 393-395; author reply 397-398 (2006).
-
-
-
-
30
-
-
11844300423
-
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa
-
Yamada S, Yashiro M, Maeda K, Nishiguchi Y, Hirakawa K: A novel high-specificity approach for colorectal neoplasia: detection of K-ras2 oncogene mutation in normal mucosa. Int. J. Cancer. 113, 1015-1021 (2005).
-
(2005)
Int. J. Cancer
, vol.113
, pp. 1015-1021
-
-
Yamada, S.1
Yashiro, M.2
Maeda, K.3
Nishiguchi, Y.4
Hirakawa, K.5
-
31
-
-
75149139024
-
Quantification of K-RAS codon 12 GAT and GTT mutation in colon tumor and non-tumor tissue by allele-specific competetive blocker PCR
-
Presented at:, Los Angeles, CA, USA, 14-18 April, abstract 5245
-
Parsons BL, Marchant KE, Verkler TL et al.: Quantification of K-RAS codon 12 GAT and GTT mutation in colon tumor and non-tumor tissue by allele-specific competetive blocker PCR. Presented at: The Centennial Annual Meeting of the American Association for Cancer Research. Los Angeles, CA, USA, 14-18 April 2007 (abstract 5245).
-
(2007)
The Centennial Annual Meeting of the American Association for Cancer Research
-
-
Parsons, B.L.1
Marchant, K.E.2
Verkler, T.L.3
-
32
-
-
49649106260
-
K-ras mutations in circulating DNA from pancreatic and lung cancers: Bridging methodology for a common validation of the molecular diagnosis value
-
Magistrelli P, Neri M, Granone P, Cesario A, Paleari L, Russo P: K-ras mutations in circulating DNA from pancreatic and lung cancers: bridging methodology for a common validation of the molecular diagnosis value. Pancreas 37, 101-102 (2008).
-
(2008)
Pancreas
, vol.37
, pp. 101-102
-
-
Magistrelli, P.1
Neri, M.2
Granone, P.3
Cesario, A.4
Paleari, L.5
Russo, P.6
-
33
-
-
1842535094
-
Serum tumor markers and molecular biological diagnosis in pancreatic cancer
-
Sawabu N, Watanabe H, Yamaguchi Y, Ohtsubo K, Motoo Y: Serum tumor markers and molecular biological diagnosis in pancreatic cancer. Pancreas 28, 263-267 (2004).
-
(2004)
Pancreas
, vol.28
, pp. 263-267
-
-
Sawabu, N.1
Watanabe, H.2
Yamaguchi, Y.3
Ohtsubo, K.4
Motoo, Y.5
-
34
-
-
45349107664
-
Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
-
Shi C, Fukushima N, Abe T et al.: Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biology Therapy 7, 353-360 (2008).
-
(2008)
Cancer Biology Therapy
, vol.7
, pp. 353-360
-
-
Shi, C.1
Fukushima, N.2
Abe, T.3
-
35
-
-
11144285448
-
Stool screening for colorectal cancer: Molecular approaches
-
Osborn NK, Ahlquist DA: Stool screening for colorectal cancer: molecular approaches. Gastroenterology 128, 192-206 (2005).
-
(2005)
Gastroenterology
, vol.128
, pp. 192-206
-
-
Osborn, N.K.1
Ahlquist, D.A.2
-
36
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: The multicenrer "RASCAL" Study
-
Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA: Kirsten ras mutations in patients with colorectal cancer: the multicenrer "RASCAL" Study. J. Natl. Cancer Inst. 90, 675-684 (1998).
-
(1998)
J. Natl. Cancer Inst
, vol.90
, pp. 675-684
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
Oates, J.R.4
Clarke, P.A.5
-
37
-
-
0035444798
-
Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
-
Andreyev HJ, Norman AR, Cunningham D et al.: Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study. Br. J. Cancer 85, 692-696 (2001).
-
(2001)
Br. J. Cancer
, vol.85
, pp. 692-696
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
-
38
-
-
68549136810
-
Assessment of K-ras mutation, a step toward personalized medicine for patients with colorectal cancer
-
Jiang Y, Kimchi ET, Staveley-O'Carroll KF, Cheng H, Ajani JA: Assessment of K-ras mutation, a step toward personalized medicine for patients with colorectal cancer. Cancer 115, 3609-3617 (2009).
