Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

BMC Structural Biology

Volumn 9, Issue , 2009, Pages

  Argiriadi, Maria A ^a   Sousa, Silvino ^a   Banach, David ^a   Marcotte, Douglas ^a,b   Xiang, Tao ^a   Tomlinson, Medha J ^a   Demers, Megan ^a,c   Harris, Christopher ^a   Kwak, Silvia ^a   Hardman, Jennifer ^a   Pietras, Margaret ^a   Quinn, Lisa ^a,d   Dimauro, Jennifer ^a   Ni, Baofu ^a   Mankovich, John ^a   Borhani, David W ^a,e   Talanian, Robert V ^a   Sadhukhan, Ramkrishna ^a  

^a ABBOTT LABORATORIES   (United States)

^b BIOGEN   (United States)

^c Genomics Institute of the Novartis Research Foundation ^*  (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^e D E SHAW RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; ISOENZYME; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOMATION; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFRACTION; DRUG DESIGN; ENTROPY; ENZYME STRUCTURE; GENE CONSTRUCT; GENE DELETION; HIGH THROUGHPUT SCREENING; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN TARGETING; REPRODUCIBILITY; ROBOTICS; STRUCTURE ANALYSIS; AMINO ACID SUBSTITUTION; BIOSYNTHESIS; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

EID: 66149087662     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-9-16     Document Type: Article

References (34)

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