메뉴 건너뛰기




Volumn 44, Issue 2, 2010, Pages 224-231

Quercetin supplementation does not alter antioxidant status in humans

Author keywords

Antioxidant; F2 isoprostanes; Ferric reducing ability of plasma (FRAP); Glutathione; Oxidative stress; Oxidized low density lipoprotein (LDL); Oxygen radical absorbance capacity (ORAC); Quercetin

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; GLUCOSE TRANSPORTER; GLUTATHIONE; ISOPROSTANE DERIVATIVE; LOW DENSITY LIPOPROTEIN; OXYGEN RADICAL; PLACEBO; QUERCETIN;

EID: 74549156348     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715760903407293     Document Type: Article
Times cited : (67)

References (61)
  • 1
    • 0141738858 scopus 로고    scopus 로고
    • Nutrient Data Laboratory (US) Food Composition Laboratory (US) Beltsville MD: US Department of Agriculture Agricultural Research Service Beltsville Human Nutrition Research Center Nutrient Data Laboratory
    • Nutrient Data Laboratory (US); Food Composition Laboratory (US). USDA database for the fl avonoid content of selected foods. Beltsville, MD: US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Nutrient Data Laboratory; 2007: ii, 128 p.
    • (2007) USDA Database for the Fl Avonoid Content of Selected Foods. , pp. 128
  • 3
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioeffi cacy of polyphenols in humans I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioeffi cacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81:230S-242S.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 4
    • 45849085449 scopus 로고    scopus 로고
    • The infl uence of wine polyphenols on reactive oxygen and nitrogen species production by murine macro-phages RAW 264.7
    • Ciz M, Pavelkova M, Gallova L, Kralova J, Kubala L, Lojek A. The infl uence of wine polyphenols on reactive oxygen and nitrogen species production by murine macro-phages RAW 264.7. Physiol Res 2008;57:393-402.
    • (2008) Physiol Res , vol.57 , pp. 393-402
    • Ciz, M.1    Pavelkova, M.2    Gallova, L.3    Kralova, J.4    Kubala, L.5    Lojek, A.6
  • 5
    • 26444581298 scopus 로고    scopus 로고
    • Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats
    • Dias AS, Porawski M, Alonso M, Marroni N, Collado PS, Gonzalez-Gallego J. Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr 2005;135:2299-2304.
    • (2005) J Nutr , vol.135 , pp. 2299-2304
    • Dias, A.S.1    Porawski, M.2    Alonso, M.3    Marroni, N.4    Collado, P.S.5    Gonzalez-Gallego, J.6
  • 6
    • 14744294057 scopus 로고    scopus 로고
    • In vivo quercitrin anti-infl ammatory effect involves release of quercetin, which inhibits infl ammation through down-regulation of the NF-kappaB pathway
    • Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, Galvez J, Zarzuelo A. In vivo quercitrin anti-infl ammatory effect involves release of quercetin, which inhibits infl ammation through down-regulation of the NF-kappaB pathway. Eur J Immunol 2005;35:584-592.
    • (2005) Eur J Immunol , vol.35 , pp. 584-592
    • Comalada, M.1    Camuesco, D.2    Sierra, S.3    Ballester, I.4    Xaus, J.5    Galvez, J.6    Zarzuelo, A.7
  • 7
    • 33645541093 scopus 로고    scopus 로고
    • The fl avonoid quercetin inhibits proinfl ammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system
    • Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. The fl avonoid quercetin inhibits proinfl ammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol 2006;13:319-328.
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 319-328
    • Nair, M.P.1    Mahajan, S.2    Reynolds, J.L.3    Aalinkeel, R.4    Nair, H.5    Schwartz, S.A.6    Kandaswami, C.7
  • 8
    • 33748580218 scopus 로고    scopus 로고
    • Inhibition of pro-infl ammatory markers in primary bone marrow-derived mouse macro-phages by naturally occurring fl avonoids: Analysis of the structure-activity relationship