-
(2009)
Cancer
, vol.115
, pp. 3609-3617
-
-
Jiang, Y.1
Kimchi, E.T.2
Staveley-O'Carroll, K.F.3
Cheng, H.4
Ajani, J.A.5
-
39
-
-
67650082332
-
Fast simultaneous detection of K-RAS mutations in colorectal cancer
-
Chang YS, Yeh KT, Chang TJ et al.: Fast simultaneous detection of K-RAS mutations in colorectal cancer. BMC Cancer 9, 179 (2009).
-
(2009)
BMC Cancer
, vol.9
, pp. 179
-
-
Chang, Y.S.1
Yeh, K.T.2
Chang, T.J.3
-
40
-
-
60849087350
-
-
Winder T, Scheithauer W, Lang A: K-ras mutations and cetuximab in colorectal cancer. N. Engl. J. Med. 360, 834-835; author reply 835-836 (2009).
-
Winder T, Scheithauer W, Lang A: K-ras mutations and cetuximab in colorectal cancer. N. Engl. J. Med. 360, 834-835; author reply 835-836 (2009).
-
-
-
-
41
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
Riely GJ, Kris MG, Rosenbaum D et al.: Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin. Cancer Res. 14, 5731-5734 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
-
42
-
-
4143133293
-
Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers
-
Wang JY, Hsieh JS, Chang MY et al.: Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. World J. Surg. 28, 721-726 (2004).
-
(2004)
World J. Surg
, vol.28
, pp. 721-726
-
-
Wang, J.Y.1
Hsieh, J.S.2
Chang, M.Y.3
-
43
-
-
33846537534
-
Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases
-
Trevisiol C, Di Fabio F, Nascimbeni R et al.: Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases. Int. J. Biol. Markers 21, 223-228 (2006).
-
(2006)
Int. J. Biol. Markers
, vol.21
, pp. 223-228
-
-
Trevisiol, C.1
Di Fabio, F.2
Nascimbeni, R.3
-
44
-
-
33745622160
-
INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study
-
INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. Ann. Oncol. 17(Suppl. 7), vii84-vii90 (2006).
-
(2006)
Ann. Oncol
, vol.17
, Issue.SUPPL. 7
-
-
Bazan, V.1
Bruno, L.2
Augello, C.3
-
45
-
-
41649114743
-
Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer
-
Frattini M, Gallino G, Signoroni S et al.: Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer. Cancer Lett. 263, 170-181 (2008).
-
(2008)
Cancer Lett
, vol.263
, pp. 170-181
-
-
Frattini, M.1
Gallino, G.2
Signoroni, S.3
-
46
-
-
67749113684
-
Results of Phase I trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation
-
Olsen CC, Schefter TE, Chen H et al.: Results of Phase I trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation. Am. J. Clin. Oncol. 32, 115-121 (2009).
-
(2009)
Am. J. Clin. Oncol
, vol.32
, pp. 115-121
-
-
Olsen, C.C.1
Schefter, T.E.2
Chen, H.3
-
47
-
-
19944430434
-
The rule of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis
-
Mascaux C, lannino N, Martin B et al.: The rule of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Br. J. Cancer 92, 131-139 (2005).
-
(2005)
Br. J. Cancer
, vol.92
, pp. 131-139
-
-
Mascaux, C.1
lannino, N.2
Martin, B.3
-
48
-
-
34547183500
-
Origin and prognostic value of circulating KRAS mutatinos in lung cancer patients
-
Gautschi O, Huegli B, Ziegler A et al.: Origin and prognostic value of circulating KRAS mutatinos in lung cancer patients. Cancer Lett. 254, 265-273 (2007).
-
(2007)
Cancer Lett
, vol.254
, pp. 265-273
-
-
Gautschi, O.1
Huegli, B.2
Ziegler, A.3
-
49
-
-
33644499780
-
Is there a prognostic role of K-ras point mutations in the serum of patients with advanced nun-small cell lung cancer?
-
Camps C, Sirera R, Bremnes R et al.: Is there a prognostic role of K-ras point mutations in the serum of patients with advanced nun-small cell lung cancer? Lung Cancer 50, 339-346 (2005).
-
(2005)
Lung Cancer
, vol.50
, pp. 339-346
-
-
Camps, C.1
Sirera, R.2
Bremnes, R.3
-
50
-
-
33746866363
-
Prognostic rule of K-ras mutations in non-small cell lung cancer: Still an issue for open debate
-
Neri M, Cesario A, Granone P et al.: Prognostic rule of K-ras mutations in non-small cell lung cancer: still an issue for open debate. Lung Cancer 53, 393-395 (2006).
