메뉴 건너뛰기




Volumn 11, Issue 3, 2000, Pages 229-234

Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE; TRIACYLGLYCEROL;

EID: 0034128280     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200006000-00002     Document Type: Review
Times cited : (123)

References (46)
  • 1
    • 13144281703 scopus 로고    scopus 로고
    • Identification of a gene encoding an acyl CoA: Diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    • 1 Cases S, Smith SJ, Zheng Y-W, Myers HM, Lear SR, Sande E, et al. Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci USA 1998; 95:13018-13023. This study reports the cloning and functional expression of a mammalian cDNA encoding a DGAT enzyme.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13018-13023
    • Cases, S.1    Smith, S.J.2    Zheng, Y.-W.3    Myers, H.M.4    Lear, S.R.5    Sande, E.6
  • 2
    • 0018846846 scopus 로고
    • Enzymes of glycerolipid synthesis in eukaryotes
    • 2 Bell RM, Coleman RA. Enzymes of glycerolipid synthesis in eukaryotes. Annu Rev Biochem 1980; 49:459-487.
    • (1980) Annu Rev Biochem , vol.49 , pp. 459-487
    • Bell, R.M.1    Coleman, R.A.2
  • 3
    • 77956857784 scopus 로고
    • Metabolism of triacylglycerols
    • Vance DE, Vance JE (editors). Amsterdam: Elsevier
    • 3 Brindley DN. Metabolism of triacylglycerols. In: Biochemistry of lipids, lipoproteins and membranes. Vance DE, Vance JE (editors). Amsterdam: Elsevier; 1991. pp. 171-203.
    • (1991) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 171-203
    • Brindley, D.N.1
  • 4
    • 0030175841 scopus 로고    scopus 로고
    • Biosynthesis of triacylglycerols
    • 4 Lehner R, Kuksis A. Biosynthesis of triacylglycerols. Prog Lipid Res 1996; 35:169-201.
    • (1996) Prog Lipid Res , vol.35 , pp. 169-201
    • Lehner, R.1    Kuksis, A.2
  • 6
    • 0021209935 scopus 로고
    • Hepatic monoacylglycerol acyltransferase. Characterization of an activity associated with the suckling period in rats
    • 6 Coleman RA, Haynes EB. Hepatic monoacylglycerol acyltransferase. Characterization of an activity associated with the suckling period in rats. J Biol Chem 1984; 259:8934-8938.
    • (1984) J Biol Chem , vol.259 , pp. 8934-8938
    • Coleman, R.A.1    Haynes, E.B.2
  • 7
    • 0026744105 scopus 로고
    • Properties of monoglycerol acyltransferase in rat adipocytes
    • 7 Jamdar SC, Cao WF. Properties of monoglycerol acyltransferase in rat adipocytes. Arch Biochem Biophys 1992; 296:419-425.
    • (1992) Arch Biochem Biophys , vol.296 , pp. 419-425
    • Jamdar, S.C.1    Cao, W.F.2
  • 8
    • 0026555853 scopus 로고
    • Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine
    • 8 Coleman RA. Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine. Methods Enzymol 1992; 209:98-104.
    • (1992) Methods Enzymol , vol.209 , pp. 98-104
    • Coleman, R.A.1
  • 10
    • 0017303551 scopus 로고
    • Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols
    • 10 Coleman R, Bell RM. Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols. J Biol Chem 1976; 251:4537-4543.
    • (1976) J Biol Chem , vol.251 , pp. 4537-4543
    • Coleman, R.1    Bell, R.M.2
  • 11
    • 0018070657 scopus 로고
    • Selective changes in microsomal enzymes of triacylglycerol phosphatidylcholine, and phosphatidylethanolamine biosynthesis during differentiation of 3T3-L1 preadipocytes
    • 11 Coleman RA, Reed BC, Mackall JC, Student AK, Lane MD, Bell RM. Selective changes in microsomal enzymes of triacylglycerol phosphatidylcholine, and phosphatidylethanolamine biosynthesis during differentiation of 3T3-L1 preadipocytes. J Biol Chem 1978; 253:7256-7261.
