메뉴 건너뛰기




Volumn 66, Issue 1, 2004, Pages 262-267

Up-regulation of hepatic Acyl CoA: Diacylglycerol acyltransferase-1 (DGAT-1) expression in nephrotic syndrome

Author keywords

DGAT; Hyperlipidemia; Liver; Nephrotic syndrome; Proteinuria; Renal disease; Triglyceride synthesis

Indexed keywords

ACYL COENZYME A; DIACYLGLYCEROL ACYLTRANSFERASE; FATTY ACID; ISOENZYME; LIVER ENZYME; MESSENGER RNA; PLACEBO; PUROMYCIN AMINONUCLEOSIDE; VERY LOW DENSITY LIPOPROTEIN;

EID: 3042845638     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00724.x     Document Type: Article
Times cited : (41)

References (41)
  • 1
    • 0037406342 scopus 로고    scopus 로고
    • Molecular mechanisms of lipid disorders in nephrotic syndrome
    • VAZIRI ND: Molecular mechanisms of lipid disorders in nephrotic syndrome. Kidney Int 63:1964-1976, 2003
    • (2003) Kidney Int , vol.63 , pp. 1964-1976
    • Vaziri, N.D.1
  • 2
    • 0025150632 scopus 로고
    • Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome
    • JOVEN J, VILLABONA C, VILELLA E, et al: Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. N Engl J Med 323:579-584, 1990
    • (1990) N Engl J Med , vol.323 , pp. 579-584
    • Joven, J.1    Villabona, C.2    Vilella, E.3
  • 3
    • 0028288403 scopus 로고
    • Lipid abnormalities in the nephrotic syndrome: Causes, consequences, and treatment
    • WHEELER DC, BERNARD DB: Lipid abnormalities in the nephrotic syndrome: Causes, consequences, and treatment. Am J Kidney Dis 23:331-346, 1994
    • (1994) Am J Kidney Dis , vol.23 , pp. 331-346
    • Wheeler, D.C.1    Bernard, D.B.2
  • 4
    • 0026031716 scopus 로고
    • Lipid abnormalities in renal disease
    • APPEL G: Lipid abnormalities in renal disease. Kidney Int 39:169-183, 1991
    • (1991) Kidney Int , vol.39 , pp. 169-183
    • Appel, G.1
  • 5
    • 0027319164 scopus 로고
    • The nephrotic syndrome, lipids, and risk factors for cardiovascular disease
    • RADHAKRISHNAN J, APPEL AS, VALERI A, APPEL GB: The nephrotic syndrome, lipids, and risk factors for cardiovascular disease. Am J Kidney Dis 22:135-142, 1993
    • (1993) Am J Kidney Dis , vol.22 , pp. 135-142
    • Radhakrishnan, J.1    Appel, A.S.2    Valeri, A.3    Appel, G.B.4
  • 6
    • 0031979035 scopus 로고    scopus 로고
    • Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis
    • DE SAIN-VAN DER VELDEN MG, KAYSEN GA, BARRETT HA: Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis. Kidney Int 53:994-1001, 1998
    • (1998) Kidney Int , vol.53 , pp. 994-1001
    • De Sain-Van Der Velden, M.G.1    Kaysen, G.A.2    Barrett, H.A.3
  • 7
    • 0021752964 scopus 로고
    • Catabolism of very low density lipoproteins in experimental nephrosis
    • GARBER DW, GOTTLIEB BA, MARSH JB, SPARKS CE: Catabolism of very low density lipoproteins in experimental nephrosis. J Clin Invest 74:1375-1383, 1984
    • (1984) J Clin Invest , vol.74 , pp. 1375-1383
    • Garber, D.W.1    Gottlieb, B.A.2    Marsh, J.B.3    Sparks, C.E.4
  • 8
    • 0025783752 scopus 로고
    • Metabolism of apolipoprotein B-containing lipoproteins in subjects with nephrotic-range proteinuria
    • WARWICK GL, PACKARD CJ, DEMANT T, et al: Metabolism of apolipoprotein B-containing lipoproteins in subjects with nephrotic-range proteinuria. Kidney Int 40:129-138, 1991
    • (1991) Kidney Int , vol.40 , pp. 129-138
    • Warwick, G.L.1    Packard, C.J.2    Demant, T.3
  • 9
    • 0026674476 scopus 로고
    • Both peripheral chylomicron catabolism and hepatic uptake of remnants are defective in nephrosis
    • KAYSEN GA, MEHENDRU L, PAN XM, STAPRANS I: Both peripheral chylomicron catabolism and hepatic uptake of remnants are defective in nephrosis. Am J Physiol 263:F335-F341, 1992
    • (1992) Am J Physiol , vol.263
    • Kaysen, G.A.1    Mehendru, L.2    Pan, X.M.3    Staprans, I.4
