메뉴 건너뛰기




Volumn 22, Issue 2, 2008, Pages 590-602

Retooling Leishmania metabolism: From sand fly gut to human macrophage

Author keywords

Gene expression; Intracellular differentiation; Metabolomics; Proteomics

Indexed keywords

ARTICLE; BUNYAVIRUS; CATABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DOWN REGULATION; ENERGY RESOURCE; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLYCOLYSIS; LEISHMANIA; MACROPHAGE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; UPREGULATION;

EID: 38949167477     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-9254com     Document Type: Article
Times cited : (229)

References (36)
  • 1
    • 33846259286 scopus 로고    scopus 로고
    • Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation
    • Saxena, A., Lahav T, Holland, N., Anupama, A., Huang, G., Volpin, H., Myler, P. J., and Zilberstein, D. (2007) Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation. Mol. Biochem.Parasitol. 152, 53-65
    • (2007) Mol. Biochem.Parasitol , vol.152 , pp. 53-65
    • Saxena, A.1    Lahav, T.2    Holland, N.3    Anupama, A.4    Huang, G.5    Volpin, H.6    Myler, P.J.7    Zilberstein, D.8
  • 2
    • 4243071596 scopus 로고    scopus 로고
    • The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
    • Bozdech, Z., Llinas, M., Pulliam, B. L., Wong, E. D., Zhu, J., and DeRisi, J. L. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 1, E5
    • (2003) PLoS Biol , vol.1
    • Bozdech, Z.1    Llinas, M.2    Pulliam, B.L.3    Wong, E.D.4    Zhu, J.5    DeRisi, J.L.6
  • 5
    • 16244392801 scopus 로고    scopus 로고
    • Differentiation of Leishmania donovani in host-free system: Analysis of signal perception and response
    • Barak, E., Amin-Spector, S., Gerliak, E., Goyard, S., Holland, N., and Zilberstein, D. (2005) Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response. Mol. Biochem. Parasitol. 141, 99-108
    • (2005) Mol. Biochem. Parasitol , vol.141 , pp. 99-108
    • Barak, E.1    Amin-Spector, S.2    Gerliak, E.3    Goyard, S.4    Holland, N.5    Zilberstein, D.6
  • 6
    • 1242294372 scopus 로고    scopus 로고
    • Generation of Leishmania donovani axenic amastigotes: Their growth and biological characteristics
    • Debrabant, A., Joshi, M. B., Pimenta, P. F., and Dwyer, D. M. (2004) Generation of Leishmania donovani axenic amastigotes: their growth and biological characteristics. Int. J. Parasitol. 34, 205-217
    • (2004) Int. J. Parasitol , vol.34 , pp. 205-217
    • Debrabant, A.1    Joshi, M.B.2    Pimenta, P.F.3    Dwyer, D.M.4
  • 7
    • 33644828887 scopus 로고    scopus 로고
    • Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicana
    • Holzer, T. R., McMaster, W. R., and Forney, J. D. (2006) Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicana. Mol. Biochem. Parasitol. 146, 198-218
    • (2006) Mol. Biochem. Parasitol , vol.146 , pp. 198-218
    • Holzer, T.R.1    McMaster, W.R.2    Forney, J.D.3
  • 8
    • 33947221526 scopus 로고    scopus 로고
    • Metabolism of Leishmania: Proven and predicted
    • Opperdoes, F. R., and Coombs, G. H. (2007) Metabolism of Leishmania: proven and predicted. Trends Parasitol.
    • (2007) Trends Parasitol
    • Opperdoes, F.R.1    Coombs, G.H.2
  • 10
    • 0030014943 scopus 로고    scopus 로고
    • Identification and overexpression of the A2 amastigote-specific protein in Leishmania donovani
    • Zhang, W. W., Charest, H., Ghedin, E., Matlashewski, G. (1996) Identification and overexpression of the A2 amastigote-specific protein in Leishmania donovani. Mol. Biochem. Parasitol. 78, 79 -90
