Early-Life exposure to dimethoate-induced reproductive toxicity: Evaluation of effects on pituitary-testicular axis of mice

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 450-458

  Verma, Ruchna ^a   Mohanty, Banalata ^a  

^a UNIVERSITY OF ALLAHABAD   (India)

Author keywords

Maternal dimethoate; Mice; Pituitary testicular axis

Indexed keywords

DIMETHOATE; LUTEINIZING HORMONE; TESTOSTERONE; INSECTICIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EPIDIDYMIS; FEMALE; HISTOPATHOLOGY; LD 50; LEYDIG CELL; LITTER SIZE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PRENATAL EXPOSURE; PREPUBERTY; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; STEROIDOGENESIS; STILLBIRTH; TESTIS; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BLOOD; DOSE RESPONSE; DRUG EFFECT; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; ORGAN SIZE; PREGNANCY; REPRODUCTION;

MUS;

ANIMALS; DIMETHOATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; FEMALE; IMMUNOHISTOCHEMISTRY; INSECTICIDES; LETHAL DOSE 50; LUTEINIZING HORMONE; MALE; MICE; ORGAN SIZE; PITUITARY GLAND; PREGNANCY; REPRODUCTION; SPERM COUNT; TESTIS;

EID: 74949119788     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp204     Document Type: Article

References (40)