-
(2006)
Lung Cancer
, vol.53
, pp. 393-395
-
-
Neri, M.1
Cesario, A.2
Granone, P.3
-
51
-
-
33646044427
-
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA
-
Marchese R, Muleti A, Pasqualetti P et al.: Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA. Pancreas 32, 171-177 (2006).
-
(2006)
Pancreas
, vol.32
, pp. 171-177
-
-
Marchese, R.1
Muleti, A.2
Pasqualetti, P.3
-
52
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ et al.: KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2, E17 (2005).
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
53
-
-
33947504732
-
Phase II clinical trial ufchemutherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer
-
Jackman DM, Yeap BY, Lindeman NI et al.: Phase II clinical trial ufchemutherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J. Clin. Oncol. 25, 760-766 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 760-766
-
-
Jackman, D.M.1
Yeap, B.Y.2
Lindeman, N.I.3
-
54
-
-
61449341457
-
Epidermal growth factor receptor-related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: An analysis of patients from German centers in the TRUST study
-
Schneider CP, Heigener D, Schurt-Von-Romer K et al.: Epidermal growth factor receptor-related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: an analysis of patients from German centers in the TRUST study. J. Thoracic Oncol. 3, 1446-1453 (2008).
-
(2008)
J. Thoracic Oncol
, vol.3
, pp. 1446-1453
-
-
Schneider, C.P.1
Heigener, D.2
Schurt-Von-Romer, K.3
-
55
-
-
41149097557
-
Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib
-
Miller VA, Riely GJ, Zakowski MF et al.: Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J. Clin. Oncol. 26, 1472-1478 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1472-1478
-
-
Miller, V.A.1
Riely, G.J.2
Zakowski, M.F.3
-
56
-
-
52749099497
-
Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
Linardou H, Dahabreh IJ, Kanaloupiti D et al.: Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 9, 962-972 (2008).
-
(2008)
Lancet Oncol
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
-
57
-
-
33646228635
-
-
Lievre A, Bachet JB, Le Corre D et al.: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66, 3992-3995 (2006). ■■ Important in establishing that K-RAS mutant tumor status could predict failure to respond to therapies directed against the EGFR.
-
Lievre A, Bachet JB, Le Corre D et al.: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66, 3992-3995 (2006). ■■ Important in establishing that K-RAS mutant tumor status could predict failure to respond to therapies directed against the EGFR.
-
-
-
-
58
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
-
Di Fiore F, Blanchard F, Charbonnier F et al.: Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br. J. Cancer 96, 1166-1169 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
-
59
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J et al.: KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann. Oncol. 19, 508-515 (2008).
-
(2008)
Ann. Oncol
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
-
60
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini M, Saletti P, Romagnani E et al.: PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br. J. Cancer 97, 1139-1145 (2007).
-
(2007)
Br. J. Cancer
, vol.97
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
-
61
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ et al.: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 25, 3230-3237 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
62
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ et al.: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359, 1757-1765 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
63
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E et al.: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360, 1408-1417 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
64
-
-
44449090596
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
-
Freeman DJ, Juan T, Reiner M et al.: Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin. Colorectal Cancer 7, 184-190 (2008).
-
(2008)
Clin. Colorectal Cancer
, vol.7
, pp. 184-190
-
-
Freeman, D.J.1
Juan, T.2
Reiner, M.3
-
65
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M et al.: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26, 1626-1634 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
66
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F et al.: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 67, 2643-2648 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
-
67
-
-
63749087499
-
The marriage of growth factor inhibitors and chemotherapy: Bliss or bust?
-
Staal S, O'connell MJ, Allegra CJ: The marriage of growth factor inhibitors and chemotherapy: bliss or bust? J. Clin. Oncol. 27, 1545-1548 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1545-1548
-
-
Staal, S.1
O'connell, M.J.2
Allegra, C.J.3
-
68
-
-
67349152647
-
Treatment in advanced colorectal cancer: What, when and how?
-
Chau I, Cunningham D: Treatment in advanced colorectal cancer: what, when and how? Br. J. Cancer 100, 1704-1719 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 1704-1719
-
-
Chau, I.1
Cunningham, D.2
-
69
-
-
65349189958
-
American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra CJ, Jessup JM, Somerfield MR et al.: American Society of Clinical Oncology Provisional Clinical Opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27, 2091-2096 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
-
71
-
-
26444574802
-
Development of farnesyl transferase inhibitors: A review
-
Appels NM, Beijnen JH, Schellens JH: Development of farnesyl transferase inhibitors: a review. Oncologist 10, 565-578 (2005).
