Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 381, Issue 1, 2010, Pages 41-57

  Łabuzek, Krzysztof ^a   Liber, Sebastian ^a   Gabryel, Bozena ^a   Bułdak, Łukasz ^a   Okopień, Bogusław ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

AMPK; Compound C; Dorsomorphin; Inflammation; Interleukin; Microglia

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 6 [4 (2 PIPERIDIN 1 YLETHOXY)PHENYL)] 3 PYRIDIN 4 YLPYRAZOLO[1,5 A]PYRIMIDINE; ADENYLATE KINASE; ARGINASE 1; CYTOKINE; DORSOMORPHIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE; PROTEIN P35; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MICROGLIA; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICROGLIA; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR;

EID: 74349114431     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0472-2     Document Type: Article

References (39)

1. R Bergeron JM Ren KS Cadman IK Moore P Perret M Pypaert LH Young CF Semenkovich GI Shulman 2001 Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis Am J Physiol Endocrinol Metab 281 1340 1346
2. MM Bradford 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding Anal Biochem 72 248 251 10.1016/0003-2697(76)90527-3 1:CAS:528: DyaE28XksVehtrY%3D 942051
3. CA Colton RT Mott H Sharpe Q Xu WE Van Nostrand MP Vitek 2006 Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD J Neuroinflammation 3 27 10.1186/1742-2094-3-27 17005052 (Pubitemid 44575752)
4. B D'Autréaux MB Toledano 2007 ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Nat Rev Mol Cell Biol 8 813 824 10.1038/nrm2256 17848967 (Pubitemid 47462134)
5. SP Davies DG Carling DG Hardie 1989 Tissue distribution of the AMP-activated protein kinase and lack of activation by cyclic-AMP-dependent protein kinase studied using a specific and sensitive peptide assay Eur J Biochem 186 123 128 10.1111/j.1432-1033.1989.tb15185.x 1:CAS:528: DyaK3cXhtlCrurw%3D 2574667 (Pubitemid 20015134)
6. S Dröse PJ Hanley U Brandt 2009 Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III Biochim Biophys Acta 1790 558 565 19364480
7. JP Edwards X Zhang KA Frauwirth DM Mosser 2006 Biochemical and functional characterization of three activated macrophage populations J Leukoc Biol 80 1298 1307 10.1189/jlb.0406249 1:CAS:528:DC%2BD28XhtlSisLnI 16905575 (Pubitemid 44904968)
8. BM Emerling B Viollet KV Tormos NS Chandel 2007 Compound C inhibits hypoxic activation of HIF-1 independent of AMPK FEBS Lett 581 5727 5731 10.1016/j.febslet.2007.11.038 1:CAS:528:DC%2BD2sXhtlykt7nI 18036344 (Pubitemid 350179784)
9. ME Fraley RS Rubino WF Hoffman SR Hambaugh KL Arrington RW Hungate MT Bilodeau AJ Tebben RZ Rutledge RL Kendall RC McFall WR Huckle KE Coll KA Thomas 2002 Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics Bioorg Med Chem Lett 12 3537 3541 10.1016/S0960-894X(02)00827-2 1:CAS:528:DC%2BD38XoslyrsL8%3D 12443771 (Pubitemid 35346484)
10. PJ Gebicke-Haerter J Bauer A Schobert H Northoff 1989 Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells J Neurosci 9 183 194 1:CAS:528: DyaL1MXhslWmurY%3D 2643682