    • (1978) J Biol Chem , vol.253 , pp. 7256-7261
    • Coleman, R.A.1    Reed, B.C.2    Mackall, J.C.3    Student, A.K.4    Lane, M.D.5    Bell, R.M.6
  • 12
    • 0019861148 scopus 로고
    • Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: Role of diacylglycerol acyltransferase
    • 12 Haagsman HP, Van Golde LMG. Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: role of diacylglycerol acyltransferase. Arch Biochem Biophys 1981; 208:395-402.
    • (1981) Arch Biochem Biophys , vol.208 , pp. 395-402
    • Haagsman, H.P.1    Van Golde, L.M.G.2
  • 13
    • 0016637006 scopus 로고
    • The composition and biosynthesis of milk fat
    • 13 Smith S, Abraham S. The composition and biosynthesis of milk fat. Adv Lipid Res 1975; 13:195-239.
    • (1975) Adv Lipid Res , vol.13 , pp. 195-239
    • Smith, S.1    Abraham, S.2
  • 14
    • 0017624954 scopus 로고
    • Biosynthesis of triacylglycerols containing short-chain fatty acids in lactating cow mammary gland. Activity of diacylglycerol acyltransferase towards short-chain acyl-CoA esters
    • 14 Marshall MO, Knudsen J. Biosynthesis of triacylglycerols containing short-chain fatty acids in lactating cow mammary gland. Activity of diacylglycerol acyltransferase towards short-chain acyl-CoA esters. Eur J Biochem 1977; 81:259-266.
    • (1977) Eur J Biochem , vol.81 , pp. 259-266
    • Marshall, M.O.1    Knudsen, J.2
  • 15
    • 0031576031 scopus 로고    scopus 로고
    • Glycerolipid metabolizing enzymes in rat ventricle and in cardiac myocytes
    • 15 Swanton EMS, Saggerson ED. Glycerolipid metabolizing enzymes in rat ventricle and in cardiac myocytes. Biochim Biophys Acta 1997; 1346:93-102.
    • (1997) Biochim Biophys Acta , vol.1346 , pp. 93-102
    • Swanton, E.M.S.1    Saggerson, E.D.2
  • 17
    • 0002119966 scopus 로고    scopus 로고
    • Transgenic oilseed crops: A transition from basic research to product development
    • 17 Lassner M. Transgenic oilseed crops: a transition from basic research to product development. Lipid Technol 1997; 9:5-9.
    • (1997) Lipid Technol , vol.9 , pp. 5-9
    • Lassner, M.1
  • 18
    • 0017056496 scopus 로고
    • Solubilization of diglyceride acyltransferase from the membrane of Mycobacterium smegmatis
    • 18 Akao T, Kusaka T. Solubilization of diglyceride acyltransferase from the membrane of Mycobacterium smegmatis. J Biochem 1976; 80:723-728.
    • (1976) J Biochem , vol.80 , pp. 723-728
    • Akao, T.1    Kusaka, T.2
  • 19
    • 0028349583 scopus 로고
    • Importance of stored triacylglycerols in Streptomyces: Possible carbon source for antibiotics
    • 19 Olukoshi ER, Packter NM. Importance of stored triacylglycerols in Streptomyces: possible carbon source for antibiotics. Microbiology 1994; 140:931-943.
    • (1994) Microbiology , vol.140 , pp. 931-943
    • Olukoshi, E.R.1    Packter, N.M.2
  • 20
    • 0030859990 scopus 로고    scopus 로고
    • Purification and characterization of diacylglycerol acyltransferase from the lipid body fraction of an oleaginous fungus
    • 20 Kamisaka Y, Mishra S, Nakahara T. Purification and characterization of diacylglycerol acyltransferase from the lipid body fraction of an oleaginous fungus. J Biochem 1997; 121:1107-1114.
    • (1997) J Biochem , vol.121 , pp. 1107-1114
    • Kamisaka, Y.1    Mishra, S.2    Nakahara, T.3
  • 21
    • 0029689690 scopus 로고    scopus 로고
    • Synthesis of sn-1,2-diacylglycerols by monoacylglycerol acyltransferase from Manduca sexta fat body
    • 21 Arrese EL, Rojas-Rivas BI, Wells MA. Synthesis of sn-1,2-diacylglycerols by monoacylglycerol acyltransferase from Manduca sexta fat body. Arch Insect Biochem Physiol 1996; 31:325-335.