    • Comalada M, Ballester I, Bailon E, Sierra S, Xaus J, Galvez J, de Medina FS, Zarzuelo A. Inhibition of pro-infl ammatory markers in primary bone marrow-derived mouse macro-phages by naturally occurring fl avonoids: analysis of the structure-activity relationship. Biochem Pharmacol 2006;72: 1010-1021.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1010-1021
    • Comalada, M.1    Ballester, I.2    Bailon, E.3    Sierra, S.4    Xaus, J.5    Galvez, J.6    De Medina, F.S.7    Zarzuelo, A.8
  • 9
    • 0041527063 scopus 로고    scopus 로고
    • In vitro antiviral activities of Caesalpinia pulcherrima and its related fl avonoids
    • Chiang LC, Chiang W, Liu MC, Lin CC. In vitro antiviral activities of Caesalpinia pulcherrima and its related fl avonoids. J Antimicrob Chemother 2003;52:194-198.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 194-198
    • Chiang, L.C.1    Chiang, W.2    Liu, M.C.3    Lin, C.C.4
  • 10
    • 0023918014 scopus 로고
    • Antiviral activity of fl avones and potentiation by ascorbate
    • Vrijsen R, Everaert L, Boeye A. Antiviral activity of fl avones and potentiation by ascorbate. J Gen Virol 1988;69: 1749-1751.
    • (1988) J Gen Virol , vol.69 , pp. 1749-1751
    • Vrijsen, R.1    Everaert, L.2    Boeye, A.3
  • 12
    • 33750496903 scopus 로고    scopus 로고
    • Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): Structure-activity relationship studies reveal salient pharmacophore features
    • Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Liew OW, Zhu W, Puah CM, Shen X, Jiang H. Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features. Bioorg Med Chem 2006;14:8295-8306.
    • (2006) Bioorg Med Chem , vol.14 , pp. 8295-8306
    • Chen, L.1    Li, J.2    Luo, C.3    Liu, H.4    Xu, W.5    Chen, G.6    Liew, O.W.7    Zhu, W.8    Puah, C.M.9    Shen, X.10    Jiang, H.11
  • 15
    • 9744242794 scopus 로고    scopus 로고
    • Dietary fl avonoids and cancer risk: Evidence from human population studies
    • Neuhouser ML. Dietary fl avonoids and cancer risk: evidence from human population studies. Nutr Cancer 2004;50:1-7.
    • (2004) Nutr Cancer , vol.50 , pp. 1-7
    • Neuhouser, M.L.1
  • 18
    • 34247898848 scopus 로고    scopus 로고
    • Estimated dietary fl avonoid intake and major food sources of U.S. adults
    • Chun OK, Chung SJ, Song WO. Estimated dietary fl avonoid intake and major food sources of U.S. adults. J Nutr 2007; 137:1244-1252.
    • (2007) J Nutr , vol.137 , pp. 1244-1252
    • Chun, O.K.1    Chung, S.J.2    Song, W.O.3
  • 22
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007;45:2179-2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 24
    • 0033901336 scopus 로고    scopus 로고
    • Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations
    • Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI, Howard AN. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem 2000;46:1162-1170.
    • (2000) Clin Chem , vol.46 , pp. 1162-1170
    • Chopra, M.1    Fitzsimons, P.E.2    Strain, J.J.3    Thurnham, D.I.4    Howard, A.N.5
  • 29
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of fl avonoids and phenolic acids
    • Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of fl avonoids and phenolic acids. Free Radic Biol Med 1996;20:933-956.
    • (1996) Free Radic Biol Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 30
    • 1842713400 scopus 로고    scopus 로고
    • Inhibition of human low density lipoprotein oxidation by fl avonols and their glycosides
    • Hou L, Zhou B, Yang L, Liu ZL. Inhibition of human low density lipoprotein oxidation by fl avonols and their glycosides. Chem Phys Lipids 2004;129:209-219.
    • (2004) Chem Phys Lipids , vol.129 , pp. 209-219
    • Hou, L.1    Zhou, B.2    Yang, L.3    Liu, Z.L.4
  • 33
    • 0034706914 scopus 로고    scopus 로고
    • The protective effect of fl avonol quercetin against ultraviolet a induced oxidative stress in rats
    • Erden Inal M, Kahraman A. The protective effect of fl avonol quercetin against ultraviolet a induced oxidative stress in rats. Toxicology 2000;154:21-29.
    • (2000) Toxicology , vol.154 , pp. 21-29
    • Erden Inal, M.1    Kahraman, A.2
  • 35
    • 11144328863 scopus 로고    scopus 로고