    • (1996) Mol. Biochem. Parasitol , vol.78 , pp. 79-90
    • Zhang, W.W.1    Charest, H.2    Ghedin, E.3    Matlashewski, G.4
  • 11
    • 0027401389 scopus 로고
    • Characterization of developmentally-regulated nucleases in promastigotes and amastigotes of Leishmania mexicana
    • Bates, P. A. (1993) Characterization of developmentally-regulated nucleases in promastigotes and amastigotes of Leishmania mexicana. FEMS Microbiol. Lett. 107, 53-58
    • (1993) FEMS Microbiol. Lett , vol.107 , pp. 53-58
    • Bates, P.A.1
  • 12
    • 0028958754 scopus 로고
    • A member of the ClpB family of stress proteins is expressed during heat shock in Leishmania spp
    • Hubel, A., Brandau, S., Dresel, A., and Clos, J. (1995) A member of the ClpB family of stress proteins is expressed during heat shock in Leishmania spp. Mol. Biochem. Parasitol. 70, 107-118
    • (1995) Mol. Biochem. Parasitol , vol.70 , pp. 107-118
    • Hubel, A.1    Brandau, S.2    Dresel, A.3    Clos, J.4
  • 13
    • 0032080107 scopus 로고    scopus 로고
    • A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host
    • Wiese, M. (1998) A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host. EMBO J. 17, 2619-2628
    • (1998) EMBO J , vol.17 , pp. 2619-2628
    • Wiese, M.1
  • 14
    • 33645847251 scopus 로고    scopus 로고
    • Identification of developmentally- regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes
    • Walker, J., Vasquez, J. J., Gomez, M. A., Drummelsmith, J., Burchmore, R., Girard, I., and Ouellette, M. (2006) Identification of developmentally- regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes. Mol. Biochem. Parasitol. 147, 64-73
    • (2006) Mol. Biochem. Parasitol , vol.147 , pp. 64-73
    • Walker, J.1    Vasquez, J.J.2    Gomez, M.A.3    Drummelsmith, J.4    Burchmore, R.5    Girard, I.6    Ouellette, M.7
  • 17
    • 2342467942 scopus 로고    scopus 로고
    • Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major
    • Akopyants, N. S., Matlib, R. S., Bukanova, E. N., Smeds, M. R., Brownstein, B. H., Stormo, G. D., and Beverley, S. M. (2004) Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major. Mol. Biochem. Parasitol. 136, 71-86
    • (2004) Mol. Biochem. Parasitol , vol.136 , pp. 71-86
    • Akopyants, N.S.1    Matlib, R.S.2    Bukanova, E.N.3    Smeds, M.R.4    Brownstein, B.H.5    Stormo, G.D.6    Beverley, S.M.7
  • 19
    • 33749325014 scopus 로고    scopus 로고
    • A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes
    • Huynh, C., Sacks, D. L., and Andrews, N. W. (2006) A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. J. Exp. Med. 203, 2363-2375
    • (2006) J. Exp. Med , vol.203 , pp. 2363-2375
    • Huynh, C.1    Sacks, D.L.2    Andrews, N.W.3
  • 20
    • 0037090528 scopus 로고    scopus 로고
    • Life without transcriptional control? From fly to man and back again
    • Clayton, C. E. (2002) Life without transcriptional control? From fly to man and back again. EMBO J. 21, 1881-1888
    • (2002) EMBO J , vol.21 , pp. 1881-1888
    • Clayton, C.E.1
  • 21
    • 33744965065 scopus 로고    scopus 로고
    • Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major
    • Besteiro, S., Williams, R. A., Morrison, L. S., Coombs, G. H., and Mottram, J. C. (2006) Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J. Biol. Chem. 281, 11384-11392
    • (2006) J. Biol. Chem , vol.281 , pp. 11384-11392
    • Besteiro, S.1    Williams, R.A.2    Morrison, L.S.3    Coombs, G.H.4    Mottram, J.C.5
  • 22
    • 33748364356 scopus 로고    scopus 로고
