Toxicological assessment of toxic element residues in swine kidney and its role in public health risk assessment

International Journal of Environmental Research and Public Health

Volumn 6, Issue 12, 2009, Pages 3127-3142

  Milićević, Dragan R ^a   Jovanović, Milijan ^b   Jurić, Verica B ^c   Petrović, Zoran I ^a   Stefanović, Srdan M ^a  

^a INSTITUTE OF MEAT HYGIENE AND TECHNOLOGY   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Horticulture and Landscape Architecture   (Serbia)

Author keywords

Kidney; Pathomorphology; Residue; Swine; Toxic elements

Indexed keywords

ARSENIC; CADMIUM; LEAD; MERCURY;

ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOACCUMULATION; CELL DEATH; CELL SWELLING; CELL VACUOLE; CONSUMER ADVOCACY; CONTROLLED STUDY; DRUG ACCUMULATION; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD SAFETY; HEALTH HAZARD; HISTOPATHOLOGY; KIDNEY HEMORRHAGE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; NEPHROTOXICITY; NONHUMAN; PREVALENCE; RESIDUE ANALYSIS; RISK ASSESSMENT; SERBIA; SWINE;

SUIDAE;

EID: 74549130046     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph6123127     Document Type: Article

References (81)

1. Satarug, S.; Baker, J.R.; Urbenjapol, S.; Haswell-Elkins, M.R.; Reilly, P.E.B.; Williams, D.J. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 2003, 137, 65-83.
2. Zaidi, M.I.; Asrar, A.; Mansoor, A.; Farooqui, M.A. The heavy metal concentrations along roadside trees of Quetta and its effects on public health. J. Appl. Sci. 2005, 5, 708-711.
3. D'Mello, J.P.F. Food Safety: Contaminants and Toxins; CABI Publishing: Wallingford, Oxon, Cambridge, MA, UK, 2003; p. 480.
4. Jarup, L. Hazards of heavy metal contamination. Br. Med. Bull. 2003, 68, 167-182.
5. Sathawara, N.G.; Parikh, D.J.; Agarwal, Y.K. Essential heavy metals in environmental samples from western India. Bull. Environ. Contam. Toxicol. 2004, 73, 756-761.
6. Caggiano R.; Macchiato M.F.; Ragosta, M. Heavy metals in ryegrass species versus metal concentrations in atmospheric particulates in an industrial area of southern Italy. Environ. Monit. Assess. 2004, 102, 67-84.
7. Diamond G.L.; Zalups, R.K. Understanding renal toxicity of heavy metals. Toxicol. Pathol. 1998, 26, 92-103.
8. Lewis, M.; Worobey, J.; Ramsay, D.S.; McCormack, M.K. Prenatal exposure to heavy metals: Effects on childhood cognitive skills and health status. Am. Acad. Ped. 1992, 89, 1010-1015.
9. Cadmium. Environmental Health Criteria. WHO: Geneva, Switzerland, 1992; Vol. 134.
10. Lead. Environmental Health Criteria, WHO: Geneva, Switzerland, 1995; Vol. 165.
11. Steenland, K.; Boffetta, P. Lead and cancer in humans: Where are we now? Am. J. Ind. Med. 2000, 38, 295-299.
12. Dolk, H.; Vrijheid, M. The impact of environmental pollution on congenital anomalies. Brit. Med. Bull. 2003, 68, 25-45.
13. Schwartz, J. Air pollution and daily mortality: A review and meta-analysis. Environ. Res. 1994, 64, 26-35.
14. Engel, R.R.; Hopenhayn-Rich, C.; Receveur, O.; Simith, H. Vascular effects of chronic arsenic exposure: A review. Epidemiol. Rev. 1994, 16, 184-209.
15. Tsuda, T.; Babazono, A.; Yamamoto, E.; Krumatani, N.; Mino, Y.; Ogawa, T.; Kishi, Y.; Aoyama, H. Ingested arsenic and internal cancer: A historical cohort study followed for 33 year. Am. J. Epidemiol. 1995, 141, 198-209.
16. Jarup, L.; Berglung, M.; Elinder, C.G.; Norduerg, G.; Vahter, M. Health effects of cadmium exposure a review of the literature and a risk estimate. Scamlintivittn J. Work. Environ. Health 1998, 24, 1-51.
17. Basu, A.; Mahata, J.; Gupta, S.; Giri, A.K. Genetic toxicology of a paradoxical human carcinogen, arsenic: A review. Mutaliini Res. 2001, 448, 171-194.
18. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans; International Agency for Research on Cancer: Lyon, France, 1993; Vol. 58, p. 444.
