Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer

Cancer Letters

Volumn 253, Issue 2, 2007, Pages 258-264

  Rennert, Gad ^a,b   Kislitsin, Dimitry ^b   Brenner, Dean E ^c,d   Rennert, Hedy S ^a,b   Lev, Zeev ^b  

^a CLALIT HEALTH SERVICES   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Colorectal cancer; Fecal occult blood tests (FOBT); K ras; Molecular testing; Positive predictive value (PPV); Screening

Indexed keywords

DNA;

ARTICLE; CANCER SCREENING; COLON ADENOCARCINOMA; COLON ADENOMA; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; FECES ANALYSIS; GENE MUTATION; HUMAN; ISRAEL; MAJOR CLINICAL STUDY; OCCULT BLOOD; OCCULT BLOOD TEST; ONCOGENE K RAS; PREDICTION; PRIORITY JOURNAL; SCREENING TEST;

AGED; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; GENES, RAS; HUMANS; MALE; MIDDLE AGED; MULTIPHASIC SCREENING; MUTATION; OCCULT BLOOD; PREDICTIVE VALUE OF TESTS;

EID: 34347355254     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.01.023     Document Type: Article

References (28)

1. Mandel J.S., Bond J.H., Church T.R., et al. Reducing mortality from colorectal cancer by screening for faecal occult blood. N. Engl. J. Med. 328 (1993) 1365-1371
2. Mandel J.S., Church T.R., Ederer F., and Bond J.H. Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood. J. Natl. Cancer Inst. 91 (1999) 434-437
3. Hardcastle J.D., Chamberlain J.O., Robinson M.H.E., et al. Randomised controlled trial of faecal occult blood screening for colorectal cancer. Lancet 348 (1996) 1472-1477
4. Kronborg O., Fenger C., Olsen J., Jorgensen O.D., and Sondergaard O. Randomised study of screening for colorectal cancer with faecal occult blood test. Lancet 348 (1996) 1467-1471
5. Rennert G. Occult blood fecal (FOB) screening - trial evidence, practice and beyond. Recent results in cancer research. Tumor Prevention Genetics 163 (2003) 248-253
6. Sidransky D., Tokino T., Hamilton S.R., et al. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256 (1992) 102-105
7. Jen J., Johnson C., and Levin B. Molecular approaches to colorectal cancer screening. Eur. J. Gastro. Hepatol. 10 (1998) 213-217
8. Imperiale T.F., Ransohoff D.F., Itzkowitz S.H., Turnbull B.A., Ross M.E., and Colorectal Cancer Study Group. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N. Engl. J. Med. 351 (2004) 2704-2714
9. Pignone M., Campbell M.K., Carr C., and Phillips C. Meta-analysis of dietary restriction during fecal occult blood testing. Eff. Clin. Pract. 4 (2001) 150-156
10. Fearon E.R., and Vogelstein B.A. genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
11. Rennert G., Rennert H.S., Miron E., and Peterburg Y. Population colorectal cancer screening with fecal occult blood test. Cancer Epidemiol. Biomark. 10 (2001) 1165-1168
12. Vogelstein B., Fearon E.R., Hamilton S.R., et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319 (1988) 525-532
13. Dong S.M., Traverso G., Johnson C., et al. Detecting colorectal cancer in stool with the use of multiple genetic targets. J. Natl. Cancer Inst. 93 (2001) 858-865
14. Ito Y., Kobayashi S., Taniguchi T., Kainuma O., Hara T., and Ochiai T. Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples. Int. J. Oncol. 20 (2002) 1263-1268
15. Calistri D., Rengucci C., Bocchini R., Saragoni L., Zoli W., and Amadori D. Fecal multiple molecular tests to detect colorectal cancer in stool. Clin. Gastroenterol. Hepatol. 1 (2003) 377-383
16. Wang M., Block T.M., Stee l.L., Brenner D.E., and Su Y.H. Preferential isolation of fragmented DNA enhances the detection of circulating mutated K-ras DNA. Clin. Chem. 50 (2004) 211-213
17. Jen J., Powell S.M., Papadopoulos N., et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54 (1994) 5523-5526
18. Puig P., Urgell E., Capella G., Sancho F.J., Pujol J., Boadas J., Farre A., Lluis F., Gonzalez-Sastre F., and Mora J. A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer. Int. J. Cancer 85 (2000) 73-77
19. Brenner D.E., and Rennert G. Fecal DNA biomarkers for the detection of colorectal neoplasia: attractive, but is it feasible?. J. Natl. Cancer Inst. 97 (2005) 1107-1109
20. Lev Z., Kislitsin D., Rennert G., and Lerner A. Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer. J. Cell Biochem. 77 (2000) 35-39
21. Fearon E.R. Human cancer syndromes: clues to the origin and nature of cancer. Science 27 (1997) 1043-1050
22. Rajagopalan H., Bardelli A., Lengauer C., Kinzler K.W., Vogelstein B., and Velculescu V.E. Tumourigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418 (2002) 934
23. Eguchi S., Kohara N., Komuta K., and Kanematsu T. Mutations of the p53 gene in the stool of patients with resectable colorectal cancer. Cancer 77 Suppl. (1996) 1707-1710
24. Tagore K.S., Lawson M.J., Yucaitis J.A., et al. Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. Clin. Colorectal Cancer 3 (2003) 47-53
25. Traverso G., Shuber A., Levin B., et al. Detection of APC mutations in fecal DNA from patients with colorectal tumors. N. Engl. J. Med. 346 (2002) 311-320
26. Muller H.M., Oberwalder M., Fiegl H., et al. Methylation changes in faecal DNA: a marker for colorectal cancer screening?. Lancet 363 (2004) 1283-1285
27. Chen W.D., Han Z.J., Skoletsky J., et al. Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J. Natl. Cancer Inst. 97 (2005) 1124-1132
28. Samuels Y., Wang Z., Bardelli A., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 (2004) 554