  • 10
    • 0025160827 scopus 로고
    • Proteinuria, not altered albumin metabolism, affects hyperlipidemia in the nephrotic rat
    • DAVIES RW, STAPRANS I, HUTCHISON FN, KAYSEN GA: Proteinuria, not altered albumin metabolism, affects hyperlipidemia in the nephrotic rat. J Clin Invest 86:600-605, 1990
    • (1990) J Clin Invest , vol.86 , pp. 600-605
    • Davies, R.W.1    Staprans, I.2    Hutchison, F.N.3    Kaysen, G.A.4
  • 11
    • 0035167588 scopus 로고    scopus 로고
    • Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome
    • SHEARER GC, STEVENSON FT, ATKINSON DN, et al: Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome. Kidney Int 59:179-189, 2001
    • (2001) Kidney Int , vol.59 , pp. 179-189
    • Shearer, G.C.1    Stevenson, F.T.2    Atkinson, D.N.3
  • 12
    • 0031258643 scopus 로고    scopus 로고
    • Gene expression of lipoprotein lipase in experimental nephrosis
    • LIANG K, VAZIRI ND: Gene expression of lipoprotein lipase in experimental nephrosis. J Lab Clin Med 130:387-394, 1997
    • (1997) J Lab Clin Med , vol.130 , pp. 387-394
    • Liang, K.1    Vaziri, N.D.2
  • 13
    • 0036147318 scopus 로고    scopus 로고
    • Downregulation of lipoprotein lipase and VLDL receptor in rats with food glomerulosclerosis
    • SATO T, LIANG K, VAZIRI ND: Downregulation of lipoprotein lipase and VLDL receptor in rats with food glomerulosclerosis. Kidney Int 61:157-162, 2002
    • (2002) Kidney Int , vol.61 , pp. 157-162
    • Sato, T.1    Liang, K.2    Vaziri, N.D.3
  • 14
    • 0030953206 scopus 로고    scopus 로고
    • Downregulation of hepatic lipase expression in experimental nephrotic syndrome
    • LIANG K, VAZIRI ND: Downregulation of hepatic lipase expression in experimental nephrotic syndrome. Kidney Int 51:1933-1937, 1997
    • (1997) Kidney Int , vol.51 , pp. 1933-1937
    • Liang, K.1    Vaziri, N.D.2
  • 15
    • 0030964202 scopus 로고    scopus 로고
    • Acquired VLDL receptor deficiency in experimental nephrosis
    • LIANG K, VAZIRI ND: Acquired VLDL receptor deficiency in experimental nephrosis. Kidney Int 51:1761-1765, 1997
    • (1997) Kidney Int , vol.51 , pp. 1761-1765
    • Liang, K.1    Vaziri, N.D.2
  • 16
    • 0028939191 scopus 로고
    • Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion
    • JOLES JA, BIJLEVELD C, VAN TOL A, et al: Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion. Kidney Int 47:566-572, 1995
    • (1995) Kidney Int , vol.47 , pp. 566-572
    • Joles, J.A.1    Bijleveld, C.2    Van Tol, A.3
  • 17
    • 0031430095 scopus 로고    scopus 로고
    • Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk
    • JOLES J A, BIJLEVELD C, VAN TOL A, et al: Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. J Am Soc Nephrol 12:1870-1876, 1997
    • (1997) J Am Soc Nephrol , vol.12 , pp. 1870-1876
    • Joles, J.A.1    Bijleveld, C.2    Van Tol, A.3
  • 18
    • 0018501733 scopus 로고
    • Lipoprotein lipid and protein synthesis in experimental nephrosis and plasmapheresis. I: Studies in rat in vivo
    • SHAFRIR E, BRENNER T: Lipoprotein lipid and protein synthesis in experimental nephrosis and plasmapheresis. I: Studies in rat in vivo. Lipids 14:695-702, 1979
    • (1979) Lipids , vol.14 , pp. 695-702
    • Shafrir, E.1    Brenner, T.2
  • 19
    • 0018835187 scopus 로고
    • Experimental nephrotic syndrome induced in the rat by puromycin aminonucleoside: Hepatic synthesis of neutral lipids and phospholipids from 3H-water and 3H-palmitate
    • GHERARDI E, CALANDRA S: Experimental nephrotic syndrome induced in the rat by puromycin aminonucleoside: Hepatic synthesis of neutral lipids and phospholipids from 3H-water and 3H-palmitate. Lipids 15:108-112, 1980
    • (1980) Lipids , vol.15 , pp. 108-112
    • Gherardi, E.1    Calandra, S.2
  • 20
    • 0034128280 scopus 로고    scopus 로고
    • Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase
    • FARESE RV, JR., CASES S, SMITH SJ: Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase. Curr Opin Lipidol 11:229-234, 2000
    • (2000) Curr Opin Lipidol , vol.11 , pp. 229-234
    • Farese Jr., R.V.1    Cases, S.2    Smith, S.J.3
  • 22
    • 0018954997 scopus 로고
    • Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase
    • POLOKOFF MA, BELL RM: Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase. Biochim Biophys Acta 818:129-142, 1980
    • (1980) Biochim Biophys Acta , vol.818 , pp. 129-142
    • Polokoff, M.A.1    Bell, R.M.2
  • 23
    • 0028323262 scopus 로고
    • Purification of diacylglycerol: Acyltransferase from rat liver to near homogeneity
    • ANDERSSON M, WETTESTEN M, BOREN J, et al: Purification of diacylglycerol: Acyltransferase from rat liver to near homogeneity. J Lipid Res 35:535-545, 1994
    • (1994) J Lipid Res , vol.35 , pp. 535-545
    • Andersson, M.1    Wettesten, M.2    Boren, J.3
  • 24
    • 13144281703 scopus 로고    scopus 로고
    • Identification of a gene encoding an acyl CoA: Diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    • CASES S, SMITH SJ, ZHENG YW, et al: Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A 95:13018-13023, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13018-13023
    • Cases, S.1    Smith, S.J.2    Zheng, Y.W.3
  • 25
    • 0037067721 scopus 로고    scopus 로고
    • DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis
    • BUHMAN KK, SMITH SJ, STONE SJ, et al: DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem 277:25474-25479, 2002
    • (2002) J Biol Chem , vol.277 , pp. 25474-25479
    • Buhman, K.K.1    Smith, S.J.2    Stone, S.J.3
  • 26
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT
    • SMITH SJ, CASES S, JENSEN DR, et al: Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT. Nat Genet 25:87-90, 2000
    • (2000) Nat Genet , vol.25 , pp. 87-90
    • Smith, S.J.1    Cases, S.2    Jensen, D.R.3
  • 27
    • 0035914356 scopus 로고    scopus 로고
    • Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
    • CASES S, STONE SJ, ZHOU P, et al: Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem 276:38870-38876, 2001
    • (2001) J Biol Chem , vol.276 , pp. 38870-38876
    • Cases, S.1    Stone, S.J.2    Zhou, P.3
  • 28
    • 0037792166 scopus 로고    scopus 로고
    • HMG-CoA reductase, cholesterol 7a-hydroxylase, LCAT, ACAT, LDL receptor and SRB-1 in hereditary analbuminemia
    • LIANG K, VAZIRI ND: HMG-CoA reductase, cholesterol 7a-hydroxylase, LCAT, ACAT, LDL receptor and SRB-1 in hereditary analbuminemia. Kidney Int 64:192-198, 2003
    • (2003) Kidney Int , vol.64 , pp. 192-198
    • Liang, K.1    Vaziri, N.D.2
  • 29
    • 0036785650 scopus 로고    scopus 로고
    • Upregulation of Acyl-CoA: Cholesterol acyl-transferase (ACAT) in chronic renal failure
    • LIANG K, VAZIRI ND: Upregulation of Acyl-CoA: Cholesterol acyl-transferase (ACAT) in chronic renal failure. Am J Physiol Endocrine Metab 283:E676-E681, 2001
    • (2001) Am J Physiol Endocrine Metab , vol.283
    • Liang, K.1    Vaziri, N.D.2
  • 30
    • 0026555853 scopus 로고
    • Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine
    • COLEMAN RA: Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine. Methods in Enzymology 209:98-101, 1992
    • (1992) Methods in Enzymology , vol.209 , pp. 98-101
    • Coleman, R.A.1
  • 31
    • 0036281211 scopus 로고    scopus 로고
    • Processing of gene expression data generated by quantitative real-time RT-PCR
    • MULLER PY, JANOVJAK H, MISEREZ AR, DOBBIE Z: Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32:1372-1379, 2002
    • (2002) Biotechniques , vol.32 , pp. 1372-1379
    • Muller, P.Y.1    Janovjak, H.2    Miserez, A.R.3    Dobbie, Z.4
  • 32