-
(2005)
Oncologist
, vol.10
, pp. 565-578
-
-
Appels, N.M.1
Beijnen, J.H.2
Schellens, J.H.3
-
72
-
-
33847209553
-
Targeting the RAS signaling pathway in malignant hematologic diseases
-
Morgan MA, Ganser A, Reuter CW: Targeting the RAS signaling pathway in malignant hematologic diseases. Curr. Drug Targets 8, 217-235 (2007).
-
(2007)
Curr. Drug Targets
, vol.8
, pp. 217-235
-
-
Morgan, M.A.1
Ganser, A.2
Reuter, C.W.3
-
73
-
-
24644522923
-
Immunization with mutant p53- and K-ras-derived peptides in cancer patients: Immune response and clinical outcome
-
Carbone DP, Ciernik IF, Kelley MJ et al.: Immunization with mutant p53- and K-ras-derived peptides in cancer patients: Immune response and clinical outcome. J. Clin. Oncol. 23, 5099-5107 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5099-5107
-
-
Carbone, D.P.1
Ciernik, I.F.2
Kelley, M.J.3
-
74
-
-
24944573845
-
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: The role of K-Ras
-
Brunner TB, Cengel KA, Hahn SM et al.: Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras. Cancer Res. 65, 8433-8441 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 8433-8441
-
-
Brunner, T.B.1
Cengel, K.A.2
Hahn, S.M.3
-
75
-
-
0347479269
-
Oligoclonality in bladder cancer: The implication for molecular therapies
-
Duggan BJ, Gray SB, Mcknight JJ, Watson CJ, Johnston SR, Williamson KE: Oligoclonality in bladder cancer: the implication for molecular therapies. J. Urol. 171, 419-425 (2004).
-
(2004)
J. Urol
, vol.171
, pp. 419-425
-
-
Duggan, B.J.1
Gray, S.B.2
Mcknight, J.J.3
Watson, C.J.4
Johnston, S.R.5
Williamson, K.E.6
-
76
-
-
33846614926
-
Polyclonal tumors in the mammalian intestine: Are interactions among multiple initiated clones necessary for tumor initiation, growth, and progression?
-
Halberg RB, Dove WF: Polyclonal tumors in the mammalian intestine: are interactions among multiple initiated clones necessary for tumor initiation, growth, and progression? Cell Cycle 6, 44-51 (2007).
-
(2007)
Cell Cycle
, vol.6
, pp. 44-51
-
-
Halberg, R.B.1
Dove, W.F.2
-
77
-
-
50049087526
-
Many different tumor types have polyclonal tumor origin: Evidence and implications
-
A discussion of how X chromosome inactivation data has heen misinterpreted and a review of evidence supporting polyclonal tumor origin, ■■
-
Parsons BL: Many different tumor types have polyclonal tumor origin: evidence and implications. Mutat. Res. 659, 232-247 (2008). ■■ A discussion of how X chromosome inactivation data has heen misinterpreted and a review of evidence supporting polyclonal tumor origin.
-
(2008)
Mutat. Res
, vol.659
, pp. 232-247
-
-
Parsons, B.L.1
-
78
-
-
0842289998
-
-
DieterIe CP, Conzelmann M, Linnemann U, Berger MR: Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients. Clin. Cancer Res. 10, 641-650 (2004). ■■ Establishes that K-RAS mutation is present in colon tumors as subpopulations.
-
DieterIe CP, Conzelmann M, Linnemann U, Berger MR: Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients. Clin. Cancer Res. 10, 641-650 (2004). ■■ Establishes that K-RAS mutation is present in colon tumors as subpopulations.
-
-
-
-
79
-
-
62549159130
-
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping
-
Beau-Faller M, Legrain M, Voegeli AC et al.: Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping. Br. J. Cancer 100, 985-992 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 985-992
-
-
Beau-Faller, M.1
Legrain, M.2
Voegeli, A.C.3
-
80
-
-
20044364933
-
EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
-
Marchetti A, Martella C, Felicioni L et al.: EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J. Clin. Oncol. 23, 857-865 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 857-865
-
-
Marchetti, A.1
Martella, C.2
Felicioni, L.3
-
81
-
-
33646336666
-
Rapid, simple, and accurate detection of K-ras mutations from body fluids using real-time PCR and DNA melting curve analysis
-
Mori S, Sugahara K, Uemura A et al.: Rapid, simple, and accurate detection of K-ras mutations from body fluids using real-time PCR and DNA melting curve analysis. Lab. Med. 37, 286-289 (2006).