11. S Giri N Nath B Smith B Viollet AK Singh I Singh 2004 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase J Neurosci 24 479 487 10.1523/JNEUROSCI.4288-03.2004 1:CAS:528: DC%2BD2cXpvVyjsA%3D%3D 14724246 (Pubitemid 38112379)
12. UK Hanisch H Kettenmann 2007 Microglia: active sensor and versatile effectors cells in the normal and pathologic brain Nat Neurosci 10 1387 1394 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE 17965659 (Pubitemid 350014685)
13. JH Hong GT Lee JH Lee SJ Kwon SH Park SJ Kim IY Kim 2009 Effect of bone morphogenetic protein-6 on macrophages Immunology 128 e442 450 10.1111/j.1365-2567.2008.02998.x 19191909
14. S Jimenez D Baglietto-Vargas C Caballero I Moreno-Gonzalez M Torres R Sanchez-Varo D Ruano M Vizuete A Gutierrez J Vitorica 2008 Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic J Neurosci 28 11650 11661 10.1523/JNEUROSCI.3024-08.2008 1:CAS:528: DC%2BD1cXhtlOgt7%2FK 18987201
15. J Kim MY Yoon SL Choi I Kang SS Kim YS Kim YK Choi J Ha 2001 Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway J Biol Chem 276 19102 19110 10.1074/jbc.M011579200 1:CAS:528: DC%2BD3MXkt12rsrg%3D 11262401
16. JH Kim HJ Na CK Kim JY Kim KS Ha H Lee HT Chung HJ Kwon YG Kwon YM Kim 2008 The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation Free Radic Biol Med 5 885 896 10.1016/j.freeradbiomed.2008. 06.019
17. K Labuzek J Kowalski B Gabryel ZS Herman 2005 Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures Eur Neuropsychopharmacol 15 23 30 10.1016/j.euroneuro. 2004.04.002 1:CAS:528:DC%2BD2cXhtVantb7O 15572270 (Pubitemid 39574396)
18. HW Lin SW Levison 2009 Context-dependent IL-6 potentiation of interferon-gamma-induced IL-12 secretion and CD40 expression in murine microglia J Neurochem 111 808 818 10.1111/j.1471-4159.2009.06366.x 1:CAS:528: DC%2BD1MXhtlOqtb7P 19712053
19. LD McCullough Z Zeng H Li LE Landree J McFadden GV Ronnett 2005 Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke J Biol Chem 280 20493 20502 10.1074/jbc.M409985200 1:CAS:528:DC%2BD2MXktlClsro%3D 15772080 (Pubitemid 40776749)
20. R Medeiros RD Prediger GF Passos P Pandolfo FS Duarte JL Franco AL Dafre G Di Giunta CP Figueiredo RN Takahashi MM Campos JB Calixto 2007 Connecting TNF alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein J Neurosci 27 5394 5404 10.1523/JNEUROSCI.5047-06.2007 1:CAS:528:DC%2BD2sXlvFGhsrg%3D 17507561 (Pubitemid 46790177)
21. T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 55 63 10.1016/0022-1759(83)90303-4 1:STN:280:DyaL2c%2FovFSmtw%3D%3D 6606682
22. M Nam WH Lee EJ Bae SG Kim 2008 Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition Arch Biochem Biophys 479 74 81 10.1016/j.abb.2008.07.029 1:CAS:528:DC%2BD1cXht1Knur7M 18721791
23. YT Oh JY Lee H Yoon EH Lee HH Baik SS Kim J Ha KS Yoon W Choe I Kang 2008 Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells Neurosci Lett 431 155 160 10.1016/j.neulet.2007.11.033 1:CAS:528:DC%2BD1cXosVOlug%3D%3D 18164813
24. H Pyo I Jou S Jung S Hong EH Joe 1998 Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia Neuroreport 9 871 874 10.1097/00001756-199803300-00020 1:CAS:528: DyaK1cXisVGiu7k%3D 9579682
