Molecular diagnosis of solid and cystic lesions of the pancreas

Clinics in Laboratory Medicine

Volumn 25, Issue 1, 2005, Pages 101-116

  Khalid, Asif ^a,b   Finkelstein, Sydney ^a   McGrath, Kevin ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b University Drive   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRCA2 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; TELOMERASE; TUMOR MARKER;

ADVANCED CANCER; ALLELE; ASPIRATION BIOPSY; BLOOD ANALYSIS; CANCER CYTODIAGNOSIS; CANCER DIAGNOSIS; CANCER SCREENING; CANCER SURGERY; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DISEASE MARKER; DNA DETERMINATION; DNA MICROARRAY; EARLY DIAGNOSIS; ENDOSCOPIC ECHOGRAPHY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE LOSS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENOTYPE; HIGH RISK POPULATION; HUMAN; MICRODISSECTION; MICROSATELLITE MARKER; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE K RAS; PANCREAS CANCER; PANCREAS CYST; PANCREAS JUICE; POINT MUTATION; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROTEOMICS; RELIABILITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; SOLID TUMOR; TUMOR SUPPRESSOR GENE;

EID: 14644405525     PISSN: 02722712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cll.2004.12.009     Document Type: Review

References (87)

1. A. Jemal, A. Thomas, T. Murray, and M. Thun Cancer statistics 2002 CA Cancer J Clin 52 2002 23 47
2. M. Trede, G. Schwall, and H.D. Sager Survival after pancreatoduodenectomy Ann Surg 211 1990 447 458
3. J.L. Cameron, D.W. Crist, J.V. Sitzmann, R.H. Hruban, J.K. Boitnott, and A.J. Seidler Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer Am J Surg 161 1991 120 125
4. T.A. Sohn, C.J. Yeo, J.L. Cameron, L. Koniaris, S. Kaushal, and R.A. Abrams Resected adenocarcinoma of the pancreas- 616 patients: results, outcomes, and prognostic indicators J Gastrointest Surg 4 2000 567 579
5. C.J. Stewart, P.R. Mills, R. Carter, J. O'Donohue, G. Fullarton, and C.W. Imrie Brush cytology in the assessment of pancreaticobiliary strictures: a review of 406 cases J Clin Pathol 54 2001 449 455
6. V. Pugliese, N. Pujic, S. Saccomanno, B. Gatteschi, C. Pera, and H. Aste Pancreatic intraductal sampling during ERCP in patients with chronic pancreatitis and pancreatic cancer: cytologic studies and k-ras-2 codon 12 molecular analysis in 47 cases Gastrointest Endosc 54 2001 595 599
7. R.J. Farrell, A.K. Jain, S.L. Brandwein, H. Wang, R. Chuttani, and D.K. Pleskow The combination of stricture dilation, endoscopic needle aspiration, and biliary brushings significantly improves diagnostic yield from malignant bile duct strictures Gastrointest Endosc 54 2001 587 594
8. E. Macken, M. Drijkoningen, E. Van Aken, and W. Van Steenbergen Brush cytology of ductal strictures during ERCP Acta Gastroenterol Belg 63 2000 254 259
9. B. Glasbrenner, M. Ardan, W. Boeck, G. Preclik, P. Moller, and G. Adler Prospective evaluation of brush cytology of biliary strictures during endoscopic retrograde cholangiopancreatography Endoscopy 31 1999 712 717
10. R.H. Hruban, R.E. Wilentz, and S.E. Kern Genetic progression in the pancreatic ducts Am J Pathol 156 2000 1821 1825
11. R.H. Hruban, N.V. Adsay, J. Albores-Saavedra, C. Comptom, E.S. Garrett, and S.N. Goodman Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions Am J Surg Pathol 25 2001 579 586
12. J.D. Day, J.A. Digiuseppe, C. Yeo, M. Lai-Goldman, S.M. Anderson, and S.N. Goodman Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms Hum Pathol 27 1996 119 124
13. R.H. Hruban, A.D. van Mansfeld, G.J. Offerhaus, D.H. van Weering, D.C. Allison, and S.N. Goodman K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization Am J Pathol 143 1993 545 554
14. C. Caldas, S.A. Hahn, R.H. Hruban, M.S. Redston, C.J. Yeo, and S.E. Kern Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia Cancer Res 54 1994 3568 3573
15. J. Luttges, B. Schlehe, M.A. Menke, I. Vogel, D. Henne-Bruns, and G. Kloppel The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium Cancer 85 1999 1703 1710
16. C.A. Moskaluk, R.H. Hruban, and S.E. Kern p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma Cancer Res 57 1997 2140 2143