    • (1996) Arch Insect Biochem Physiol , vol.31 , pp. 325-335
    • Arrese, E.L.1    Rojas-Rivas, B.I.2    Wells, M.A.3
  • 22
    • 0031260040 scopus 로고    scopus 로고
    • Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus
    • 22 Tabata N, Ito M, Tomoda H, Omura S. Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 1997; 46:683-687.
    • (1997) Phytochemistry , vol.46 , pp. 683-687
    • Tabata, N.1    Ito, M.2    Tomoda, H.3    Omura, S.4
  • 23
    • 0032864381 scopus 로고    scopus 로고
    • Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040
    • 23 Tomoda H, Ohyama Y, Abe T, Tabata N, Namikoshi M, Yamaguchi Y, et al. Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040. J Antibiot 1999; 52:689-694.
    • (1999) J Antibiot , vol.52 , pp. 689-694
    • Tomoda, H.1    Ohyama, Y.2    Abe, T.3    Tabata, N.4    Namikoshi, M.5    Yamaguchi, Y.6
  • 24
    • 0024215029 scopus 로고
    • Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase
    • 24 Rustan AC, Nossen J, Christiansen EN, Drevon CA. Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase. J Lipid Res 1988; 29:1417-1426.
    • (1988) J Lipid Res , vol.29 , pp. 1417-1426
    • Rustan, A.C.1    Nossen, J.2    Christiansen, E.N.3    Drevon, C.A.4
  • 25
    • 0018634543 scopus 로고
    • Enhancement of microsomal phosphatidate phosphohydrolase and diacylglycerol acyltransferase activity by insulin during growth of rat adipocyte precursors in culture
    • 25 Roncari DAK, Mack EYW, Yip DK. Enhancement of microsomal phosphatidate phosphohydrolase and diacylglycerol acyltransferase activity by insulin during growth of rat adipocyte precursors in culture. Can J Biochem 1979; 57:573-577.
    • (1979) Can J Biochem , vol.57 , pp. 573-577
    • Roncari, D.A.K.1    Mack, E.Y.W.2    Yip, D.K.3
  • 26
    • 0018160654 scopus 로고
    • A decrease in diacylglycerol acyltransferase after treatment of rat adipocytes with adrenaline
    • 26 Sooranna SR, Saggerson ED. A decrease in diacylglycerol acyltransferase after treatment of rat adipocytes with adrenaline. FEBS Lett 1978; 95:85-87.
    • (1978) FEBS Lett , vol.95 , pp. 85-87
    • Sooranna, S.R.1    Saggerson, E.D.2
  • 27
    • 0020356864 scopus 로고
    • Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro
    • 27 Haagsman HP, de Haas CGM, Geelen MJH, van Golde LMG. Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro. J Biol Chem 1982; 257:10593-10598.
    • (1982) J Biol Chem , vol.257 , pp. 10593-10598
    • Haagsman, H.P.1    De Haas, C.G.M.2    Geelen, M.J.H.3    Van Golde, L.M.G.4
  • 28
    • 0029927907 scopus 로고    scopus 로고
    • A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase
    • 28 Lau TE, Rodriguez MA. A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase. Lipids 1996; 31:277-283.
    • (1996) Lipids , vol.31 , pp. 277-283
    • Lau, T.E.1    Rodriguez, M.A.2
  • 29
    • 0018954997 scopus 로고
    • Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase
    • 29 Polokoff MA, Bell RM. Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase. Biochim Biophys Acta 1980; 618:129-142.
    • (1980) Biochim Biophys Acta , vol.618 , pp. 129-142
    • Polokoff, M.A.1    Bell, R.M.2
  • 31
    • 0032500641 scopus 로고    scopus 로고
    • Characterization of two human genes encoding acyl coenzyme A cholesterol acyltransferase-related enzymes
    • 31 Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL. Characterization of two human genes encoding acyl coenzyme A cholesterol acyltransferase-related enzymes. J Biol Chem 1998; 273:26765-26771. This study reports sequence data for ACAT-related gene product 1, the human homolog for DGAT.
