Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

ChemMedChem

Volumn 5, Issue 1, 2010, Pages 52-55

  Ortial, Stéphanie ^a   Denoyelle, Séverine ^a   Wein, Sharon ^b   Berger, Olivier ^a   Durand, Thierry ^a   Escale, Roger ^a   Pellet, Alain ^c   Vial, Henri ^b   Vo Hoang, Yen ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c SANOFI   (France)

Author keywords

Biological activity; Hybrid bis cations; Malaria; Phospholipid metabolism; Structure activity relationships

Indexed keywords

5 (2 HYDROXYETHYL) 3 [8 [4 [IMINO(PYRROLIDIN 1 YL)METHYL]PHENOXY]OCTYL] 4 METHYL 1,3 THIAZOL 3 IUM DICHLORIDE; ANTIMALARIAL AGENT; BENZAMIDINE DERIVATIVE; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IC 50; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; CATIONS; FURANS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 74849120876     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900427     Document Type: Article

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