GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei

Biochemical Journal

Volumn 425, Issue 3, 2010, Pages 603-614

  Denton, Helen ^a   Fyffe, Stewart ^a   Smith, Terry K ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Essentiality; Glycosylphosphatidylinositol; Guanidine diphosphomannose pyrophosphorylase; N glycosylation; Trypanosoma brucei; Variant surface glycoprotein

Indexed keywords

CELL SURFACES; CYTOSOLIC; GLYCOSYLPHOSPHATIDYLINOSITOL; KINETIC ANALYSIS; KINETIC STUDY; MRNA LEVEL; N-GLYCANS; N-GLYCOSYLATION; POTENTIAL DRUG; RNA INTERFERENCE; TRYPANOSOMA BRUCEI; VARIANT SURFACE GLYCOPROTEINS; WILD-TYPE LEVELS;

ESTERIFICATION; GLYCOPROTEINS; RNA;

GLYCOSYLATION;

ASPARAGINE; CELL SURFACE PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; GLYCOSYLTRANSFERASE; GUANIDINE DIPHOSPHOMANNOSE PYROPHOSPHORYLASE; GUANOSINE DIPHOSPHATE MANNOSE; GUANOSINE TRIPHOSPHATE; MANNOSE PHOSPHATE; MESSENGER RNA; PROTOZOAL RNA; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; VARIANT SURFACE GLYCOPROTEIN;

ARTICLE; CELL DEATH; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN GLYCOSYLATION; PROTOZOAL GENETICS; RNA INTERFERENCE; TRYPANOSOMA BRUCEI; WILD TYPE;

ANIMALS; CATALYSIS; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; GLYCOSYLATION; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; PHENOTYPE; RECOMBINANT PROTEINS; RNA INTERFERENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

TRYPANOSOMA BRUCEI;

EID: 74349118194     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090896     Document Type: Article

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