    • 0028876322 scopus 로고
    • Hepatic HMG-CoA reductase gene expression during the course of puromycin-induced nephrosis
    • VAZIRI ND, LIANG KH: Hepatic HMG-CoA reductase gene expression during the course of puromycin-induced nephrosis. Kidney Int 48:1979-1985, 1995
    • (1995) Kidney Int , vol.48 , pp. 1979-1985
    • Vaziri, N.D.1    Liang, K.H.2
  • 33
    • 0037406315 scopus 로고    scopus 로고
    • Molecular mechanism of altered cholesterol metabolism in focal glomerulosclerosis
    • VAZIRI ND, SATO T, LIANG K, et al: Molecular mechanism of altered cholesterol metabolism in focal glomerulosclerosis. Kidney Int 63:1756-1763, 2003
    • (2003) Kidney Int , vol.63 , pp. 1756-1763
    • Vaziri, N.D.1    Sato, T.2    Liang, K.3
  • 34
    • 0029947618 scopus 로고    scopus 로고
    • Gene expression of hepatic cholesterol 7 alpha-hydroxylase in the course of puromycin induced nephrosis
    • LIANG KH, OVEISI F, VAZIRI ND: Gene expression of hepatic cholesterol 7 alpha-hydroxylase in the course of puromycin induced nephrosis. Kidney Int 49:855-860, 1996
    • (1996) Kidney Int , vol.49 , pp. 855-860
    • Liang, K.H.1    Oveisi, F.2    Vaziri, N.D.3
  • 35
    • 0029785877 scopus 로고    scopus 로고
    • Downregulation of hepatic LDL, receptor expression in experimental nephrosis
    • VAZIRI ND, LIANG K: Downregulation of hepatic LDL, receptor expression in experimental nephrosis. Kidney Int 50:887-893, 1996
    • (1996) Kidney Int , vol.50 , pp. 887-893
    • Vaziri, N.D.1    Liang, K.2
  • 36
    • 0035026173 scopus 로고    scopus 로고
    • Acquired lecithin: Cholesterol acyl-transferase (LCAT) deficiency in nephrotic syndrome
    • VAZIRI ND, LIANG K, PARK JS: Acquired lecithin: Cholesterol acyl-transferase (LCAT) deficiency in nephrotic syndrome. Am J Phsyiol 49:F823-F829, 2001
    • (2001) Am J Phsyiol , vol.49
    • Vaziri, N.D.1    Liang, K.2    Park, J.S.3
  • 37
    • 0032810637 scopus 로고    scopus 로고
    • Downregulation of hepatic high-density lipoprotein receptor, SR-B1 in nephrotic syndrome
    • LIANG K, VAZIRI ND: Downregulation of hepatic high-density lipoprotein receptor, SR-B1 in nephrotic syndrome. Kidney Int 56:621-626, 1999
    • (1999) Kidney Int , vol.56 , pp. 621-626
    • Liang, K.1    Vaziri, N.D.2
  • 38
    • 0036233724 scopus 로고    scopus 로고
    • Upregulation of acyl-coenzyme A: Cholesterol acyltransferase (ACAT) in nephrotic syndrome
    • VAZIRI ND, LIANG KH: Upregulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome. Kidney Int 61:1769-1775, 2002
    • (2002) Kidney Int , vol.61 , pp. 1769-1775
    • Vaziri, N.D.1    Liang, K.H.2
  • 39
    • 0020356864 scopus 로고
    • Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro
    • HAAGSMAN HP, DE HAAS CG, GEELEN MJ, VAN GOLDE LM: Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro. J Biol Chem 257:10593-10598, 1982
    • (1982) J Biol Chem , vol.257 , pp. 10593-10598
    • Haagsman, H.P.1    De Haas, C.G.2    Geelen, M.J.3    Van Golde, L.M.4
  • 40
    • 0019861148 scopus 로고
    • Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: Role of diacylglycerol acyltransferase
    • HAAGSMAN HP, VAN GOLDE LM: Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: Role of diacylglycerol acyltransferase. Arch Biochem Biophys 208:395-402, 1981
    • (1981) Arch Biochem Biophys , vol.208 , pp. 395-402
    • Haagsman, H.P.1    Van Golde, L.M.2
  • 41
    • 0016268661 scopus 로고
    • Effect of different fatty acids on glycerolipid synthesis in isolated rat hepatocytes
    • SUNDLER R, AKESSON B, NILSSON A: Effect of different fatty acids on glycerolipid synthesis in isolated rat hepatocytes. J Biol Chem 249:5102-5107, 1974
    • (1974) J Biol Chem , vol.249 , pp. 5102-5107
    • Sundler, R.1    Akesson, B.2    Nilsson, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.