    • (1998) J Biol Chem , vol.273 , pp. 26765-26771
    • Oelkers, P.1    Behari, A.2    Cromley, D.3    Billheimer, J.T.4    Sturley, S.L.5
  • 32
    • 0032965889 scopus 로고    scopus 로고
    • Cloning of a cDNA encoding diacylglycerol acyltransferase from Arabidopsis thaliana and its functional expression
    • 32 Hobbs DH, Lu C, Hills MJ. Cloning of a cDNA encoding diacylglycerol acyltransferase from Arabidopsis thaliana and its functional expression. FEBS Lett 1999; 452:145-149. This study reports the cloning and functional expression of a plant DGAT homolog.
    • (1999) FEBS Lett , vol.452 , pp. 145-149
    • Hobbs, D.H.1    Lu, C.2    Hills, M.J.3
  • 33
    • 0033971564 scopus 로고    scopus 로고
    • Expression in yeast and tobacco of plant cDNAs encoding acyl CoA: Diacylglycerol acyltransferase
    • 33 Bouvier-Navé P, Benveniste P, Oelkers P, Sturley SL, Schaller H. Expression in yeast and tobacco of plant cDNAs encoding acyl CoA: diacylglycerol acyltransferase. Eur J Biochem 2000; 267:85-96. This study reports the cloning and functional expression of two plant DGAT homologs.
    • (2000) Eur J Biochem , vol.267 , pp. 85-96
    • Bouvier-Navé, P.1    Benveniste, P.2    Oelkers, P.3    Sturley, S.L.4    Schaller, H.5
  • 34
    • 0033197608 scopus 로고    scopus 로고
    • The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene
    • 34 Zou J, Wei Y, Jako C, Kumar A, Selvaraj G, Taylor DC. The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene. Plant J 1999; 19:645-653. This study identifies a DGAT mutation as the cause of decreased DGAT activity and reduced seed triglycerides in a chemically induced mutant A. thaliana line.
    • (1999) Plant J , vol.19 , pp. 645-653
    • Zou, J.1    Wei, Y.2    Jako, C.3    Kumar, A.4    Selvaraj, G.5    Taylor, D.C.6
  • 35
    • 0033551669 scopus 로고    scopus 로고
    • Human acyl-CoA: Cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    • 35 Lin S, Cheng D, Liu M-S, Chen J, Chang T-Y. Human acyl-CoA: cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. J Biol Chem 1999; 274:23276-23285.
    • (1999) J Biol Chem , vol.274 , pp. 23276-23285
    • Lin, S.1    Cheng, D.2    Liu, M.-S.3    Chen, J.4    Chang, T.-Y.5
  • 36
    • 0033579429 scopus 로고    scopus 로고
    • Human acyl-CoA: Cholesterol acyltransferase-1 is a homotetrameric enzyme in intact cells and in vitro
    • 36 Yu C, Chen J, Lin S, Liu J, Chang CCY, Chang T-Y. Human acyl-CoA: cholesterol acyltransferase-1 is a homotetrameric enzyme in intact cells and in vitro. J Biol Chem 1999; 274:36139-36145.
    • (1999) J Biol Chem , vol.274 , pp. 36139-36145
    • Yu, C.1    Chen, J.2    Lin, S.3    Liu, J.4    Chang, C.C.Y.5    Chang, T.-Y.6
  • 37
    • 0004385394 scopus 로고    scopus 로고
    • DGAT knockout mice: Obesity resistance and evidence for an alternative triacylglycerol synthesis pathway
    • 37 Smith SJ, Cases S, Sande E, Tow B, Yu T, Newland D, et al. DGAT knockout mice: obesity resistance and evidence for an alternative triacylglycerol synthesis pathway [Abstract]. Circulation 1999; 100:1-609.
