-
1
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40:499-507.
-
(2008)
Nat Genet
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
Thomson, M.W.2
Carey, V.J.3
Ge, R.4
Bell, G.W.5
Regev, A.6
-
2
-
-
41449118521
-
Module map of stem cell genes guides creation of epithelial cancer stem cells
-
Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008; 2:333-44.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 333-344
-
-
Wong, D.J.1
Liu, H.2
Ridky, T.W.3
Cassarino, D.4
Segal, E.5
Chang, H.Y.6
-
3
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006; 442:818-22.
-
(2006)
Nature
, vol.442
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
Stubbs, M.C.4
Wang, Y.5
Faber, J.6
-
4
-
-
58949102947
-
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
-
Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, et al. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009; 4:129-40.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 129-140
-
-
Somervaille, T.C.1
Matheny, C.J.2
Spencer, G.J.3
Iwasaki, M.4
Rinn, J.L.5
Witten, D.M.6
-
5
-
-
0035499267
-
Stem cells, cancer and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer and cancer stem cells. Nature 2001; 414:105-11.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
7
-
-
52549087785
-
Cancer stem cells in solid tumors: Accumulating evidence and unresolved questions
-
Visvader JE, Lindeman GJ. Cancer stem cells in solid tumors: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8:755-68.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
8
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432:324-31.
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
10
-
-
6944244084
-
A module map showing conditional activity of expression modules in cancer
-
Segal E, Friedman N, Koller D, Regev A. A module map showing conditional activity of expression modules in cancer. Nat Genet 2004; 36:1090-8.
-
(2004)
Nat Genet
, vol.36
, pp. 1090-1098
-
-
Segal, E.1
Friedman, N.2
Koller, D.3
Regev, A.4
-
11
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34:267-73.
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
-
12
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102:15545-50.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
-
13
-
-
20144386127
-
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
-
Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci USA 2005; 102:3738-43.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3738-3743
-
-
Chang, H.Y.1
Nuyten, D.S.2
Sneddon, J.B.3
Hastie, T.4
Tibshirani, R.5
Sørlie, T.6
-
14
-
-
0035923521
-
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
-
Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001; 98:13790-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13790-13795
-
-
Bhattacharjee, A.1
Richards, W.G.2
Staunton, J.3
Li, C.4
Monti, S.5
Vasa, P.6
-
15
-
-
3042694117
-
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression
-
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, et al. Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 2004; 101:9309-14.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9309-9314
-
-
Rhodes, D.R.1
Yu, J.2
Shanker, K.3
Deshpande, N.4
Varambally, R.5
Ghosh, D.6
-
16
-
-
33846425793
-
The prognostic role of a gene signature from tumorigenic breast-cancer cells
-
Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007; 356:217-26.
-
(2007)
N Engl J Med
, vol.356
, pp. 217-226
-
-
Liu, R.1
Wang, X.2
Chen, G.Y.3
Dalerba, P.4
Gurney, A.5
Hoey, T.6
-
17
-
-
40949116308
-
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors
-
Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, et al. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells 2008; 26:364-71.
-
(2008)
Stem Cells
, vol.26
, pp. 364-371
-
-
Cho, R.W.1
Wang, X.2
Diehn, M.3
Shedden, K.4
Chen, G.Y.5
Sherlock, G.6
-
18
-
-
33646358694
-
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
-
Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006; 9:391-403.
-
(2006)
Cancer Cell
, vol.9
, pp. 391-403
-
-
Lee, J.1
Kotliarova, S.2
Kotliarov, Y.3
Li, A.4
Su, Q.5
Donin, N.M.6
-
19
-
-
42549112141
-
Cancer stem cell and cancer stemloids: From biology to therapy
-
Blagosklonny MV. Cancer stem cell and cancer stemloids: from biology to therapy. Cancer Biol Ther 2007; 6:1684-90.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1684-1690
-
-
Blagosklonny, M.V.1
-
20
-
-
40549116312
-
Metastatic cancer stem cells: A new target for anti-cancer therapy?
-
Hermann PC, Huber SL, Heeschen C. Metastatic cancer stem cells: a new target for anti-cancer therapy? Cell Cycle 2008; 7:188-93.
-
(2008)
Cell Cycle
, vol.7
, pp. 188-193
-
-
Hermann, P.C.1
Huber, S.L.2
Heeschen, C.3
-
21
-
-
45749114065
-
Cancer stem cells: Models, mechanisms and implications for improved treatment
-
Zhou J, Zhang Y. Cancer stem cells: Models, mechanisms and implications for improved treatment. Cell Cycle 2008; 7:1360-70.
-
(2008)
Cell Cycle
, vol.7
, pp. 1360-1370
-
-
Zhou, J.1
Zhang, Y.2
-
23
-
-
48649103982
-
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
-
Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl EE, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol 2008; 10:987-93.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 987-993
-
-
Rybak, A.1
Fuchs, H.2
Smirnova, L.3
Brandt, C.4
Pohl, E.E.5
Nitsch, R.6
-
24
-
-
65349162096
-
-
Peter ME. Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 2009; 8:843-52.