19. Pitot, C.H.; Dragon, P.Y. Chemical carcinogenesis. In Casarett and Doull's Toxicology, 5th ed., International Edition; McGraw Hill: New York, NY, USA, 1996; pp. 201-260.
20. Abou-Arab, A.A.K. Heavy metal contents in Egyptian meat and the role of detergent washing on their levels. Food Chem Toxicol. 2001, 39, 593-599.
21. Lazarus, M.; Vickovic, I. Šoštari?, B.; Blanuš, M. Heavy metal levels in tissues of Red Deer (Cervus elaphus) from Eastern Croatia. Arh Hig Rada Toksikol. 2005, 56, 233-240.
22. Villar, T.d.C.; Elaine, J.; Kaligayahan, P.; Flavier, M.E. Lead and cadmium levls in edible internal organs and blood of poultry chicken. J. Appl. Sci. 2005, 5, 1250-1253.
23. UNEP (United Nations Environment Programme). Draft final review of scientific information on cadmium, 2008. Available online: http://www.chem.unep.ch/Pb-and-Cd/SR/Draft-final-reviews/ Cd-Review/Final-UNEP.
24. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Evaluation of Certain Food Additives and Contaminants. Fifty third report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series no. 896. World Health Organization: Geneva, Switzerland, 2000.
25. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Evaluation of certain food additives and contaminants. Fiftyfifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series no. 901. World Health Organization: Geneva, Switzerland, 2001.
26. Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs, Official Journal of the European Union, L364/5. European Parliament and of the Council: Brussels, Belgium, 2006.
27. Karavoltsos, S.; Sakellari, A.; Dimopoulos, M.; Dasenakis, M.; Scoullos, M. Cadmium content in foodstuffs from the Greek market. Food Addit. Contam. 2002, 19, 954-962.
28. Milacic, R.; Kralj, B. Determination of Zn, Cu, Cd, Pb, Ni and Cr in some Slovenian foodstuffs. Eur. Food Res. Technol. 2003, 217, 211-214.
29. EEA (European Environmental Agency). Trends in metals and persistent organic pollutants. In Hazardous Substances in the European Marine Environment; Green, N., Bjerkeng, B., Hylland, K., Ruus, A., Rygg, B., Eds.; Norwegian Institute for Water Research: Copenhagen, Denmark, 2003; pp. 1-85.
30. European Food Safety Authority (EFSA). Scientific opinion of the Panel on Contaminants in the Food Chain Mercury as undesirable substance in animal feed. EFSA J. 2008, 654, 2-74.
31. Brzóska, M.M.; Moniuszko-Jakoniuk, J. The influence of calcium content in diet on cumulation and toxicity of cadmium in the organism. Arch. Toxicol. 1998, 72, 63-73.
32. Brzóska, M.M.; Moniuszko-Jakoniuk, J. Interactions between cadmium and zinc in the organism. Fd. Chem. Toxicol. 2001, 39, 967-980.
33. Scoullos, M.; Vonekeman, G.H.; Thornton, I. EUPHEMET-Towards an integrated EU policy for heavy metals. EC-DG Research: Brussels, Belgium, 2001.
34. Satarug, S.; Haswell-Elkins, M.R.; Moore, M.R. Safe levels of cadmium intake to prevent renal toxicity in human subjects. Br. J. Nutr. 2000, 84, 791-802.
35. Goering, P.L.; Waalkes, M.P.; Klaassen, C.D. Toxicology of cadmium. In Toxicology of Metals: Biochemical Aspects. Handbook of Experimental Pharmacology; Goyer, R.A., Cherian, M.G., Eds.; Springer: New York, NY, USA, 1995; Vol. 115, pp. 189-213.
36. Jiang, J.; McCool, B.A.; Parrish, A.R. Cadmium- and mercury-induced intercellular adhesion molecule-1 expression in immortalized proximal tubule cells: Evidence for a role of decreased transforming growth factor-beta1. Toxicol. Appl. Pharmacol. 2002, 179, 13-20.
37. Prozialeck, W.C.; Lamar, P.C. Cadmium nephrotoxicity is associated with a loss of N-cadherin-mediated adhesion and alterations in epithelial polarity in the proximal tubule. Toxicol. Sci. 2005, 84, S327.
