Stage-specific expression of the glycine cleavage complex subunits in Leishmania infantum

Molecular and Biochemical Parasitology

Volumn 170, Issue 1, 2010, Pages 17-27

  Müller, Michaela ^a   Papadopoulou, Barbara ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

3 UTR; Glycine cleavage complex (GCC); Glycine inducibility; L. infantum; SIDER2 retroposon; Stage specific gene expression; T protein (GCVT)

Indexed keywords

AMINOMETHYLTRANSFERASE; GLYCINE CLEAVAGE SYSTEM;

3' UNTRANSLATED REGION; AMASTIGOTE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC REGULATION; HEAT STRESS; LEISHMANIA INFANTUM; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTIST LIFE CYCLE STAGE;

ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCINE DECARBOXYLASE COMPLEX; LEISHMANIA INFANTUM; LIFE CYCLE STAGES; MOLECULAR SEQUENCE DATA; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; UNTRANSLATED REGIONS;

LEISHMANIA INFANTUM; PROTOZOA;

EID: 74449084727     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.11.009     Document Type: Article

References (56)

1. Rodriguez-Ezpeleta N., Brinkmann H., Burger G., et al. Toward resolving the eukaryotic tree: the phylogenetic positions of jakobids and cercozoans. Curr Biol 17 (2007) 1420-1425
2. Ivens A.C., Peacock C.S., Worthey E.A., et al. The genome of the kinetoplastid parasite. Leishmania major. Science 309 (2005) 436-442
3. Martinez-Calvillo S., Nguyen D., Stuart K., and Myler P.J. Transcription initiation and termination on Leishmania major chromosome 3. Eukaryot Cell 3 (2004) 506-517
4. Martinez-Calvillo S., Yan S., Nguyen D., Fox M., Stuart K., and Myler P.J. Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol Cell 11 (2003) 1291-1299
5. Agabian N. Trans splicing of nuclear pre-mRNAs. Cell 61 (1990) 1157-1160
6. Clayton C., and Shapira M. Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. Mol Biochem Parasitol 156 (2007) 93-101
7. Haile S., and Papadopoulou B. Developmental regulation of gene expression in trypanosomatid parasitic protozoa. Curr Opin Microbiol 10 (2007) 569-577
8. Bringaud F., Muller M., Cerqueira G.C., et al. Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. PLoS Pathog 3 (2007) 1291-1307
9. Smith M., Bringaud F., and Papadopoulou B. Organization and evolution of two SIDER retroposon subfamilies and their impact on the Leishmania genome. BMC Genomics 10 (2009) 240
10. Boucher N., Wu Y., Dumas C., et al. A common mechanism of stage-regulated gene expression in Leishmania mediated by a conserved 3′-untranslated region element. J Biol Chem 277 (2002) 19511-19520
11. McNicoll F., Muller M., Cloutier S., et al. Distinct 3′-untranslated region elements regulate stage-specific mRNA accumulation and translation in Leishmania. J Biol Chem 280 (2005) 35238-35246
12. Douce R., Bourguignon J., Neuburger M., and Rebeille F. The glycine decarboxylase system: a fascinating complex. Trends Plant Sci 6 (2001) 167-176
13. Kikuchi G., Motokawa Y., Yoshida T., and Hiraga K. Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia. Proc Jpn Acad Ser B Phys Biol Sci 84 (2008) 246-263
14. Gagnon D., Foucher A., Girard I., and Ouellette M. Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Mol Biochem Parasitol 150 (2006) 63-71
15. Scott D.A., Hickerson S.M., Vickers T.J., and Beverley S.M. The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major. J Biol Chem 283 (2008) 155-165
16. Capelluto D.G., Hellman U., Cazzulo J.J., and Cannata J.J. Purification and some properties of serine hydroxymethyltransferase from Trypanosoma cruzi. Eur J Biochem 267 (2000) 712-719
17. Berriman M., Ghedin E., Hertz-Fowler C., et al. The genome of the African trypanosome Trypanosoma brucei. Science 309 (2005) 416-422
18. Salcedo E., Sims P.F., and Hyde J.E. A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum. Trends Parasitol 21 (2005) 406-411
19. Ouellette M., Drummelsmith J., El-Fadili A., Kundig C., Richard D., and Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. Int J Parasitol 32 (2002) 385-398
20. Roy G., Kundig C., Olivier M., Papadopoulou B., and Ouellette M. Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin. Exp Parasitol 97 (2001) 161-168
21. Sereno D., Roy G., Lemesre J.L., Papadopoulou B., and Ouellette M. DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening. Antimicrob Agents Chemother 45 (2001) 1168-1173
22. Rochette A., Raymond F., Ubeda J.M., et al. Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. BMC Genomics 9 (2008) 255
23. Papadopoulou B., Roy G., and Ouellette M. A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO J 11 (1992) 3601-3608
24. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. (1989), Cold Spring Harbor Laboratory Press, New York
25. Feinberg A.P., and Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132 (1983) 6-13
26. Foucher A.L., Papadopoulou B., and Ouellette M. Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum. J Proteome Res 5 (2006) 1741-1750