25. F Re SL Belyanskaya RJ Riese B Cipriani FR Fischer F Granucci P Ricciardi-Castagnoli C Brosnan LJ Stern JL Strominger L Santambrogio 2002 Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation J Immunol 169 2264 2273 1:CAS:528:DC%2BD38XmsF2gt7Y%3D 12193691
26. J Satoh SU Kim 1995 Ganglioside markers GD3, GD2, and A2B5 in fetal human neurons and glial cells in culture Dev Neurosci 17 137 148 10.1159/000111282 1:CAS:528:DyaK2MXptFWqtr8%3D 8549425
27. QS Si Y Nakamura P Schubert K Rudolphi K Kataoka 1996 Adenosine and propentofylline inhibit the proliferation of cultured microglial cells Exp Neurol 137 345 349 10.1006/exnr.1996.0035 1:CAS:528:DyaK28XitVyjs7s%3D 8635550 (Pubitemid 26081893)
28. J Sonoda J Laganière IR Mehl GD Barish LW Chong X Li IE Scheffler DC Mock AR Bataille F Robert CH Lee V Giguère RM Evans 2007 Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense Genes Dev 21 1909 1920 10.1101/gad.1553007 1:CAS:528: DC%2BD2sXps1alsrs%3D 17671090 (Pubitemid 47204930)
29. T Sonoki A Nagasaki T Gotoh M Takiguchi M Takeya H Matsuzaki M Mori 1997 Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide J Biol Chem 272 3689 3693 10.1074/jbc.272.6.3689 1:CAS:528:DyaK2sXhtFCjs70%3D 9013624 (Pubitemid 27066877)
30. DI Stott 1989 Immunoblotting and dot blotting J Immunol Methods 119 153 187 10.1016/0022-1759(89)90394-3 1:STN:280:DyaL1M3ls1OisQ%3D%3D 2656867 (Pubitemid 19132273)
31. 2+ in T lymphocytes J Exp Med 203 1665 1670 10.1084/jem.20052469 16818670 (Pubitemid 44036271)
32. H Towbin T Staehelin J Gordon 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci U S A 76 4350 4354 10.1073/pnas.76.9.4350 1:CAS:528:DyaE1MXmtVKltLw%3D 388439
33. MC Towler DG Hardie 2007 AMP-activated protein kinase in metabolic control and insulin signaling Circ Res 100 328 341 10.1161/01.RES.0000256090. 42690.05 1:CAS:528:DC%2BD2sXhsF2kur0%3D 17307971 (Pubitemid 46272405)
34. JM Tusell A Ejarque-Ortiz P Mancera C Solà J Saura J Serratosa 2009 Upregulation of p21Cip1 in activated glial cells Glia 57 524 534 10.1002/glia.20781 18814231
35. D Vats L Mukundan JI Odegaard L Zhang KL Smith CR Morel RA Wagner DR Greaves PJ Murray A Chawla 2006 Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation Cell Metab 4 13 24 10.1016/j.cmet.2006.05.011 1:CAS:528:DC%2BD28XmvFyiu7g%3D 16814729 (Pubitemid 43942258)
36. Z Xie M Wei TE Morgan P Fabrizio D Han CE Finch VD Longo 2002 Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia J Neurosci 22 3484 3492 1:CAS:528:DC%2BD38Xjs1SgsrY%3D 11978825
37. PB Yu CC Hong C Sachidanandan JL Babitt DY Deng SA Hoyng HY Lin KD Bloch RT Peterson 2008a Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism Nat Chem Biol 4 33 41 10.1038/nchembio.2007.54 1:CAS:528:DC%2BD2sXhsVegtbnF (Pubitemid 350273653)
38. PB Yu DY Deng CS Lai CC Hong GD Cuny ML Bouxsein DW Hong PM McManus T Katagiri C Sachidanandan N Kamiya T Fukuda Y Mishina RT Peterson KD Bloch 2008b BMP type I receptor inhibition reduces heterotopic [corrected] ossification Nat Med 14 1363 1369 10.1038/nm.1888 1:CAS:528:DC%2BD1cXhsVWhu7nM
39. G Zhou R Myers Y Li Y Chen X Shen J Fenyk-Melody M Wu J Ventre T Doebber N Fujii N Musi MF Hirshman LJ Goodyear DE Moller 2001 Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 1167 1174 1:CAS:528:DC%2BD3MXns1ChsL4%3D 11602624