    • (1999) Circulation , vol.100 , pp. 1-609
    • Smith, S.J.1    Cases, S.2    Sande, E.3    Tow, B.4    Yu, T.5    Newland, D.6
  • 38
    • 0027412424 scopus 로고
    • Triacylglycerol synthesis by an sn-1,2(2,3)-diacylglycerol transacylase from rat intestinal microsomes
    • 38 Lehner R, Kuksis A. Triacylglycerol synthesis by an sn-1,2(2,3)-diacylglycerol transacylase from rat intestinal microsomes. J Biol Chem 1993; 268:8781-8786.
    • (1993) J Biol Chem , vol.268 , pp. 8781-8786
    • Lehner, R.1    Kuksis, A.2
  • 39
    • 0030957455 scopus 로고    scopus 로고
    • Overt and latent activities of diacylglycerol acyltransferase in rat liver microsomes: Possible roles in very-low-density lipoprotein triacylglycerol secretion
    • 39 Owen MR, Corstorphine CC, Zammit VA. Overt and latent activities of diacylglycerol acyltransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion. Biochem J 1997; 323:17-21.
    • (1997) Biochem J , vol.323 , pp. 17-21
    • Owen, M.R.1    Corstorphine, C.C.2    Zammit, V.A.3
  • 40
    • 0033544873 scopus 로고    scopus 로고
    • Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases
    • 40 Abo-Hashema KAH, Cake MH, Power GW, Clarke D. Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases. J Biol Chem 1999; 274:35577-35582.
    • (1999) J Biol Chem , vol.274 , pp. 35577-35582
    • Abo-Hashema, K.A.H.1    Cake, M.H.2    Power, G.W.3    Clarke, D.4
  • 42
    • 12644304902 scopus 로고    scopus 로고
    • Disruption of the acyl-CoA: Cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
    • 42 Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, et al. Disruption of the acyl-CoA: cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci USA 1996; 93:14041-14046.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14041-14046
    • Meiner, V.L.1    Cases, S.2    Myers, H.M.3    Sande, E.R.4    Bellosta, S.5    Schambelan, M.6
  • 43
    • 15444348784 scopus 로고    scopus 로고
    • ACAT-2, a second mammalian acyl-CoA:Cholesterol acyltransferase. Its cloning, expression, and characterization
    • 43 Cases S, Novak S, Zheng Y-W, Myers HM, Lear SR, Sande E, et al. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem 1998; 273:26755-26764.
    • (1998) J Biol Chem , vol.273 , pp. 26755-26764
    • Cases, S.1    Novak, S.2    Zheng, Y.-W.3    Myers, H.M.4    Lear, S.R.5    Sande, E.6
  • 44
    • 0032500649 scopus 로고    scopus 로고
    • Identification of a form of Acyl-CoA: Cholesterol acyltransferase specific to liver and intestine in nonhuman primates
    • 44 Anderson RA, Joyce C, Davis M, Reagan JW, Clark M, Shelness GS, et al. Identification of a form of Acyl-CoA: cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J Biol Chem 1998; 273:26747-26754.
    • (1998) J Biol Chem , vol.273 , pp. 26747-26754
    • Anderson, R.A.1    Joyce, C.2    Davis, M.3    Reagan, J.W.4    Clark, M.5    Shelness, G.S.6
  • 45
    • 0024232868 scopus 로고
    • Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine
    • 45 MacDonald PN, Ong DE. Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine. J Biol Chem 1988; 263:12478-12482.
    • (1988) J Biol Chem , vol.263 , pp. 12478-12482
    • MacDonald, P.N.1    Ong, D.E.2
  • 46
    • 0013688369 scopus 로고    scopus 로고
    • Characterization of a lecithin cholesterol acyl transferase like yeast enzyme involved in triglyceride synthesis
    • 46 Oelkers PM, Tknkelenberg AH, Erdenitz N, Sturley SL. Characterization of a lecithin cholesterol acyl transferase like yeast enzyme involved in triglyceride synthesis [Abstract]. Circulation 1999; 100:1-745.
    • (1999) Circulation , vol.100 , pp. 1-745
    • Oelkers, P.M.1    Tknkelenberg, A.H.2    Erdenitz, N.3    Sturley, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.