Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4882-4884

  Anderson, David R ^a   Meyers, Marvin J ^a   Kurumbail, Ravi G ^a   Caspers, Nicole ^a   Poda, Gennadiy I ^a   Long, Scott A ^a   Pierce, Betsy S ^a   Mahoney, Matthew W ^a   Mourey, Robert J ^a   Parikh, Mihir D ^a  

^a PFIZER INC   (United States)

Author keywords

Kinase inhibitor; MAPKAP K2; MK2

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CRYSTAL STRUCTURE; CYCLIZATION; DEPROTECTION REACTION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; REACTION OPTIMIZATION; X RAY ANALYSIS;

BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; DRUG DESIGN; HUMANS; MAP KINASE KINASE 2; PROTEIN KINASE INHIBITORS; THIOPHENES;

EID: 67651115814     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.017     Document Type: Article

References (3)

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