17. M. Tada, M. Ohashi, Y. Shiratori, T. Okudaira, Y. Komatsu, and T. Kawabe Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease Gastroenterology 110 1996 227 231
18. P.G. Terhune, D.M. Phifer, T.D. Tosteson, and D.S. Longnecker K-ras mutation in focal proliferative lesions of human pancreas Cancer Epidemiol Biomarkers Prev 7 1998 515 521
19. R.E. Wilentz, J. Geradts, R. Maynard, G.J.A. Offerhaus, M. Kang, and M. Goggins Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression Cancer Res 58 1998 4740 4744
20. R.E. Wilentz, C.A. Iacobuzio-Donahue, P. Argani, D.M. McCarthy, J.L. Parsons, and C.J. Yeo Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression Cancer Res 60 2000 2002 2006
21. M. Goggins, R.H. Hruban, and S.E. Kern BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications Am J Pathol 156 2000 1767 1771
22. C. Almoguera, D. Shibata, K. Forrester, J. Martin, N. Arnheim, and M. Perucho Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes Cell 53 1988 549 554
23. G. Berrozpe, J. Schaeffer, M.A. Peinado, F.X. Real, and M. Perucho Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer Int J Cancer 58 1994 185 191
24. N.F. Gonzalez-Cadavid, D. Zhou, H. Battifora, M. Bar-Eli, and M.J. Cline Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas Oncogene 4 1989 1137 1140
25. N.S. Pellegata, F. Sessa, B. Renault, M. Bonato, B.E. Leone, and E. Solcia K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions Cancer Res 54 1994 1556 1560
26. K. Grunewald, J. Lyons, A. Frohlich, H. Feichtinger, R.A. Weger, and G. Schwab High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas Int J Cancer 43 1989 1037 1041
27. K. Motojima, T. Tsunoda, T. Kanematsu, Y. Nagata, T. Urano, and H. Shiku Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene Ann Surg 214 1991 657 662
28. G. Capella, S. Cronauer-Mitra, M.A. Pienado, and M. Perucho Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors Environ Health Perspect 93 1991 125 131
29. M. Tada, M. Omata, S. Kawai, H. Saisho, M. Ohto, and R.K. Saiki Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma Cancer Res 53 1993 2472 2474
30. H. Kondo, K. Sugano, N. Fukayama, A. Kyogoku, H. Nose, and K. Shimada Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma Cancer 73 1994 1589 1594
31. J.L. Abbruzzese, D.B. Evans, L. Larry, T. King, I. Raijman, and M.L. Frazier Molecular diagnosis of cancer of the exocrine pancreas Int J Pancreatol 16 1994 331
32. D. Shibata, C. Almoguera, K. Forrester, J. Dunitz, S.E. Martin, and M.M. Cosgrove Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas Cancer Res 50 1990 1279 1283
33. D.B. Evans, M.L. Frazier, C. Charnsangavej, R.L. Katz, L. Lilly, and J.L. Abbruzzese Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique Ann Surg Oncol 3 1996 241 246
34. P. Berthelemy, M. Bouisson, J. Escourrou, N. Vaysse, J.L. Rumeau, and L. Pradayrol Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer Ann Intern Med 123 1995 188 191
35. L. Trumper, M. Menges, H. Daus, D. Kohler, J.O. Reinhard, and M. Sackman Lowe sensitivity of the k-ras polymerase chain reaction for diagnosing pancreatic cancer from pancreatic juice and bile: a multi-center prospective trial J Clin Oncol 20 2002 4331 4337
36. N. Furuya, S. Kawa, T. Akamatsu, and K. Furihata Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice Gastroenterology 113 1997 593 598
37. A. Castells, P. Puig, J. Mora, J. Boadas, L. Boix, and E. Urgell K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance J Clin Oncol 17 1999 578 584
38. H.E. Mulcahy, J. Lyautey, C. Lederrey, X. qi Chen, P. Anker, and E.M. Alstead A prospective study of K-ras mutations in the plasma of pancreatic cancer patients Clin Cancer Res 4 1998 271 275
39. T. Yamada, S. Nakamori, H. Ohzato, S. Oshima, T. Aoki, and N. Higaki Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features Clin Cancer Res 4 1998 1527 1532
40. N. Suehara, K. Mizumoto, T. Muta, Y. Tominaga, H. Shimura, and S. Kitajima Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states Clin Cancer Res 3 1997 993 998
41. C.P. Morales, J.S. Burdick, H.S. Saboorian, W.E. Wright, and J.W. Shay In situ hybridization for telomerase RNA in routine cytology brushing for the diagnosis of pancreatobiliary malignancies Gastrointest Endosc 48 1998 402 405