1. Afifi, N. A., Ramadan, A., Abd-El-Aziz, M. I., and Saki, E. E. (1991). Influence of dimethoate on testicular and epididymal organs, testosterone plasma level and their tissue residues in rats. Dtsch. Tierarztl. Wochenschr. 98, 419-423.
2. Akingbemi, B. T., Ren-Shan, G. E., Klinefelter, G. R., Gunsalus, G. L., and Hardy, M. P. (2000). A metabolite methoxychlor, 2,2-Bis (p-Hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat Leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. Biol. Reprod. 62, 571-578.
3. Anas, M. K. I., Guillemette, C., Ayotte, P., Pereg, D., Giguere, F., and Bailey, J. L. (2005). In utero and lactational exposure to an environmentally relevant organochlorine mixture disrupts reproductive development and function in male rats. Biol. Reprod. 73, 414-426.
4. Ben Rhouma, K., Tebourbi, O., Krichah, R., and Sakly, M. (2001). Reproductive toxicity of DDT in adult male rats. Hum. Exp. Toxicol. 20, 393-397.
5. Berge, G. N., and Nafstad, I. (1986). Distribution and placental transfer of trichlorfon in guinea pigs. Arch. Toxicol. 59, 26-29.
6. Choudhary, N., Goyal, R., and Joshi, S. C. (2008). Effect of malathion on reproductive system of male rats. J. Environ. Biol. 29, 259-262.
7. Colborn, T. (2006). A case for revisiting the safety of pesticides: a closer look at neurodevelopment. Environ. Health Perspect. 114, 10-17.
8. Cooper, R. L., and Kavlock, R. J. (1997). Endocrine disruptors and reproductive development: a weight-of-evidence overview. J. Endocrinol. 152, 159-166.
9. Dalsenter, P. R., Faqi, A. S., and Chahoud, I. (1997). Serum testosterone and sexual behavior in rats after prenatal exposure to lindane. Bull. Environ. Contam. Toxicol. 59, 360-366.
10. Extension Toxicology Network (EXTOXNET). (1996). Pesticide information profiles. Dimethoate. www.extoxnet.orst.edu/pips/dimethoate. Accessed September 10, 2009.
11. Farag, A. T., El-Aswad, A. F., and Shaaban, N. A. (2007). Assessment of reproductive toxicity of orally administered dimethoate in male mice. Reprod. Toxicol. 23, 232-238.
12. Farag, A. T., Karkour, T. A. Z., and Okazy, A. E. (2006). Developmental toxicity of orally administered technical dimethoate in rats. Birth Defects Res. (Part B) 77, 40-46.
13. Farag, A. T., Okazy, A. E., and El-Aswad, A. F. (2003). Developmental toxicity study of chlorpyrifos in rats. Reprod. Toxicol. 17, 203-208.
14. Gray, L. E., Jr, Wolf, C., Lambright, C., Mann, P., Price, M., Cooper, R. L., and Ostby, J. (1999). Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p'-DDE, and ketoconazole) and toxic substances (dibutyl-and diethylhexyl phthalate, PCB 169, and ethane dimethane sulfonate) during sexual differentiation produces diverse profiles of reproductive malformations in male rats. Toxicol. Ind. Health 15, 94-118.
15. Griswold, M. D. (1995). Interactions between germ cells and Sertoli cells in the testis. Biol. Reprod. 52, 211-216.
16. Hallegue, D., Ben Rhouma, K., Tebourbi, O., and Sakly, M. (2003). Impairment of testicular endocrine functions after dieldrin exposure in adult rats. Pol. J. Environ. Studies 12, 557-561.
17. Hellwig, J., van Ravenzwaay, B., Mayer, M., and Gembardt, C. (2000). Pre and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans rats. Regul. Toxicol. Pharmacol. 10, 105-111.
18. Hojo, H., Aoyama, H., Takahashi, K. L., Shimizu, N., Araki, N., Takizawa, Y., Sakasai, K., Kuwahara, M., Saka, M., and Teramoto, S. (2006). Two-generation reproduction toxicity study in rats with 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p, p'-DDT). Congenit. Anom. 46, 105-114.
19. Hsu, S. M., Raine, L., and Fanger, H. (1981). Use of avidine-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29, 577-580.
20. Huang, L. G., Lin, P., Gong, C. Y., Zhang, J., Zhou, Q., Gong, X. D., and Zeng, L. (2006). Pathological changes in the testes of the rats with hypospadia induced by dichlorvos. Zhonghua Nan Ke Xue 12, 693-695.
21. Joshi, S. C., Mathur, R., and Gulati, N. (2007). Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat. Toxicol. Ind. Health 23, 439-444.
22. Kaur, S., and Dhanju, C. K. (2005). Biochemical effects of some organophosphorus pesticides on the ovaries of albino rats. Indian J. Physiol. Pharmacol. 49, 148-152.
23. Kniewald, J., Tomlienovi, A., Jakommi, M., Romac, P., Vrane, D. J., and Kniewald, Z. (1998). Atrazine toxicity in male rat reproductive process. Toxicol. Lett. 95, 214-219.
24. Ma, X., Dong, Y., Matzuk, M. M., and Kumar, T. R. (2004). Targeted disruption of luteinizing hormone β-subunit leads to hypogonadism, defects in gonadal steroidogenesis and infertility. Proc. Natl. Acad. Sci. U.S.A. 101, 17294-17299.
25. Mahadevaswami, M. P., and Kaliwal, B. B. (2002). Effect of dimethoate administration schedules on compensatory ovarian hypertrophy, follicular dynamics, and estrous cycle in hemicastrated mice. J. Basic Clin. Physiol. Pharmacol. 13, 225-248.
26. Mahadevaswami, M. P., and Kaliwal, B. B. (2004). Evaluation of dimethoate toxicity on pregnancy in albino mice. J. Basic Clin. Physiol. Pharmacol. 15, 211-221.
27. Okamura, A., Kamijima, M., and Shibata, E. (2005). A comprehensive evaluation of the testicular toxicity of dichlorvos in wistar rats. Toxicology 213, 129-137.
28. Rawlings, N. C., Cook, S. J., and Waldbillig, D. (1998). Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D and pentachlorphenol on the metabolic endocrine and reproductive endocrine system in ewes. J. Toxicol. Environ. Health 54, 21-36.
29. Rignell-Hydbom, A., Rylander, L., Giwercman, A., Jonsson, B. A. G., Nilsson-Ehle, P., and Hagmar, L. (2004). Exposure to CB-153 and p, p′ and male reproductive function. Hum. Reprod. 19, 2066-2075.
30. Sayim, F. (2007). Histopathologic effects of dimethoate on testis in rats. Bull. Environ. Contam. Toxicol. 78, 479-484.
31. Sobarzo, C., and Bustos-Obregón, E. (2000). Sperm quality in mice acutely treated with parathion. Asian J. Androl. 2, 147-150.
32. Srivastava, M. K., and Raizada, R. B. (1996). Development effect of technical dimethoate in rats: maternal and fetal toxicity evaluation. Indian J. Exp. Biol. 34, 329-333.
33. Srivastava, M. K., Raizada, R. B., and Dikshith, T. S. (1992). Fetotoxic response of quinalphos in rats. Vet. Hum. Toxicol. 34, 131-133.
34. Turner, K. J., Barlow, N. J., Struve, M. F., Wallace, D. G., Gaido, K. W., Dorman, D. C., and Foster, P. M. D. (2002). Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat. Toxicol. Sci. 68, 174-183.
35. Uzumcu, M., Kuhn, B. E., Marano, J. E., Armenti, A. E., and Passantino, L. (2006). Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-mullerian hormone production in the rat ovary. J. Endocrinol. 191, 549-558.
36. Walker, C. H. (2003). Neurotoxic pesticides and behavioral effects upon birds. Ecotoxicology 12, 307-316.
37. Walsh, L. P., Webster, D. R., and Stocco, D. M. (2000). Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. J. Endocrinol. 167, 253-263.
38. Weddington, S. C., Hansson, V., Purvis, K., Varaas, T., Verjans, H. L., Eik-Nes, K. B., Ryan, W. H., French, F. S., and Ritzen, E. M. (1976). Biphasic effect of testosterone propionate on Sertoli cell secretory function. Mol. Cell. Endocrinol. 5, 137-145.
39. Wilson, V. S., and LeBlanc, G. A. (1998). Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice. Toxicol. Appl. Pharmacol. 148, 158-168.
40. Wolf, C. J., LeBlanc, G. A., and Gray, L. E., Jr. (2004). Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD rat. Toxicol. Sci. 78, 135-143.