Structural analysis of an MK2-inhibitor complex: Insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800

Acta Crystallographica Section D: Biological Crystallography

Volumn 66, Issue 1, 2010, Pages 80-87

  Fujino, Aiko ^a   Fukushima, Kei ^a   Namiki, Naoko ^a   Kosugi, Tomomi ^a   Takimoto Kamimura, Midori ^a  

^a Teijin Institute for Biomedical Research   (Japan)

Author keywords

Conformational change; Gly rich loop; Inhibitors; MK2

Indexed keywords

MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SIGNAL PEPTIDE; TEI I01800;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74549142415     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909046411     Document Type: Article

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