KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders

Heart Rhythm

Volumn 7, Issue 2, 2010, Pages 199-205

  Wu, Jie ^a   Shimizu, Wataru ^b   Ding, Wei Guang ^c   Ohno, Seiko ^d   Toyoda, Futoshi ^c   Itoh, Hideki ^c   Zang, Wei Jin ^a   Miyamoto, Yoshihiro ^b   Kamakura, Shiro ^b   Matsuura, Hiroshi ^c   Nademanee, Koonlawee ^e   Brugada, Josep ^f   Brugada, Pedro ^g   Brugada, Ramon ^h   Vatta, Matteo ⁱ   Towbin, Jeffrey A ⁱ   Antzelevitch, Charles ^j   Horie, Minoru ^c  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF BARCELONA   (Spain)

^g UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^h UNIVERSITY OF GIRONA   (Spain)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j MASONIC MEDICAL RESEARCH LABORATORY   (United States)

more..

Author keywords

Cardiac arrhythmia; I57T variation; KCNE2; Kv4.3; M54T variation; Sudden cardiac death

Indexed keywords

POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNE2; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL KV4.3;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENETIC VARIABILITY; HEART ARRHYTHMIA; HUMAN; HUMAN TISSUE; NONHUMAN; PATCH CLAMP; PATHOGENESIS; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; WILD TYPE;

ARRHYTHMIAS, CARDIAC; CELLS, CULTURED; CLONING, MOLECULAR; DEATH, SUDDEN, CARDIAC; ELECTROPHYSIOLOGY; GENETIC VECTORS; HEART CONDUCTION SYSTEM; HUMANS; KINETICS; KV CHANNEL-INTERACTING PROTEINS; MEMBRANE POTENTIALS; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; SHAL POTASSIUM CHANNELS; TRANSFECTION;

EID: 74449089865     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.10.012     Document Type: Article

References (32)

1. Kass R.S., and Freeman L.C. Potassium channels in the heart: cellular, molecular, and clinical implications. Trends Cardiovasc Med 3 (1993) 149-159
2. MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 350 (1991) 232-235
3. Abbott G.W., and Goldstein S.A. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys 31 (1998) 357-398
4. Ks cardiac potassium current. Nature 384 (1996) 78-80
5. Ks potassium channel. Nature 384 (1996) 80-83
6. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97 (1999) 175-187
7. Sesti F., Abbott G.W., Wei J., et al. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci U S A 97 (2000) 10613-10618
8. Tinel N., Diochot S., Borsotto M., Lazdunski M., and Barhanin J. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19 (2000) 6326-6330
9. Ks) current amplitude in the heart. Heart Rhythm 3 (2006) 1469-1480
10. Toyoda F., Ueyama H., Ding W.G., and Matsuura H. Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2. Biochem Biophys Res Commun 344 (2006) 814-820
11. Yu H., Wu J., Potapova I., et al. MinK-related peptide 1: a beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res 88 (2001) E84-E87
12. McCrossan Z.A., Roepke T.K., Lewis A., Panaghie G., and Abbott G.W. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol 228 (2009) 1-14
13. Zhang M., Jiang M., and Tseng G.N. MinK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?. Circ Res 88 (2001) 1012-1019
14. Delpon E., Cordeiro J.M., Nunez L., et al. Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol 1 (2008) 209-218
15. to,f. FASEB J 22 (2008) 3648-3660
16. Calloe K., Cordeiro J.M., Di Diego J.M., et al. A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc Res 81 (2009) 686-694
17. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 79 (1996) 659-668
18. Kääb S., Dixon J., Duc J., et al. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98 (1998) 1383-1393
19. Benitah J.P., Gomez A.M., Bailly P., et al. Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. J Physiol 469 (1993) 111-138
20. Singleton C.B., Valenzuela S.M., Walker B.D., et al. Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells. Br J Pharmacol 127 (1999) 941-948
21. Deschênes I., and Tomaselli G.F. Modulation of Kv4.3 current by accessory subunits. FEBS Lett 528 (2002) 183-188
22. o dependence. J Physiol 557 (2004) 705-717
23. An W.F., Bowlby M.R., Betty M., et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403 (2000) 553-556
24. Decher N., Uyguner O., Scherer C.R., et al. hKChIP2b is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2b splice variant. Cardiovasc Res 52 (2001) 255-264
25. to by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res 1 (2006) 695-703
26. to?. Circulation 106 (2002) 423-429
27. Radicke R., Vaquero M., Caballero R., et al. Effects of MiRP1 and DPP6 β-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels. Br J Pharmacol 154 (2008) 774-786
28. Wettwer E., Amos G.J., Posival H., and Ravens U. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75 (1994) 473-482
29. to," phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569 (2005) 7-39
30. Antzelevitch C. Brugada syndrome. Pacing Clin Electrophysiol 29 (2006) 1130-1159
31. + channel mutation causing both long-QT and Brugada syndromes. Circ Res 85 (1999) 1206-1213
32. Van den Berg M.P., Wilde A.A., Viersma T.J.W., et al. Possible bradycardic mode of death and successful pacemaker treatment in a large family with features of long QT syndrome type 3 and Brugada syndrome. J Cardiovasc Electrophysiol 12 (2001) 630-636