    • High-coverage quantitative proteomics using amine-specific isotopic labeling
    • Melanson, J. E., Avery, S. L., and Pinto, D. M. (2006) High-coverage quantitative proteomics using amine-specific isotopic labeling. Proteomics 6, 4466-4474
    • (2006) Proteomics , vol.6 , pp. 4466-4474
    • Melanson, J.E.1    Avery, S.L.2    Pinto, D.M.3
  • 24
    • 0022373073 scopus 로고
    • Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate
    • Van Schaftingen, E., Opperdoes, F. R., and Hers, H. G. (1985) Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate. Eur. J. Biochem. 153, 403-406
    • (1985) Eur. J. Biochem , vol.153 , pp. 403-406
    • Van Schaftingen, E.1    Opperdoes, F.R.2    Hers, H.G.3
  • 25
    • 0020353207 scopus 로고
    • Leishmania mexicana: Energy metabolism of amastigotes and promastigotes
    • Hart, D. T., and Coombs, G. H. (1982) Leishmania mexicana: energy metabolism of amastigotes and promastigotes. Exp. Parasitol. 54, 397-409
    • (1982) Exp. Parasitol , vol.54 , pp. 397-409
    • Hart, D.T.1    Coombs, G.H.2
  • 26
    • 0017738601 scopus 로고
    • A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry, J. D., Mannaerts, G. P., and Foster, D. W. (1977) A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60, 265-270
    • (1977) J. Clin. Invest , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 28
    • 1842337450 scopus 로고    scopus 로고
    • Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite
    • Hubel, A., Krobitsch, S., Horauf, A., and Clos, J. (1997) Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite. Mol. Cell. Biol. 17, 5987-5995
    • (1997) Mol. Cell. Biol , vol.17 , pp. 5987-5995
    • Hubel, A.1    Krobitsch, S.2    Horauf, A.3    Clos, J.4
  • 29
    • 22244437571 scopus 로고    scopus 로고
    • Ivens, A. C, Peacock, C. S, Worthey, E. A, Murphy, L, Aggarwal, G, Berriman, M, Sisk, E, Rajandream, M. A, Adlem, E, Aert, R, Anupama, A, Apostolou, Z, Attipoe, P, Bason, N, Bauser, C, Beck, A, Beverley, S. M, Bianchettin, G, Borzym, K, Bothe, G, Bruschi, C. V, Collins, M, Cadag, E, Ciarloni, L, Clayton, C, Coulson, R. M, Cronin, A, Cruz, A. K, Davies, R. M, De, G. J, Dobson, D. E, Duesterhoeft, A, Fazelina, G, Fosker, N, Frasch, A. C, Fraser, A, Fuchs, M, Gabel, C, Goble, A, Goffeau, A, Harris, D, Hertz-Fowler, C, Hilbert, H, Horn, D, Huang, Y, Klages, S, Knights, A, Kube, M, Larke, N, Litvin, L, Lord, A, Louie, T, Marra, M, Masuy, D, Matthews, K, Michaeli, S, Mottram, J. C, Muller-Auer, S, Munden, H, Nelson, S, Norbertczak, H, Oliver, K, O'Neil, S, Pentony, M, Pohl, T. M, Price, C, Purnelle, B, Quail, M. A, Rabbinowitsch, E, Reinhardt, R, Rieger, M, Rinta, J, Robben, J, Robertson, L, Ruiz, J. C, Rutter, S, Sa
    • Ivens, A. C., Peacock, C. S., Worthey, E. A., Murphy, L., Aggarwal, G., Berriman, M., Sisk, E., Rajandream, M. A., Adlem, E., Aert, R., Anupama, A., Apostolou, Z., Attipoe, P., Bason, N., Bauser, C., Beck, A., Beverley, S. M., Bianchettin, G., Borzym, K., Bothe, G., Bruschi, C. V., Collins, M., Cadag, E., Ciarloni, L., Clayton, C., Coulson, R. M., Cronin, A., Cruz, A. K., Davies, R. M., De, G. J., Dobson, D. E., Duesterhoeft, A., Fazelina, G., Fosker, N., Frasch, A. C., Fraser, A., Fuchs, M., Gabel, C., Goble, A., Goffeau, A., Harris, D., Hertz-Fowler, C., Hilbert, H., Horn, D., Huang, Y., Klages, S., Knights, A., Kube, M., Larke, N., Litvin, L., Lord, A., Louie, T., Marra, M., Masuy, D., Matthews, K., Michaeli, S., Mottram, J. C., Muller-Auer, S., Munden, H., Nelson, S., Norbertczak, H., Oliver, K., O'Neil, S., Pentony, M., Pohl, T. M., Price, C., Purnelle, B., Quail, M. A., Rabbinowitsch, E., Reinhardt, R., Rieger, M., Rinta, J., Robben, J., Robertson, L., Ruiz, J. C., Rutter, S., Saunders, D., Schafer, M., Schein, J., Schwartz, D. C., Seeger, K., Seyler, A., Sharp, S., Shin, H., Sivam, D., Squares, R., Squares, S., Tosato, V., Vogt, C., Volckaert, G., Wambutt, R., Warren, T., Wedler, H., Woodward, J., Zhou, S., Zimmermann, W., Smith, D. F., Blackwell, J. M., Stuart, K. D., Barrell, B., and