Chlorpromazine and loxapine reduce interleukin-1β and interleukin-2 release by rat mixed glial and microglial cell cultures

European Neuropsychopharmacology

Volumn 15, Issue 1, 2005, Pages 23-30

  Labuzek, Krzysztof ^a   Kowalski, Jan ^a   Gabryel, Bozena ^a   Herman, Zbigniew S ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Antipsychotics; Glia; Interleukin 1 ; Interleukin 2; Microglia; Rat

Indexed keywords

CHLORPROMAZINE; INTERLEUKIN 1BETA; INTERLEUKIN 2; LEUCINE METHYL ESTER; LOXAPINE; QUINPIROLE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL MODEL; ARTICLE; CATECHOLAMINERGIC SYSTEM; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; GLIA CELL; INCUBATION TIME; MICROGLIA; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTIPSYCHOTIC AGENTS; CELLS, CULTURED; CEREBRAL CORTEX; CHLORPROMAZINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-1; INTERLEUKIN-2; LOXAPINE; NEUROGLIA; QUINPIROLE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 9644303364     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2004.04.002     Document Type: Article

References (27)

1. Alonso R., Chaudieu I., Diorio J., Krishnamurthy A., Quirion R., Boksa P. Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells. J. Neurochem. 61:1993;1284-1290
2. Araujo D.M., Cotman C.W. Differential effects of interleukin-13 and interleukin-2 on glia and hippocampal neurons in culture. Int. J. Dev. Neurosci. 13(3/4):1995;201-212
3. Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function and mechanism of action. Am. J. Phsiol. 263:1992;C1-C16. (Cell Physiol 32)
4. Bertini S., Garattini R., Delgado P., Ghezzi P. Pharmacological activities of chlorpromazine involved in the inhibition of tumor necrosis factor production in vivo in mice. Immunology. 79:1993;217-219
5. Chao C.C., Hu S.X., Close K., Choi C.S., Molitor T.W., Novick W.J., Peterson P.K. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J. Infect. Dis. 166:1992;847-853
6. De Bock F., Dornand J., Rondouin G. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. NeuroReport. 7:1996;1125-1129
7. Fontana A., Constam D., Frei K., Koedel U., Pfister W., Weller M. Cytokines and defense against CNS infection. Ransohoff R.M., Benveniste E.N. Cytokines and the CNS. 1996;187-219 CRC Press, Boca Raton, FL
8. Frei K., Siepl C., Groscurth P., Bodmer S., Schwerdel C., Fontana A. Antigen presentation and tumor cytotoxity by interferon-gamma-treated microglial cells. Eur. J. Immunol. 17:1987;1271-1278
9. Giulian D., Li J., Li X., George J., Rutecki P.A. The impact of microglia-derived cytokines upon gliosis in the CNS. Dev. Neurosci. 16:1994;128-136
10. Hetier E., Ayala J., Denefle P., Bousseau A., Mallat M., Prochiantz A. Brain macrophages synthesize IL-1 and IL-1 mRNAs in vitro. J. Neurosci. Res. 21:1988;391-397
11. Kong L.Y., Lai C., Wilson B.C., Simpson J.N., Hong J.S. Protein tyrosine kinase inhibitors decrease lipopolisaccharide-induced proinflammatory cytokine production in mixed glia, microglia-enriched or astrocyte-enriched cultures. Neurochem. Int. 30:1997;491-497
12. Kowalski J., Blada P., Kucia K., Lawniczek T., Madej A., Belowski D., Herman Z.S. In vitro immunomodulatory effects of haloperidol and perazine in schizophrenia. World J. Biol. Psychiatry. 1:2000;190-196
13. Kowalski J., Blada P., Kucia K., Madej A., Herman Z.S. Neuroleptics normalize increased release of interleukin-1β and tumor necrosis factor-α from monocytes in schizophrenia. Schizophr. Res. 50:2001;169-175
14. Maes M., Meltzer H.Y., Bosmans E. Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine. Acta Psychiatr. Scand. 89:1994;346-351
15. Maes M., Bosmans E., Ranjan R., Vandoolaeghe B., Meltzer H.Y., Ley M., Berghmans R., Stans G., Desnyder R. Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs. Schizophr. Res. 21:1996;39-50
16. McAllister C.G., Rapaport M.H., Pickar D., Paul S.M. Effect of short term administration of antipsychotic drugs on lymphocyte subsets in schizophrenic patients. Arch. Gen. Psychiatry. 46:1989;956-957
17. McAllister C.G., VanKammen D.P., Rehn T.J., Miler A.L., Gurklis J., Kelly M.E., Yao J., Peters J.L. Increases in CSF levels of interleukin 2 in schizophrenia. Effects of recurrence of psychosis and medication status. Am. J. Psychiatry. 152:1995;1291-1297
18. Merill J.E. Tumor necrosis factor alpha, interleukin-1 and related cytokines in brain development: normal and pathological. Dev. Neurosci. 14:1992;1-10
19. Moots R.J., Al-Saffar Z., Hutchinson D., Golding S.P., Young S.P., Bacon P.A., McLaughlin P.J. Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines. Ann. Rheum. Dis. 58:1999;585-587
20. Müller N., Ackenheil M., Hofschuster E., Mempel W., Eckstein R. Cellular immunity in schizophrenic patients before and during neuroleptic therapy. Psychiatry Res. 37:1991;147-160
21. Müller N., Ackenheil M., Hofschuster E., Mempel W., Eckstein R. T-cells and psychopathology in schizophrenia: relationship to the outcome of neuroleptic therapy. Acta Psychiatr. Scand. 87:1993;66-71
22. Müller N., Empl M., Riedel M., Schwartz M., Ackenheil M. Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 247:1997;308-309
23. Saito K., Suyama K., Nishida K., Basile A.S. Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischaemia in gerbil brain. Neurosci. Lett. 206:1996;149-152
24. Tsuneizumi T., Babb S.M., Cohen B.M. Drug distribution between blood and brain as a determinant of antipsychotic drug effects. Biol. Psychiatry. 32:1992;817-824
25. Winek C.L., Wahba W.W., Winek C.L. Jr., Balzer T.W. Drug and chemical blood-level data 2001. Forensic Sci. Int. 122:2001;107-123
26. Zahn J., Moller T., Kettenmann H., Nolte Ch. Microglial phagocytosis is modulated by pro-and anti-inflammatory cytokines. NeuroReport. 8:1997;3851-3856
27. Zalcman S., Green-Johnson J.M., Murray L., Nance D.M., Dyck D., Anisman H., Greenberg A.H. Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res. 643:1994;40-49