38. Edwards, J.R.; Lamar, P.C.; Diamantakos, E.; Peuler, J.D.; Liu, J.; Waalkes, M. Cadmium-induced disruption of proximal tubule cell adhesion is associated with redistribution of cell adhesion molecules and loss of epithelial polarity. Toxicol. Sci. 2006, 90, S414.
39. Agency for Toxic Substances and Disease Registry (ATSDR), 1998: Toxicological profiles for arsenic, update.
40. Goering, P.L.; Aposhian, H.V.; Mass, M.J.; Cebrian, M.; Beck, B.D.; Waalkes, M.P. The enigma of arsenic carcinogenesis: Role of metabolism. Toxicol. Sci. 1999, 49, 5-14.
41. Bucheli, T.D.; Fent, K. Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems. Crit. Rev. Environ. Sci. Technol. 1995, 25, 201-268.
42. Yasutake, A.; Nakano, A.; Hirayama, K. Induction by mercury compounds of brain metallothionein in rats: Hg0 exposure induces long-lived brain metallothionein. Arch. Toxicol. 1998, 72, 187-191.
43. Yoshida, M.; Satoh, H.; Sumi, Y. Effect of ethanol pretreatment on mercury distribution in organs of fetal guinea pigs following in utero exposure to mercury vapor. Toxicology 1997, 119, 193-201.
44. Yoshida, M.; Satoh, M.; Yasutake, A.; Shimada, A.; Sumi, Y.; Tohyama, C. Distribution and retention of mercury in metallothionein-null mice after exposure to mercury vapor. Toxicology 1999, 139, 129-136.
45. Klaassen, C.D.; Liu, J. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. Environ. Health Perspect. 1998, 106, 297-300.
46. Liu, J.; Liu, Y.; Habeebu, S.S.; Klaassen, C.D. Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure. Toxicol. Appl. Pharmacol. 1999, 159, 98-108.
47. George, S.G.; Langston, W.J. Metallothionein as an indicator of water quality-Assessment of the bioavailability of cadmium, copper, mercury and zinc in aquatic animals at the cellular level. In Water Quality and Stress Indicators in Marine and Freshwater Ecosystems: Linking Levels of Organization; Sutcliffe, D.W., Ed.; Freshwater Biological Association: Ambleside, UK, 1994; pp. 138-153.
48. Chan; H.M.; Zhu, L.F.; Zhong, R.; Grand, D.; Goyer, R.A.; Cherian, M.G. Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appl. Pharmacol. 1993, 123, 89-96.
49. Sudo, J.; Hayashi, T.; Kimura, S.; Kakuno, K.; Terui, J.; Takashima, K. Mechanism of nephrotoxicity induced by repeated administration of cadmium chloride in rats. J. Toxicol. Environ. Health 1996, 48, 333-348.
50. Youn, J.; Lynes, M.A. Metallothionein-induced suppression of cytotoxic T lymphocyte function: An important immunoregulatory control. Toxicol Sci. 1999, 52, 199-208.
51. Conner, E.A.; Fowler, B.A. Mechanisms of metal-induced nephrotoxicity. In Toxicology of the Kidney, 2nd ed.; Hook, J.B., Goldstein, R.S., Eds.; Raven Press: New York, NY, USA, 1993; pp. 437-457.
52. Jacquillet, G.; Barbier, O.; Cougnon, M.; Tauc, M.; Namorado, M.C.; Martin, D. Zinc protects renal function during cadmium intoxication in the rat. Am. J. Physiol. Renal Physiol. 2006, 290, F127-F137.
53. Jiang, J.; Dean, D.; Burghardt, R.C.; Parrish, A.R. Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity. Toxicol. Sci. 2004, 80, 170-182.
54. Leussink, B.T.; Litvinov, S.V.; de Heer, E.; Slikkerveer, A.; van der Voet, G.B.; Bruijn, J.A. Loss of homotypic epithelial cell adhesion by selective N-cadherin displacement in bismuth nephrotoxicity. Toxicol. Appl. Pharmacol. 2001, 175, 54-59.
55. Corbett, J.R. The Biochemical Mode of Action of Pesticides; Academic Press: London, UK, 1974; pp. 253-255.
56. Olinescu, R.; Smith, T.L.; Hertoghe, J. The Body's Battle against Pollution; Nova: Commack, NY, USA, 1998; pp. 97-223.
57. Massaro, E.J. Tissue uptake and subcellular distribution of mercury. In Handbook of Human Toxicology; Massaro, E.J., Ed.; CRC Press: Boca Raton, FL, USA, 1997; pp. 285-301.
58. Wang, W.; Ballatori, N. Endogenous glutathione conjugates: Occurrence and biological functions. Pharmacol. Rev. 1998, 50, 335-354.