    • Quercetin, a fl avonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    • Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a fl avonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 2005;51:117-123.
    • (2005) Pharmacol Res , vol.51 , pp. 117-123
    • Coskun, O.1    Kanter, M.2    Korkmaz, A.3    Oter, S.4
  • 36
    • 0035370769 scopus 로고    scopus 로고
    • Identifi cation of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin
    • Moon JH, Tsushida T, Nakahara K, Terao J. Identifi cation of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 2001;30:1274-1285.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1274-1285
    • Moon, J.H.1    Tsushida, T.2    Nakahara, K.3    Terao, J.4
  • 37
    • 73749083955 scopus 로고    scopus 로고
    • Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study
    • Egert S, Bosy-Westphal A, Seiberl J, Kurbitz C, Settler U, Plachta-Danielzik S, Wagner AE, Frank J, Schrezenmeir J, Rimbach G, Wolffram S, Muller MJ. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr 2009;102: 1065-1074.
    • (2009) Br J Nutr , vol.102 , pp. 1065-1074
    • Egert, S.1    Bosy-Westphal, A.2    Seiberl, J.3    Kurbitz, C.4    Settler, U.5    Plachta-Danielzik, S.6    Wagner, A.E.7    Frank, J.8    Schrezenmeir, J.9    Rimbach, G.10    Wolffram, S.11    Muller, M.J.12
  • 43
    • 51749090447 scopus 로고    scopus 로고
    • F2-isoprostanes in human health and diseases: From molecular mechanisms to clinical implications
    • Basu S. F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Antioxid Redox Signal 2008;10:1405-1434.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1405-1434
    • Basu, S.1
  • 44
    • 13244279737 scopus 로고    scopus 로고
    • Quantifi cation of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans
    • Morrow JD. Quantifi cation of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol 2005;25:279-286.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 279-286
    • Morrow, J.D.1
  • 45
    • 33750721631 scopus 로고    scopus 로고
    • Clinical oxidation parameters of aging
    • Voss P, Siems W. Clinical oxidation parameters of aging. Free Radic Res 2006;40:1339-1349.
    • (2006) Free Radic Res , vol.40 , pp. 1339-1349
    • Voss, P.1    Siems, W.2
  • 47
    • 13144259660 scopus 로고    scopus 로고
    • Mass spectrometric quanti-fication of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress
    • Morrow JD, Roberts LJ, 2nd. Mass spectrometric quanti-fication of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol 1999;300:3-12.
    • (1999) Methods Enzymol , vol.300 , pp. 3-12
    • Morrow, J.D.1    Roberts II, L.J.2
  • 49
    • 44249104442 scopus 로고    scopus 로고
    • Jr Association between circulating oxidized low-density lipopro-tein and incidence of the metabolic syndrome
    • Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR, Jr. Association between circulating oxidized low-density lipopro-tein and incidence of the metabolic syndrome. JAMA 2008; 299:2287-2293.
    • (2008) JAMA , vol.299 , pp. 2287-2293
    • Holvoet, P.1    Lee, D.H.2    Steffes, M.3    Gross, M.4    Jacobs, D.R.5
  • 50
    • 18544394874 scopus 로고    scopus 로고
    • Antioxidant defence of red blood cells and plasma in stored human blood
    • Jozwik M, Szczypka M, Gajewska J, Laskowska-Klita T. Antioxidant defence of red blood cells and plasma in stored human blood. Clin Chim Acta 1997;267:129-142.
    • (1997) Clin Chim Acta , vol.267 , pp. 129-142
    • Jozwik, M.1    Szczypka, M.2    Gajewska, J.3    Laskowska-Klita, T.4
  • 51
    • 0030586361 scopus 로고    scopus 로고
    • The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': The FRAP assay
    • Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 1996;239:70-76.
    • (1996) Anal Biochem , vol.239 , pp. 70-76
    • Benzie, I.F.1    Strain, J.J.2
  • 52
    • 0027400453 scopus 로고
    • Oxygen-radical absorbance capacity assay for antioxidants
    • Cao G, Alessio HM, Cutler RG. Oxygen-radical absorbance capacity assay for antioxidants. Free Radic Biol Med 1993; 14:303-311.