27. Peacock C.S., Seeger K., Harris D., et al. Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet 39 (2007) 839-847
28. McConville M.J., de Souza D., Saunders E., Likic V.A., and Naderer T. Living in a phagolysosome; metabolism of Leishmania amastigotes. Trends Parasitol 23 (2007) 368-375
29. Opperdoes F.R., and Coombs G.H. Metabolism of Leishmania: proven and predicted. Trends Parasitol 23 (2007) 149-158
30. Rochette A., Raymond F., Corbeil J., Ouellette M., and Papadopoulou B. Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum. Mol Biochem Parasitol 165 (2009) 32-47
31. Rosenzweig D., Smith D., Opperdoes F., Stern S., Olafson R.W., and Zilberstein D. Retooling Leishmania metabolism: from sand fly gut to human macrophage. Faseb J 22 (2008) 590-602
32. Mottram J.C., Frame M.J., Brooks D.R., et al. The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate pReferences. J Biol Chem 272 (1997) 14285-14293
33. Quijada L., Soto M., Alonso C., and Requena J.M. Analysis of post-transcriptional regulation operating on transcription products of the tandemly linked Leishmania infantum hsp70 genes. J Biol Chem 272 (1997) 4493-4499
34. Barak E., Amin-Spector S., Gerliak E., Goyard S., Holland N., and Zilberstein D. Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response. Mol Biochem Parasitol 141 (2005) 99-108
35. Zilberstein D., and Shapira M. The role of pH and temperature in the development of Leishmania parasites. Annu Rev Microbiol 48 (1994) 449-470
36. Gueiros-Filho F.J., and Beverley S.M. Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major. Mol Cell Biol 16 (1996) 5655-5663
37. Piper M.D., Hong S.P., Ball G.E., and Dawes I.W. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. J Biol Chem 275 (2000) 30987-30995
38. Schluter A., Wiesgigl M., Hoyer C., et al. Expression and subcellular localization of cpn60 protein family members in Leishmania donovani. Biochim Biophys Acta 1491 (2000) 65-74
39. Müller M, Padmanabhan PK, Rochette A, et al. Rapid turnover of unstable mRNAs in Leishmania conferred by conserved retroposon sequences in the 3′UTR is initiated by a site-specific endonucleolytic cleavage. PLoS Pathogens, submitted for publication.
40. Besteiro S., Williams R.A., Coombs G.H., and Mottram J.C. Protein turnover and differentiation in Leishmania. Int J Parasitol 37 (2007) 1063-1075
41. Naderer T., and McConville M.J. The Leishmania-macrophage interaction: a metabolic perspective. Cell Microbiol 10 (2008) 301-308
42. Geraldo M.V., Silber A.M., Pereira C.A., and Uliana S.R. Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis. FEMS Microbiol Lett 242 (2005) 275-280
43. Alves C.R., Corte-Real S., Bourguignon S.C., Chaves C.S., and Saraiva E.M. Leishmania amazonensis: early proteinase activities during promastigote-amastigote differentiation in vitro. Exp Parasitol 109 (2005) 38-48
44. Besteiro S., Williams R.A., Morrison L.S., Coombs G.H., and Mottram J.C. Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J Biol Chem 281 (2006) 11384-11396
45. Naderer T., Ellis M.A., Sernee M.F., et al. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc Natl Acad Sci USA 103 (2006) 5502-5507
46. Horn D. Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. BMC Genomics 9 (2008) 2
47. Zhang K., and Rathod P.K. Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science 296 (2002) 545-547
48. Mandal M., Lee M., Barrick J.E., et al. A glycine-dependent riboswitch that uses cooperative binding to control gene expression. Science 306 (2004) 275-279
49. Ghrist A.C., Heil G., and Stauffer G.V. GcvR interacts with GcvA to inhibit activation of the Escherichia coli glycine cleavage operon. Microbiology 147 (2001) 2215-2221
50. Ghrist A.C., and Stauffer G.V. Promoter characterization and constitutive expression of the Escherichia coli gcvR gene. J Bacteriol 180 (1998) 1803-1807
51. Bauwe H., Chu C.C., Kopriva S., and Nan Q. Structure and expression analysis of the gdcsPA and gdcsPB genes encoding two P-isoproteins of the glycine-cleavage system from Flaveria pringlei. Eur J Biochem 234 (1995) 116-124
52. Kopriva S., Cossu R., and Bauwe H. Alternative splicing results in two different transcripts for H-protein of the glycine cleavage system in the C4 species Flaveria trinervia. Plant J 8 (1995) 435-441
53. Hong P.C., Tsolis R.M., and Ficht T.A. Identification of genes required for chronic persistence of Brucella abortus in mice. Infect Immun 68 (2000) 4102-4107
54. Vereecke D., Cornelis K., Temmerman W., Holsters M., and Goethals K. Versatile persistence pathways for pathogens of animals and plants. Trends Microbiol 10 (2002) 485-488
55. Vogel J. A rough guide to the non-coding RNA world of Salmonella. Mol Microbiol 71 (2009) 1-11
56. Papadopoulou B., Roy G., and Ouellette M. Autonomous replication of bacterial DNA plasmid oligomers in Leishmania. Mol Biochem Parasitol 65 (1994) 39-49