59. Crosby, D.G. Environmental Toxicology and Chemistry; Oxford University Press: New York, NY, USA, 1998; pp. 212-213.
60. Christie, N.T.; Costa, M. In vitro assessment of the toxicity of metal compounds IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA. Biol. Trace Elem. Res. 1984, 6, 139-158.
61. Bhattacharya, S. Mechanisms of signal transduction in the stress response of hepatocytes. In International Review of Cytology; Jeon, K.W., Ed.; Academic Press: San Diego, CA, USA, 1998; Vol. 184, pp. 109-156.
62. O'Flaherty, E.J. Physiologically based models of metal kinetics. Crit. Rev. Toxicol. 1998, 28, 271-317.
63. Liang, G.; Järlebark, L.; Ulfendahl, M.; Moore, E.J. Mercury (Hg2+) suppression of potassium currents of outer hair cells. Neurotoxicol. Teratol. 2003, 25, 349-359.
64. Leong, C.C.; Syed, N.I.; Lorscheider, F.L. Retrograde degeneration of neurite membrane structural integrity of nerve growth cones following in vitro exposure to mercury. NeuroReport 2001, 12, 733-737.
65. Denny, M.F.; Atchison, W.D. Mercurial-induced alterations in neuronal divalent cation homeostasis. Neurotoxicology 1996, 17, 47-62.
66. Sirois, J.E.; Atchison, W.D. Effects of mercurials on ligand- and voltage-gated ion channels: A review. Neurotoxicology 1996, 17, 63-84.
67. Castoldi, A.F.; Coccini, T.; Ceccatelli, S.; Manzo, L. Neurotoxicity and molecular effects of methylmercury. Brain Res. Bull. 2001, 55, 197-203.
68. Shafer, T.J.; Meacham, C.A.; Barone, S., Jr. Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltagesensitive sodium and calcium currents in PC12 cells. Brain Res. Dev. Brain Res. 2002, 136, 151-164.
69. Yoshida, M.; Satoh, M.; Shimada, A.; Yamamoto, E.; Yasutake, A.; Tohyama, C. Maternal-to-fetus transfer of mercury in metallothionein- null pregnant mice after exposure to mercury vapor. Toxicology, 2002, 175, 215-222.
70. Gopal, K.V. Neurotoxic effects of mercury on auditory cortex networks growing on microelectrode arrays: A preliminary analysis. Neurotoxicol. Teratol. 2003, 25, 69-76.
71. Liu, J.; Liu, Y-P.; Habeebu, S.M.; Klaassen, C.D. Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicol. Sci. 1998, 46, 197-203.
72. Liu, J.; Liu, Y.-P.; Goyer, R.A.; Achanzar W.; Waalkes, M.P. Metallothionein-I:II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Toxicol. Sci. 2000, 55, 460-467.
73. Stohs, S.J.; Bagchi, D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 1995, 18, 321-336.
74. Shaikh, Z.A.; Vu, T.T.; Zaman, K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol. 1999, 154, 256-263.
75. Sabolic I. Common mechanisms in nephropathy induced by toxic metals. Nephron Physiol. 2006, 104, 107-114.
76. Yamanaka, K.; Hasegawa, A.; Sawunura, R.; Okada, S. Cellular response to oxidative damage in lung induced by the administration of dimethylarsenic acid, a major metabolite of inorganic arsenics, in mice. Toxicol. Appl. Pharmacol. 1991, 108, 205-213.
77. Barchowsky, A.; Dudek, E.J.; Treadwell, M.D.; Wetterhahn, K.E. Arsenic induces oxidant stress and NF-kB in cultured aortic endothelial cells. Free Radic. Biol. Med. 1996, 21, 783-790.
78. Liu, J.; Waalkes, M. Focal adhesion kinase as a potential target in arsenic toxicity. Toxicol Sci. 2005, 84, 212-213.
79. Yancy, S.L.; Shelden, E.A.; Gilmont, R.R.; Welsh, M.J. Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol Sci. 2005, 84, 278-286.
80. Diaz-Barriga, F.; Llamas, E.; de Jesus Mejia, J.; Carrizales, L.; Santoyo, M.E.; Vega-Vega, L.; Yanez, L. Arsenic-cadmium interaction in rats. Toxicology 1990, 64, 191-203.
81. WHO-IPCS (World Health Organization-International Programme on Chemical Safety). Elemental mercury and inorganic mercury compounds: Human health aspects. Concise Iinternational Chemical Assessment Document 50. Geneva, Switzerland, 2003.