-
(2006)
Lab. Med
, vol.37
, pp. 286-289
-
-
Mori, S.1
Sugahara, K.2
Uemura, A.3
-
82
-
-
48349089925
-
Clinical interest of KRAS mutation detection in blood for anti-EGFR therapies in metastatic colorectal cancer
-
Di Fiore F, Charbonnier F, Lefebure B et al.: Clinical interest of KRAS mutation detection in blood for anti-EGFR therapies in metastatic colorectal cancer. Br. J. Cancer 99, 551-552 (2008).
-
(2008)
Br. J. Cancer
, vol.99
, pp. 551-552
-
-
Di Fiore, F.1
Charbonnier, F.2
Lefebure, B.3
-
83
-
-
51649084560
-
Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer
-
Artale S, Sartore-Bianchi A, Veronese SM et al.: Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. J. Clin. Oncol. 26, 4217-4219 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 4217-4219
-
-
Artale, S.1
Sartore-Bianchi, A.2
Veronese, S.M.3
-
84
-
-
23444451456
-
Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer
-
Trombino S, Neri M, Puntoni R et al.: Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer. Clin. Chem. 51, 1313-1314 (2005).
-
(2005)
Clin. Chem
, vol.51
, pp. 1313-1314
-
-
Trombino, S.1
Neri, M.2
Puntoni, R.3
-
85
-
-
68849120567
-
KRAS mutation testing in colorectal cancer
-
Plesec TP, Hunt JL: KRAS mutation testing in colorectal cancer. Adv. Anat. Pathol. 16, 196-203 (2009).
-
(2009)
Adv. Anat. Pathol
, vol.16
, pp. 196-203
-
-
Plesec, T.P.1
Hunt, J.L.2
-
86
-
-
54249098184
-
KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program
-
Van Krieken JH, Jung A, Kirchner T et al.: KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program. Virchows Arch. 453, 417-431 (2008).
-
(2008)
Virchows Arch
, vol.453
, pp. 417-431
-
-
Van Krieken, J.H.1
Jung, A.2
Kirchner, T.3
-
87
-
-
61449154484
-
KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: Practical application of patient selection
-
Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG: KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J. Clin. Oncol. 27, 1130-1136 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1130-1136
-
-
Jimeno, A.1
Messersmith, W.A.2
Hirsch, F.R.3
Franklin, W.A.4
Eckhardt, S.G.5
-
88
-
-
48249093095
-
Integration and use of biomarkers in drug development, regulation and clinic practice: A US regulatory perspective
-
Amur S, Frueh FW, Lesko LJ, Huang S: Integration and use of biomarkers in drug development, regulation and clinic practice: a US regulatory perspective. Biomarkers Med. 2, 305-311 (2008).
-
(2008)
Biomarkers Med
, vol.2
, pp. 305-311
-
-
Amur, S.1
Frueh, F.W.2
Lesko, L.J.3
Huang, S.4
-
89
-
-
52249114928
-
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine
-
Su YH, Song J, Wang Z et al.: Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine. Ann. NY Acad. Sci. 1137, 82-91 (2008).
-
(2008)
Ann. NY Acad. Sci
, vol.1137
, pp. 82-91
-
-
Su, Y.H.1
Song, J.2
Wang, Z.3
-
90
-
-
0037182166
-
Detection of rare K-RAS codon 12 mutations using allele-specific competitive blocker PCR
-
Mckinzie PB, Parsons BL: Detection of rare K-RAS codon 12 mutations using allele-specific competitive blocker PCR. Mutat. Res. 517(1-2), 209-220 (2002).
-
(2002)
Mutat. Res
, vol.517
, Issue.1-2
, pp. 209-220
-
-
Mckinzie, P.B.1
Parsons, B.L.2
-
91
-
-
51349141191
-
Circulating mutant DNA to assess tumor dynamics
-
Diehl F, Schmidt K, Choti MA et al.: Circulating mutant DNA to assess tumor dynamics. Nat. Med. 14, 985-990 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 985-990
-
-
Diehl, F.1
Schmidt, K.2
Choti, M.A.3
-
92
-
-
1542269094
-
Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: Comparison with restriction fragment length polymorphism analysis
-
Chen CY, Shiesh SC, Wu SJ: Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: comparison with restriction fragment length polymorphism analysis. Clin. Chem. 50, 481-489 (2004).
