Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals

Toxicological Sciences

Volumn 55, Issue 2, 2000, Pages 460-467

  Liu, Jie ^a   Liu, Yaping ^b   Goyer, Robert A ^a   Achanzar, William ^a   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Arsenate; Arsenite; Chronic exposures; Glutathione; Hepatotoxicity; Metallothionein I II null mice; Nephrotoxicity; Serum cytokines

Indexed keywords

ARSENIC; CADMIUM; COPPER; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MERCURY; METALLOTHIONEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FEMALE; LIVER TOXICITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; TOXICITY TESTING; UREA NITROGEN BLOOD LEVEL;

ANIMALIA;

EID: 0034078265     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.2.460     Document Type: Article

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