Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2

Biochemical and Biophysical Research Communications

Volumn 344, Issue 3, 2006, Pages 814-820

  Toyoda, Futoshi ^a   Ueyama, Hisao ^a   Ding, Wei Guang ^a   Matsuura, Hiroshi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Heart; IKs; K+ channel; KCNE1; KCNE2; KCNQ1; Long QT syndrome; Mefenamic acid; Patch clamp

Indexed keywords

KCNE1 PROTEIN; KCNE2 PROTEIN; MEFENAMIC ACID; POTASSIUM CHANNEL KCNQ1; PROTEIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN COS7; DEPOLARIZATION; FEMALE; KINETICS; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; POTASSIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 33646127798     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.03.213     Document Type: Article

References (27)

1. McCrossan Z.A., and Abbott G.W. The MinK-related peptides. Neuropharmacology 47 (2004) 787-821
2. Ks cardiac potassium current. Nature 384 (1996) 78-80
3. Ks potassium channel. Nature 384 (1996) 80-83
4. Splawski I., Shen J., Timothy K.W., Lehmann M.H., Priori S., Robinson J.L., Moss A.J., Schwartz P.J., Towbin J.A., Vincent G.M., and Keating M.T. Spectrum of mutations in long-QT syndrome genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102 (2000) 1178-1185
5. Schroeder B.C., Waldegger S., Fehr S., Bleich M., Warth R., Greger R., and Jentsch T.J. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403 (2000) 196-199
6. Tinel N., Diochot S., Borsotto M., Lazdunski M., and Barhanin J. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 19 (2000) 6326-6330
7. Angelo K., Jespersen T., Grunnet M., Nielsen M.S., Klaerke D.A., and Olesen S.P. KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys. J. 83 (2002) 1997-2006
8. Grunnet M., Jespersen T., Rasmussen H.B., Lijungstrøm T., Jorgensen N.K., Olesen S.P., and Klaerke D.A. KCNE4 is an inhibitory subunit to the KCNQ1 channel. J. Physiol. 542 (2002) 119-130
9. Bendahhou S., Marionneau C., Haurogne K., Larroque M.M., Derand R., Szuts V., Escande D., Demolombe S., and Barhanin J. In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart. Cardiovasc. Res. 67 (2005) 529-538
10. Ks. J. Mol. Cell. Cardiol. 38 (2005) 277-287
11. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97 (1999) 175-187
12. Zhang M., Jiang M., and Tseng G.N. MinK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as β subunit of cardiac transient outward channel?. Circ. Res. 88 (2001) 1012-1019
13. Yu H., Wu J., Potapova I., Wymore R.T., Holmes B., Zuckerman J., Pan Z., Wang H., Shi W., Robinson R.B., El-Maghrabi M.R., Benjamin W., Dixon J., McKinnon D., Cohen I.S., and Wymore R. MinK-related peptide 1: A β subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ. Res. 88 (2001) e84-e87
14. Yang Y., Xia M., Jin Q., Bendahhou S., Shi J., Chen Y., Liang B., Lin J., Liu Y., Liu B., Zhou Q., Zhang D., Wang R., Ma N., Su X., Niu K., Pei Y., Xu W., Chen Z., Wan H., Cui J., Barhanin J., and Chen Y. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am. J. Hum. Genet. 75 (2004) 899-905
15. sK channel. J. Biol. Chem. 273 (1998) 34069-34074
16. Ks pore demonstrates two MinK subunits in each channel complex. Neuron 40 (2003) 15-23
17. Ks channel complex. Br. J. Pharmacol. 122 (1997) 187-189
18. KS channel function induced by an LQT5 mutation and other IsK mutants. EMBO J. 18 (1999) 4137-4148
19. + channel KCNQ1 to cytosolic pH changes and alters its pharmacology and sensitivity to temperature. Pflügers Arch. 441 (2000) 368-378
20. Mazhari R., Nuss H.B., Armoundas A.A., Winslow R.L., and Marbán E. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. J. Clin. Invest. 109 (2002) 1083-1090
21. Melman Y.F., Domènech A., de la Luna S., and McDonald T.V. Structural determinants of KvLQT1 control by the KCNE family of proteins. J. Biol. Chem. 276 (2001) 6439-6444
22. Melman Y.F., Krumerman A., and McDonald T.V. A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. J. Biol. Chem. 277 (2002) 25187-25194
23. Melman Y.F., Um S.Y., Krumerman A., Kagan A., and McDonald T.V. KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron 42 (2004) 927-937
24. Heitzmann D., Grahammer F., von Hahn T., Schmitt-Gräff A., Romeo E., Nitschke R., Gerlach U., Lang H.J., Verrey F., Barhanin J., and Warth R. Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J. Physiol. 561 (2004) 547-557
25. Pourrier M., Zicha S., Ehrlich J., Han W., and Nattel S. Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers. Circ. Res. 93 (2003) 189-191
26. + channel subunits during mouse heart development. Cardiovasc. Res. 52 (2001) 65-75
27. Jiang M., Zhang M., Tang D.G., Clemo H.F., Liu J., Holwitt D., Kasirajan V., Pond A.L., Wettwer E., and Tseng G.N. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Circulation 109 (2004) 1783-1788