42. R. Dahse, W. Fiedler, and G. Ernst Telomeres and telomerase: biological and clinical importance Clin Chem 43 5 1997 708 714
43. K. Yoshida, T. Sugino, S. Goodison, B.F. Warren, D. Nolan, and S. Wadsworth Detection of telomerase activity in exfoliated cancer cells in colonic luminal washings and its related clinical implications Br J Cancer 75 1997 548 553
44. E. Hiyama, T. Kodama, K. Shinbara, T. Iwoa, M. Itoh, and K. Hyama Telomerase activity is detected in pancreatic cancer but not in benign tumors Cancer Res 57 1997 326 331
45. K. Mizumoto, M. Suehara, T. Muta, S. Kitajima, N. Hamasaki, and Y. Tominaga Semi-quantitative analysis of telomerase in pancreatic ductal adenocarcinoma J Gastroenterol 31 6 1996 894 897
46. C. Chadeneau, K. Hay, H.W. Hirte, S. Gallinger, and S. Bacchetti Telomerase activity associated with acquisition of malignancy in human colorectal cancer Cancer Res 55 1995 2533 2536
47. E. Hiyama, T. Yokoyama, N. Tatsumoto, K. Hiyama, Y. Imamura, and Y. Murakami Telomerase activity in gastric cancer Cancer Res 55 1995 3258 3262
48. H. Tahara, T. Nakanishi, M. Kitamoto, R. Nakashio, J.W. Shay, and E. Tahara Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas Cancer Res 55 1995 2734 2736
49. N. Suehara, K. Mizumoto, M. Tanaka, H. Niiyama, K. Yokohata, and Y. Tominaga Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis Clin Cancer Res 3 1997 2479 2483
50. T. Iwao, E. Hiyama, T. Yokoyama, A. Tsuchida, K. Hiyama, and Y. Murakami Telomerase activity for the preoperative diagnosis of pancreatic cancer J Natl Cancer Inst 89 1997 1621 1623
51. N. Suehara, K. Mizumoto, M. Kusumoto, H. Niiyama, T. Ogawa, and K. Yamaguchi Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer Am J Gastroenterol 93 1998 1967 1971
52. A.S. Pearson, P. Chiao, L. Zhang, W. Zhang, L. Larry, and R.L. Katz The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration Int J Oncol 17 2000 381 385
53. N. Kim, M. Piatyzek, K. Prowse, C.B. Harley, M.D. West, and P.L. Ho Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2014
54. P. Buchler, J.R. Conejo-Garcia, G. Lehmann, M. Muller, T. Emrich, and H.A. Reber Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders Pancreas 22 2001 331 340
55. K. Uemura, E. Hiyama, Y. Murakami, T. Kanehiro, H. Ohge, and T. Sueda Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours Oncol Rep 10 2003 277 283
56. H. Uehara, A. Nakaizumi, M. Tatsuta, M. Baba, A. Takenaka, and N. Uedo Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations Am J Gastroenterol 94 1999 2513 2518
57. S.K. Apple, J.R. Hecht, D.N. Lewin, S.A. Jahromi, W.W. Grody, and R.K. Nieberg Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multi-step carcinogenesis Hum Pathol 30 1999 123 129
58. R.M. Schmid Genetic basis of pancreatic cancer Best Pract and Clin Gastroenterol 16 2002 421 433
59. E. Rozenblum, M. Schutte, M. Goggins, S.A. Hahn, S. Panzer, and M. Zahurak Tumor suppressive pathways in pancreatic carcinoma Cancer Res 57 1997 1731 1734
60. K. Mizumoto, and M. Tanaka Genetic diagnosis of pancreatic cancer J Hepatobiliary Pancreat Surg 9 2002 39 44
61. C.A. Griffin, R.H. Hruban, L.A. Morsberger, T. Ellingham, P.P. Long, and E.M. Jaffee Consistent chromosome abnormalities in adenocarcinoma of the pancreas Cancer Res 55 1995 2394 2399
62. A. Rashid Cellular and molecular biology of biliary tract cancers Surg Oncol Clin N Am 11 2002 995 1009
63. J.L. Ku, K.A. Yoon, I.J. Kim, W.H. Kim, J.Y. Jang, and K.S. Suh Establishment and characterization of six human biliary tract cancer cell lines Br J Cancer 87 2002 187 193
64. Y.K. Kang, Y.I. Kim, and W.H. Kim Allelotype analysis of intrahepatic cholangiocarcinoma Mod Pathol 13 2000 627 631
65. A. Khalid, E. Sasatomi, P. Swalsky, and S. Finkelstein Microdissection based broad panel LOH analysis improves the diagnostic accuracy of ERCP brush cytology of biliary strictures Gastrointest Endosc 55 2002 AB92
66. A. Khalid, K. McGrath, R. Pal, D. Brody, A. Slivka, P. Swalsky, and S. Finkelstein Microdissection-based genotyping improves the accuracy of EUS-guided FNA of pancreatic tumors Gastrointest Endosc 59 2004 AB94