-
Peter ME. Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 2009; 8:843-52.
-
-
-
-
26
-
-
67650561891
-
Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression
-
Hurteau GJ, Carlson JA, Roos E, Brock GJ. Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression. Cell Cycle 2009; 8:2064-9.
-
(2009)
Cell Cycle
, vol.8
, pp. 2064-2069
-
-
Hurteau, G.J.1
Carlson, J.A.2
Roos, E.3
Brock, G.J.4
-
27
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, et al. RAS is regulated by the let-7 microRNA family. Cell 2005; 120:635-47.
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
Byrom, M.4
Jarvis, R.5
Cheng, A.6
-
28
-
-
36849078711
-
let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131:1109-23.
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
Gong, C.6
-
29
-
-
42049103216
-
The let-7 microRNA reduces tumor growth in mouse models of lung cancer
-
Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008; 7:759-64.
-
(2008)
Cell Cycle
, vol.7
, pp. 759-764
-
-
Esquela-Kerscher, A.1
Trang, P.2
Wiggins, J.F.3
Patrawala, L.4
Cheng, A.5
Ford, L.6
-
30
-
-
50549095181
-
let-7 microRNAs in development, stem cells and cancer
-
Büssing I, Slack FJ, Grosshans H. let-7 microRNAs in development, stem cells and cancer. Trends Mol Med 2008; 14:400-9.
-
(2008)
Trends Mol Med
, vol.14
, pp. 400-409
-
-
Büssing, I.1
Slack, F.J.2
Grosshans, H.3
-
31
-
-
33748951151
-
Morphogen to mitogen: The multiple roles of hedgehog signalling in vertebrate neural development
-
Fuccillo M, Joyner AL, Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 2006; 7:772-83.
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 772-783
-
-
Fuccillo, M.1
Joyner, A.L.2
Fishell, G.3
-
32
-
-
33846237601
-
HEDGEHOG-GLI1. signaling regulates human glioma growth, cancer stem cell selfrenewal, and tumorigenicity
-
Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1. signaling regulates human glioma growth, cancer stem cell selfrenewal, and tumorigenicity. Curr Biol 2007; 17:165-72.
-
(2007)
Curr Biol
, vol.17
, pp. 165-172
-
-
Clement, V.1
Sanchez, P.2
de Tribolet, N.3
Radovanovic, I.4
Ruiz i Altaba, A.5
-
33
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells
-
Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, et al. Hedgehog signaling and Bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells. Cancer Res 2006; 66:6063-71.
-
(2006)
Cancer Res
, vol.66
, pp. 6063-6071
-
-
Liu, S.1
Dontu, G.2
Mantle, I.D.3
Patel, S.4
Ahn, N.S.5
Jackson, K.W.6
-
34
-
-
0035907041
-
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
-
Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001; 105:533-45.
-
(2001)
Cell
, vol.105
, pp. 533-545
-
-
Huelsken, J.1
Vogel, R.2
Erdmann, B.3
Cotsarelis, G.4
Birchmeier, W.5
-
35
-
-
41649089525
-
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
-
Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, et al. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 2008; 452:650-3.
-
(2008)
Nature
, vol.452
, pp. 650-653
-
-
Malanchi, I.1
Peinado, H.2
Kassen, D.3
Hussenet, T.4
Metzger, D.5
Chambon, P.6
-
36
-
-
33847740988
-
Wnt/beta-catenin signaling in cancer stemness and malignant behavior
-
Fodde R, Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007; 19:150-8.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 150-158
-
-
Fodde, R.1
Brabletz, T.2
-
37
-
-
42049113612
-
A context dependent role for Wnt signaling in tumorigenesis and stem cells
-
Matushansky I, Maki RG, Cordon-Cardo C. A context dependent role for Wnt signaling in tumorigenesis and stem cells. Cell Cycle 2008; 7:720-4.
-
(2008)
Cell Cycle
, vol.7
, pp. 720-724
-
-
Matushansky, I.1
Maki, R.G.2
Cordon-Cardo, C.3
-
38
-
-
2942691389
-
Stem cell origin of cancer and differentiation therapy
-
Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 2004; 51:1-28.
-
(2004)
Crit Rev Oncol Hematol
, vol.51
, pp. 1-28
-
-
Sell, S.1
-
39
-
-
34547889548
-
A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
-
Kangsamaksin T, Park HJ, Trempus CS, Morris RJ. A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer. Mol Carcinog 2007; 46:579-84.
-
(2007)
Mol Carcinog
, vol.46
, pp. 579-584
-
-
Kangsamaksin, T.1
Park, H.J.2
Trempus, C.S.3
Morris, R.J.4
-
40
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009; 457:608-11.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
van Es, J.H.3
van de Wetering, M.4
Begthel, H.5
van den Born, M.6
-
41
-
-
59049087696
-
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
-
Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 2009; 457:603-7.
-
(2009)
Nature
, vol.457
, pp. 603-607
-
-
Zhu, L.1
Gibson, P.2
Currle, D.S.3
Tong, Y.4
Richardson, R.J.5
Bayazitov, I.T.6
|