    • (1993) Free Radic Biol Med , vol.14 , pp. 303-311
    • Cao, G.1    Alessio, H.M.2    Cutler, R.G.3
  • 53
    • 53849146739 scopus 로고    scopus 로고
    • Pure dietary fl avonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
    • Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary fl avonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 2008;88: 1018-1025.
    • (2008) Am J Clin Nutr , vol.88 , pp. 1018-1025
    • Loke, W.M.1    Hodgson, J.M.2    Proudfoot, J.M.3    McKinley, A.J.4    Puddey, I.B.5    Croft, K.D.6
  • 54
    • 33750455858 scopus 로고    scopus 로고
    • Consumption of fl avonoid-rich foods and increased plasma antioxidant capacity in humans: Cause consequence or epiphenomenon?
    • Lotito SB, Frei B. Consumption of fl avonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 2006;41: 1727-1746.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1727-1746
    • Lotito, S.B.1    Frei, B.2
  • 55
    • 38949207932 scopus 로고    scopus 로고
    • Metabolic transformation has a profound effect on anti-infl ammatory activity of fl avonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity
    • Loke WM, Proudfoot JM, Stewart S, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Metabolic transformation has a profound effect on anti-infl ammatory activity of fl avonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol 2008;75:1045-1053.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1045-1053
    • Loke, W.M.1    Proudfoot, J.M.2    Stewart, S.3    McKinley, A.J.4    Needs, P.W.5    Kroon, P.A.6    Hodgson, J.M.7    Croft, K.D.8
  • 56
    • 0032562766 scopus 로고    scopus 로고
    • Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
    • Manach C, Morand C, Crespy V, Demigne C, Texier O, Regerat F, Remesy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett 1998;426:331-336.
    • (1998) FEBS Lett , vol.426 , pp. 331-336
    • Manach, C.1    Morand, C.2    Crespy, V.3    Demigne, C.4    Texier, O.5    Regerat, F.6    Remesy, C.7
  • 57
    • 36248931572 scopus 로고    scopus 로고
    • Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformation
    • Chen CY, Milbury PE, Chung SK, Blumberg J. Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformation. J Nutr Biochem 2007;18:785-794.
    • (2007) J Nutr Biochem , vol.18 , pp. 785-794
    • Chen, C.Y.1    Milbury, P.E.2    Chung, S.K.3    Blumberg, J.4
  • 58
    • 37549031270 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of the biofl avonoid biochanin A: Effects of quercetin and EGCG on biochanin A disposition in rats
    • Moon YJ, Morris ME. Pharmacokinetics and bioavailability of the biofl avonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm 2007;4:865-872.
    • (2007) Mol Pharm , vol.4 , pp. 865-872
    • Moon, Y.J.1    Morris, M.E.2
  • 59
    • 33746885901 scopus 로고    scopus 로고
    • Intestinal anti-infl ammatory activity of combined quercitrin and dietary olive oil supplemented with fi sh oil, rich in EPA and DHA (n-3) polyun-saturated fatty acids, in rats with DSS-induced colitis
    • Camuesco D, Comalada M, Concha A, Nieto A, Sierra S, Xaus J, Zarzuelo A, Galvez J. Intestinal anti-infl ammatory activity of combined quercitrin and dietary olive oil supplemented with fi sh oil, rich in EPA and DHA (n-3) polyun-saturated fatty acids, in rats with DSS-induced colitis. Clin Nutr 2006;25:466-476.
    • (2006) Clin Nutr , vol.25 , pp. 466-476
    • Camuesco, D.1    Comalada, M.2    Concha, A.3    Nieto, A.4    Sierra, S.5    Xaus, J.6    Zarzuelo, A.7    Galvez, J.8
  • 60
    • 40049092280 scopus 로고    scopus 로고
    • Protective effects of a combination of quercetin and vitamin e against cyclosporine A-induced oxidative stress and hepatotoxicity in rats
    • Mostafavi-Pour Z, Zal F, Monabati A, Vessal M. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res 2008;38:385-392.
    • (2008) Hepatol Res , vol.38 , pp. 385-392
    • Mostafavi-Pour, Z.1    Zal, F.2    Monabati, A.3    Vessal, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.