Effects of quercetin and egcg on mitochondrial biogenesis and immunity

Medicine and Science in Sports and Exercise

Volumn 41, Issue 7, 2009, Pages 1467-1475

  Nieman, David C ^a,b   Henson, Dru A ^b   Maxwell, Kendra R ^b   Williams, Ashley S ^b   Mcanulty, Steven R ^a   Jin, Fuxia ^a   Shanely, R Andrew ^a   Lines, Thomas C ^a  

^a Leisure and Exercise Science ^*  (United States)

^b APPALACHIAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; C REACTIVE PROTEIN; CITRATE SYNTHASE; CYTOCHROME C; DOCOSAHEXAENOIC ACID; EPIGALLOCATECHIN GALLATE; FLAVONOID; FOLIC ACID; GRANULOCYTE COLONY STIMULATING FACTOR; ICOSAPENTAENOIC ACID; INTERLEUKIN 10; INTERLEUKIN 6; ISOQUERCETIN; MESSENGER RNA; NICOTINAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLACEBO; QUERCETIN; UNCLASSIFIED DRUG; ANTIOXIDANT; CATECHIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNSATURATED FATTY ACID;

ADULT; ARTICLE; BIOGENESIS; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYCLING; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; EVENING DOSAGE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNITY; INFLAMMATION; MALE; MORNING DOSAGE; MUSCLE BIOPSY; MUSCLE EXERCISE; MUSCLE MITOCHONDRION; RANDOMIZED CONTROLLED TRIAL; SALIVA ANALYSIS; SINGLE BLIND PROCEDURE; TREATMENT DURATION; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECTS; MITOCHONDRION; OXIDATIVE STRESS;

ADULT; ANTIOXIDANTS; C-REACTIVE PROTEIN; CATECHIN; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; FATTY ACIDS, UNSATURATED; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MITOCHONDRIA; OXIDATIVE STRESS; PPAR GAMMA; QUERCETIN; RNA, MESSENGER; EICOSAPENTAENOIC ACID;

EID: 67650033132     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318199491f     Document Type: Article

References (37)

1. 1 adenosine receptors. Phytother Res. 2006;20:1009-12.
2. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585: 325-37.
3. Boots AW, Wilms LC, Swennen EL, Kleinjans JC, Bast A, Haenen GR. In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition. 2008;24:703-10.
4. Camuesco D, Comalada M, Concha A, et al. Intestinal antiinflammatory activity of combined quercitrin and dietary olive oil supplementedwithfish oil,richinEPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. Clin Nutr. 2006;25:466-76.
5. Chen CY, Milbury PE, Chung SK, Blumberg J. Effect of almond skin polyphenolics and quercetin on human LDL and apolipopro- tein B-100 oxidation and conformation. JNutr Biochem. 2007;18: 785-94.
6. Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C- reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. JNutr. 2008;138:753-60.
7. Chun OK, Chung SJ, Song WO. Estimated dietary flavonoid intake and major food sources of U.S. adults. J Nutr. 2007;137: 1244-52.
8. Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009; 296:R1071-7.
9. Davis JM, Murphy EA, McClellan JL, Carmichael MD, Gangemi JD. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol. 2008;295(2):R505-9.
10. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974;37:247-8.
11. Evans WJ, Phinney SD, Young VR. Suction applied to muscle biopsy maximizes sample size. Med Sci Sports Exerc. 1982;14(1): 101-2.
12. Feng WY. Metabolism of green tea catechins: an overview. Curr Drug Metab. 2006;7:755-809.
13. Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargoni- din inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007;2007:45673.
14. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45:2179-205.
15. Henson D, Nieman D, Davis JM, et al. Post-160-km race illness rates and decreases in granulocyte respiratory burst and salivary IgA output are not countered by quercetin ingestion. Int J Sports Med. 2008;29:856-63.
16. Ivanov V, Ivanova S, Kalinovsky T, Niedzwiecki A, Rath M. Plant-derived micronutrients suppress monocyte adhesion to cultured human aortic endothelial cell layer by modulating its extracellular matrix composition. J Cardiovasc Pharmacol. 2008; 52:55-65.
17. Keating E, Lemos C, Goncalves P, Martel F. Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem. 2008;19:91-100.
18. -Δct method. Methods. 2001;25:402-8.
19. Loke WM, Proudfoot JM, McKinley AJ, et al. Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipopro- tern oxidation. J Agric Food Chem. 2008;56:3609-15.
20. Loke WM, Proudfoot JM, Stewart S, et al. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol. 2008;75:1045-53.
21. MacRae HS, Mefferd KM. Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int Sport Nutr Exerc Metab. 2006;16:405-19.
22. Manach C, Williamson G, Morand C, Scalbert A, Résy C. Bioavailability and bioefficacy of polyphenols in humans. I: Review of 97 bioavailability studies. Am Clin Nutr. 2005; 81(Suppl 1):S230-42.
23. McAnulty SR, McAnulty LS, Nieman DC, et al. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Appl Physiol Nutr Metab. 2008;33:254-62.
24. Moon YJ, Morris ME. Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm. 2007;4:865-72.
25. Moon YJ, Wang L, DiCenzo R, Morris ME. Quercetin pharma- cokinetics in humans. Biopharm Drug Dispos. 2008;29:205-17.
26. Murase T, Haramizu S, Shimotoyodome A, Tokimitsu I, Hase T. Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise. Am Physiol Regul Integr Comp Physiol. 2006;290:R1550-6.
27. Neuhouser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer. 2004;50:1-7.
28. Nieman DC, Davis JM, Henson DA, et al. Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol. 2003;94:1917-25.
29. Nieman DC, Henson DA, Davis JM, et al. Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. J Interferon Cytokine Res. 2007; 27:1003-11.
30. Nieman DC, Henson DA, Davis JM, et al. Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol. 2007;103:1728-35.
31. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007;39(9):1561-9.
32. Smith LL, Brunetz MH, Chenier TC, et al. The effects of static and ballistic stretching on delayed onset muscle soreness and creatine kinase. Res Q Exerc Sport. 1993;64:103-7.
33. Suri S, Taylor MA, Verity A, et al. A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro. Biochem Pharmacol. 2008; 76:645-53.
34. United States Department of Agriculture (USDA). USDA Database for the Flavonoid Content of Selected Foods. Beltsville (MD): United States Department of Agriculture (USDA); 2007. p. 2.
35. Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat Res. 2008;654: 38-44.
36. Vrijsen R, Everaert L, Boeyé A. Antiviral activity of flavones and potentiation by ascorbate. J Gen Virol. 1988;69(Pt 7):1749-51.
37. Wolffram S, Blöck M, Ader P. Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. J Nutr. 2002;132:630-5.