Myler, P. J. (2005) The genome of the kinetoplastid parasite, Leishmania major. Science 309, 436-442
  • 30
    • 33846025784 scopus 로고    scopus 로고
    • Binding of the universal minicircle sequence binding protein at the kinetoplast DNA replication origin
    • Onn, I., Kapeller, I., bu-Elneel, K., and Shlomai, J. (2006) Binding of the universal minicircle sequence binding protein at the kinetoplast DNA replication origin. J. Biol. Chem. 281, 37468-37476
    • (2006) J. Biol. Chem , vol.281 , pp. 37468-37476
    • Onn, I.1    Kapeller, I.2    bu-Elneel, K.3    Shlomai, J.4
  • 31
    • 0021986626 scopus 로고
    • Leishmania mexicana: Enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals
    • Mottram, J. C., and Coombs, G. H. (1985) Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. Exp. Parasitol. 59, 151-160
    • (1985) Exp. Parasitol , vol.59 , pp. 151-160
    • Mottram, J.C.1    Coombs, G.H.2
  • 32
    • 0021779287 scopus 로고
    • Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana
    • Hassan, H. F., Mottram, J. C., and Coombs, G. H. (1985) Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana. Comp. Biochem. Physiol. B. 81, 1037-1040
    • (1985) Comp. Biochem. Physiol. B , vol.81 , pp. 1037-1040
    • Hassan, H.F.1    Mottram, J.C.2    Coombs, G.H.3
  • 33
    • 0020103971 scopus 로고
    • A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations
    • Coombs, G. H., Craft, J. A., and Hart, D. T. (1982) A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations. Mol. Biochem. Parasitol. 5, 199-211
    • (1982) Mol. Biochem. Parasitol , vol.5 , pp. 199-211
    • Coombs, G.H.1    Craft, J.A.2    Hart, D.T.3
  • 34
    • 0021869320 scopus 로고
    • Enhanced metabolism of Leishmania donovani amastigotes at acid pH: An adaptation for intracellular growth
    • Mukkada, A. J., Meade, J. C., Glaser, T. A., Bonventre, P. F. (1985) Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth. Science 229, 1099-1101
    • (1985) Science , vol.229 , pp. 1099-1101
    • Mukkada, A.J.1    Meade, J.C.2    Glaser, T.A.3    Bonventre, P.F.4
  • 35
    • 0030893919 scopus 로고    scopus 로고
    • Carbohydrate digestion in sandflies: Alpha-glucosidase activity in the midgut of Phlebotomus langeroni
    • Dillon, R. J., and el-Kordy, E. (1997) Carbohydrate digestion in sandflies: alpha-glucosidase activity in the midgut of Phlebotomus langeroni. Comp. Biochem.Physiol. B Biochem. Mol. Biol. 116, 35-40
    • (1997) Comp. Biochem.Physiol. B Biochem. Mol. Biol , vol.116 , pp. 35-40
    • Dillon, R.J.1    el-Kordy, E.2
  • 36
    • 0016192910 scopus 로고
    • Delayed in vitro utilization of glucose by Leishmania tropica promastigotes
    • Mukkada, A. J., Schaefer, F. W. I., Simon, M. W., and Neu, C. (1974) Delayed in vitro utilization of glucose by Leishmania tropica promastigotes. J. Protozool. 21, 393-397
    • (1974) J. Protozool , vol.21 , pp. 393-397
    • Mukkada, A.J.1    Schaefer, F.W.I.2    Simon, M.W.3    Neu, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.