-
(2004)
Clin. Chem
, vol.50
, pp. 481-489
-
-
Chen, C.Y.1
Shiesh, S.C.2
Wu, S.J.3
-
93
-
-
4344636975
-
Isothermal multiple displacement amplification: A highly reliable approach for generating unlimited high molecular weight genomic DNA from clinical specimens
-
Luthra R, Medeiros U: Isothermal multiple displacement amplification: a highly reliable approach for generating unlimited high molecular weight genomic DNA from clinical specimens. J. Mol. Diagn. 6, 236-242 (2004).
-
(2004)
J. Mol. Diagn
, vol.6
, pp. 236-242
-
-
Luthra, R.1
Medeiros, U.2
-
94
-
-
24344441905
-
Detection of circulating cancer cells with K-ras oncogene using membrane array
-
Chen YF, Wang JY, Wu CH, Chen FM, Cheng TL, Lin SR: Detection of circulating cancer cells with K-ras oncogene using membrane array. Cancer Lett. 229, 115-122 (2005).
-
(2005)
Cancer Lett
, vol.229
, pp. 115-122
-
-
Chen, Y.F.1
Wang, J.Y.2
Wu, C.H.3
Chen, F.M.4
Cheng, T.L.5
Lin, S.R.6
-
95
-
-
43249116705
-
Replacing PCR with COLD -PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
-
Li J, Wang L, Mamon H, Kulke MH, Berbeco R, Makrigiorgos GM: Replacing PCR with COLD -PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing. Nat. Med. 14, 579-584 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 579-584
-
-
Li, J.1
Wang, L.2
Mamon, H.3
Kulke, M.H.4
Berbeco, R.5
Makrigiorgos, G.M.6
-
96
-
-
66049147740
-
Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis
-
Chen YL, Chang YS, Chang JG, Wu SM: Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis. J. Chromatography A 1216, 5147-5154 (2009).
-
(2009)
J. Chromatography A
, vol.1216
, pp. 5147-5154
-
-
Chen, Y.L.1
Chang, Y.S.2
Chang, J.G.3
Wu, S.M.4
-
97
-
-
67349119870
-
A novel mutant allele specific amplification and electrochemiluminescence method for the detection of point mutation in clinical samples
-
Zhu D, Xing D, Tang Y, Zhang L: A novel mutant allele specific amplification and electrochemiluminescence method for the detection of point mutation in clinical samples. Biosensors Bioelectronics 24, 3306-3310 (2009).
-
(2009)
Biosensors Bioelectronics
, vol.24
, pp. 3306-3310
-
-
Zhu, D.1
Xing, D.2
Tang, Y.3
Zhang, L.4
-
98
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A et al.: Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N. Engl. J. Med. 360, 563-572 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
99
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A et al.: Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 27, 663-671 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
100
-
-
59949102930
-
A randomized Phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T et al.: A randomized Phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 27, 672-680 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
101
-
-
75149154727
-
-
Catalogue of Somatic Mutations in Cancer. www.sanger.ac.uk/genetics/CGP/ cosmic/ ■ A valuable resource for quick retrieval of pertinent information regarding the propensity for particular tumor types to carry particular tumor-associated mutations, includes data for many different oncogenes and tumor suppressor genes
-
Catalogue of Somatic Mutations in Cancer. www.sanger.ac.uk/genetics/CGP/ cosmic/ ■ A valuable resource for quick retrieval of pertinent information regarding the propensity for particular tumor types to carry particular tumor-associated mutations, includes data for many different oncogenes and tumor suppressor genes
-
-
-
-
102
-
-
75149131243
-
-
College of American Pathologists Perspectives on Emerging Technology POET
-
College of American Pathologists Perspectives on Emerging Technology (POET) report. www.cap.org/apps/docs/committees/ technology/KRAS.pdf
-
report
-
-
-
103
-
-
75149185004
-
-
Draft guidance for industry, clinical laboratories, and FDA staff on in vitro diagnostic multivariate index assays. www.fda.gov/cdrh/oivd/ guidance/1610.pdf
-
Draft guidance for industry, clinical laboratories, and FDA staff on in vitro diagnostic multivariate index assays. www.fda.gov/cdrh/oivd/ guidance/1610.pdf
-
-
-
|