67. C. Rosty, L. Christa, S. Kuzdzal, W. Baldwin, M. Zahurak, and F. Carnot Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology Cancer Res 62 2002 1868 1875
68. T. Yamada, S. Nakamori, H. Ohzato, S. Oshima, T. Aoki, and N. Higaki Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features Clin Cancer Res 4 1998 1527 1532
69. R.E. Wilentz, C.H. Chung, P.D. Sturm, A. Musler, T.A. Sohn, and G.J. Offerhaus K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma Cancer 82 1988 96 103
70. D.L. Conwell, G. Zuccaro Jr., J.J. Vargo, P.A. Trolli, F. Vanlente, and N. Obuchowski An endoscopic pancreatic function test with synthetic porcine secretin for the evaluation of chronic abdominal pain and suspected chronic pancreatitis Gastrointest Endosc 57 2003 37 40
71. H. Zhou, M. Schotanus, D. Dillon, R. Brand, J. Costa, and P. Lizardi Highly multiplexed protein analysis of sera from pancreatic cancer patients and controls using antibody microarrays Pancreas 27 2003 419A
72. P. Argani, C. Iacobuzio-Donahue, B. Ryu, C. Rosty, M. Goggins, and R.E. Wilentz Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE) Clin Cancer Res 7 2001 3862 3868
73. C.A. Iacubuzio-Donahue, A. Maitra, M. Olsen, A.W. Lowe, N.T. Van Heek, and C. Rosty Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays Am J Pathol 162 2003 1151 1162
74. T. van Heek, A.E. Rader, G.J. Offerhaus, D.M. McCarthy, M. Goggins, and R.H. Hruban K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis Am J Clin Pathol 117 2002 755 765
75. N. Fukushima, N. Sato, T. Ueki, C. Rosty, K.M. Walter, and R.E. Wilentz Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma Am J Pathol 160 2002 1573 1581
76. N. Fukushima, K.M. Walter, T. Uek, N. Sato, H. Matsubayashi, and J.L. Cameron Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice Cancer Biol Ther 2 2003 78 83
77. M. Tascilar, G.J. Offerhaus, R. Altink, P. Argani, T.A. Sohn, and C.J. Yeo Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct Am J Clin Pathol 116 2001 831 837
78. C.A. Iacobuzio-Donahue, A. Maitra, G.L. Shen-Ong, T. van Heek, R. Ashfaq, and R. Meyer Discovery of novel tumor markers of pancreatic cancer using global gene expression technology Am J Pathol 160 2002 1239 1249
79. C. Fernandez-del Castillo, J. Targarona, S.P. Thayer, D.W. Rattner, W.R. Brugge, and A.L. Warshaw Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients Arch Surg 138 4 2003 433 434
80. B. Gerdes, A. Wild, J. Wittenberg, P. Barth, A. Ramaswamy, and M. Kersting Tumor-suppressing pathways in cystic pancreatic tumors Pancreas 26 2003 42 48
81. H. Inoue, A. Tsuchida, Y. Kawasaki, Y. Fujimoto, S. Yamasaki, and G. Kajiyama Preoperative diagnosis of intraductal papillary-mucinous tumors of the pancreas with attention to telomerase activity Cancer 91 2001 35 41
82. Y. Murakami, T. Yokoyama, E. Hiyama, Y. Yokoyama, T. Kanehiro, and K. Uemura Successful pre-operative diagnosis of malignant intraductal papillary mucinous tumor of the pancreas by detecting telomerase activity Int J Gastrointest Cancer 31 2002 117 121
83. D. Bartsch, D. Bastian, P. Barth, A. Schudy, C. Nies, and O. Kisker K-ras oncogene mutations indicate malignancy in cystic tumor of the pancreas Ann Surg 228 1998 79 86
84. R.E. Jimenez, A.L. Warshaw, K. Z'graggen, W. Hartwig, D.Z. Taylor, C.C. Compton, and C. Fernandez-del-Castillo Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy Ann Surg 230 1999 501 511
85. T.S. Yeh, A.J. Cheng, T.C. Chen, Y.Y. Jan, T.L. Hwang, and L.B. Jeng Telomerase activity is a useful marker to distinguish malignant pancreatic cystic tumors from benign neoplasms and pseudocysts J Surg Res 87 1999 171 177
86. A. Khalid, K. McGrath, D. Brody, E. Sasatomi, A. Slivka, and J.A. Martin Free floating DNA mutational allelotyping of EUS guided aspirates of pancreatic cysts is predictive of underlying biological behavior: Preliminary data on a novel technique Pancreas 27 2003 391A
87. A. Khalid, S. Finkelstein, D. Brody, R. Pal, A. Slivka, and K. Lee Mutational allelotyping of aspirated free-floating DNA predicts the biological behavior of cystic pancreatic neoplasms Gastrointest Endosc 59 2004 AB95